Adrb1 (adrenoceptor beta 1) - Rat Genome Database

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Gene: Adrb1 (adrenoceptor beta 1) Rattus norvegicus
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Symbol: Adrb1
Name: adrenoceptor beta 1
RGD ID: 2059
Description: Enables amine binding activity and beta1-adrenergic receptor activity. Involved in several processes, including positive regulation of cell communication; regulation of heart contraction; and regulation of muscle system process. Located in plasma membrane. Used to study congestive heart failure; dilated cardiomyopathy; myocardial infarction; periodontitis; and renovascular hypertension. Biomarker of hyperglycemia; hypertension; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including chronic obstructive pulmonary disease; hypertension (multiple); low tension glaucoma; obstructive sleep apnea; and periodontitis. Orthologous to human ADRB1 (adrenoceptor beta 1); PARTICIPATES IN Rho/Rac/Cdc42 mediated signaling pathway; acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; INTERACTS WITH (R)-adrenaline; (R)-noradrenaline; 3',5'-cyclic AMP.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Adrenergic receptor beta 1; adrenergic receptor, beta 1; adrenergic, beta-1-, receptor; B1AR; beta 1-adrenergic receptor beta 1-AR; beta 1-adrenergic receptor, beta 1-AR; beta-1 adrenergic receptor; beta-1 adrenoceptor; beta-1 adrenoreceptor; RATB1AR
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Lnnr2
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81265,777,103 - 265,780,114 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1265,766,079 - 265,849,237 (+)EnsemblGRCr8
mRatBN7.21255,771,962 - 255,774,973 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1255,771,597 - 255,807,259 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1263,982,114 - 263,983,514 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01270,688,166 - 270,689,566 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01263,333,589 - 263,334,989 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01277,537,585 - 277,538,985 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1277,537,585 - 277,538,985 (+)Ensemblrn6Rnor6.0
Rnor_5.01284,917,872 - 284,919,272 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41263,025,655 - 263,027,055 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1251,470,349 - 251,471,554 (+)NCBICelera
RGSC_v3.11263,236,699 - 263,238,100 (+)NCBI
Cytogenetic Map1q55NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(R)-adrenaline  (EXP,ISO)
(R)-noradrenaline  (EXP,ISO)
(R)-octopamine  (ISO)
(S)-nicotine  (ISO)
(S)-timolol (anhydrous)  (ISO)
1,2-dichloroethane  (ISO)
1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol  (ISO)
17beta-estradiol  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
3',5'-cyclic AMP  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-azacytidine  (ISO)
acebutolol  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
albuterol  (EXP,ISO)
alprenolol  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
arbutamine  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
asbestos  (ISO)
atenolol  (EXP,ISO)
atrazine  (EXP)
befunolol  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
betaxolol  (EXP,ISO)
bevantolol  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisoprolol  (EXP,ISO)
bisphenol A  (EXP,ISO)
bupranolol  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP)
cannabidiol  (EXP)
capsaicin  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
carteolol  (ISO)
carvedilol  (EXP,ISO)
CGP 12177  (EXP,ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
cicloprolol  (EXP)
clofibrate  (ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (ISO)
columbamine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
dibenz[a,h]anthracene  (ISO)
dichloromethane  (ISO)
dieldrin  (EXP)
Dihydroalprenolol  (EXP)
diltiazem  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
dobutamine  (EXP,ISO)
dorsomorphin  (ISO)
doxazosin  (EXP)
doxorubicin  (EXP,ISO)
enalapril  (EXP)
enalaprilat dihydrate  (EXP)
endosulfan  (EXP)
fenoterol  (ISO)
fipronil  (ISO)
formaldehyde  (ISO)
formoterol fumarate  (ISO)
genistein  (ISO)
harmaline  (ISO)
harmine  (ISO)
hexane  (ISO)
icariin  (ISO)
ICI 118551  (EXP,ISO)
idazoxan  (EXP)
imipramine  (EXP)
iodocyanopindolol  (EXP,ISO)
isoprenaline  (EXP,ISO)
labetalol  (EXP,ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
metoprolol  (EXP,ISO)
N,N-diethyl-m-toluamide  (ISO)
nadolol  (ISO)
nebivolol  (EXP,ISO)
nickel atom  (ISO)
nicotine  (ISO)
octopamine  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
palmatine  (ISO)
paracetamol  (ISO)
Phenoxybenzamine  (EXP)
phenylmercury acetate  (ISO)
pindolol  (EXP,ISO)
potassium atom  (ISO)
propafenone  (ISO)
propanal  (ISO)
propranolol  (EXP,ISO)
putrescine  (ISO)
reserpine  (EXP)
resveratrol  (ISO)
Salmeterol xinafoate  (ISO)
SB 431542  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sotalol  (ISO)
spermidine  (ISO)
spermine  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
terbutaline  (EXP,ISO)
testosterone  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
trandolapril  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
troglitazone  (ISO)
tyrphostin AG 1478  (ISO)
valproic acid  (EXP,ISO)
verapamil  (ISO)
vincristine  (ISO)
vortioxetine  (ISO)
Xamoterol  (EXP,ISO)
yohimbine  (EXP)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating adrenergic receptor signaling pathway  (IBA,ISO,ISS)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
adrenergic receptor signaling pathway  (IEA)
brown fat cell differentiation  (ISO)
diet induced thermogenesis  (ISO)
fear response  (ISO)
G protein-coupled receptor signaling pathway  (IDA,IEA)
glycogen catabolic process  (IDA)
heat generation  (ISO)
inhibitory postsynaptic potential  (IMP)
lipid homeostasis  (IMP)
memory  (IMP)
negative regulation of multicellular organism growth  (ISO)
negative regulation of multicellular organismal process  (IEA)
negative regulation of smooth muscle contraction  (IMP)
negative regulation of urine volume  (IDA,IEA)
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure  (IBA,ISO)
positive regulation of adenylate cyclase activity  (IMP)
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IMP)
positive regulation of apoptotic process  (IMP)
positive regulation of calcium ion import across plasma membrane  (IDA,IEA)
positive regulation of cardiac muscle cell apoptotic process  (ISO,ISS)
positive regulation of cation channel activity  (IDA)
positive regulation of cell growth involved in cardiac muscle cell development  (IMP)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of developmental growth  (IEA)
positive regulation of heart contraction  (IEA)
positive regulation of heart rate  (IMP)
positive regulation of heart rate by epinephrine-norepinephrine  (ISO)
positive regulation of long-term synaptic potentiation  (IDA)
positive regulation of MAPK cascade  (IBA)
positive regulation of systemic arterial blood pressure  (IMP)
positive regulation of the force of heart contraction by epinephrine-norepinephrine  (IEA,ISO)
positive regulation of the force of heart contraction by norepinephrine  (IDA)
protein localization to organelle  (IDA)
regulation of calcium ion transport  (IDA)
regulation of cardiac muscle cell contraction  (IDA,IMP)
regulation of circadian sleep/wake cycle, sleep  (ISO,ISS)
response to cold  (ISO)
Rho protein signal transduction  (IMP)
signal transduction  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway   (ISO)
calcium/calcium-mediated signaling pathway  (IEA)
carvedilol pharmacodynamics pathway  (ISO)
dilated cardiomyopathy pathway  (IEA)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
endocytosis pathway   (IEA)
epinephrine signaling pathway via adrenergic receptor beta  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
G protein mediated signaling pathway via Galphas family  (TAS)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
Rho/Rac/Cdc42 mediated signaling pathway  (IMP)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Cardioprotective and survival benefits of long-term combined therapy with beta2 adrenoreceptor (AR) agonist and beta1 AR blocker in dilated cardiomyopathy postmyocardial infarction. Ahmet I, etal., J Pharmacol Exp Ther. 2008 May;325(2):491-9. Epub 2008 Feb 20.
2. Therapeutic efficacy of a combination of a beta1-adrenoreceptor (AR) blocker and beta2-AR agonist in a rat model of postmyocardial infarction dilated heart failure exceeds that of a beta1-AR blocker plus angiotensin-converting enzyme inhibitor. Ahmet I, etal., J Pharmacol Exp Ther. 2009 Oct;331(1):178-85. Epub 2009 Jul 8.
3. Specific beta1-adrenergic receptor silencing with small interfering RNA lowers high blood pressure and improves cardiac function in myocardial ischemia. Arnold AS, etal., J Hypertens. 2007 Jan;25(1):197-205.
4. betaAR signaling required for diet-induced thermogenesis and obesity resistance. Bachman ES, etal., Science 2002 Aug 2;297(5582):843-5.
5. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
6. Polymorphisms in alpha- and beta-Adrenergic Receptor Genes, Hypertension, and Obstructive Sleep Apnea: The Skaraborg Sleep Study. Bengtsson Bostrom K, etal., Int J Hypertens. 2010 Mar 30;2010. pii: 458410.
7. Functional beta-adrenergic receptor signalling on nuclear membranes in adult rat and mouse ventricular cardiomyocytes. Boivin B, etal., Cardiovasc Res. 2006 Jul 1;71(1):69-78. Epub 2006 Mar 24.
8. beta1, beta2, and beta3 adrenoceptors and Na+/H+ exchanger regulatory factor 1 expression in human bronchi and their modifications in cystic fibrosis. Bossard F, etal., Am J Respir Cell Mol Biol. 2011 Jan;44(1):91-8. Epub 2010 Mar 4.
9. Beta-adrenoceptor alterations coupled with secretory response and experimental periodontitis in rat submandibular glands. Busch L, etal., Arch Oral Biol. 2008 Jun;53(6):509-16. Epub 2008 Feb 13.
10. Opposite action of beta1- and beta2-adrenergic receptors on Ca(V)1 L-channel current in rat adrenal chromaffin cells. Cesetti T, etal., J Neurosci 2003 Jan 1;23(1):73-83.
11. Inotropy and L-type Ca2+ current, activated by beta1- and beta2-adrenoceptors, are differently controlled by phosphodiesterases 3 and 4 in rat heart. Christ T, etal., Br J Pharmacol. 2009 Jan;156(1):62-83.
12. Role of beta-adrenergic and cholinergic systems in acclimatization to hypoxia in the rat. Clancy RL, etal., Respir Physiol. 1997 Jan;107(1):75-84.
13. Analysis of the beta 1 and beta 2 adrenoceptor interactions of the partial agonist, clenbuterol (NAB365), in the rat jugular vein and atria. Cohen ML, etal., Naunyn Schmiedebergs Arch Pharmacol. 1982 Aug;320(2):145-51.
14. Opposing effects of beta(1)- and beta(2)-adrenergic receptors on cardiac myocyte apoptosis : role of a pertussis toxin-sensitive G protein. Communal C, etal., Circulation. 1999 Nov 30;100(22):2210-2.
15. Long-term treatment of angina pectoris with bisoprolol or atenolol in patients with chronic obstructive bronchitis: a randomized, double-blind crossover study. Dorow P, etal., J Cardiovasc Pharmacol. 1990;16 Suppl 5:S36-44.
16. beta-Adrenergic agonists differentially regulate highly selective and nonselective epithelial sodium channels to promote alveolar fluid clearance in vivo. Downs CA, etal., Am J Physiol Lung Cell Mol Physiol. 2012 Jun 1;302(11):L1167-78. Epub 2012 Apr 13.
17. Beta-adrenergic stimulation and myocardial function in the failing heart. El-Armouche A and Eschenhagen T, Heart Fail Rev. 2009 Dec;14(4):225-41.
18. Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-epsilon to RACK2 in adult rat and mouse. Fenton RA, etal., Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H718-25. Epub 2009 Jun 12.
19. Hidden prenatal malnutrition in the rat: role of beta(1)-adrenoceptors on synaptic plasticity in the frontal cortex. Flores O, etal., J Neurochem. 2011 Oct;119(2):314-23. doi: 10.1111/j.1471-4159.2011.07429.x. Epub 2011 Sep 20.
20. beta-Adrenergic blockers: a 50-year historical perspective. Frishman WH Am J Ther. 2008 Nov-Dec;15(6):565-76.
21. Down-regulation of beta1-adrenoceptors gene expression by short interfering RNA impairs the memory retrieval in the basolateral amygdala of rats. Fu AL, etal., Neurosci Lett. 2007 Nov 27;428(2-3):77-81. Epub 2007 Sep 26.
22. Adrenergic beta-1 receptor genetic variation predicts longitudinal rate of GFR decline in hypertensive nephrosclerosis. Fung MM, etal., Nephrol Dial Transplant. 2009 Dec;24(12):3677-86. doi: 10.1093/ndt/gfp471. Epub 2009 Sep 10.
23. Cardiac beta-adrenoceptors and adenylyl cyclase activity in human left ventricular hypertrophy due to pressure overload. Galinier M, etal., Fundam Clin Pharmacol. 1994;8(1):90-9.
24. Autoantibody against cardiac beta1-adrenoceptor induces apoptosis in cultured neonatal rat cardiomyocytes. Gao Y, etal., Acta Biochim Biophys Sin (Shanghai). 2006 Jul;38(7):443-9.
25. AKAP79-mediated targeting of the cyclic AMP-dependent protein kinase to the beta1-adrenergic receptor promotes recycling and functional resensitization of the receptor. Gardner LA, etal., J Biol Chem. 2006 Nov 3;281(44):33537-53. Epub 2006 Aug 28.
26. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
27. Role of beta-adrenergic receptors in regulation of hepatic fat accumulation during aging. Ghosh PM, etal., J Endocrinol. 2012 Jun;213(3):251-61. Epub 2012 Mar 28.
28. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
29. Circadian-related heteromerization of adrenergic and dopamine D4 receptors modulates melatonin synthesis and release in the pineal gland. González S, etal., PLoS Biol. 2012;10(6):e1001347. doi: 10.1371/journal.pbio.1001347. Epub 2012 Jun 19.
30. Post-treatment with selective beta1 adrenoceptor antagonists provides neuroprotection against transient focal ischemia in rats. Goyagi T, etal., Brain Res. 2010 Jul 9;1343:213-7. Epub 2010 May 6.
31. Cellular and subcellular distributions of beta1- and beta2-adrenoceptors in the CA1 and CA3 regions of the rat hippocampus. Guo NN and Li BM, Neuroscience. 2007 Apr 25;146(1):298-305. Epub 2007 Mar 2.
32. Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins. He J, etal., J Biol Chem. 2006 Feb 3;281(5):2820-7. Epub 2005 Nov 29.
33. G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. Head BP, etal., J Biol Chem. 2005 Sep 2;280(35):31036-44. Epub 2005 Jun 16.
34. beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors. Hu LA, etal., J Biol Chem. 2000 Dec 8;275(49):38659-66.
35. Polymorphism of beta-adrenergic receptors and susceptibility to open-angle glaucoma. Inagaki Y, etal., Mol Vis. 2006 Jun 12;12:673-80.
36. Renal denervation causes chronic hypotension in rats: role of beta1-adrenoceptor activity. Jacob F, etal., Clin Exp Pharmacol Physiol. 2005 Apr;32(4):255-62.
37. Beta1-adrenoceptors in rat anterior pituitary may be constitutively active. Inverse agonism of CGP 20712A on basal 3',5'-cyclic adenosine 5'-monophosphate levels. Janssens K, etal., Endocrinology. 2008 May;149(5):2391-402. Epub 2008 Jan 17.
38. beta2-adrenoceptor transfection enhances contractile reserve of isolated rat ventricular myocytes exposed to chronic isoprenaline stimulation by improving beta1-adrenoceptor responsiveness. Jiang X, etal., J Recept Signal Transduct Res. 2012 Feb;32(1):36-41.
39. Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting. Jimenez M, etal., FEBS Lett. 2002 Oct 23;530(1-3):37-40.
40. Age-related increase of beta1-adrenergic receptor gene expression in rat liver: a potential mechanism contributing to increased beta-adrenergic receptor density and responsiveness during aging. Jin W J Recept Signal Transduct Res. 2010 Feb;30(1):24-30.
41. Crosstalk between adenosine A1 and beta1-adrenergic receptors regulates translocation of PKCepsilon in isolated rat cardiomyocytes. Komatsu S, etal., J Cell Physiol. 2012 Sep;227(9):3201-7. doi: 10.1002/jcp.24008.
42. Intense exercise training induces adaptation in expression and responsiveness of cardiac beta-adrenoceptors in diabetic rats. Lahaye Sle D, etal., Cardiovasc Diabetol. 2010 Nov 5;9:72.
43. Beta-1 adrenergic receptor antisense-oligodeoxynucleotides ameliorates left ventricular remodeling in 2-Kidney, 1-Clip rats. Liang Y, etal., J Biomed Sci. 2007 Jan;14(1):155-64. Epub 2007 Feb 3.
44. [Dynamic changes of alpha-AR, beta1-AR and beta2-AR expression during hepatic fibrogenesis]. Liu N, etal., Zhonghua Gan Zang Bing Za Zhi. 2009 Sep;17(9):653-6.
45. Mechanisms underlying the nociceptive responses induced by platelet-activating factor (PAF) in the rat paw. Marotta DM, etal., Biochem Pharmacol. 2009 Apr 1;77(7):1223-35.
46. Greater glycogen utilization during 1- than 2-adrenergic receptor stimulation in the isolated perfused rat heart. McConville P, etal., Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1828-35. Epub 2007 Oct 2.
47. beta1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. Meitzen J, etal., J Neurochem. 2011 Mar;116(6):984-95. doi: 10.1111/j.1471-4159.2010.07137.x. Epub 2011 Jan 19.
48. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
49. Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure. Mialet Perez J, etal., Nat Med 2003 Oct;9(10):1300-5. Epub 2003 Sep 14.
50. Endocytosis machinery is required for beta1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes. Morisco C, etal., Cardiovasc Res. 2008 Apr 1;78(1):36-44. Epub 2008 Jan 14.
51. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
52. The impact of alpha1-adrenoceptors up-regulation accompanied by the impairment of beta-adrenergic vasodilatation in hypertension. Oliver E, etal., J Pharmacol Exp Ther. 2009 Mar;328(3):982-90. Epub 2008 Dec 5.
53. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
54. Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activation. Pak Y, etal., Mol Cell Biol. 2002 Nov;22(22):7942-52.
55. The insulin-melatonin antagonism: studies in the LEW.1AR1-iddm rat (an animal model of human type 1 diabetes mellitus). Peschke E, etal., Diabetologia. 2011 Jul;54(7):1831-40. Epub 2011 Apr 15.
56. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
57. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
58. GOA pipeline RGD automated data pipeline
59. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
60. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
61. beta-1 and beta-2, but not alpha-1 and alpha-2, adrenoceptor blockade delays rat cutaneous wound healing. Romana-Souza B, etal., Wound Repair Regen. 2009 Mar-Apr;17(2):230-9.
62. Beta-adrenoreceptors in rat brown adipose tissue: proportions of beta 1- and beta 2-subtypes. Rothwell NJ, etal., Am J Physiol. 1985 Apr;248(4 Pt 1):E397-402.
63. Interactions of epinephrine, norepinephrine, dopamine and their corresponding alpha-methyl-substituted derivatives with alpha and beta adrenoceptors in the pithed rat. Ruffolo RR Jr, etal., J Pharmacol Exp Ther. 1984 Sep;230(3):595-600.
64. Effects of landiolol on mechanical and metabolic changes in rat reperfused ischaemic hearts. Sakanashi M, etal., Clin Exp Pharmacol Physiol. 2007 Jan-Feb;34(1-2):55-60.
65. The specific binding of broxaterol, a new beta 2-selective agonist, to beta-adrenoceptors. Sala R, etal., Eur J Pharmacol. 1991 Oct 2;203(1):17-23.
66. Role of anti-beta1 adrenergic antibodies from patients with periodontitis in cardiac dysfunction. Segovia M, etal., J Oral Pathol Med. 2012 Mar;41(3):242-8. doi: 10.1111/j.1600-0714.2011.01090.x. Epub 2011 Sep 30.
67. High concentrations of landiolol, a beta(1)-adrenoceptor antagonist, stimulate smooth muscle contraction of the rat trachea through the Rho-kinase pathway. Shibata O, etal., J Anesth. 2008;22(1):21-6. Epub 2008 Feb 27.
68. Primary structure of the rat beta-1 adrenergic receptor gene. Shimomura H and Terada A, Nucleic Acids Res 1990 Aug 11;18(15):4591.
69. Distinct down-regulation of cardiac beta 1- and beta 2-adrenoceptors in different human heart diseases. Steinfath M, etal., Naunyn Schmiedebergs Arch Pharmacol. 1991 Feb;343(2):217-20.
70. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
71. Reduced CGP12177 binding to cardiac beta-adrenoceptors in hyperglycemic high-fat-diet-fed, streptozotocin-induced diabetic rats. Thackeray JT, etal., Nucl Med Biol. 2011 Oct;38(7):1059-66. Epub 2011 Aug 9.
72. Effects of beta 1- and beta 2-adrenoceptor agonists applied into the hypothalamic paraventricular nuclei of spontaneously hypertensive rats on urine production. Tsushima H, etal., Jpn J Pharmacol. 1994 Mar;64(3):201-7.
73. ß(1) Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice. Ueta CB, etal., J Endocrinol. 2012 Sep;214(3):359-65. doi: 10.1530/JOE-12-0155. Epub 2012 Jun 22.
74. Labetalol facilitates GABAergic transmission to rat periaqueductal gray neurons via antagonizing beta1-adrenergic receptors--a possible mechanism underlying labetalol-induced analgesia. Xiao C, etal., Brain Res. 2008 Mar 10;1198:34-43. Epub 2008 Jan 18.
75. Effect of stellate ganglionectomy on basal cardiovascular function and responses to beta1-adrenoceptor blockade in the rat. Yoshimoto M, etal., Am J Physiol Heart Circ Physiol. 2008 Dec;295(6):H2447-54. Epub 2008 Oct 17.
76. Effects of beta-adrenoceptor antagonists on anaphylactic hypotension in conscious rats. Zhang W, etal., Eur J Pharmacol. 2011 Jan 10;650(1):303-8. Epub 2010 Oct 17.
77. Enhanced cardiac L-type calcium current response to beta2-adrenergic stimulation in heart failure. Zhang ZS, etal., J Pharmacol Exp Ther. 2001 Jul;298(1):188-96.
78. [Positive rate of autoantibodies against adrenergic receptors beta1 and angiotensin II type 1 receptors in the type 2 diabetes mellitus with or without hypertension]. Zhao LS, etal., Zhonghua Xin Xue Guan Bing Za Zhi. 2010 Feb;38(2):139-42.
79. Changes in autoantibodies against beta1-adrenoceptor and M2-muscarinic receptor during development of renovascular hypertension in rats. Zhi JM, etal., Acta Biochim Biophys Sin (Shanghai). 2004 Dec;36(12):793-7.
Additional References at PubMed
PMID:1695899   PMID:7738011   PMID:7761854   PMID:8693001   PMID:9305915   PMID:10358009   PMID:10595521   PMID:11526121   PMID:11641423   PMID:12529373   PMID:12742828   PMID:12832552  
PMID:15066288   PMID:15375008   PMID:15381255   PMID:15539636   PMID:15840637   PMID:16005083   PMID:17053072   PMID:17158652   PMID:17671986   PMID:17869266   PMID:18006556   PMID:18154937  
PMID:18202120   PMID:18296565   PMID:18396264   PMID:18423428   PMID:18469068   PMID:18487315   PMID:18583384   PMID:18596687   PMID:18680159   PMID:19003918   PMID:19111114   PMID:19120131  
PMID:19120133   PMID:19283875   PMID:19336623   PMID:19442879   PMID:19900965   PMID:19932173   PMID:20096470   PMID:20417717   PMID:20547682   PMID:20667477   PMID:21170495   PMID:21540189  
PMID:21777029   PMID:21787468   PMID:21901315   PMID:22099178   PMID:22165287   PMID:22248722   PMID:22253850   PMID:22270541   PMID:22425752   PMID:22506532   PMID:22609523   PMID:22715380  
PMID:23373597   PMID:23488860   PMID:23533220   PMID:23696820   PMID:23916734   PMID:23969695   PMID:24037783   PMID:24121510   PMID:24161401   PMID:24412308   PMID:24744110   PMID:24836853  
PMID:25083013   PMID:25096537   PMID:25211027   PMID:25634756   PMID:25881071   PMID:25966954   PMID:26248277   PMID:26462734   PMID:27035432   PMID:27577254   PMID:28060734   PMID:28160015  
PMID:28167537   PMID:28339772   PMID:28343149   PMID:29212811   PMID:29709009   PMID:30355197   PMID:30591463   PMID:30836825   PMID:31433293   PMID:31553425   PMID:32471715   PMID:34555397  
PMID:35053304  


Genomics

Comparative Map Data
Adrb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81265,777,103 - 265,780,114 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1265,766,079 - 265,849,237 (+)EnsemblGRCr8
mRatBN7.21255,771,962 - 255,774,973 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1255,771,597 - 255,807,259 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1263,982,114 - 263,983,514 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01270,688,166 - 270,689,566 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01263,333,589 - 263,334,989 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01277,537,585 - 277,538,985 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1277,537,585 - 277,538,985 (+)Ensemblrn6Rnor6.0
Rnor_5.01284,917,872 - 284,919,272 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41263,025,655 - 263,027,055 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1251,470,349 - 251,471,554 (+)NCBICelera
RGSC_v3.11263,236,699 - 263,238,100 (+)NCBI
Cytogenetic Map1q55NCBI
ADRB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810114,043,866 - 114,046,904 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10114,043,866 - 114,046,904 (+)Ensemblhg38GRCh38
GRCh3710115,803,625 - 115,806,663 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610115,793,796 - 115,796,657 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3410115,793,804 - 115,795,518NCBI
Celera10109,531,177 - 109,534,039 (+)NCBICelera
Cytogenetic Map10q25.3ENTREZGENE
HuRef10109,429,477 - 109,432,333 (+)NCBIHuRef
CHM1_110116,087,711 - 116,090,573 (+)NCBICHM1_1
T2T-CHM13v2.010114,935,524 - 114,938,557 (+)NCBIT2T-CHM13v2.0
Adrb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391956,710,549 - 56,713,582 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1956,710,631 - 56,721,545 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381956,722,117 - 56,725,150 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1956,722,199 - 56,733,113 (+)Ensemblmm10GRCm38
MGSCv371956,796,862 - 56,799,352 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361956,775,622 - 56,777,022 (+)NCBIMGSCv36mm8
Celera1958,910,911 - 58,913,400 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1951.96NCBI
Adrb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543119,025,663 - 19,027,026 (+)NCBIChiLan1.0ChiLan1.0
ADRB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28125,927,146 - 125,930,192 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110125,932,482 - 125,935,528 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010110,642,491 - 110,646,595 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110114,075,628 - 114,076,596 (+)NCBIPanPan1.1PanPan1.1panPan2
ADRB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12824,908,224 - 24,909,684 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2824,908,224 - 24,909,684 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2825,059,492 - 25,060,922 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02825,441,579 - 25,443,005 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2825,441,579 - 25,443,005 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12824,997,230 - 24,998,684 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02825,011,917 - 25,013,353 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02825,206,065 - 25,207,486 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Adrb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721321,159,710 - 21,160,831 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364864,399,915 - 4,403,149 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364864,400,467 - 4,401,588 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADRB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14124,400,330 - 124,401,739 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114124,400,330 - 124,401,739 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214135,520,692 - 135,522,044 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADRB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19106,920,520 - 106,923,424 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9106,920,610 - 106,922,058 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604868,152,893 - 68,156,014 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adrb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473732,541,598 - 32,563,424 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473732,536,096 - 32,563,721 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Adrb1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1259,434,985 - 59,438,003 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:73
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000022813
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1263946994269633915Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1578775Iddm21Insulin dependent diabetes mellitus QTL 214.13blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1245782829270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1248619887269633915Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1247133834270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1600390Niddm64Non-insulin dependent diabetes mellitus QTL 640.003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1257624997270518180Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1255849111270518180Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat

Markers in Region
D1Arb28  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1q55UniSTS
D1Smu1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21255,785,337 - 255,785,506 (+)MAPPERmRatBN7.2
Rnor_6.01277,550,706 - 277,550,874NCBIRnor6.0
Rnor_5.01284,930,993 - 284,931,161UniSTSRnor5.0
RGSC_v3.41263,038,775 - 263,038,943UniSTSRGSC3.4
Celera1251,483,273 - 251,483,441UniSTS
Cytogenetic Map1q55UniSTS
UniSTS:141043  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21255,773,467 - 255,773,567 (+)MAPPERmRatBN7.2
Rnor_6.01277,538,836 - 277,538,935NCBIRnor6.0
Rnor_5.01284,919,123 - 284,919,222UniSTSRnor5.0
RGSC_v3.41263,026,906 - 263,027,005UniSTSRGSC3.4
Celera1251,471,405 - 251,471,504UniSTS
Cytogenetic Map1q55UniSTS
Adrb1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21255,772,489 - 255,773,011 (+)MAPPERmRatBN7.2
Rnor_6.01277,537,858 - 277,538,379NCBIRnor6.0
Rnor_5.01284,918,145 - 284,918,666UniSTSRnor5.0
RGSC_v3.41263,025,928 - 263,026,449UniSTSRGSC3.4
Celera1251,470,427 - 251,470,948UniSTS
Cytogenetic Map1q55UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 11 67 164 89 88 57 85 57 6 336 183 11 141 75 89 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000022813   ⟹   ENSRNOP00000022813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1265,776,491 - 265,814,572 (+)Ensembl
mRatBN7.2 Ensembl1255,771,915 - 255,795,087 (+)Ensembl
Rnor_6.0 Ensembl1277,537,585 - 277,538,985 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102657   ⟹   ENSRNOP00000082710
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1265,776,491 - 265,814,572 (+)Ensembl
mRatBN7.2 Ensembl1255,771,597 - 255,807,259 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000123057   ⟹   ENSRNOP00000106579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1265,776,496 - 265,848,813 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000133911   ⟹   ENSRNOP00000112757
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1265,774,649 - 265,848,813 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000136976   ⟹   ENSRNOP00000109706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1265,775,305 - 265,849,237 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000139443   ⟹   ENSRNOP00000104543
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1265,776,528 - 265,848,813 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000139837   ⟹   ENSRNOP00000104540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1265,767,003 - 265,780,146 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000151103   ⟹   ENSRNOP00000109573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1265,770,952 - 265,830,946 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000152890   ⟹   ENSRNOP00000098975
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1265,770,952 - 265,846,065 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000173091   ⟹   ENSRNOP00000105435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1265,766,079 - 265,849,237 (+)Ensembl
RefSeq Acc Id: NM_012701   ⟹   NP_036833
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81265,777,103 - 265,780,114 (+)NCBI
mRatBN7.21255,771,962 - 255,774,973 (+)NCBI
Rnor_6.01277,537,585 - 277,538,985 (+)NCBI
Rnor_5.01284,917,872 - 284,919,272 (+)NCBI
RGSC_v3.41263,025,655 - 263,027,055 (+)RGD
Celera1251,470,349 - 251,471,554 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036833 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40792 (Get FASTA)   NCBI Sequence Viewer  
  ALD83745 (Get FASTA)   NCBI Sequence Viewer  
  BAA00527 (Get FASTA)   NCBI Sequence Viewer  
  EDL94502 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022813
GenBank Protein P18090 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036833   ⟸   NM_012701
- UniProtKB: P18090 (UniProtKB/Swiss-Prot),   A0A0G2JSP7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022813   ⟸   ENSRNOT00000022813
Ensembl Acc Id: ENSRNOP00000082710   ⟸   ENSRNOT00000102657
Ensembl Acc Id: ENSRNOP00000106579   ⟸   ENSRNOT00000123057
Ensembl Acc Id: ENSRNOP00000109706   ⟸   ENSRNOT00000136976
Ensembl Acc Id: ENSRNOP00000105435   ⟸   ENSRNOT00000173091
Ensembl Acc Id: ENSRNOP00000104540   ⟸   ENSRNOT00000139837
Ensembl Acc Id: ENSRNOP00000104543   ⟸   ENSRNOT00000139443
Ensembl Acc Id: ENSRNOP00000098975   ⟸   ENSRNOT00000152890
Ensembl Acc Id: ENSRNOP00000112757   ⟸   ENSRNOT00000133911
Ensembl Acc Id: ENSRNOP00000109573   ⟸   ENSRNOT00000151103
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18090-F1-model_v2 AlphaFold P18090 1-466 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2059 AgrOrtholog
BioCyc Gene G2FUF-55309 BioCyc
Ensembl Genes ENSRNOG00000017002 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000022813 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro ADR_fam UniProtKB/Swiss-Prot
  ADRB1_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:24925 UniProtKB/Swiss-Prot
NCBI Gene 24925 ENTREZGENE
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
  BETA-1 ADRENERGIC RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB ADRB1 RGD
PhenoGen Adrb1 PhenoGen
PRINTS ADRENERGICR UniProtKB/Swiss-Prot
  ADRENRGCB1AR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017002 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
TIGR TC235823
UniProt A0A0G2JSP7 ENTREZGENE, UniProtKB/TrEMBL
  A0A0M4LAM5_RAT UniProtKB/TrEMBL
  A6JI28_RAT UniProtKB/TrEMBL
  ADRB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-13 Adrb1  adrenoceptor beta 1  Adrb1  adrenergic, beta-1-, receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Adrb1  adrenergic, beta-1-, receptor  Adrb1  adrenergic receptor, beta 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Adrb1  adrenergic receptor, beta 1    Adrenergic receptor beta 1  Name updated 625702 APPROVED
2002-06-10 Adrb1  Adrenergic receptor beta 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a putative N-linked glycosylation site at Asn-15 632157
gene_domains contains three putative sites for cAMP-dependent protein kinase phosphorylation at Ser-296, Ser-301, and Ser-401 632157
gene_expression mRNA detected in many tissues including pineal gland and other regions of the brain, and heart 632157
gene_function binds beta-adrenergic receptor agonists isoproterenol, norepinephrine, and epinephrine 632157
gene_process mediates induction of adenylylcyclase 632157
gene_process mediates regulation of calcium current 632158
gene_product member of the G-protein coupled receptor family 632157
gene_protein protein sequence contains 466 amino acids 632157