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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2406
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcar1
Name: BCAR1 scaffold protein, Cas family member
Acc ID: CHEBI:41774
Term: tamoxifen
Definition: A stilbenoid that has formula 371.51460.
Chemical ID: MESH:D013629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcar1decreases response to substanceISOBCAR1 (Homo sapiens)6480464CTDBCAR1 protein results in decreased susceptibility to TamoxifenPMID:19330798
Bcar1multiple interactionsISOBCAR1 (Homo sapiens)6480464CTDTamoxifen promotes the reaction [BCAR1 protein mutant form results in decreased expression of BCL2 protein]PMID:19330798
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