ADRB1 (adrenoceptor beta 1) - Rat Genome Database

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Pathways
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Gene: ADRB1 (adrenoceptor beta 1) Pan paniscus
Analyze
Symbol: ADRB1
Name: adrenoceptor beta 1
RGD ID: 11709277
Description: ENCODES a protein that exhibits alpha-2A adrenergic receptor binding (ortholog); amine binding (ortholog); beta1-adrenergic receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating adrenergic receptor signaling pathway (ortholog); adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); brown fat cell differentiation (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH Anaphylaxis (ortholog); Angina Pectoris (ortholog); aortic valve stenosis (ortholog); FOUND IN early endosome (ortholog); membrane (ortholog); neuronal dense core vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: beta-1 adrenergic receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28125,927,146 - 125,930,192 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110125,932,482 - 125,935,528 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010110,642,491 - 110,646,595 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110114,075,628 - 114,076,596 (+)NCBIpanpan1.1PanPan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating adrenergic receptor signaling pathway  (ISO)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
brown fat cell differentiation  (ISO)
diet induced thermogenesis  (ISO)
fear response  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
glycogen catabolic process  (ISO)
heat generation  (ISO)
inhibitory postsynaptic potential  (ISO)
lipid homeostasis  (ISO)
memory  (ISO)
negative regulation of multicellular organism growth  (ISO)
negative regulation of smooth muscle contraction  (ISO)
negative regulation of urine volume  (ISO)
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure  (ISO)
positive regulation of adenylate cyclase activity  (ISO)
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of calcium ion import across plasma membrane  (ISO)
positive regulation of cation channel activity  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of cold-induced thermogenesis  (ISO)
positive regulation of heart rate  (ISO)
positive regulation of heart rate by epinephrine-norepinephrine  (ISO)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of systemic arterial blood pressure  (ISO)
positive regulation of the force of heart contraction by epinephrine-norepinephrine  (ISO)
positive regulation of the force of heart contraction by norepinephrine  (ISO)
protein localization to organelle  (ISO)
regulation of calcium ion transport  (ISO)
regulation of cardiac muscle cell contraction  (ISO)
regulation of circadian sleep/wake cycle, sleep  (ISO)
response to cold  (ISO)
Rho protein signal transduction  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway   (ISO)
epinephrine signaling pathway via adrenergic receptor beta  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
G protein mediated signaling pathway via Galphas family  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
Rho/Rac/Cdc42 mediated signaling pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ADRB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28125,927,146 - 125,930,192 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110125,932,482 - 125,935,528 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010110,642,491 - 110,646,595 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110114,075,628 - 114,076,596 (+)NCBIpanpan1.1PanPan1.1panPan2
ADRB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810114,043,866 - 114,046,904 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10114,043,866 - 114,046,904 (+)EnsemblGRCh38hg38GRCh38
GRCh3710115,803,625 - 115,806,663 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610115,793,796 - 115,796,657 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410115,793,804 - 115,795,518NCBI
Celera10109,531,177 - 109,534,039 (+)NCBICelera
Cytogenetic Map10q25.3ENTREZGENE
HuRef10109,429,477 - 109,432,333 (+)NCBIHuRef
CHM1_110116,087,711 - 116,090,573 (+)NCBICHM1_1
T2T-CHM13v2.010114,935,524 - 114,938,557 (+)NCBIT2T-CHM13v2.0
Adrb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391956,710,549 - 56,713,582 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1956,710,631 - 56,721,545 (+)EnsemblGRCm39 Ensembl
GRCm381956,722,117 - 56,725,150 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1956,722,199 - 56,733,113 (+)EnsemblGRCm38mm10GRCm38
MGSCv371956,796,862 - 56,799,352 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361956,775,622 - 56,777,022 (+)NCBIMGSCv36mm8
Celera1958,910,911 - 58,913,400 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1951.96NCBI
Adrb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81265,777,103 - 265,780,114 (+)NCBIGRCr8
mRatBN7.21255,771,962 - 255,774,973 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1255,771,597 - 255,807,259 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1263,982,114 - 263,983,514 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01270,688,166 - 270,689,566 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01263,333,589 - 263,334,989 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01277,537,585 - 277,538,985 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1277,537,585 - 277,538,985 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01284,917,872 - 284,919,272 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41263,025,655 - 263,027,055 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11263,236,699 - 263,238,100 (+)NCBI
Celera1251,470,349 - 251,471,554 (+)NCBICelera
Cytogenetic Map1q55NCBI
Adrb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543119,025,663 - 19,027,026 (+)NCBIChiLan1.0ChiLan1.0
ADRB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12824,908,224 - 24,909,684 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2824,908,224 - 24,909,684 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2825,059,492 - 25,060,922 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02825,441,579 - 25,443,005 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2825,441,579 - 25,443,005 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12824,997,230 - 24,998,684 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02825,011,917 - 25,013,353 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02825,206,065 - 25,207,486 (+)NCBIUU_Cfam_GSD_1.0
Adrb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721321,159,710 - 21,160,831 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364864,399,915 - 4,403,149 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364864,400,467 - 4,401,588 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADRB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14124,400,330 - 124,401,739 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114124,400,330 - 124,401,739 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214135,520,692 - 135,522,044 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADRB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19106,920,520 - 106,923,424 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9106,920,610 - 106,922,058 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604868,152,893 - 68,156,014 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adrb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473732,541,598 - 32,563,424 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473732,536,096 - 32,563,721 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_034931523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_034931523   ⟹   XP_034787414
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v28125,927,146 - 125,930,192 (+)NCBI
NHGRI_mPanPan110125,932,482 - 125,935,528 (+)NCBI
Mhudiblu_PPA_v010110,642,491 - 110,646,595 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034787414 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_034787414   ⟸   XM_034931523


Additional Information

Database Acc Id Source(s)
NCBI Gene ADRB1 ENTREZGENE