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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2054
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adra1b
Name: adrenoceptor alpha 1B
Acc ID: CHEBI:8081
Term: phentolamine
Definition: A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.
Chemical ID: MESH:D010646
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adra1baffects bindingISOADRA1B (Homo sapiens)6480464CTDPhentolamine binds to ADRA1B proteinPMID:15306222
Adra1bmultiple interactionsISOADRA1B (Homo sapiens)6480464CTDPhentolamine inhibits the reaction [[Epinephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]PMID:15306222
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