Gene:	Cd247 ( Rattus norvegicus ) Cd247 molecule
Description:	component of T cell receptor (TCR) complex that plays a role in TCR assembly and signaling; does not promote surface expression of Fc gamma RIII, unlike human homolog
Synonyms:	Cd3z; T-cell receptor CD3, subunit zeta; CD247 antigen; T-cell receptor CD3 subunit zeta; TCRzeta; CD3 antigen, zeta polypeptide;  (details...)
ArrayIDs:	D13555_at; 1388026_at; 1370621_at; 6235596; 6570760; 6194250; 6709911; 6092129; A_44_P463805; 6553184; GE19466; 5881022; 6340924; 6247592;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: CD247     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Cd247     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Cd247 Rat Celera Assembly 13 77754426 - 77829076     RGSC genome assembly v3.4 13 81515383 - 81594699     Cytogenetic 13 q23     genome assembly 3.1 13 81529570 - 81608887 Mus musculus Cd247 Mouse genome assembly build 36.1 1 167718854 - 167797565     Cytogenetic 1 1 G-H Homo sapiens CD247 human genome assembly 1 164131542 - 164219484     Human genome assembly build 36.2 1 165666505 - 165754450     Cytogenetic 1 q22-q23   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Note Reference component of T cell receptor complex 634717 Gene Ontology protein binding,  transmembrane receptor activity,  molecular_function (details...)
Biological Process	Note Reference has a role in TCR assembly and TCR-mediated signaling 634717 does not promote surface expression of Fc gamma RIII, unlike human CD3 zeta chain 728653 Gene Ontology cell surface receptor linked signal transduction,  T cell receptor signaling pathway (details...)
Cellular Component	Gene Ontology cytoplasm,  membrane,  alpha-beta T cell receptor complex ...  (details...)
External Links
Databases	DATABASE ID SOURCE SMART: ITAM IPI PROSITE: ITAM_1 IPI UNIPARC: UPI00001149B3 IPI KEGG Report: rno:25300 ENTREZGENE HomoloGene Group ID: 12818 ENTREZGENE Germonline: 2305 Pfam: ITAM IPI KEGG Pathway: 04650 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE InterPro: Phos_immunorcpt_sig_ITAM. IPI Ensembl Protein: ENSRNOP00000004403 IPI IPI: IPI00209883 IPI Entrez Gene: Cd247 ENTREZGENE IMAGE_CLONE: IMAGE:7384006 IMAGE-MGC_LOAD MGC_CLONE: MGC:116047 IMAGE-MGC_LOAD TIGR: TC216715 UniProt: Q4V7G0_RAT IPI Ensembl Genes: ENSRNOG00000003298 IPI RatMap: 41184 ENTREZGENE
Sequences	Nucleotide: BC097933 Get FASTA Search GEO Profiles Nucleotide: CH473958 Get FASTA Search GEO Profiles Nucleotide: D13555 Get FASTA Search GEO Profiles Nucleotide: NM_170789 Get FASTA Search GEO Profiles Nucleotide: L08447 Get FASTA Search GEO Profiles (View all 5 Nucleotide Accessions) Protein: BAA02753 Get FASTA Protein: NP_740770 Get FASTA Protein: AAH97933 Get FASTA Protein: EDM09312 Get FASTA Protein: AAA40900 Get FASTA Protein: EDM09313 Get FASTA Protein: Q4V7G0 Get FASTA (View all 7 Protein Accessions)
Clusters	UniGene: 9997
References
Curated References	9 references in RGD related to Cd247
Other References	5 other references at PubMed related to Cd247
Database Information
RGD ID	2305
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 27-JUN-08: Cd247 Cd247 molecule Cd247 CD247 antigen APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 15-FEB-08: Cd247 CD247 antigen Cd3z CD3 antigen, zeta polypeptide APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 06-NOV-02: Cd3z CD3 antigen, zeta polypeptide T-cell receptor CD3, subunit zeta APPROVED Name updated 625702 10-JUN-02: Cd3z T-cell receptor CD3, subunit zeta APPROVED Symbol and Name status set to approved 70586