Alox5ap (arachidonate 5-lipoxygenase activating protein) - Rat Genome Database

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Gene: Alox5ap (arachidonate 5-lipoxygenase activating protein) Rattus norvegicus
Analyze
Symbol: Alox5ap
Name: arachidonate 5-lipoxygenase activating protein
RGD ID: 2097
Description: Enables enzyme binding activity and identical protein binding activity. Contributes to arachidonate 5-lipoxygenase activity. Involved in leukotriene biosynthetic process; lipoxygenase pathway; and positive regulation of acute inflammatory response. Located in nuclear envelope. Used to study pulmonary hypertension. Biomarker of glomerulonephritis. Human ortholog(s) of this gene implicated in several diseases, including asthma; brain infarction (multiple); breast cancer; cerebral palsy; and coronary artery disease (multiple). Orthologous to human ALOX5AP (arachidonate 5-lipoxygenase activating protein); PARTICIPATES IN leukotriene metabolic pathway; lipoxygenase mediated pathway of arachidonic acid metabolism; INTERACTS WITH (R)-noradrenaline; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 5-lipoxygenase-activating protein FLAP; 5-lipoxygenase-activating protein, FLAP; arachidonate 5-lipoxygenase-activating protein; FLAP; MK-886-binding protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,785,254 - 10,809,295 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1210,785,257 - 10,817,038 (-)EnsemblGRCr8
mRatBN7.2125,748,941 - 5,772,986 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl125,748,944 - 5,772,986 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx126,415,168 - 6,438,995 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0127,038,642 - 7,062,468 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0126,066,300 - 6,090,127 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0126,854,930 - 6,879,112 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl126,854,920 - 6,879,154 (-)Ensemblrn6Rnor6.0
Rnor_5.0128,950,727 - 8,974,708 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4126,245,808 - 6,269,796 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera127,507,392 - 7,531,448 (-)NCBICelera
RGSC_v3.1126,245,808 - 6,269,796 (-)NCBI
Cytogenetic Map12p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-noradrenaline  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
choline  (ISO)
cisplatin  (ISO)
clopidogrel  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-penicillamine  (EXP)
DDE  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
folpet  (ISO)
furan  (EXP)
herbicide  (ISO)
hexachlorobenzene  (EXP)
histamine  (ISO)
hydrogen peroxide  (ISO)
imidazopyrazole  (ISO)
indinavir  (ISO)
kainic acid  (EXP)
L-methionine  (ISO)
lamivudine  (ISO)
leukotriene B4  (ISO)
leukotriene C4  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
medroxyprogesterone acetate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrobenzenes  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (EXP)
Phenelzine  (ISO)
phenobarbital  (ISO)
picrotoxin  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propanal  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP)
saquinavir  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
streptozocin  (ISO)
sulforaphane  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
vinclozolin  (EXP)
warfarin  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Possible involvement of the lipoxygenase and leukotriene signaling pathways in cisplatin-mediated renal toxicity. Alkhamees OA, etal., Cancer Chemother Pharmacol. 2017 Jul;80(1):55-64. doi: 10.1007/s00280-017-3331-8. Epub 2017 May 13.
2. 5-Lipoxygenase-activating protein: a potential link between innate and adaptive immunity in atherosclerosis and adipose tissue inflammation. Back M, etal., Circ Res. 2007 Apr 13;100(7):946-9. Epub 2007 Mar 22.
3. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
4. Localization of 5-lipoxygenase to the nucleus of unstimulated rat basophilic leukemia cells. Brock TG, etal., J Biol Chem. 1994 Sep 2;269(35):22059-66.
5. In situ amplification of 5-lipoxygenase and 5-lipoxygenase-activating protein in allergic airway inflammation and inhibition by leukotriene blockade. Chu SJ, etal., J Immunol. 2000 Oct 15;165(8):4640-8.
6. Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Dixon RA, etal., Nature 1990 Jan 18;343(6255):282-4.
7. Increased expression of cytosolic phospholipase A2, 5-lipoxygenase and 5-lipoxygenase-activating protein in rat peritoneal macrophages during ovalbumin-induced sensitization. Escoubet-Lozach L, etal., Clin Exp Allergy 2001 Jul;31(7):1094-104.
8. Decreased paraoxonase-2 expression in human carotids during the progression of atherosclerosis. Fortunato G, etal., Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):594-600. Epub 2008 Feb 7.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Candidate genes and cerebral palsy: a population-based study. Gibson CS, etal., Pediatrics. 2008 Nov;122(5):1079-85.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Helgadottir A, etal., Nat Genet. 2004 Mar;36(3):233-9. Epub 2004 Feb 8.
13. The importance of leukotrienes in airway inflammation in a mouse model of asthma. Henderson WR Jr, etal., J Exp Med. 1996 Oct 1;184(4):1483-94.
14. The role of LTA4H and ALOX5AP polymorphism in asthma and allergy susceptibility. Holloway JW, etal., Allergy. 2008 Aug;63(8):1046-53. Epub 2008 Jun 10.
15. Hyperoxia increases protein mass of 5-lipoxygenase and its activating protein, flap, and leukotriene B(4) output in newborn rat lungs. Hosford GE, etal., Exp Lung Res. 2002 Dec;28(8):671-84.
16. Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4. Jame AJ, etal., Clin Exp Allergy. 2007 Jun;37(6):880-92.
17. Polymorphisms in the 5-lipoxygenase activating protein (ALOX5AP) gene are not associated with asthma in an Australian population. Kedda MA, etal., Clin Exp Allergy. 2005 Mar;35(3):332-8.
18. Expression of 5-lipoxygenase and 5-lipoxygenase-activating protein mRNAs in the peripheral blood leukocytes of asthmatics. Koshino T, etal., Biochem Biophys Res Commun. 1998 Jun 18;247(2):510-3.
19. Novel polymorphism of the 5-lipoxygenase activating protein (FLAP) promoter gene associated with asthma. Koshino T, etal., Mol Cell Biol Res Commun. 1999 Jul;2(1):32-5.
20. Differential gene signatures in rat mammary tumors induced by DMBA and those induced by fractionated gamma radiation. Lee HJ, etal., Radiat Res. 2008 Nov;170(5):579-90.
21. Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. Lemaitre RN, etal., Atherosclerosis. 2009 Jun;204(2):e58-63. Epub 2008 Nov 1.
22. Association of three-gene interaction among MTHFR, ALOX5AP and NOTCH3 with thrombotic stroke: a multicenter case-control study. Liu J, etal., Hum Genet. 2009 Jun;125(5-6):649-56. Epub 2009 Apr 17.
23. Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation. Lorrain DS, etal., Eur J Pharmacol. 2010 Aug 25;640(1-3):211-8. Epub 2010 May 21.
24. Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2 -ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces acute and chronic inflammation. Lorrain DS, etal., J Pharmacol Exp Ther. 2009 Dec;331(3):1042-50. Epub 2009 Sep 11.
25. The membrane organization of leukotriene synthesis. Mandal AK, etal., Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6587-92. Epub 2004 Apr 14.
26. The nuclear membrane organization of leukotriene synthesis. Mandal AK, etal., Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20434-9. Epub 2008 Dec 15.
27. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
28. Increased 5-lipoxygenase activating protein in immune-mediated experimental nephritis. Montero A, etal., J Nephrol. 2003 Sep-Oct;16(5):682-90.
29. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
30. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
31. Placenta growth factor induces 5-lipoxygenase-activating protein to increase leukotriene formation in sickle cell disease. Patel N, etal., Blood. 2009 Jan 29;113(5):1129-38. Epub 2008 Oct 22.
32. GOA pipeline RGD automated data pipeline
33. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population. Sayers I, etal., Clin Exp Allergy. 2003 Aug;33(8):1103-10.
36. Rhinovirus infection increases 5-lipoxygenase and cyclooxygenase-2 in bronchial biopsy specimens from nonatopic subjects. Seymour ML, etal., J Infect Dis. 2002 Feb 15;185(4):540-4. Epub 2002 Jan 31.
37. Increased urinary leukotriene E4 excretion in obstructive sleep apnea: effects of obesity and hypoxia. Stanke-Labesque F, etal., J Allergy Clin Immunol. 2009 Aug;124(2):364-70, 370.e1-2. Epub 2009 Jul 12.
38. Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy. Sveinbjornsson B, etal., FASEB J. 2008 Oct;22(10):3525-36. Epub 2008 Jun 30.
39. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
40. 5-Lipoxygenase pathway gene polymorphisms: lack of association with asthma in a Spanish population. Torres-Galvan SM, etal., J Investig Allergol Clin Immunol. 2009;19(6):453-8.
41. Associations of genetic polymorphisms of arachidonate 5-lipoxygenase-activating protein with risk of coronary artery disease in a European-American population. Tsai AK, etal., Atherosclerosis. 2009 Jun 18.
42. The role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos. Via M, etal., Clin Exp Allergy. 2010 Apr;40(4):582-9. Epub 2010 Jan 11.
43. Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats. Voelkel NF, etal., J Clin Invest 1996 Jun 1;97(11):2491-8.
44. 5-lipoxygenase and 5-lipoxygenase-activating protein gene polymorphisms, dietary linoleic acid, and risk for breast cancer. Wang J, etal., Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2748-54.
45. Nasal mucosal expression of the leukotriene and prostanoid pathways in seasonal and perennial allergic rhinitis. Westergren VS, etal., Clin Exp Allergy. 2009 Jun;39(6):820-8. Epub 2009 Apr 2.
46. 5-Lipoxygenase and 5-lipoxygenase activating protein (FLAP) immunoreactivity in lungs from patients with primary pulmonary hypertension. Wright L, etal., Am J Respir Crit Care Med. 1998 Jan;157(1):219-29.
47. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics Xu XW, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007 Oct;24(5):491-4.
48. Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome. Yamada Y, etal., Int J Mol Med. 2008 Jun;21(6):801-8.
49. Association of genetic variants with chronic kidney disease in Japanese individuals with type 2 diabetes mellitus. Yoshida T, etal., Int J Mol Med. 2009 Apr;23(4):529-37.
Additional References at PubMed
PMID:2300172   PMID:8245774   PMID:8440384   PMID:9091580   PMID:10779800   PMID:12477932   PMID:17600184   PMID:19233132   PMID:19946888   PMID:24641614   PMID:29936999   PMID:30735559  
PMID:31010302  


Genomics

Comparative Map Data
Alox5ap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,785,254 - 10,809,295 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1210,785,257 - 10,817,038 (-)EnsemblGRCr8
mRatBN7.2125,748,941 - 5,772,986 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl125,748,944 - 5,772,986 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx126,415,168 - 6,438,995 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0127,038,642 - 7,062,468 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0126,066,300 - 6,090,127 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0126,854,930 - 6,879,112 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl126,854,920 - 6,879,154 (-)Ensemblrn6Rnor6.0
Rnor_5.0128,950,727 - 8,974,708 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4126,245,808 - 6,269,796 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera127,507,392 - 7,531,448 (-)NCBICelera
RGSC_v3.1126,245,808 - 6,269,796 (-)NCBI
Cytogenetic Map12p11NCBI
ALOX5AP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381330,713,485 - 30,764,426 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1330,713,478 - 30,765,072 (+)Ensemblhg38GRCh38
GRCh371331,287,622 - 31,338,563 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361330,207,669 - 30,236,556 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341330,207,668 - 30,236,556NCBI
Celera1312,378,644 - 12,407,516 (+)NCBICelera
Cytogenetic Map13q12.3NCBI
HuRef1312,105,618 - 12,156,585 (+)NCBIHuRef
CHM1_11331,255,200 - 31,306,135 (+)NCBICHM1_1
T2T-CHM13v2.01329,935,580 - 29,986,538 (+)NCBIT2T-CHM13v2.0
Alox5ap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395149,201,814 - 149,224,963 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5149,201,577 - 149,224,963 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385149,265,004 - 149,288,153 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5149,264,767 - 149,288,153 (+)Ensemblmm10GRCm38
MGSCv375150,076,634 - 150,099,623 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365149,575,407 - 149,596,895 (+)NCBIMGSCv36mm8
Celera5147,280,239 - 147,303,063 (+)NCBICelera
Cytogenetic Map5G3NCBI
cM Map589.18NCBI
Alox5ap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543115,069,089 - 15,097,580 (-)Ensembl
ChiLan1.0NW_00495543115,071,535 - 15,097,496 (-)NCBIChiLan1.0ChiLan1.0
ALOX5AP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21430,318,849 - 30,348,046 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11321,425,689 - 21,454,792 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01312,012,399 - 12,041,557 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11330,425,510 - 30,476,607 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1330,425,510 - 30,476,607 (+)EnsemblpanPan2panpan1.1
ALOX5AP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,320,868 - 9,351,056 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,320,864 - 9,351,836 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha259,363,720 - 9,390,082 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
Alox5ap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945170,449,329 - 170,475,151 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647225,477,010 - 25,502,840 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647225,477,094 - 25,502,823 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALOX5AP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl117,411,644 - 7,438,108 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1117,371,328 - 7,438,111 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2117,222,771 - 7,287,566 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ALOX5AP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.139,618,030 - 9,642,990 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl39,617,949 - 9,643,184 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605734,722,809 - 34,747,583 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alox5ap
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247767,475,200 - 7,506,283 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247767,475,269 - 7,646,805 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Alox5ap
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1164,574,947 - 4,597,401 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Alox5ap
89 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:51
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000001207
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12592191825247790Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12115486827Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)12124849755Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1357337Gluco3Glucose level QTL 30.0004adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)12116966671Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
61334Gluco17Glucose level QTL 176.3adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)12116966671Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12790162533938215Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12111869600Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 353 192 11 143 78 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000001207   ⟹   ENSRNOP00000001207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1210,785,257 - 10,809,295 (-)Ensembl
mRatBN7.2 Ensembl125,748,944 - 5,772,986 (-)Ensembl
Rnor_6.0 Ensembl126,854,920 - 6,879,154 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000122536   ⟹   ENSRNOP00000100551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1210,785,257 - 10,815,178 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000125511   ⟹   ENSRNOP00000102699
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1210,785,257 - 10,817,038 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000128793   ⟹   ENSRNOP00000111719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1210,785,257 - 10,794,241 (-)Ensembl
RefSeq Acc Id: NM_017260   ⟹   NP_058956
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81210,785,254 - 10,809,295 (-)NCBI
mRatBN7.2125,748,941 - 5,772,986 (-)NCBI
Rnor_6.0126,854,930 - 6,879,112 (-)NCBI
Rnor_5.0128,950,727 - 8,974,708 (-)NCBI
RGSC_v3.4126,245,808 - 6,269,796 (-)RGD
Celera127,507,392 - 7,531,448 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058956 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH86593 (Get FASTA)   NCBI Sequence Viewer  
  CAA36442 (Get FASTA)   NCBI Sequence Viewer  
  EDL89525 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001207
  ENSRNOP00000001207.3
GenBank Protein P20291 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058956   ⟸   NM_017260
- UniProtKB: Q5RJL3 (UniProtKB/Swiss-Prot),   P20291 (UniProtKB/Swiss-Prot),   A6K167 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001207   ⟸   ENSRNOT00000001207
Ensembl Acc Id: ENSRNOP00000102699   ⟸   ENSRNOT00000125511
Ensembl Acc Id: ENSRNOP00000100551   ⟸   ENSRNOT00000122536
Ensembl Acc Id: ENSRNOP00000111719   ⟸   ENSRNOT00000128793

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20291-F1-model_v2 AlphaFold P20291 1-161 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698391
Promoter ID:EPDNEW_R8915
Type:multiple initiation site
Name:Alox5ap_1
Description:arachidonate 5-lipoxygenase activating protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0126,879,131 - 6,879,191EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2097 AgrOrtholog
BioCyc Gene G2FUF-20189 BioCyc
Ensembl Genes ENSRNOG00000000907 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001207 ENTREZGENE
  ENSRNOT00000001207.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.550 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7310271 IMAGE-MGC_LOAD
InterPro 5_LipOase_AP UniProtKB/Swiss-Prot
  FLAP/GST2/LTC4S_CS UniProtKB/Swiss-Prot
  MAPEG UniProtKB/Swiss-Prot
  MAPEG-like_dom_sf UniProtKB/Swiss-Prot
  Membr-assoc_MAPEG UniProtKB/Swiss-Prot
KEGG Report rno:29624 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105473 IMAGE-MGC_LOAD
NCBI Gene 29624 ENTREZGENE
PANTHER ARACHIDONATE 5-LIPOXYGENASE-ACTIVATING PROTEIN UniProtKB/Swiss-Prot
  MICROSOMAL GLUTATHIONE S-TRANSFERASE UniProtKB/Swiss-Prot
Pfam MAPEG UniProtKB/Swiss-Prot
PhenoGen Alox5ap PhenoGen
PRINTS 5LPOXGNASEAP UniProtKB/Swiss-Prot
PROSITE FLAP_GST2_LTC4S UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000907 RatGTEx
Superfamily-SCOP SSF161084 UniProtKB/Swiss-Prot
TIGR TC220528
UniProt A0ABK0LB77_RAT UniProtKB/TrEMBL
  A0ABK0LBV0_RAT UniProtKB/TrEMBL
  A0ABK0LLA4_RAT UniProtKB/TrEMBL
  A6K167 ENTREZGENE, UniProtKB/TrEMBL
  AL5AP_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5RJL3 ENTREZGENE
UniProt Secondary Q5RJL3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Alox5ap  arachidonate 5-lipoxygenase activating protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in macrophages 632195
gene_function binds MK-886, a protein that blocks leukotriene synthesis 69749
gene_process required for leukotriene synthesis 69749
gene_process plays a role in macrophage immediate hypersensitivity response 632195
gene_regulation expression is induced by ovalbumin challenge 632195