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Strain Registration

Strain: SS-Cd247em1Mcwi

Symbol: SS-Cd247em1Mcwi
Strain: SS-Cd247em1
Substrain: Mcwi
RGD ID: 6484582
Citation ID: RRID:RGD_6484582
Ontology ID: RS:0003276
Alleles: Cd247em1Mcwi
Also Known As: SS-Cd247em1Mcwi; SS-Cd247^[em1Mcwi]
Type: mutant
Available Source: Not Available
Origination: PhysGen Knockouts
Description: This strain was produced by injecting ZFNs targeting the sequence CTCGCCTGCATCCTTCAAGtgcagtTCCCAGGAGCAGGTAAGG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 11-bp frameshift deletion in exon 1.
Last Known Status: Cryopreserved Sperm (as of 2021-11-03)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21378,043,460 - 78,043,470RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01383,996,233 - 83,996,243RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01388,876,046 - 88,951,003RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41381,515,383 - 81,594,699RGD_MAPPER_PIPELINERGSC3.4





References

References - curated
# Reference Title Reference Citation
1. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
2. PhysGen Knockouts PhysGen Knockout strains
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney. Rudemiller N, etal., Hypertension. 2014 Mar;63(3):559-64. doi: 10.1161/HYPERTENSIONAHA.113.02191. Epub 2013 Dec 16.

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Cd247em1Mcwi-var1 chr13 78043460 78043470 TTCAAGTGCAG - deletion mRatBN7.2
Cd247em1Mcwi-var1 chr13 83996233 83996243 TTCAAGTGCAG - deletion Rnor_6.0

Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-04-03 SS-Cd247em1Mcwi    SS-Cd247em1Mcwi    Symbol updated 68687 APPROVED
2014-04-03 SS-Cd247em1Mcwi    SS-Cd247em1Mcwi    Symbol updated 68687 APPROVED
2014-04-03 SS-Cd247em1Mcwi    SS-Cd247em1Mcwi    Name updated 68913 APPROVED
2014-04-03 SS-Cd247em1Mcwi    SS-Cd247em1Mcwi    Name updated 68913 APPROVED
2013-08-15 SS-Cd247em1Mcwi    SS-Cd247em1Mcwi    Name updated 68913 APPROVED
2013-08-15 SS-Cd247em1Mcwi    SS-Cd247em1Mcwi    Name updated 68913 APPROVED