Bcat1 (branched chain amino acid transaminase 1) - Rat Genome Database

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Gene: Bcat1 (branched chain amino acid transaminase 1) Rattus norvegicus
Analyze
Symbol: Bcat1
Name: branched chain amino acid transaminase 1
RGD ID: 2195
Description: Enables branched-chain-amino-acid transaminase activity and identical protein binding activity. Predicted to be involved in L-leucine biosynthetic process and L-valine biosynthetic process. Predicted to act upstream of or within branched-chain amino acid catabolic process. Is active in cytoplasm. Orthologous to human BCAT1 (branched chain amino acid transaminase 1); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BCAT(c); Bcatc; branched chain amino acid transaminase 1, cytosolic; branched chain aminotransferase 1, cytosolic; branched-chain-amino-acid aminotransferase, cytosolic; MGC105472
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Bcat1em2Mcwi
Genetic Models: SS-Bcat1em2Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84179,695,662 - 179,777,973 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4179,695,662 - 179,777,288 (-)EnsemblGRCr8
mRatBN7.24177,964,834 - 178,046,573 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4177,964,834 - 178,046,597 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4184,266,200 - 184,349,150 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04180,050,703 - 180,133,655 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04178,671,128 - 178,754,073 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04179,259,305 - 179,340,021 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4179,259,308 - 179,339,795 (-)Ensemblrn6Rnor6.0
Rnor_5.04243,463,299 - 243,491,574 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.04243,444,839 - 243,460,481 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44182,641,517 - 182,692,917 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4166,483,269 - 166,533,125 (-)NCBICelera
RGSC_v3.14182,886,640 - 182,938,041 (-)NCBI
Cytogenetic Map4q44NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
allyl alcohol  (EXP)
Allylamine  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
brequinar  (ISO)
bucladesine  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcidiol  (EXP)
carbamazepine  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloroacetaldehyde  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (EXP,ISO)
DDT  (EXP)
deguelin  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dieldrin  (EXP)
diethyl phthalate  (EXP)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (EXP,ISO)
diquat  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
heptachlor  (EXP)
hydrogen peroxide  (ISO)
ifosfamide  (ISO)
isoprenaline  (EXP)
lead diacetate  (EXP,ISO)
maneb  (ISO)
medroxyprogesterone acetate  (ISO)
metacetamol  (ISO)
metaproterenol  (EXP)
methapyrilene  (EXP,ISO)
methyl methanesulfonate  (ISO)
mirex  (EXP)
mitoxantrone  (EXP)
Moniliformin  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
neomycin  (ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
orciprenaline  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenylbutazone  (EXP)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
rotenone  (ISO)
scopolamine  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
titanium dioxide  (EXP,ISO)
triamterene  (EXP)
tributylstannane  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA,IEA)
cytosol  (ISO)
mitochondrion  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Cellular distribution of branched-chain amino acid aminotransferase isoenzymes among rat brain glial cells in culture. Bixel MG, etal., J Histochem Cytochem. 1997 May;45(5):685-94.
2. Changes in butyrylcholinesterase activity and serum lipids after oxprenolol and glibenclamide treatments in non-diabetic rats. Bradamante V, etal., Arzneimittelforschung. 2006;56(2):64-9.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Branched chain aminotransferase isoenzymes. Purification and characterization of the rat brain isoenzyme. Hall TR, etal., J Biol Chem. 1993 Feb 15;268(5):3092-8.
5. Cloning and expression of the mammalian cytosolic branched chain aminotransferase isoenzyme. Hutson SM, etal., J Biol Chem 1995 Dec 22;270(51):30344-52.
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Upregulation of cytosolic branched chain aminotransferase in substantia nigra following developmental striatal target injury. Kholodilov NG, etal., Brain Res Mol Brain Res 2000 Feb 22;75(2):281-6.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932   PMID:14755340   PMID:15489334   PMID:16141215   PMID:17348860   PMID:18614015   PMID:22871113   PMID:38871197  


Genomics

Comparative Map Data
Bcat1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84179,695,662 - 179,777,973 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4179,695,662 - 179,777,288 (-)EnsemblGRCr8
mRatBN7.24177,964,834 - 178,046,573 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4177,964,834 - 178,046,597 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4184,266,200 - 184,349,150 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04180,050,703 - 180,133,655 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04178,671,128 - 178,754,073 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04179,259,305 - 179,340,021 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4179,259,308 - 179,339,795 (-)Ensemblrn6Rnor6.0
Rnor_5.04243,463,299 - 243,491,574 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.04243,444,839 - 243,460,481 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44182,641,517 - 182,692,917 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4166,483,269 - 166,533,125 (-)NCBICelera
RGSC_v3.14182,886,640 - 182,938,041 (-)NCBI
Cytogenetic Map4q44NCBI
BCAT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381224,810,024 - 24,949,340 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1224,810,024 - 24,949,556 (-)Ensemblhg38GRCh38
GRCh371224,962,958 - 25,102,274 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361224,855,545 - 24,993,499 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341224,855,561 - 24,993,499NCBI
Celera1230,109,823 - 30,249,287 (-)NCBICelera
Cytogenetic Map12p12.1NCBI
HuRef1224,732,841 - 24,872,358 (-)NCBIHuRef
CHM1_11224,928,106 - 25,067,454 (-)NCBICHM1_1
T2T-CHM13v2.01224,679,997 - 24,819,416 (-)NCBIT2T-CHM13v2.0
Bcat1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396144,939,561 - 145,021,883 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6144,939,561 - 145,021,910 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm386144,993,835 - 145,076,157 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6144,993,835 - 145,076,184 (-)Ensemblmm10GRCm38
MGSCv376144,942,355 - 145,024,677 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366144,956,312 - 145,033,242 (-)NCBIMGSCv36mm8
Celera6148,047,506 - 148,145,066 (-)NCBICelera
Cytogenetic Map6G3NCBI
cM Map677.27NCBI
Bcat1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541319,981,328 - 20,087,638 (-)Ensembl
ChiLan1.0NW_00495541319,975,395 - 20,087,656 (-)NCBIChiLan1.0ChiLan1.0
BCAT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21071,867,317 - 72,003,917 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11271,863,725 - 72,000,314 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01261,364,154 - 61,500,827 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11263,978,116 - 64,114,127 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1263,978,116 - 64,107,463 (+)EnsemblpanPan2panpan1.1
BCAT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12722,536,297 - 22,643,350 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2722,535,254 - 22,636,959 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2723,725,637 - 23,832,733 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02722,769,835 - 22,843,576 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2722,735,227 - 22,841,025 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12722,584,192 - 22,657,415 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02722,569,213 - 22,676,273 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02723,897,853 - 24,005,177 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bcat1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494584,462,896 - 84,532,986 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365482,386,207 - 2,450,142 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365482,385,756 - 2,454,423 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCAT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl548,814,313 - 48,925,973 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1548,814,212 - 48,925,632 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2552,534,770 - 52,624,453 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BCAT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11124,578,760 - 24,709,541 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1124,579,487 - 24,709,132 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606910,417,680 - 10,554,451 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bcat1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475214,106,884 - 14,164,064 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475214,074,701 - 14,166,075 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Bcat1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v162,759,449 - 2,807,287 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bcat1
635 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:109
Count of miRNA genes:90
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000021193
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155834926184426481Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4157292416184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4160623982184426481Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4176806581181925369Rat

Markers in Region
RH137483  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24178,010,417 - 178,010,618 (+)MAPPERmRatBN7.2
Rnor_6.04179,304,131 - 179,304,331NCBIRnor6.0
Rnor_5.04243,488,610 - 243,488,810UniSTSRnor5.0
RGSC_v3.44182,689,953 - 182,690,153UniSTSRGSC3.4
Celera4166,530,161 - 166,530,361UniSTS
Cytogenetic Map4q44UniSTS
AU048984  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24177,986,839 - 177,987,023 (+)MAPPERmRatBN7.2
Rnor_6.04179,280,467 - 179,280,650NCBIRnor6.0
Rnor_5.04243,465,541 - 243,465,724UniSTSRnor5.0
RGSC_v3.44182,665,427 - 182,665,610UniSTSRGSC3.4
Celera4166,506,352 - 166,506,535UniSTS
Cytogenetic Map4q44UniSTS
RH128559  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24177,964,886 - 177,965,077 (+)MAPPERmRatBN7.2
Rnor_6.04179,259,358 - 179,259,548NCBIRnor6.0
Rnor_5.04243,444,892 - 243,445,082UniSTSRnor5.0
RGSC_v3.44182,641,570 - 182,641,760UniSTSRGSC3.4
Celera4166,483,322 - 166,483,512UniSTS
Cytogenetic Map4q44UniSTS
RH138612  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24178,011,088 - 178,011,232 (+)MAPPERmRatBN7.2
Rnor_6.04179,304,801 - 179,304,944NCBIRnor6.0
Rnor_5.04243,489,280 - 243,489,423UniSTSRnor5.0
RGSC_v3.44182,690,623 - 182,690,766UniSTSRGSC3.4
Celera4166,530,831 - 166,530,974UniSTS
RH 3.4 Map41077.3UniSTS
Cytogenetic Map4q44UniSTS


Genetic Models
This gene Bcat1 is modified in the following models/strains:
SS-Bcat1em2Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 90 89 58 92 58 6 355 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000021193   ⟹   ENSRNOP00000021193
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4179,695,662 - 179,742,927 (-)Ensembl
mRatBN7.2 Ensembl4177,964,834 - 178,012,316 (-)Ensembl
Rnor_6.0 Ensembl4179,259,310 - 179,307,095 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080410   ⟹   ENSRNOP00000074245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4179,695,662 - 179,777,288 (-)Ensembl
mRatBN7.2 Ensembl4177,964,834 - 178,046,597 (-)Ensembl
Rnor_6.0 Ensembl4179,259,308 - 179,339,795 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097702   ⟹   ENSRNOP00000093677
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4177,964,842 - 178,012,123 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117044   ⟹   ENSRNOP00000090195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4179,695,662 - 179,777,288 (-)Ensembl
mRatBN7.2 Ensembl4177,964,834 - 178,046,411 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119115   ⟹   ENSRNOP00000085607
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4179,695,662 - 179,744,458 (-)Ensembl
mRatBN7.2 Ensembl4177,964,839 - 178,013,847 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120070   ⟹   ENSRNOP00000082839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4177,964,836 - 178,013,245 (-)Ensembl
RefSeq Acc Id: NM_001394001   ⟹   NP_001380930
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84179,695,662 - 179,777,288 (-)NCBI
mRatBN7.24177,964,834 - 178,046,463 (-)NCBI
RefSeq Acc Id: NM_017253   ⟹   NP_058949
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84179,695,662 - 179,744,208 (-)NCBI
mRatBN7.24177,964,834 - 178,013,383 (-)NCBI
Rnor_6.04179,259,305 - 179,307,095 (-)NCBI
Rnor_5.04243,444,839 - 243,460,481 (-)NCBI
Rnor_5.04243,463,299 - 243,491,574 (-)NCBI
RGSC_v3.44182,641,517 - 182,692,917 (-)RGD
Celera4166,483,269 - 166,533,125 (-)RGD
Sequence:
RefSeq Acc Id: XM_008763370   ⟹   XP_008761592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84179,695,662 - 179,744,006 (-)NCBI
mRatBN7.24177,964,834 - 178,013,087 (-)NCBI
Rnor_6.04179,259,305 - 179,306,810 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008763372   ⟹   XP_008761594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84179,695,662 - 179,777,490 (-)NCBI
mRatBN7.24177,964,834 - 178,046,573 (-)NCBI
Rnor_6.04179,259,305 - 179,339,936 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008763373   ⟹   XP_008761595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84179,695,662 - 179,743,629 (-)NCBI
mRatBN7.24177,964,834 - 178,012,429 (-)NCBI
Rnor_6.04179,259,305 - 179,306,141 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063285687   ⟹   XP_063141757
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84179,695,662 - 179,744,496 (-)NCBI
RefSeq Acc Id: XM_063285688   ⟹   XP_063141758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84179,695,662 - 179,777,973 (-)NCBI
RefSeq Acc Id: XM_063285689   ⟹   XP_063141759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84179,695,662 - 179,775,405 (-)NCBI
RefSeq Acc Id: NP_058949   ⟸   NM_017253
- Peptide Label: isoform 1
- UniProtKB: P54690 (UniProtKB/Swiss-Prot),   A6IMZ1 (UniProtKB/TrEMBL),   A6IMZ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761594   ⟸   XM_008763372
- Peptide Label: isoform X3
- UniProtKB: Q99JD5 (UniProtKB/TrEMBL),   A0A0G2K7K5 (UniProtKB/TrEMBL),   A6IMZ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761592   ⟸   XM_008763370
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZVC5 (UniProtKB/TrEMBL),   A6IMZ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761595   ⟸   XM_008763373
- Peptide Label: isoform X5
- UniProtKB: A6IMZ4 (UniProtKB/TrEMBL),   A0A8L2QAQ9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074245   ⟸   ENSRNOT00000080410
Ensembl Acc Id: ENSRNOP00000021193   ⟸   ENSRNOT00000021193
Ensembl Acc Id: ENSRNOP00000082839   ⟸   ENSRNOT00000120070
Ensembl Acc Id: ENSRNOP00000090195   ⟸   ENSRNOT00000117044
Ensembl Acc Id: ENSRNOP00000093677   ⟸   ENSRNOT00000097702
Ensembl Acc Id: ENSRNOP00000085607   ⟸   ENSRNOT00000119115
RefSeq Acc Id: NP_001380930   ⟸   NM_001394001
- Peptide Label: isoform 2
- UniProtKB: Q99JD5 (UniProtKB/TrEMBL),   A0A0G2K7K5 (UniProtKB/TrEMBL),   A6IMZ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141758   ⟸   XM_063285688
- Peptide Label: isoform X3
- UniProtKB: A6IMZ3 (UniProtKB/TrEMBL),   A0A0G2K7K5 (UniProtKB/TrEMBL),   Q99JD5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141759   ⟸   XM_063285689
- Peptide Label: isoform X4
- UniProtKB: A6IMZ3 (UniProtKB/TrEMBL),   A0A0G2K7K5 (UniProtKB/TrEMBL),   Q99JD5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141757   ⟸   XM_063285687
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A0J2 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P54690-F1-model_v2 AlphaFold P54690 1-411 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693495
Promoter ID:EPDNEW_R4020
Type:initiation region
Name:Bcat1_2
Description:branched chain amino acid transaminase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4021  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04179,307,089 - 179,307,149EPDNEW
RGD ID:13693500
Promoter ID:EPDNEW_R4021
Type:initiation region
Name:Bcat1_1
Description:branched chain amino acid transaminase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4020  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04179,339,774 - 179,339,834EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2195 AgrOrtholog
BioCyc Gene G2FUF-42461 BioCyc
Ensembl Genes ENSRNOG00000015514 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000021193 ENTREZGENE
  ENSRNOT00000080410 ENTREZGENE
  ENSRNOT00000117044 ENTREZGENE
  ENSRNOT00000119115 ENTREZGENE
Gene3D-CATH 3.20.10.10 UniProtKB/Swiss-Prot
  3.30.470.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7315507 IMAGE-MGC_LOAD
InterPro Aminotrans_IV UniProtKB/Swiss-Prot
  Aminotrans_IV_CS UniProtKB/Swiss-Prot
  Aminotransferase-like UniProtKB/Swiss-Prot
  B_amino_transII UniProtKB/Swiss-Prot
  BCAT-like_C UniProtKB/Swiss-Prot
  BCAT-like_N UniProtKB/Swiss-Prot
  BCAT_family UniProtKB/Swiss-Prot
KEGG Report rno:29592 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105472 IMAGE-MGC_LOAD
NCBI Gene 29592 ENTREZGENE
PANTHER BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC UniProtKB/Swiss-Prot
  PTHR11825 UniProtKB/Swiss-Prot
Pfam Aminotran_4 UniProtKB/Swiss-Prot
PhenoGen Bcat1 PhenoGen
PIRSF BCAT1 UniProtKB/Swiss-Prot
PROSITE AA_TRANSFER_CLASS_4 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015514 RatGTEx
Superfamily-SCOP SSF56752 UniProtKB/Swiss-Prot
UniProt A0A0G2K7K5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZVC5 ENTREZGENE
  A0A8I6A0J2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QAQ9 ENTREZGENE, UniProtKB/TrEMBL
  A6IMY5_RAT UniProtKB/TrEMBL
  A6IMY6_RAT UniProtKB/TrEMBL
  A6IMY7_RAT UniProtKB/TrEMBL
  A6IMY8_RAT UniProtKB/TrEMBL
  A6IMZ1 ENTREZGENE, UniProtKB/TrEMBL
  A6IMZ3 ENTREZGENE, UniProtKB/TrEMBL
  A6IMZ4 ENTREZGENE, UniProtKB/TrEMBL
  BCAT1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q99JD5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-28 Bcat1  branched chain amino acid transaminase 1, cytosolic  Bcat1  branched chain aminotransferase 1, cytosolic  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Bcat1  branched chain aminotransferase 1, cytosolic      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the substantia nigra 631308
gene_function transferase 631308
gene_process may play a role in maintaining neuronal viability following striatal target injury 631308
gene_protein 46.0 kDa 69773
gene_regulation mRNA is upregulated in neurons following striatal target injury 631308