RGD Reference Report - betaAR signaling required for diet-induced thermogenesis and obesity resistance. - Rat Genome Database

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betaAR signaling required for diet-induced thermogenesis and obesity resistance.

Authors: Bachman, ES  Dhillon, H  Zhang, CY  Cinti, S  Bianco, AC  Kobilka, BK  Lowell, BB 
Citation: Bachman ES, etal., Science 2002 Aug 2;297(5582):843-5.
RGD ID: 737773
Pubmed: PMID:12161655   (View Abstract at PubMed)
DOI: DOI:10.1126/science.1073160   (Journal Full-text)

Excessive caloric intake is thought to be sensed by the brain, which then activates thermogenesis as a means of preventing obesity. The sympathetic nervous system, through beta-adrenergic receptor (betaAR) action on target tissues, is likely the efferent arm of this homeostatic mechanism. To test this hypothesis, we created mice that lack the three known betaARs (beta-less mice). beta-less mice on a Chow diet had a reduced metabolic rate and were slightly obese. On a high-fat diet, beta-less mice, in contrast to wild-type mice, developed massive obesity that was due entirely to a failure of diet-induced thermogenesis. These findings establish that betaARs are necessary for diet-induced thermogenesis and that this efferent pathway plays a critical role in the body's defense against diet-induced obesity.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
obesity  ISOAdrb2 (Mus musculus)737773; 737773 RGD 
obesity  IGIAdrb1 (Mus musculus) and Adrb3 (Mus musculus)737773 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Adrb2  (adrenoceptor beta 2)

Genes (Mus musculus)
Adrb2  (adrenergic receptor, beta 2)

Genes (Homo sapiens)
ADRB2  (adrenoceptor beta 2)

Objects referenced in this article
Gene ADRB1 adrenoceptor beta 1 Homo sapiens
Gene ADRB3 adrenoceptor beta 3 Homo sapiens
Gene Adrb1 adrenergic receptor, beta 1 Mus musculus
Gene Adrb3 adrenergic receptor, beta 3 Mus musculus
Gene Adrb1 adrenoceptor beta 1 Rattus norvegicus
Gene Adrb3 adrenoceptor beta 3 Rattus norvegicus

Additional Information