RGD Reference Report - Upregulation of cytosolic branched chain aminotransferase in substantia nigra following developmental striatal target injury. - Rat Genome Database

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Upregulation of cytosolic branched chain aminotransferase in substantia nigra following developmental striatal target injury.

Authors: Kholodilov, NG  Neystat, M  Oo, TF  Hutson, SM  Burke, RE 
Citation: Kholodilov NG, etal., Brain Res Mol Brain Res 2000 Feb 22;75(2):281-6.
RGD ID: 631308
Pubmed: PMID:10686349   (View Abstract at PubMed)

We have previously shown that apoptotic cell death can be induced in substantia nigra (SN) by developmental striatal target lesion. In this model, only a portion of nigral neurons dies, so it provides a paradigm to examine not only the molecular basis of cell death, but also the cellular responses of adjacent neurons which survive. Using a differential display approach, we have found that cytosolic branched chain aminotransferase (BCATc) mRNA is upregulated in SN in this model. This upregulation is associated with an increased number of BCATc-positive neuronal profiles, demonstrated by immunostaining. BCATc-positive neurons show normal morphology and rarely contain apoptotic chromatin. We conclude that BCATc is upregulated in neurons, which are likely to survive, and plays a role in either maintenance of viability or restoration of normal function.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Brain Injuries  ISOBcat1 (Rattus norvegicus)631308; 631308Protein:increased expression:neuronsRGD 
Brain Injuries  IEP 631308Protein:increased expression:neuronsRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
branched-chain-amino-acid transaminase activity  TAS 631308 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bcat1  (branched chain amino acid transaminase 1)

Genes (Mus musculus)
Bcat1  (branched chain aminotransferase 1, cytosolic)

Genes (Homo sapiens)
BCAT1  (branched chain amino acid transaminase 1)


Additional Information