Bcar1 (BCAR1 scaffold protein, Cas family member) - Rat Genome Database

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Gene: Bcar1 (BCAR1 scaffold protein, Cas family member) Rattus norvegicus
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Symbol: Bcar1
Name: BCAR1 scaffold protein, Cas family member
RGD ID: 2406
Description: Enables protein domain specific binding activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; cellular response to endothelin; and cellular response to nitric oxide. Located in focal adhesion. Human ortholog(s) of this gene implicated in breast ductal carcinoma. Orthologous to human BCAR1 (BCAR1 scaffold protein, Cas family member); PARTICIPATES IN endothelin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; insulin-like growth factor signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BCAR1, Cas family scaffold protein; BCAR1, Cas family scaffolding protein; breast cancer anti-estrogen resistance 1; breast cancer anti-estrogen resistance protein 1; Cas; CRK-associated substrate; Crkas; P130CAS; v-crk-associated tyrosine kinase substrate
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau8
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81956,588,500 - 56,623,190 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1956,588,500 - 56,623,190 (-)EnsemblGRCr8
mRatBN7.21939,679,215 - 39,713,907 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1939,679,204 - 39,713,907 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1946,538,528 - 46,573,365 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01947,191,851 - 47,226,683 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01949,436,088 - 49,470,662 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01943,932,543 - 43,967,452 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1943,932,554 - 43,955,783 (-)Ensemblrn6Rnor6.0
Rnor_5.01954,739,915 - 54,774,486 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41941,646,190 - 41,669,234 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1939,039,406 - 39,062,496 (-)NCBICelera
RGSC_v3.11941,651,070 - 41,674,115 (-)NCBI
Cytogenetic Map19q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atropine  (ISO)
azathioprine  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
blebbistatin  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clozapine  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyproconazole  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (EXP)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
L-methionine  (ISO)
lovastatin  (EXP)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
mevalonic acid  (EXP)
ML-7  (ISO)
N-Vinyl-2-pyrrolidone  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
nitric oxide  (EXP)
okadaic acid  (ISO)
oxotremorine M  (ISO)
ozone  (EXP)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenethyl caffeate  (ISO)
phenobarbital  (EXP,ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP)
pirinixic acid  (ISO)
potassium chloride  (EXP)
quercetin  (ISO)
reactive oxygen species  (ISO)
retinyl acetate  (ISO)
rotenone  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulindac sulfide  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
tetrahydropalmatine  (ISO)
thiram  (ISO)
triticonazole  (EXP)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin cytoskeleton  (IEA,ISO)
axon  (IEA)
cytoplasm  (IBA,IEA,ISO,ISS)
focal adhesion  (IBA,IDA,IEA,ISO)
lamellipodium  (IEA,ISO)
membrane  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO)
ruffle  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular mapping of tyrosine-phosphorylated proteins in focal adhesions using fluorescence resonance energy transfer. Ballestrem C, etal., J Cell Sci. 2006 Mar 1;119(Pt 5):866-75. Epub 2006 Feb 14.
2. The prognostic value of BCAR1 in patients with primary breast cancer. Dorssers LC, etal., Clin Cancer Res. 2004 Sep 15;10(18 Pt 1):6194-202.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. p130Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase. Harte MT, etal., J Biol Chem. 1996 Jun 7;271(23):13649-55.
5. Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas. Honda H, etal., Nat Genet 1998 Aug;19(4):361-5.
6. Phosphorylation-dependent cleavage of p130cas in apoptotic rat-1 cells. Hoon Kim D, etal., Biochem Biophys Res Commun 2003 Jan 3;300(1):141-8.
7. Differential regulation of cell migration, actin stress fiber organization, and cell transformation by functional domains of Crk-associated substrate. Huang J, etal., J Biol Chem 2002 Jul 26;277(30):27265-72. Epub 2002 May 14.
8. Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting. Ko J, etal., J Neurosci. 2003 Mar 1;23(5):1667-77.
9. Selective involvement of p130Cas/Crk/Pyk2/c-Src in endothelin-1-induced JNK activation. Kodama H, etal., Hypertension. 2003 Jun;41(6):1372-9. Epub 2003 Apr 28.
10. Glucose stimulates the tyrosine phosphorylation of Crk-associated substrate in pancreatic beta-cells. Konrad RJ, etal., J Biol Chem 2003 Jul 25;278(30):28116-22. Epub 2003 May 12.
11. Nitric oxide-induced inhibition of aortic smooth muscle cell motility: role of PTP-PEST and adaptor proteins p130cas and Crk. Lin Y, etal., Am J Physiol Heart Circ Physiol 2003 Aug;285(2):H710-21. Epub 2003 Apr 24.
12. Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas). Liu F, etal., J Biol Chem. 1996 Dec 6;271(49):31290-5.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Molecular basis for regulation of Src by the docking protein p130Cas. Nasertorabi F, etal., J Mol Recognit. 2006 Jan-Feb;19(1):30-8.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Functional roles of BCAR3 in the signaling pathways of insulin leading to DNA synthesis, membrane ruffling and GLUT4 translocation. Oh MJ, etal., Biochem Biophys Res Commun. 2013 Nov 29;441(4):911-6. doi: 10.1016/j.bbrc.2013.10.161. Epub 2013 Nov 9.
17. Epidermal growth factor modulates tyrosine phosphorylation of p130Cas. Involvement of phosphatidylinositol 3'-kinase and actin cytoskeleton. Ojaniemi M and Vuori K, J Biol Chem. 1997 Oct 10;272(41):25993-8.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Nerve growth factor stimulates the tyrosine phosphorylation of endogenous Crk-II and augments its association with p130Cas in PC-12 cells. Ribon V and Saltiel AR, J Biol Chem. 1996 Mar 29;271(13):7375-80.
22. Src-dependent association of Cas and p85 phosphatidylinositol 3'-kinase in v-crk-transformed cells. Riggins RB, etal., Mol Cancer Res 2003 Apr;1(6):428-37.
23. A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. Sakai R, etal., EMBO J 1994 Aug 15;13(16):3748-56.
24. p130cas but not paxillin is essential for Caco-2 intestinal epithelial cell spreading and migration on collagen IV. Sanders MA and Basson MD, J Biol Chem. 2005 Jun 24;280(25):23516-22. Epub 2005 Apr 6.
25. Crk protein binds to PDGF receptor and insulin receptor substrate-1 with different modulating effects on PDGF- and insulin-dependent signaling pathways. Sorokin A, etal., Oncogene. 1998 May 14;16(19):2425-34.
26. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
27. Immunohistochemical study of the BCAR1/p130Cas protein in non-malignant and malignant human breast tissue. van der Flier S, etal., Int J Biol Markers. 2001 Jul-Sep;16(3):172-8.
28. Localized regulation of axonal RanGTPase controls retrograde injury signaling in peripheral nerve. Yudin D, etal., Neuron. 2008 Jul 31;59(2):241-52. doi: 10.1016/j.neuron.2008.05.029.
Additional References at PubMed
PMID:8649368   PMID:9020138   PMID:9038154   PMID:9083073   PMID:9348226   PMID:9360983   PMID:9425168   PMID:9472046   PMID:9832615   PMID:9915838   PMID:10026197   PMID:10587647  
PMID:11146548   PMID:11181827   PMID:11864995   PMID:15272013   PMID:15485652   PMID:15728191   PMID:15795225   PMID:16105984   PMID:16354758   PMID:16861698   PMID:17129785   PMID:17615370  
PMID:17617061   PMID:19086031   PMID:20623582   PMID:21245381  


Genomics

Comparative Map Data
Bcar1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81956,588,500 - 56,623,190 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1956,588,500 - 56,623,190 (-)EnsemblGRCr8
mRatBN7.21939,679,215 - 39,713,907 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1939,679,204 - 39,713,907 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1946,538,528 - 46,573,365 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01947,191,851 - 47,226,683 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01949,436,088 - 49,470,662 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01943,932,543 - 43,967,452 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1943,932,554 - 43,955,783 (-)Ensemblrn6Rnor6.0
Rnor_5.01954,739,915 - 54,774,486 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41941,646,190 - 41,669,234 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1939,039,406 - 39,062,496 (-)NCBICelera
RGSC_v3.11941,651,070 - 41,674,115 (-)NCBI
Cytogenetic Map19q12NCBI
BCAR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381675,228,181 - 75,268,007 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1675,228,181 - 75,268,053 (-)Ensemblhg38GRCh38
GRCh371675,262,079 - 75,301,905 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361673,820,429 - 73,843,004 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341673,820,429 - 73,843,004NCBI
Celera1659,556,476 - 59,596,268 (-)NCBICelera
Cytogenetic Map16q23.1NCBI
HuRef1661,013,718 - 61,052,474 (-)NCBIHuRef
CHM1_11676,675,047 - 76,714,069 (-)NCBICHM1_1
T2T-CHM13v2.01681,274,930 - 81,314,755 (-)NCBIT2T-CHM13v2.0
Bcar1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398112,437,106 - 112,470,481 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8112,437,106 - 112,470,441 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm388111,710,474 - 111,743,849 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8111,710,474 - 111,743,809 (-)Ensemblmm10GRCm38
MGSCv378114,234,374 - 114,267,709 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368114,597,147 - 114,630,482 (-)NCBIMGSCv36mm8
Celera8115,938,849 - 115,972,131 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map857.98NCBI
Bcar1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554842,227,337 - 2,260,565 (+)Ensembl
ChiLan1.0NW_0049554842,223,306 - 2,258,444 (+)NCBIChiLan1.0ChiLan1.0
BCAR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21884,947,203 - 84,987,033 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11690,869,485 - 90,909,393 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01655,798,578 - 55,838,448 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11675,149,280 - 75,186,883 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1675,150,122 - 75,188,775 (-)EnsemblpanPan2panpan1.1
BCAR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1575,463,906 - 75,499,557 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl575,463,926 - 75,512,476 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha575,439,949 - 75,476,374 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0575,819,916 - 75,856,356 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl575,820,630 - 75,856,356 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1575,712,186 - 75,748,588 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0575,547,221 - 75,583,635 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0576,038,420 - 76,074,849 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bcar1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934935,556,294 - 35,594,421 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647523,992,193 - 24,033,031 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647523,994,130 - 24,032,829 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCAR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl612,367,758 - 12,404,818 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1612,369,332 - 12,404,822 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2612,225,439 - 12,247,561 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BCAR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1560,709,409 - 60,749,071 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl560,707,006 - 60,732,882 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604715,305,423 - 15,350,551 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bcar1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474611,660,426 - 11,695,988 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474611,660,859 - 11,695,991 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Bcar1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11731,404,835 - 31,440,000 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bcar1
20 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:47
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000041815, ENSRNOT00000058891
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 66 59 6 330 166 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000041815   ⟹   ENSRNOP00000039940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1956,588,500 - 56,611,628 (-)Ensembl
mRatBN7.2 Ensembl1939,679,204 - 39,702,247 (-)Ensembl
Rnor_6.0 Ensembl1943,932,554 - 43,955,783 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000058891   ⟹   ENSRNOP00000055678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1956,588,500 - 56,623,190 (-)Ensembl
mRatBN7.2 Ensembl1939,679,229 - 39,713,907 (-)Ensembl
Rnor_6.0 Ensembl1943,932,946 - 43,955,747 (-)Ensembl
RefSeq Acc Id: NM_001395122   ⟹   NP_001382051
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81956,588,500 - 56,623,190 (-)NCBI
mRatBN7.21939,679,215 - 39,713,907 (-)NCBI
RefSeq Acc Id: NM_001395123   ⟹   NP_001382052
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81956,588,500 - 56,611,628 (-)NCBI
mRatBN7.21939,679,215 - 39,702,345 (-)NCBI
RefSeq Acc Id: NM_012931   ⟹   NP_037063
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81956,588,500 - 56,611,628 (-)NCBI
mRatBN7.21939,679,215 - 39,702,345 (-)NCBI
Rnor_6.01943,932,554 - 43,955,783 (-)NCBI
Rnor_5.01954,739,915 - 54,774,486 (-)NCBI
RGSC_v3.41941,646,190 - 41,669,234 (-)RGD
Celera1939,039,406 - 39,062,496 (-)RGD
Sequence:
RefSeq Acc Id: NP_037063   ⟸   NM_012931
- Peptide Label: isoform 3
- UniProtKB: A6IZA8 (UniProtKB/TrEMBL),   D3ZE30 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000039940   ⟸   ENSRNOT00000041815
Ensembl Acc Id: ENSRNOP00000055678   ⟸   ENSRNOT00000058891
RefSeq Acc Id: NP_001382051   ⟸   NM_001395122
- Peptide Label: isoform 1
- UniProtKB: F1LVA8 (UniProtKB/TrEMBL),   A6IZA6 (UniProtKB/TrEMBL),   D3ZE30 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001382052   ⟸   NM_001395123
- Peptide Label: isoform 2
- UniProtKB: A6IZA7 (UniProtKB/TrEMBL),   D3ZE30 (UniProtKB/TrEMBL)
Protein Domains
SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63767-F1-model_v2 AlphaFold Q63767 1-968 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701152
Promoter ID:EPDNEW_R11676
Type:multiple initiation site
Name:Bcar1_1
Description:BCAR1, Cas family scaffolding protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01943,955,804 - 43,955,864EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2406 AgrOrtholog
BioCyc Gene G2FUF-5642 BioCyc
Ensembl Genes ENSRNOG00000019253 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000041815 ENTREZGENE
  ENSRNOT00000058891 ENTREZGENE
Gene3D-CATH 1.20.120.830 UniProtKB/Swiss-Prot
  Alpha-catenin/vinculin-like UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
InterPro BCAR1_C UniProtKB/Swiss-Prot
  BCAR1_SH3 UniProtKB/Swiss-Prot
  CAS_C UniProtKB/Swiss-Prot
  CAS_fam UniProtKB/Swiss-Prot
  Serine_rich_dom UniProtKB/Swiss-Prot
  Serine_rich_sf UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
KEGG Report rno:25414 UniProtKB/Swiss-Prot
NCBI Gene 25414 ENTREZGENE
PANTHER PTHR10654 UniProtKB/Swiss-Prot
  PTHR10654:SF15 UniProtKB/Swiss-Prot
Pfam CAS_C UniProtKB/Swiss-Prot
  Serine_rich UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot
PharmGKB BCAR1 RGD
PhenoGen Bcar1 PhenoGen
PRINTS SH3DOMAIN UniProtKB/Swiss-Prot
  SPECTRNALPHA UniProtKB/Swiss-Prot
PROSITE SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019253 RatGTEx
SMART SH3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot
TIGR TC205306
UniProt A6IZA5_RAT UniProtKB/TrEMBL
  A6IZA6 ENTREZGENE, UniProtKB/TrEMBL
  A6IZA7 ENTREZGENE, UniProtKB/TrEMBL
  A6IZA8 ENTREZGENE, UniProtKB/TrEMBL
  BCAR1_RAT UniProtKB/Swiss-Prot
  D3ZE30 ENTREZGENE, UniProtKB/TrEMBL
  F1LVA8 ENTREZGENE, UniProtKB/TrEMBL
  Q63767 ENTREZGENE
UniProt Secondary Q63766 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-03-27 Bcar1  BCAR1 scaffold protein, Cas family member  Bcar1  BCAR1, Cas family scaffold protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2018-03-13 Bcar1  BCAR1, Cas family scaffold protein  Bcar1  BCAR1, Cas family scaffolding protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-04-27 Bcar1  BCAR1, Cas family scaffolding protein  Bcar1  breast cancer anti-estrogen resistance 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Bcar1  breast cancer anti-estrogen resistance 1  Crkas  v-crk-associated tyrosine kinase substrate  Symbol and Name updated 1299863 APPROVED
2002-06-10 Crkas  v-crk-associated tyrosine kinase substrate      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains an SH3 domain and a repetitive stretch of tyrosine-containing motifs 1298806
gene_physical_interaction tyrosine-phosphorylated protein forms stable interactions with v-Src and v-Crk kinases and serves as a substrate for both kinases 1298805
gene_process may serve to assemble signals from multiple SH2 domain-containing molecules 1298805
gene_process essential for oncogenesis, actin cytoskeleton organization and cellular migration 1298806
gene_protein tyrosine phosphorylated upon cellular transformation with p60v-src or v-Crk 1298805
gene_regulation degraded during apoptosis via cleavage by caspase following dephosphorylation 1298807
gene_regulation tyrosine phosphorylated in beta cells upon treatment with glucose 1298808