Adra1b (adrenoceptor alpha 1B) - Rat Genome Database

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Gene: Adra1b (adrenoceptor alpha 1B) Rattus norvegicus
Analyze
Symbol: Adra1b
Name: adrenoceptor alpha 1B
RGD ID: 2054
Description: Enables alpha1-adrenergic receptor activity. Involved in several processes, including positive regulation of cytosolic calcium ion concentration; response to estrogen; and response to steroid hormone. Acts upstream of or within negative regulation of Rho protein signal transduction. Located in T-tubule and intercalated disc. Biomarker of polycystic ovary syndrome. Orthologous to human ADRA1B (adrenoceptor alpha 1B); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adrenergic alpha 1B receptor; Adrenergic alpha 1B- receptor; adrenergic receptor, alpha 1b; adrenergic, alpha 1B, receptor; Adrenergic, alpha 1B-, receptor; adrenergic, alpha-1B-, receptor; alpha 1B-adrenoceptor; alpha 1B-adrenoreceptor; alpha-1B adrenergic receptor; alpha-1B adrenoceptor; alpha-1B adrenoreceptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81028,756,461 - 28,874,831 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1028,756,461 - 28,814,347 (-)EnsemblGRCr8
mRatBN7.21028,255,025 - 28,373,418 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1028,255,025 - 28,312,919 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1033,014,641 - 33,072,459 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0101,553,026 - 1,610,850 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01027,985,197 - 28,043,019 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01029,392,762 - 29,450,644 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1029,392,762 - 29,450,644 (-)Ensemblrn6Rnor6.0
Rnor_5.01029,233,972 - 29,291,344 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41028,889,092 - 28,946,889 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1027,744,674 - 27,802,198 (-)NCBICelera
RGSC_v3.11028,890,140 - 28,947,938 (-)NCBI
Cytogenetic Map10q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-adrenaline  (ISO)
(R)-noradrenaline  (ISO)
(S)-amphetamine  (ISO)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
1D-myo-inositol 1,4,5-trisphosphate  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-aminopyridine  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
alfuzosin  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
Bardoxolone methyl  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP)
Butylbenzyl phthalate  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
carvedilol  (ISO)
CGP 52608  (ISO)
chlorpromazine  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclazosin  (EXP)
dexamethasone  (ISO)
diazinon  (EXP)
doxazosin  (ISO)
ethylparaben  (ISO)
fipronil  (ISO)
folic acid  (ISO)
glycidol  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
indometacin  (ISO)
inulin  (ISO)
iron dichloride  (ISO)
isoprenaline  (ISO)
kainic acid  (ISO)
ketanserin  (ISO)
lipopolysaccharide  (ISO)
methamphetamine  (ISO)
methoxychlor  (EXP)
methylphenidate  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
okadaic acid  (ISO)
oxymetazoline  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phentolamine  (ISO)
phenylephrine  (EXP,ISO)
picrotoxin  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
prazosin  (EXP,ISO)
propiconazole  (ISO)
quinidine  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sarpogrelate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP)
sunitinib  (ISO)
taurine  (ISO)
terazosin  (ISO)
terbutaline  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
verapamil  (ISO)
Xylometazoline  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating adrenergic receptor signaling pathway  (IBA)
adrenergic receptor signaling pathway  (IEA)
adult heart development  (ISO)
behavioral response to cocaine  (ISO)
blood vessel remodeling  (ISO)
cell growth involved in cardiac muscle cell development  (ISO)
cell-cell signaling  (IBA)
G protein-coupled receptor signaling pathway  (IEA)
glucose homeostasis  (ISO)
locomotory behavior  (ISO)
negative regulation of glycogen catabolic process  (ISO)
negative regulation of Rho protein signal transduction  (IEA,IMP)
neuron-glial cell signaling  (ISO)
organ growth  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IBA,IEA,ISO)
positive regulation of cardiac muscle hypertrophy  (IEA,ISO)
positive regulation of cytosolic calcium ion concentration  (IBA,IDA)
positive regulation of glycogen catabolic process  (ISO)
positive regulation of heart rate by epinephrine-norepinephrine  (ISO)
positive regulation of MAPK cascade  (IBA,IEA,ISO,ISS)
positive regulation of the force of heart contraction by epinephrine-norepinephrine  (ISO)
regulation of blood pressure  (ISO)
regulation of cardiac muscle contraction  (IEA)
regulation of muscle contraction  (IEA)
regulation of vasoconstriction  (IEA)
response to amphetamine  (ISO)
response to estrogen  (IEP)
response to hormone  (IMP)
response to morphine  (ISO)
response to steroid hormone  (IMP)
response to xenobiotic stimulus  (IEP)
signal transduction  (IEA)
vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure  (ISO)
visual learning  (ISO)

Cellular Component
caveola  (IEA)
cytoplasm  (IEA,ISO,ISS)
intercalated disc  (IDA)
membrane  (IEA,ISO)
nuclear membrane  (IEA,ISO,ISS)
nucleus  (IEA,ISO,ISS)
plasma membrane  (IBA,IEA,ISO)
T-tubule  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Impaired glucose homeostasis in mice lacking the alpha1b-adrenergic receptor subtype. Burcelin R, etal., J Biol Chem. 2004 Jan 9;279(2):1108-15. Epub 2003 Oct 27.
2. Effects of castration and of testosterone replacement on alpha(1)-adrenoceptor subtypes in the rat vas deferens. Campos M, etal., Eur J Pharmacol. 2003 Jun 20;471(2):149-55.
3. Adrenaline (via alpha(1B)-adrenoceptors) and ethanol stimulate OH* radical production in isolated rat hepatocytes. Castrejon-Sosa M, etal., Life Sci. 2002 Oct 11;71(21):2469-74.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Circadian-related heteromerization of adrenergic and dopamine D4 receptors modulates melatonin synthesis and release in the pineal gland. González S, etal., PLoS Biol. 2012;10(6):e1001347. doi: 10.1371/journal.pbio.1001347. Epub 2012 Jun 19.
7. Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors. Hague C, etal., J Biol Chem. 2004 Apr 9;279(15):15541-9. Epub 2004 Jan 21.
8. Modulation of intracellular Ca(2+) via alpha(1B)-adrenoreceptor signaling molecules, G alpha(h) (transglutaminase II) and phospholipase C-delta 1. Kang SK, etal., Biochem Biophys Res Commun 2002 Apr 26;293(1):383-90.
9. Nandrolone treatment decreases the alpha1B-adrenoceptor mRNA level in rat kidney, but not the density of alpha1B-adrenoceptors in cultured MDCK-D1 kidney cells. Lindblom J, etal., Eur J Pharmacol. 2005 Dec 19;527(1-3):157-62. Epub 2005 Nov 23.
10. Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5. Lomasney JW, etal., J Biol Chem 1991 Apr 5;266(10):6365-9.
11. Ovarian expression of alpha (1)- and beta (2)-adrenoceptors and p75 neurotrophin receptors in rats with steroid-induced polycystic ovaries. Manni L, etal., Auton Neurosci. 2005 Mar 31;118(1-2):79-87.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Interaction of alpha1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel. O-Uchi J, etal., Circ Res. 2008 Jun 6;102(11):1378-88. Epub 2008 May 8.
15. MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance. Ogata T, etal., Mol Cell Biol. 2008 May;28(10):3424-36. doi: 10.1128/MCB.02186-07. Epub 2008 Mar 10.
16. Alpha-1B adrenoceptors mediate neurogenic constriction in mesenteric arteries of normotensive and DOCA-salt hypertensive mice. Perez-Rivera AA, etal., Auton Neurosci. 2005 Aug 31;121(1-2):64-73.
17. Alpha1-adrenergic receptors: new insights and directions. Piascik MT and Perez DM, J Pharmacol Exp Ther. 2001 Aug;298(2):403-10.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. Functional interactions between estrogen and insulin-like growth factor-I in the regulation of alpha 1B-adrenoceptors and female reproductive function. Quesada A and Etgen AM, J Neurosci. 2002 Mar 15;22(6):2401-8.
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
24. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
25. Sequence of a rat brain cDNA encoding an alpha-1B adrenergic receptor. Voigt MM, etal., Nucleic Acids Res 1990 Feb 25;18(4):1053.
Additional References at PubMed
PMID:7911220   PMID:7989580   PMID:8406017   PMID:9326654   PMID:10409668   PMID:10493741   PMID:11222061   PMID:11923452   PMID:12184796   PMID:12595294   PMID:12782680   PMID:12871582  
PMID:12880866   PMID:15174080   PMID:15231500   PMID:15793568   PMID:16026926   PMID:16308429   PMID:17915215   PMID:17936747   PMID:18204069   PMID:18246093   PMID:18297111   PMID:18336813  
PMID:19120133   PMID:19302553   PMID:20882287   PMID:21958220   PMID:22120526   PMID:22302710   PMID:24567387   PMID:25283507   PMID:25630693   PMID:25775528   PMID:27923787   PMID:29229557  
PMID:29624247   PMID:34062902  


Genomics

Comparative Map Data
Adra1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81028,756,461 - 28,874,831 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1028,756,461 - 28,814,347 (-)EnsemblGRCr8
mRatBN7.21028,255,025 - 28,373,418 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1028,255,025 - 28,312,919 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1033,014,641 - 33,072,459 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0101,553,026 - 1,610,850 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01027,985,197 - 28,043,019 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01029,392,762 - 29,450,644 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1029,392,762 - 29,450,644 (-)Ensemblrn6Rnor6.0
Rnor_5.01029,233,972 - 29,291,344 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41028,889,092 - 28,946,889 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1027,744,674 - 27,802,198 (-)NCBICelera
RGSC_v3.11028,890,140 - 28,947,938 (-)NCBI
Cytogenetic Map10q21NCBI
ADRA1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385159,865,086 - 159,989,205 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5159,865,080 - 159,973,012 (+)Ensemblhg38GRCh38
GRCh375159,343,489 - 159,400,019 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365159,276,318 - 159,332,595 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345159,276,317 - 159,332,129NCBI
Celera5155,374,535 - 155,430,824 (+)NCBICelera
Cytogenetic Map5q33.3NCBI
HuRef5154,438,201 - 154,494,477 (+)NCBIHuRef
CHM1_15158,776,756 - 158,833,023 (+)NCBICHM1_1
T2T-CHM13v2.05160,393,464 - 160,517,778 (+)NCBIT2T-CHM13v2.0
Adra1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391143,665,432 - 43,792,076 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1143,665,433 - 43,792,037 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381143,774,605 - 43,901,250 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1143,774,606 - 43,901,210 (-)Ensemblmm10GRCm38
MGSCv371143,588,108 - 43,649,834 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361143,618,029 - 43,679,755 (-)NCBIMGSCv36mm8
Celera1148,401,465 - 48,463,919 (-)NCBICelera
Cytogenetic Map11B1.1NCBI
cM Map1125.81NCBI
Adra1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540813,883,574 - 13,937,709 (+)Ensembl
ChiLan1.0NW_00495540813,883,574 - 13,937,798 (+)NCBIChiLan1.0ChiLan1.0
ADRA1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24155,101,569 - 155,158,235 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15153,241,121 - 153,297,783 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05155,307,148 - 155,363,785 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15161,923,708 - 161,954,901 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5161,923,895 - 161,979,461 (+)EnsemblpanPan2panpan1.1
ADRA1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1450,676,816 - 50,724,999 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl450,677,255 - 50,724,999 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha450,570,905 - 50,619,105 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0451,111,625 - 51,159,868 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl451,111,625 - 51,159,868 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1450,919,759 - 50,967,913 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0451,043,059 - 51,091,264 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0451,563,698 - 51,612,138 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Adra1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213105,074,452 - 105,123,271 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365153,523,797 - 3,572,596 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365153,523,799 - 3,572,467 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADRA1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1663,550,130 - 63,603,034 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11663,550,123 - 64,010,838 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21669,039,634 - 69,092,211 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADRA1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12362,281,500 - 62,338,290 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603415,270,198 - 15,333,460 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adra1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473329,545,789 - 29,662,028 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473329,545,870 - 29,661,954 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Adra1b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1926,622,813 - 26,679,811 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Adra1b
1103 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)102342212132490778Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
D10Wox8  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map10298.61UniSTS
RH 3.4 Map10298.61RGD
RH 2.0 Map10367.3RGD
Cytogenetic Map10q21UniSTS
RH133503  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21028,255,057 - 28,255,254 (+)MAPPERmRatBN7.2
Rnor_6.01029,392,795 - 29,392,991NCBIRnor6.0
Rnor_5.01029,234,005 - 29,234,201UniSTSRnor5.0
RGSC_v3.41028,889,125 - 28,889,321UniSTSRGSC3.4
Celera1027,744,707 - 27,744,903UniSTS
RH 3.4 Map10296.7UniSTS
Cytogenetic Map10q21UniSTS
PMC150908P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01029,449,417 - 29,450,205NCBIRnor6.0
Rnor_5.01029,290,117 - 29,290,905UniSTSRnor5.0
RGSC_v3.41028,945,662 - 28,946,450UniSTSRGSC3.4
Cytogenetic Map10q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 11 67 138 90 89 59 28 59 6 286 126 8 111 81 88 30 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000087937   ⟹   ENSRNOP00000073309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1028,756,461 - 28,814,347 (-)Ensembl
mRatBN7.2 Ensembl1028,255,025 - 28,312,919 (-)Ensembl
Rnor_6.0 Ensembl1029,392,762 - 29,450,644 (-)Ensembl
RefSeq Acc Id: NM_016991   ⟹   NP_058687
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81028,756,461 - 28,814,347 (-)NCBI
mRatBN7.21028,255,025 - 28,312,919 (-)NCBI
Rnor_6.01029,392,762 - 29,450,644 (-)NCBI
Rnor_5.01029,233,972 - 29,291,344 (-)NCBI
RGSC_v3.41028,889,092 - 28,946,889 (-)RGD
Celera1027,744,674 - 27,802,198 (-)RGD
Sequence:
RefSeq Acc Id: XM_039085165   ⟹   XP_038941093
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81028,756,461 - 28,874,831 (-)NCBI
mRatBN7.21028,255,025 - 28,373,418 (-)NCBI
RefSeq Acc Id: XM_063268387   ⟹   XP_063124457
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81028,757,484 - 28,874,831 (-)NCBI
RefSeq Acc Id: XM_063268388   ⟹   XP_063124458
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81028,795,424 - 28,874,831 (-)NCBI
RefSeq Acc Id: NP_058687   ⟸   NM_016991
- UniProtKB: Q63215 (UniProtKB/Swiss-Prot),   P15823 (UniProtKB/Swiss-Prot),   Q6IRH4 (UniProtKB/TrEMBL),   A0A0G2K564 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073309   ⟸   ENSRNOT00000087937
RefSeq Acc Id: XP_038941093   ⟸   XM_039085165
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063124457   ⟸   XM_063268387
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063124458   ⟸   XM_063268388
- Peptide Label: isoform X2
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15823-F1-model_v2 AlphaFold P15823 1-515 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697119
Promoter ID:EPDNEW_R7643
Type:single initiation site
Name:Adra1b_1
Description:adrenoceptor alpha 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01029,450,685 - 29,450,745EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2054 AgrOrtholog
BioCyc Gene G2FUF-25438 BioCyc
Ensembl Genes ENSRNOG00000060087 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000087937 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7105608 IMAGE-MGC_LOAD
InterPro ADR_fam UniProtKB/Swiss-Prot
  ADRA1B_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
MGC_CLONE MGC:91757 IMAGE-MGC_LOAD
NCBI Gene 24173 ENTREZGENE
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
  PTHR24248:SF17 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Adra1b PhenoGen
PRINTS ADRENERGICR UniProtKB/Swiss-Prot
  ADRENRGCA1BR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000060087 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A0A0G2K564 ENTREZGENE
  A6HDN8_RAT UniProtKB/TrEMBL
  ADA1B_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63215 ENTREZGENE
  Q6IRH4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q63215 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-13 Adra1b  adrenoceptor alpha 1B  Adra1b  adrenergic, alpha-1B-, receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Adra1b  adrenergic, alpha-1B-, receptor  Adra1b  adrenergic receptor, alpha 1b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Adra1b  adrenergic receptor, alpha 1b    adrenergic, alpha 1B, receptor  Name updated 629478 APPROVED
2002-06-10 Adra1b  adrenergic, alpha 1B, receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction associates with G proteins that activate a phosphatidylinositol- calcium second messenger system 61489
gene_process mediates blood pressure and aorta contractile responses induced by alpha-1 agonists