RGD Reference Report - Ovarian expression of alpha (1)- and beta (2)-adrenoceptors and p75 neurotrophin receptors in rats with steroid-induced polycystic ovaries. - Rat Genome Database

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Ovarian expression of alpha (1)- and beta (2)-adrenoceptors and p75 neurotrophin receptors in rats with steroid-induced polycystic ovaries.

Authors: Manni, L  Holmang, A  Lundeberg, T  Aloe, L  Stener-Victorin, E 
Citation: Manni L, etal., Auton Neurosci. 2005 Mar 31;118(1-2):79-87.
RGD ID: 5508374
Pubmed: PMID:15795180   (View Abstract at PubMed)
DOI: DOI:10.1016/j.autneu.2005.01.004   (Journal Full-text)

Polycystic ovary syndrome (PCOS) is the main cause of infertility in women. Despite extensive research aimed at identifying the pathogenetic mechanism underlying this condition, the aetiology of the disease is still unknown. Evidence from studies on women with PCOS and on an experimental rat polycystic ovary (PCO) model suggests that the sympathetic regulatory drive to the ovary may be unbalanced. The present study was designed to investigate this hypothesis. Accordingly, we used the well-defined rat PCO model, where PCO is induced by a single intramuscular (i.m.) injection of estradiol valerate (EV), and compared the model with oil-injected controls. We studied the ovarian expression of the alpha1- and beta2-adrenoceptors (ARs), the neurotrophin receptor p75 (p75NTR), and the sympathetic marker tyrosine hydroxylase (TH) at two time points: 30 and 60 days after EV injection. Our data demonstrate for the first time that all of the alpha1-AR subtypes are expressed in normal rat ovaries at both the mRNA and the protein levels. Furthermore, the expression of the alpha1-AR subtypes was differentially modulated in a time- and subtype-dependent manner in rats with EV-induced PCO. The ovaries in rats with steroid-induced PCO are characterised by an early overexpression of these molecules and p75NTR, while the beta2-AR was downregulated. An increase in the expression of ovarian TH after EV injection was also detected, suggesting a structural and functional remodelling of ovarian sympathetic innervation in PCO rats. Our evidence strongly indicates that the role of the sympathetic nervous system is crucial in the pathogenesis of EV-induced PCO. Overall, our findings suggest that therapeutical approaches aimed at down-regulating the sympathetic tone to the ovary could be useful in the prevention and clinical treatment of PCOS.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
polycystic ovary syndrome  ISOAdra1a (Rattus norvegicus)5508374; 5508374mRNA and protein:increased expression:ovary (rat)RGD 
polycystic ovary syndrome  ISOAdra1b (Rattus norvegicus)5508374; 5508374mRNA and protein:increased expression:ovary (rat)RGD 
polycystic ovary syndrome  ISOAdra1d (Rattus norvegicus)5508374; 5508374mRNA and protein:increased expression:ovary (rat)RGD 
polycystic ovary syndrome  ISOAdrb2 (Rattus norvegicus)5508374; 5508374mRNA and protein:decreased expression:ovary (rat)RGD 
polycystic ovary syndrome  IEP 5508374; 5508374; 5508374; 5508374; 5508374mRNA and protein:increased expression:ovaryRGD 
polycystic ovary syndrome  IEP 5508374mRNA and protein:decreased expression:ovaryRGD 
polycystic ovary syndrome  ISONgfr (Rattus norvegicus)5508374; 5508374mRNA and protein:increased expression:ovary (rat)RGD 
polycystic ovary syndrome  ISOTh (Rattus norvegicus)5508374; 5508374mRNA and protein:increased expression:ovary (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Adra1a  (adrenoceptor alpha 1A)
Adra1b  (adrenoceptor alpha 1B)
Adra1d  (adrenoceptor alpha 1D)
Adrb2  (adrenoceptor beta 2)
Ngfr  (nerve growth factor receptor)
Th  (tyrosine hydroxylase)

Genes (Mus musculus)
Adra1a  (adrenergic receptor, alpha 1a)
Adra1b  (adrenergic receptor, alpha 1b)
Adra1d  (adrenergic receptor, alpha 1d)
Adrb2  (adrenergic receptor, beta 2)
Ngfr  (nerve growth factor receptor (TNFR superfamily, member 16))
Th  (tyrosine hydroxylase)

Genes (Homo sapiens)
ADRA1A  (adrenoceptor alpha 1A)
ADRA1B  (adrenoceptor alpha 1B)
ADRA1D  (adrenoceptor alpha 1D)
ADRB2  (adrenoceptor beta 2)
NGFR  (nerve growth factor receptor)
TH  (tyrosine hydroxylase)


Additional Information