Atp1b3 (ATPase Na+/K+ transporting subunit beta 3) - Rat Genome Database

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Gene: Atp1b3 (ATPase Na+/K+ transporting subunit beta 3) Rattus norvegicus
Analyze
Symbol: Atp1b3
Name: ATPase Na+/K+ transporting subunit beta 3
RGD ID: 2172
Description: Enables P-type sodium:potassium-exchanging transporter activity. Involved in potassium ion transport and sodium ion transport. Located in apical plasma membrane; basolateral plasma membrane; and caveola. Part of sodium:potassium-exchanging ATPase complex. Orthologous to human ATP1B3 (ATPase Na+/K+ transporting subunit beta 3); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATPase Na+K+ transporting beta polypeptide 3; ATPase, Na+/K+ transporting, beta 3 polypeptide; ATPase, Na+K+ transporting, beta polypeptide 3; ATPB-3; Na+/K+ -ATPase beta 3 subunit; NKAB3S; sodium/potassium-dependent ATPase subunit beta-3; sodium/potassium-transporting ATPase subunit beta-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88105,789,824 - 105,821,151 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl865,253,361 - 65,254,304 (+)EnsemblGRCr8
GRCr8 Ensembl8105,755,092 - 105,821,154 (-)EnsemblGRCr8
mRatBN7.2896,910,265 - 96,941,592 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl856,357,316 - 56,358,259 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl896,910,309 - 96,941,598 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8102,575,419 - 102,606,805 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08100,774,668 - 100,806,054 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0898,613,628 - 98,645,015 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08104,190,032 - 104,221,342 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8104,190,032 - 104,221,342 (-)Ensemblrn6Rnor6.0
Rnor_5.08103,638,324 - 103,669,634 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48101,405,877 - 101,437,757 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera896,353,742 - 96,384,785 (-)NCBICelera
RGSC_v3.18101,425,331 - 101,457,212 (-)NCBI
Cytogenetic Map8q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxynon-2-enal  (ISO)
4-tert-Octylphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
aconitine  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
Azoxymethane  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
caffeine  (ISO)
chlordecone  (ISO)
ciglitazone  (EXP)
cisplatin  (EXP)
cocaine  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP)
dimethyl sulfoxide  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
furfural  (ISO)
genistein  (EXP)
gentamycin  (EXP)
haloperidol  (EXP)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
lycopene  (ISO)
mercury atom  (EXP)
mercury(0)  (EXP)
Mesaconitine  (EXP)
methimazole  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (ISO)
okadaic acid  (ISO)
p-tert-Amylphenol  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
tacrolimus hydrate  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway   (ISO)
aldosterone signaling pathway  (IEA)
alfentanil pharmacodynamics pathway  (ISO)
amiloride pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
bendroflumethiazide pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bile acid transport pathway  (IEA)
bisoprolol pharmacodynamics pathway  (ISO)
bumetanide pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
chlorothiazide pharmacodynamics pathway  (ISO)
chlorthalidone pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
cystinuria pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
eplerenone pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
etacrynic acid pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
furosemide pharmacodynamics pathway  (ISO)
Hartnup disease pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrochlorothiazide pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydroflumethiazide pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
iminoglycinuria pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
lactose degradation pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lysinuric protein intolerance pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
metolazone pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
spironolactone pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
torasemide pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)
trehalose degradation pathway  (ISO)
triamterene pharmacodynamics pathway  (ISO)
trichlormethiazide pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Training-induced changes in skeletal muscle Na+-K+ pump number and isoform expression in rats with chronic heart failure. Helwig B, etal., J Appl Physiol 2003 Jun;94(6):2225-36.
4. The effect of beta-subunit assembly on function and localization of the colonic H+,K+-ATPase alpha-subunit. Li J, etal., Kidney Int. 2004 Sep;66(3):1068-75.
5. Beta-subunit of cardiac Na+-K+-ATPase dictates the concentration of the functional enzyme in caveolae. Liu L and Askari A, Am J Physiol Cell Physiol. 2006 Oct;291(4):C569-78. Epub 2006 Apr 19.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Colonic H-K-ATPase beta-subunit: identification in apical membranes and regulation by dietary K depletion. Sangan P, etal., Am J Physiol. 1999 Feb;276(2):C350-60. doi: 10.1152/ajpcell.1999.276.2.C350.
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:10636900   PMID:10837135   PMID:15489334   PMID:15718050   PMID:16861705   PMID:18522992   PMID:19542013   PMID:20458337   PMID:23106098  


Genomics

Comparative Map Data
Atp1b3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88105,789,824 - 105,821,151 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl865,253,361 - 65,254,304 (+)EnsemblGRCr8
GRCr8 Ensembl8105,755,092 - 105,821,154 (-)EnsemblGRCr8
mRatBN7.2896,910,265 - 96,941,592 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl856,357,316 - 56,358,259 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl896,910,309 - 96,941,598 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8102,575,419 - 102,606,805 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08100,774,668 - 100,806,054 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0898,613,628 - 98,645,015 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08104,190,032 - 104,221,342 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8104,190,032 - 104,221,342 (-)Ensemblrn6Rnor6.0
Rnor_5.08103,638,324 - 103,669,634 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48101,405,877 - 101,437,757 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera896,353,742 - 96,384,785 (-)NCBICelera
RGSC_v3.18101,425,331 - 101,457,212 (-)NCBI
Cytogenetic Map8q31NCBI
ATP1B3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383141,876,643 - 141,926,549 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3141,876,124 - 141,926,549 (+)Ensemblhg38GRCh38
GRCh373141,595,485 - 141,645,391 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363143,078,160 - 143,128,072 (+)NCBIBuild 36Build 36hg18NCBI36
Build 343143,078,167 - 143,128,080NCBI
Celera3140,019,481 - 140,069,148 (+)NCBICelera
Cytogenetic Map3q23NCBI
HuRef3138,968,275 - 139,018,182 (+)NCBIHuRef
CHM1_13141,558,509 - 141,608,405 (+)NCBICHM1_1
T2T-CHM13v2.03144,623,941 - 144,673,839 (+)NCBIT2T-CHM13v2.0
Atp1b3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39996,214,708 - 96,246,368 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl996,214,708 - 96,246,495 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38996,332,655 - 96,364,431 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl996,332,655 - 96,364,442 (-)Ensemblmm10GRCm38
MGSCv37996,233,092 - 96,264,718 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36996,142,025 - 96,173,651 (-)NCBIMGSCv36mm8
Celera995,886,766 - 95,920,080 (-)NCBICelera
Cytogenetic Map9E3.3NCBI
cM Map950.31NCBI
Atp1b3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555083,859,399 - 3,875,276 (-)Ensembl
ChiLan1.0NW_0049555083,848,745 - 3,875,992 (-)NCBIChiLan1.0ChiLan1.0
ATP1B3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22139,780,084 - 139,831,746 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13139,784,817 - 139,836,609 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03138,903,371 - 138,954,915 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13146,500,493 - 146,550,164 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3146,500,493 - 146,550,164 (+)EnsemblpanPan2panpan1.1
ATP1B3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12337,684,507 - 37,727,535 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2337,684,506 - 37,726,746 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2337,675,590 - 37,719,488 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02338,214,455 - 38,258,634 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2338,214,096 - 38,258,581 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12337,897,059 - 37,940,955 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02337,974,038 - 38,017,944 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02338,217,485 - 38,261,376 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Atp1b3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560276,881,663 - 76,901,102 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365403,621,710 - 3,640,875 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365403,621,656 - 3,640,885 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP1B3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11382,680,442 - 82,727,052 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21390,496,250 - 90,523,579 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP1B3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11548,691,224 - 48,742,336 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1548,690,667 - 48,742,385 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604121,627,404 - 21,678,499 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp1b3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473018,510,844 - 18,544,836 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473018,510,840 - 18,544,528 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Atp1b3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1887,777,872 - 87,808,833 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Atp1b3
262 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:87
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000015476
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
8693654Alc32Alcohol consumption QTL 3220.755drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)897492344116428905Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat

Markers in Region
RH129716  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2896,910,632 - 96,910,846 (+)MAPPERmRatBN7.2
mRatBN7.2856,358,515 - 56,358,729 (+)MAPPERmRatBN7.2
Rnor_6.0860,619,898 - 60,620,111NCBIRnor6.0
Rnor_6.08104,190,395 - 104,190,608NCBIRnor6.0
Rnor_5.0859,190,496 - 59,190,709UniSTSRnor5.0
Rnor_5.08103,638,687 - 103,638,900UniSTSRnor5.0
RGSC_v3.4859,552,137 - 59,552,350UniSTSRGSC3.4
RGSC_v3.48101,406,240 - 101,406,453UniSTSRGSC3.4
Celera855,839,413 - 55,839,626UniSTS
Celera896,354,105 - 96,354,318UniSTS
Cytogenetic Map8q24UniSTS
Cytogenetic Map8q31UniSTS
RH143868  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2856,357,333 - 56,357,580 (+)MAPPERmRatBN7.2
Rnor_6.0860,618,716 - 60,618,962NCBIRnor6.0
Rnor_5.0859,189,314 - 59,189,560UniSTSRnor5.0
RGSC_v3.4859,550,955 - 59,551,201UniSTSRGSC3.4
Celera855,838,231 - 55,838,477UniSTS
RH 3.4 Map11138.7UniSTS
Cytogenetic Map8q24UniSTS
Cytogenetic Map8q31UniSTS
BF406252  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2896,927,605 - 96,927,772 (+)MAPPERmRatBN7.2
Rnor_6.08104,207,368 - 104,207,534NCBIRnor6.0
Rnor_5.08103,655,660 - 103,655,826UniSTSRnor5.0
RGSC_v3.48101,423,213 - 101,423,379UniSTSRGSC3.4
Celera896,371,090 - 96,371,256UniSTS
RH 3.4 Map81050.8UniSTS
Cytogenetic Map8q31UniSTS
RH125905  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2896,910,291 - 96,910,529 (+)MAPPERmRatBN7.2
Rnor_6.08104,190,054 - 104,190,291NCBIRnor6.0
Rnor_5.08103,638,346 - 103,638,583UniSTSRnor5.0
RGSC_v3.48101,405,899 - 101,406,136UniSTSRGSC3.4
Celera896,353,764 - 96,354,001UniSTS
Cytogenetic Map8q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015476   ⟹   ENSRNOP00000015475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8105,789,829 - 105,821,151 (-)Ensembl
mRatBN7.2 Ensembl896,910,309 - 96,941,598 (-)Ensembl
Rnor_6.0 Ensembl8104,190,032 - 104,221,342 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000036260   ⟹   ENSRNOP00000091519
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl865,253,361 - 65,254,304 (+)Ensembl
mRatBN7.2 Ensembl856,357,316 - 56,358,259 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000042885   ⟹   ENSRNOP00000049635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8105,755,092 - 105,821,154 (-)Ensembl
RefSeq Acc Id: NM_012913   ⟹   NP_037045
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88105,789,829 - 105,821,151 (-)NCBI
mRatBN7.2896,910,270 - 96,941,592 (-)NCBI
Rnor_6.08104,190,032 - 104,221,342 (-)NCBI
Rnor_5.08103,638,324 - 103,669,634 (-)NCBI
RGSC_v3.48101,405,877 - 101,437,757 (-)RGD
Celera896,353,742 - 96,384,785 (-)RGD
Sequence:
RefSeq Acc Id: XM_039080877   ⟹   XP_038936805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88105,789,824 - 105,803,386 (-)NCBI
mRatBN7.2896,910,265 - 96,923,811 (-)NCBI
RefSeq Acc Id: NP_037045   ⟸   NM_012913
- UniProtKB: Q63377 (UniProtKB/Swiss-Prot),   A6I275 (UniProtKB/TrEMBL),   A0A8I6AFS5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015475   ⟸   ENSRNOT00000015476
RefSeq Acc Id: XP_038936805   ⟸   XM_039080877
- Peptide Label: isoform X1
- UniProtKB: A6I277 (UniProtKB/TrEMBL),   A0A8I6AFS5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000091519   ⟸   ENSRNOT00000036260
Ensembl Acc Id: ENSRNOP00000049635   ⟸   ENSRNOT00000042885

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63377-F1-model_v2 AlphaFold Q63377 1-279 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696192
Promoter ID:EPDNEW_R6717
Type:single initiation site
Name:Atp1b3_1
Description:ATPase Na+/K+ transporting subunit beta 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08104,221,252 - 104,221,312EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2172 AgrOrtholog
BioCyc Gene G2FUF-29459 BioCyc
Ensembl Genes ENSRNOG00000011501 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000022382 Ensembl
Ensembl Transcript ENSRNOT00000015476 ENTREZGENE
  ENSRNOT00000015476.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.1660 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5598284 IMAGE-MGC_LOAD
InterPro Na/K_ATPase_sub_beta UniProtKB/Swiss-Prot
  Na/K_ATPase_sub_beta_sf UniProtKB/Swiss-Prot
KEGG Report rno:25390 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72545 IMAGE-MGC_LOAD
NCBI Gene 25390 ENTREZGENE
PANTHER PTHR11523 UniProtKB/Swiss-Prot
  SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-3 UniProtKB/Swiss-Prot
Pfam Na_K-ATPase UniProtKB/Swiss-Prot
PhenoGen Atp1b3 PhenoGen
PROSITE ATPASE_NA_K_BETA_1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011501 RatGTEx
  ENSRNOG00000022382 RatGTEx
TIGR TC217120
UniProt A0A8I6AFS5 ENTREZGENE, UniProtKB/TrEMBL
  A6I275 ENTREZGENE, UniProtKB/TrEMBL
  A6I277 ENTREZGENE, UniProtKB/TrEMBL
  A6I278_RAT UniProtKB/TrEMBL
  A6I279_RAT UniProtKB/TrEMBL
  AT1B3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Atp1b3  ATPase Na+/K+ transporting subunit beta 3  Atp1b3  ATPase, Na+/K+ transporting, beta 3 polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Atp1b3  ATPase, Na+/K+ transporting, beta 3 polypeptide    ATPase, Na+K+ transporting, beta polypeptide 3  Name updated 629478 APPROVED
2002-06-10 Atp1b3  ATPase, Na+K+ transporting, beta polypeptide 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in skeletal muscle 631758
gene_function Na+/K+ ATPase subunit 631758
gene_process Na+/K+ ATPase activity 631758