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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2059
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adrb1
Name: adrenoceptor beta 1
Acc ID: CHEBI:6904
Term: metoprolol
Definition: A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.
Chemical ID: MESH:D008790
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adrb1affects bindingEXP 6480464CTDMetoprolol binds to ADRB1 proteinPMID:9593075
Adrb1decreases methylationEXP 6480464CTDMetoprolol results in decreased methylation of ADRB1 promoterPMID:22165287
Adrb1increases expressionEXP 6480464CTDMetoprolol results in increased expression of ADRB1 mRNA; Metoprolol results in increased expression of ADRB1 proteinPMID:18703049 PMID:22165287
Adrb1multiple interactionsEXP 6480464CTDMetoprolol binds to and results in increased activity of ADRB1 protein; Metoprolol inhibits the reaction [Isoproterenol results in decreased expression of ADRB1 mRNA]; Metoprolol inhibits the reaction [Streptozocin results in decreased expression of ADRB1 protein]PMID:1312942 PMID:18703049 PMID:20590644
Adrb1affects bindingISOADRB1 (Homo sapiens)6480464CTDMetoprolol binds to ADRB1 proteinPMID:10372227
Adrb1affects response to substanceISOADRB1 (Homo sapiens)6480464CTDADRB1 gene affects the susceptibility to Metoprolol; ADRB1 gene polymorphism affects the susceptibility to Metoprolol; ADRB1 protein polymorphism affects the susceptibility to MetoprololPMID:12844134 PMID:15864115 PMID:19094446 PMID:21311897 PMID:22192668
Adrb1decreases activityISOADRB1 (Homo sapiens)6480464CTDMetoprolol results in decreased activity of ADRB1 proteinPMID:1389726
Adrb1increases expressionISOAdrb1 (Mus musculus)6480464CTDMetoprolol results in increased expression of ADRB1 mRNAPMID:20675662
Adrb1multiple interactionsISOADRB1 (Homo sapiens)6480464CTD[ADRB1 gene polymorphism co-treated with ADRA2C gene polymorphism] affects the susceptibility to Metoprolol; [Metoprolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP; ADRB1 gene polymorphism affects the susceptibility to [Dobutamine co-treated with Metoprolol]; Metoprolol binds to and results in decreased activity of ADRB1 protein; Metoprolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Metoprolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]PMID:11562432 PMID:14730417 PMID:15060759 PMID:17200720 PMID:17496726 PMID:20821015
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