Apod (apolipoprotein D) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Apod (apolipoprotein D) Rattus norvegicus
Analyze
Symbol: Apod
Name: apolipoprotein D
RGD ID: 2137
Description: Predicted to enable cholesterol binding activity. Involved in peripheral nervous system axon regeneration; response to xenobiotic stimulus; and tissue regeneration. Located in cytosolic ribosome; dendrite; and neuronal cell body. Biomarker of status epilepticus and vasculogenic impotence. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human APOD (apolipoprotein D); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AOPDGN; apo-D
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81182,936,216 - 82,957,264 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1182,936,038 - 82,957,263 (+)EnsemblGRCr8
mRatBN7.21169,431,261 - 69,452,306 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1169,431,260 - 69,452,305 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1178,268,259 - 78,289,302 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01170,921,321 - 70,942,415 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01169,957,346 - 69,978,387 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01172,705,204 - 72,726,263 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1172,705,129 - 72,726,301 (+)Ensemblrn6Rnor6.0
Rnor_5.01175,781,496 - 75,804,020 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1168,851,395 - 68,872,467 (+)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2-acetamidofluorene  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-anilinonaphthalene-1-sulfonic acid  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alachlor  (EXP)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
chloroquine  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
DAUDA  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dioxygen  (ISO)
diquat  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
flurbiprofen  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
haloperidol  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
medroxyprogesterone acetate  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylseleninic acid  (ISO)
monosodium L-glutamate  (ISO)
naphthalene  (ISO)
nickel atom  (ISO)
nitrofen  (EXP)
Nutlin-3  (ISO)
ospemifene  (ISO)
oxidopamine  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phencyclidine  (ISO)
progesterone  (ISO)
propanal  (ISO)
raloxifene  (ISO)
S-nitrosoglutathione  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
thyroxine  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)
vinyl carbamate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Apolipoprotein D gene polymorphism: a new genetic marker for type 2 diabetic subjects in Nauru and south India. Baker WA, etal., Diabet Med. 1994 Dec;11(10):947-52.
2. Accumulation of apolipoproteins in the regenerating and remyelinating mammalian peripheral nerve. Identification of apolipoprotein D, apolipoprotein A-IV, apolipoprotein E, and apolipoprotein A-I. Boyles JK, etal., J Biol Chem. 1990 Oct 15;265(29):17805-15.
3. Meta-analysis of age-related gene expression profiles identifies common signatures of aging. de Magalhaes JP, etal., Bioinformatics. 2009 Apr 1;25(7):875-81. Epub 2009 Feb 2.
4. Increased expression of apolipoprotein D following experimental traumatic brain injury. Franz G, etal., J Neurochem. 1999 Oct;73(4):1615-25.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Expression profiling of insulin action in human myotubes: induction of inflammatory and pro-angiogenic pathways in relationship with glycogen synthesis and type 2 diabetes. Hansen L, etal., Biochem Biophys Res Commun. 2004 Oct 15;323(2):685-95.
8. Antipsychotic drugs differentially modulate apolipoprotein D in rat brain. Khan MM, etal., J Neurochem. 2003 Sep;86(5):1089-100.
9. Factors affecting the lipid and apolipoprotein levels of cord sera. Lane DM and McConathy WJ, Pediatr Res. 1983 Feb;17(2):83-91.
10. Gene expression profiling of an arteriogenic impotence model. Lin CS, etal., Biochem Biophys Res Commun. 2001 Jul 13;285(2):565-9.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Hippocampal alterations of apolipoprotein E and D mRNA levels in vivo and in vitro following kainate excitotoxicity. Montpied P, etal., Epilepsy Res. 1999 Jun;35(2):135-46.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Apolipoprotein D gene expression in the rat brain and light and electron microscopic immunocytochemistry of apolipoprotein D expression in the cerebellum of neonatal, immature and adult rats. Ong WY, etal., Neuroscience. 1999 Mar;90(3):913-22.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. Apolipoprotein D is elevated in oligodendrocytes in the peri-infarct region after experimental stroke: influence of enriched environment. Rickhag M, etal., J Cereb Blood Flow Metab. 2008 Mar;28(3):551-62. Epub 2007 Sep 12.
20. Apolipoprotein D inhibits platelet-derived growth factor-BB-induced vascular smooth muscle cell proliferated by preventing translocation of phosphorylated extracellular signal regulated kinase 1/2 to the nucleus. Sarjeant JM, etal., Arterioscler Thromb Vasc Biol. 2003 Dec;23(12):2172-7. Epub 2003 Oct 9.
21. Regeneration-associated high level expression of apolipoprotein D mRNA in endoneurial fibroblasts of peripheral nerve. Spreyer P, etal., EMBO J 1990 Aug;9(8):2479-84.
22. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
23. Increased levels of apolipoprotein D in cerebrospinal fluid and hippocampus of Alzheimer's patients. Terrisse L, etal., J Neurochem. 1998 Oct;71(4):1643-50.
24. Apolipoprotein-D polymorphism: a genetic marker for obesity and hyperinsulinemia. Vijayaraghavan S, etal., J Clin Endocrinol Metab. 1994 Aug;79(2):568-70.
Additional References at PubMed
PMID:2090718   PMID:9278274   PMID:11344130   PMID:11744388   PMID:15192024   PMID:16502470   PMID:18419796   PMID:18842892   PMID:19056867   PMID:19176353   PMID:19414061   PMID:19429117  
PMID:20551380   PMID:21705670   PMID:23376485   PMID:23533145   PMID:24082102   PMID:27068509   PMID:27566528  


Genomics

Comparative Map Data
Apod
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81182,936,216 - 82,957,264 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1182,936,038 - 82,957,263 (+)EnsemblGRCr8
mRatBN7.21169,431,261 - 69,452,306 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1169,431,260 - 69,452,305 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1178,268,259 - 78,289,302 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01170,921,321 - 70,942,415 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01169,957,346 - 69,978,387 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01172,705,204 - 72,726,263 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1172,705,129 - 72,726,301 (+)Ensemblrn6Rnor6.0
Rnor_5.01175,781,496 - 75,804,020 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1168,851,395 - 68,872,467 (+)NCBICelera
Cytogenetic Map11q22NCBI
APOD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383195,568,705 - 195,583,940 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3195,568,705 - 195,584,033 (-)Ensemblhg38GRCh38
GRCh373195,295,576 - 195,310,811 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363196,776,865 - 196,792,278 (-)NCBIBuild 36Build 36hg18NCBI36
Celera3193,705,274 - 193,720,781 (-)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3192,666,066 - 192,681,572 (-)NCBIHuRef
CHM1_13195,258,489 - 195,273,995 (-)NCBICHM1_1
T2T-CHM13v2.03198,275,776 - 198,291,015 (-)NCBIT2T-CHM13v2.0
Apod
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391631,115,010 - 31,133,626 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1631,115,010 - 31,133,626 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381631,296,192 - 31,314,808 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1631,296,192 - 31,314,808 (-)Ensemblmm10GRCm38
MGSCv371631,296,278 - 31,314,682 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361631,215,939 - 31,234,343 (-)NCBIMGSCv36mm8
Celera1631,811,354 - 31,812,738 (-)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1621.41NCBI
Apod
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542013,553,058 - 13,573,690 (+)Ensembl
ChiLan1.0NW_00495542013,553,254 - 13,570,357 (+)NCBIChiLan1.0ChiLan1.0
APOD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22193,479,636 - 193,495,178 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13193,484,335 - 193,499,805 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03192,852,887 - 192,868,233 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13203,152,476 - 203,167,888 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3203,152,476 - 203,168,060 (-)EnsemblpanPan2panpan1.1
APOD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13330,490,149 - 30,504,804 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3330,488,135 - 30,509,289 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3330,513,383 - 30,531,252 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03330,739,971 - 30,756,943 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3330,737,959 - 30,803,155 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13330,534,404 - 30,551,475 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03330,570,143 - 30,588,341 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03331,191,636 - 31,209,901 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Apod
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602143,660,676 - 143,676,991 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936833259,660 - 277,246 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936833260,798 - 277,060 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13132,514,949 - 132,562,599 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113132,514,546 - 132,562,594 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213142,076,180 - 142,096,088 (+)NCBISscrofa10.2Sscrofa10.2susScr3
APOD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11589,612,210 - 89,624,038 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1589,612,040 - 89,624,012 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604163,376,402 - 63,388,926 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apod
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473062,530,673 - 62,555,129 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473062,535,005 - 62,552,405 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Apod
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1416,199,064 - 16,220,042 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Apod
92 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:163
Count of miRNA genes:129
Interacting mature miRNAs:139
Transcripts:ENSRNOT00000073330
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)118295102896351019Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat

Markers in Region
D11Rat61  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81182,951,028 - 82,951,192 (+)Marker Load Pipeline
mRatBN7.21169,446,070 - 69,446,234 (+)MAPPERmRatBN7.2
Rnor_6.01172,720,029 - 72,720,192NCBIRnor6.0
Rnor_5.01175,797,786 - 75,797,949UniSTSRnor5.0
Celera1168,866,233 - 68,866,396UniSTS
SHRSP x BN Map1133.2098RGD
SHRSP x BN Map1133.2098UniSTS
Cytogenetic Map11q11UniSTS
RH128953  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21169,452,109 - 69,452,296 (+)MAPPERmRatBN7.2
Rnor_6.01172,726,068 - 72,726,254NCBIRnor6.0
Rnor_5.01175,803,825 - 75,804,011UniSTSRnor5.0
Celera1168,872,272 - 68,872,458UniSTS
RH 3.4 Map11404.4UniSTS
Cytogenetic Map11q11UniSTS
RH94864  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81182,957,084 - 82,957,263 (+)Marker Load Pipeline
Cytogenetic Map11q11UniSTS
BF405372  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21169,441,466 - 69,441,567 (+)MAPPERmRatBN7.2
Rnor_6.01172,715,425 - 72,715,525NCBIRnor6.0
Rnor_5.01175,793,182 - 75,793,282UniSTSRnor5.0
Celera1168,861,628 - 68,861,728UniSTS
Cytogenetic Map11q11UniSTS
BE118763  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21169,443,298 - 69,443,476 (+)MAPPERmRatBN7.2
Rnor_6.01172,717,257 - 72,717,434NCBIRnor6.0
Rnor_5.01175,795,014 - 75,795,191UniSTSRnor5.0
Celera1168,863,461 - 68,863,638UniSTS
RH 3.4 Map11555.73UniSTS
Cytogenetic Map11q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 157 81 81 50 30 50 6 253 129 11 137 50 89 31 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000073330   ⟹   ENSRNOP00000064368
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1182,936,098 - 82,957,263 (+)Ensembl
mRatBN7.2 Ensembl1169,431,260 - 69,452,305 (+)Ensembl
Rnor_6.0 Ensembl1172,705,129 - 72,726,301 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000144387   ⟹   ENSRNOP00000100734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1182,936,038 - 82,957,263 (+)Ensembl
RefSeq Acc Id: NM_012777   ⟹   NP_036909
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,936,220 - 82,957,263 (+)NCBI
mRatBN7.21169,431,261 - 69,452,305 (+)NCBI
Rnor_6.01172,705,204 - 72,726,263 (+)NCBI
Rnor_5.01175,781,496 - 75,804,020 (+)NCBI
Celera1168,851,395 - 68,872,467 (+)RGD
Sequence:
RefSeq Acc Id: XM_039087998   ⟹   XP_038943926
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,936,216 - 82,957,264 (+)NCBI
mRatBN7.21169,431,283 - 69,452,306 (+)NCBI
RefSeq Acc Id: XM_039087999   ⟹   XP_038943927
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,936,352 - 82,957,264 (+)NCBI
mRatBN7.21169,431,303 - 69,452,306 (+)NCBI
RefSeq Acc Id: NP_036909   ⟸   NM_012777
- Peptide Label: precursor
- UniProtKB: P23593 (UniProtKB/Swiss-Prot),   M0R4S2 (UniProtKB/TrEMBL),   A6IRW8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064368   ⟸   ENSRNOT00000073330
RefSeq Acc Id: XP_038943926   ⟸   XM_039087998
- Peptide Label: isoform X1
- UniProtKB: P23593 (UniProtKB/Swiss-Prot),   A6IRW7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943927   ⟸   XM_039087999
- Peptide Label: isoform X1
- UniProtKB: P23593 (UniProtKB/Swiss-Prot),   A6IRW7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000100734   ⟸   ENSRNOT00000144387
Protein Domains
Lipocalin/cytosolic fatty-acid binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23593-F1-model_v2 AlphaFold P23593 1-189 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698223
Promoter ID:EPDNEW_R8746
Type:single initiation site
Name:Apod_1
Description:apolipoprotein D
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01172,705,203 - 72,705,263EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2137 AgrOrtholog
BioCyc Gene G2FUF-21055 BioCyc
Ensembl Genes ENSRNOG00000048273 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000073330 ENTREZGENE
  ENSRNOT00000144387 ENTREZGENE
Gene3D-CATH 2.40.128.20 UniProtKB/Swiss-Prot
InterPro ApoD_vertbrte UniProtKB/Swiss-Prot
  ApolipopD UniProtKB/Swiss-Prot
  Calycin UniProtKB/Swiss-Prot
  Lipocalin_ApoD UniProtKB/Swiss-Prot
  Lipocalin_CS UniProtKB/Swiss-Prot
  Lipocln_cytosolic_FA-bd_dom UniProtKB/Swiss-Prot
KEGG Report rno:25239 UniProtKB/Swiss-Prot
NCBI Gene 25239 ENTREZGENE
PANTHER APOLIPOPROTEIN D UniProtKB/Swiss-Prot
  APOLIPOPROTEIN D UniProtKB/Swiss-Prot
Pfam Lipocalin_2 UniProtKB/Swiss-Prot
PhenoGen Apod PhenoGen
PIRSF Lipocalin_ApoD UniProtKB/Swiss-Prot
PRINTS APODVERTBRTE UniProtKB/Swiss-Prot
  APOLIPOPROTD UniProtKB/Swiss-Prot
  LIPOCALIN UniProtKB/Swiss-Prot
PROSITE LIPOCALIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000048273 RatGTEx
Superfamily-SCOP SSF50814 UniProtKB/Swiss-Prot
TIGR TC205684
UniProt A0ABK0KZG4_RAT UniProtKB/TrEMBL
  A6IRW7 ENTREZGENE, UniProtKB/TrEMBL
  A6IRW8 ENTREZGENE, UniProtKB/TrEMBL
  A6IRX0_RAT UniProtKB/TrEMBL
  APOD_RAT UniProtKB/Swiss-Prot
  M0R4S2 ENTREZGENE, UniProtKB/TrEMBL
  P23593 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Apod  apolipoprotein D    Apolipoprotein D  Name updated 629478 APPROVED
2002-06-10 Apod  Apolipoprotein D      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to extracellular space 634662
gene_process may play a role in nerve repair after injury 634662
gene_regulation increased mRNA levels are detected in injured nerves 634662