GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Adra1b | decreases expression | EXP | | 6480464 | CTD | Phenylephrine results in decreased expression of ADRA1B mRNA; Phenylephrine results in decreased expression of ADRA1B protein | PMID:11693201 | Adra1b | increases response to substance | EXP | | 6480464 | CTD | ADRA1B protein results in increased susceptibility to Phenylephrine | PMID:18480251 | Adra1b | multiple interactions | EXP | | 6480464 | CTD | 4-Aminopyridine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]; ADRA1B protein affects the reaction [Phenylephrine results in decreased activity of TGM2 protein]; chlorethylclonidine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]; Estradiol promotes the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine] | PMID:10801782 PMID:18480251 | Adra1b | affects response to substance | ISO | ADRA1B (Homo sapiens) | 6480464 | CTD | ADRA1B protein affects the susceptibility to Phenylephrine | PMID:18257748 | Adra1b | increases activity | ISO | ADRA1B (Homo sapiens) | 6480464 | CTD | Phenylephrine results in increased activity of ADRA1B protein | PMID:15306222 PMID:16498073 | Adra1b | increases response to substance | ISO | Adra1b (Mus musculus) | 6480464 | CTD | ADRA1B protein results in increased susceptibility to Phenylephrine | PMID:11499749 | Adra1b | multiple interactions | ISO | Adra1b (Mus musculus) | 6480464 | CTD | [Phenylephrine co-treated with ADRA1B protein] results in decreased expression of ATP2A2 protein; [Phenylephrine co-treated with ADRA1B protein] results in decreased expression of NPY protein; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of ACTA1 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of GRK2 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of NPPA protein | PMID:11499749 | Adra1b | multiple interactions | ISO | ADRA1B (Homo sapiens) | 6480464 | CTD | [Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium] | PMID:15306222 PMID:16498073 | | ||||||||||||||||||||||
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