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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2097 Species: Rattus norvegicus RGD Object: Gene Symbol: Alox5ap Name: arachidonate 5-lipoxygenase activating protein

Acc ID: CHEBI:63621 Term: saquinavir Definition: An aspartic acid derivative obtained by formal condensation of the primary amino group of (2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-ylamine with the carboxy group of N(2)(-quinolin-2-ylcarbonyl)-L-asparagine. An inhibitor of HIV-1 protease. CasRN: 127779-20-8 Chemical ID: MESH:D019258

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:736461	6480464	CTD	[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ALOX5AP mRNA	PMID:16931933