Acvrl1 (activin A receptor like type 1) - Rat Genome Database

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Gene: Acvrl1 (activin A receptor like type 1) Rattus norvegicus
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Symbol: Acvrl1
Name: activin A receptor like type 1
RGD ID: 2029
Description: Predicted to enable several functions, including ATP binding activity; activin binding activity; and transmembrane receptor protein serine/threonine kinase activity. Involved in response to hypoxia. Located in cell surface; dendrite; and neuronal cell body. Biomarker of pulmonary hypertension and transient cerebral ischemia. Human ortholog(s) of this gene implicated in hereditary hemorrhagic telangiectasia and pulmonary hypertension. Orthologous to human ACVRL1 (activin A receptor like type 1); PARTICIPATES IN activin signaling pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: activin A receptor type II-like 1; activin A receptor type IL; Activin receptor like kinase 1; activin receptor like kinase 1; activin receptor type-1-like; Alk1; MGC91691; R-3; R3; serine/threonine-protein kinase receptor R3; SETHKIR; SKR3; TGF-B superfamily receptor type I; TSR-I
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,117,917 - 134,135,306 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7134,118,024 - 134,135,305 (+)EnsemblGRCr8
mRatBN7.27132,239,200 - 132,256,592 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,239,729 - 132,256,591 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7134,047,098 - 134,058,156 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,276,614 - 136,287,668 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,187,385 - 136,198,468 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07142,769,942 - 142,787,336 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,776,252 - 142,787,335 (+)Ensemblrn6Rnor6.0
Rnor_5.07140,571,236 - 140,588,083 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47139,873,596 - 139,884,675 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7128,712,554 - 128,723,633 (+)NCBICelera
RGSC_v3.17139,944,251 - 139,961,111 (+)NCBI
Cytogenetic Map7q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R,R,R)-alpha-tocopherol  (EXP)
1,2-dimethylhydrazine  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
Aflatoxin B2 alpha  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
DDD  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dieldrin  (ISO)
dioxygen  (ISO)
enalapril  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
furan  (EXP)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indometacin  (ISO)
kojic acid  (ISO)
lead diacetate  (ISO)
levetiracetam  (EXP)
manganese(II) chloride  (EXP)
methamphetamine  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
N-nitrosodiethylamine  (EXP)
naled  (ISO)
nickel atom  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
oxybenzone  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
propanal  (ISO)
raloxifene  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
tamibarotene  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activin receptor signaling pathway  (IEA)
angiogenesis  (IBA,IEA,ISO)
artery development  (ISO)
blood circulation  (ISO)
blood vessel morphogenesis  (ISO)
blood vessel remodeling  (ISO)
BMP signaling pathway  (IBA,ISO)
cell differentiation  (IBA)
cell surface receptor protein serine/threonine kinase signaling pathway  (IEA)
cellular response to BMP stimulus  (ISO)
cellular response to growth factor stimulus  (IBA)
cellular response to transforming growth factor beta stimulus  (ISO)
dorsal aorta morphogenesis  (ISO)
dorsal/ventral pattern formation  (IBA)
endocardial cushion morphogenesis  (ISO)
endocardial cushion to mesenchymal transition  (ISO)
endothelial tube morphogenesis  (ISO)
heart development  (IBA)
in utero embryonic development  (ISO)
lymphangiogenesis  (ISO)
lymphatic endothelial cell differentiation  (ISO)
negative regulation of blood vessel endothelial cell migration  (ISO)
negative regulation of cell adhesion  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of endothelial cell differentiation  (ISO)
negative regulation of endothelial cell migration  (ISO)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of focal adhesion assembly  (ISO)
negative regulation of gene expression  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of bicellular tight junction assembly  (ISO)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of endothelial cell differentiation  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial cell differentiation  (ISO)
positive regulation of Notch signaling pathway  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
protein phosphorylation  (TAS)
regulation of blood pressure  (ISO)
regulation of DNA-templated transcription  (ISO)
response to hypoxia  (IEP)
retina vasculature development in camera-type eye  (ISO)
signal transduction  (ISO)
transforming growth factor beta receptor signaling pathway  (IBA,ISO)
venous blood vessel development  (ISO)
wound healing, spreading of epidermal cells  (ISO)

Cellular Component
BMP receptor complex  (IBA)
cell surface  (IDA,ISO)
dendrite  (IDA)
membrane  (IEA)
neuronal cell body  (IDA)
plasma membrane  (IBA,IEA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Three novel mutations in the activin receptor-like kinase 1 (ALK-1) gene in hereditary hemorrhagic telangiectasia type 2 in Brazilian patients. Assis AM, etal., J Hum Genet. 2007;52(3):237-43. Epub 2007 Jan 12.
2. Novel mutations in ENG and ACVRL1 identified in a series of 200 individuals undergoing clinical genetic testing for hereditary hemorrhagic telangiectasia (HHT): correlation of genotype with phenotype. Bossler AD, etal., Hum Mutat. 2006 Jul;27(7):667-75.
3. The transforming growth factor-beta superfamily of receptors. de Caestecker M Cytokine Growth Factor Rev. 2004 Feb;15(1):1-11.
4. Ovarian follicle populations of the rat express TGF-beta signalling pathways. Drummond AE, etal., Mol Cell Endocrinol. 2003 Apr 28;202(1-2):53-7.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Clinical outcomes of pulmonary arterial hypertension in patients carrying an ACVRL1 (ALK1) mutation. Girerd B, etal., Am J Respir Crit Care Med. 2010 Apr 15;181(8):851-61. Epub 2010 Jan 7.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia. Harrison RE, etal., J Med Genet. 2003 Dec;40(12):865-71.
9. TGF-{beta}1 activates two distinct type I receptors in neurons: implications for neuronal NF-{kappa}B signaling. Konig HG, etal., J Cell Biol. 2005 Mar 28;168(7):1077-86. Epub 2005 Mar 21.
10. Molecular screening of ALK1/ACVRL1 and ENG genes in hereditary hemorrhagic telangiectasia in France. Lesca G, etal., Hum Mutat 2004 Apr;23(4):289-99.
11. Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura. Levy GG, etal., Nature. 2001 Oct 4;413(6855):488-94.
12. Adenosine protected against pulmonary edema through transporter- and receptor A2-mediated endothelial barrier enhancement. Lu Q, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Jun;298(6):L755-67. Epub 2010 Mar 12.
13. [Mutations of ACVRL1 gene in a pedigree with hereditary hemorrhagic telangiectasia]. Luo JW, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2008 Jun;25(3):308-10.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. Type I receptor serine-threonine kinase preferentially expressed in pulmonary blood vessels. Panchenko MP, etal., Am J Physiol 1996 Apr;270(4 Pt 1):L547-58.
18. Activin signal transduction pathways. Pangas SA and Woodruff TK, Trends Endocrinol Metab. 2000 Oct;11(8):309-14.
19. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
20. RefSeq and LocusLink: NCBI gene-centered resources Pruitt KD and Maglott DR, Nucleic Acids Res. 2001 Jan 1;29(1):137-40.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2. Srinivasan S, etal., Hum Mol Genet. 2003 Mar 1;12(5):473-82.
25. Hypoxia induces alteration of bone morphogenetic protein receptor signaling in pulmonary artery endothelial cell. Takahashi K, etal., Pediatr Res. 2007 Apr;61(4):392-7.
26. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
27. Arteriovenous malformations in mice lacking activin receptor-like kinase-1. Urness LD, etal., Nat Genet 2000 Nov;26(3):328-31.
28. The TGF-{beta}/Smad2,3 signalling axis is impaired in experimental pulmonary hypertension. Zakrzewicz A, etal., Eur Respir J. 2007 Mar 28;.
Additional References at PubMed
PMID:8242742   PMID:8395914   PMID:10716993   PMID:12065756   PMID:12393874   PMID:12453878   PMID:12477932   PMID:12941632   PMID:14580334   PMID:15489334   PMID:15702480   PMID:15851468  
PMID:17068149   PMID:17530030   PMID:17911384   PMID:19366699   PMID:19494318   PMID:19592636   PMID:19903896   PMID:20406889   PMID:22783020   PMID:23868260   PMID:25424912   PMID:26176610  
PMID:26540443   PMID:30262595   PMID:31322216  


Genomics

Comparative Map Data
Acvrl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,117,917 - 134,135,306 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7134,118,024 - 134,135,305 (+)EnsemblGRCr8
mRatBN7.27132,239,200 - 132,256,592 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,239,729 - 132,256,591 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7134,047,098 - 134,058,156 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,276,614 - 136,287,668 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,187,385 - 136,198,468 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07142,769,942 - 142,787,336 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,776,252 - 142,787,335 (+)Ensemblrn6Rnor6.0
Rnor_5.07140,571,236 - 140,588,083 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47139,873,596 - 139,884,675 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7128,712,554 - 128,723,633 (+)NCBICelera
RGSC_v3.17139,944,251 - 139,961,111 (+)NCBI
Cytogenetic Map7q36NCBI
ACVRL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381251,906,944 - 51,923,361 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1251,906,908 - 51,923,361 (+)Ensemblhg38GRCh38
GRCh371252,300,728 - 52,317,145 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361250,587,469 - 50,603,412 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341250,587,468 - 50,601,120NCBI
Celera1251,103,338 - 51,119,286 (+)NCBICelera
Cytogenetic Map12q13.13ENTREZGENE
HuRef1249,334,280 - 49,350,228 (+)NCBIHuRef
CHM1_11252,267,590 - 52,283,516 (+)NCBICHM1_1
T2T-CHM13v2.01251,870,516 - 51,886,934 (+)NCBIT2T-CHM13v2.0
Acvrl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,026,403 - 101,043,217 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15101,026,403 - 101,043,217 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3815101,128,522 - 101,145,336 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,128,522 - 101,145,336 (+)Ensemblmm10GRCm38
MGSCv3715100,958,968 - 100,975,767 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3615100,956,556 - 100,986,456 (+)NCBIMGSCv36mm8
Celera15103,276,934 - 103,293,737 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.41NCBI
Acvrl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555472,279,042 - 2,294,443 (+)Ensembl
ChiLan1.0NW_0049555472,278,548 - 2,293,865 (+)NCBIChiLan1.0ChiLan1.0
ACVRL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21042,272,321 - 42,288,400 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11242,269,084 - 42,282,021 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01236,839,869 - 36,856,351 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11237,615,888 - 37,631,691 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1237,615,888 - 37,631,691 (-)EnsemblpanPan2panpan1.1
ACVRL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,075,373 - 3,090,549 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,076,124 - 3,092,469 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2743,166,746 - 43,181,176 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0273,072,148 - 3,086,549 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl273,072,149 - 3,081,623 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,088,717 - 3,103,128 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0273,075,021 - 3,089,444 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02743,565,141 - 43,579,587 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Acvrl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494563,786,735 - 63,800,651 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365129,364,149 - 9,379,431 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365129,364,551 - 9,379,131 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACVRL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl517,268,130 - 17,286,276 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1517,267,483 - 17,284,155 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2517,850,783 - 17,871,395 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACVRL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11148,063,099 - 48,091,705 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1148,082,135 - 48,093,630 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037197,998,886 - 198,027,294 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acvrl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624816404,358 - 426,217 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624816402,412 - 426,217 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Acvrl1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11261,949,088 - 261,965,955 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Acvrl1
58 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:214
Count of miRNA genes:148
Interacting mature miRNAs:179
Transcripts:ENSRNOT00000008673
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)7132099939137014596Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
RH133448  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27132,256,311 - 132,256,506 (+)MAPPERmRatBN7.2
Rnor_6.07142,787,056 - 142,787,250NCBIRnor6.0
Rnor_5.07140,587,803 - 140,587,997UniSTSRnor5.0
RGSC_v3.47139,884,395 - 139,884,589UniSTSRGSC3.4
Celera7128,723,353 - 128,723,547UniSTS
RH 3.4 Map71063.0UniSTS
Cytogenetic Map7q36UniSTS
BE100434  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27132,238,307 - 132,238,470 (+)MAPPERmRatBN7.2
Rnor_6.07142,769,050 - 142,769,212NCBIRnor6.0
Rnor_5.07140,569,802 - 140,569,964UniSTSRnor5.0
RGSC_v3.47139,866,394 - 139,866,556UniSTSRGSC3.4
Celera7128,705,352 - 128,705,514UniSTS
RH 3.4 Map71065.1UniSTS
Cytogenetic Map7q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 86 59 6 349 186 11 142 80 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC119007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC083173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L36088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000008673   ⟹   ENSRNOP00000008673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7134,118,184 - 134,135,304 (+)Ensembl
mRatBN7.2 Ensembl7132,239,729 - 132,256,591 (+)Ensembl
Rnor_6.0 Ensembl7142,776,252 - 142,787,335 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081047   ⟹   ENSRNOP00000072526
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7142,776,580 - 142,787,335 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000129074   ⟹   ENSRNOP00000109151
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7134,118,024 - 134,135,305 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000162298   ⟹   ENSRNOP00000104153
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7134,124,679 - 134,135,305 (+)Ensembl
RefSeq Acc Id: NM_022441   ⟹   NP_071886
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,124,227 - 134,135,306 (+)NCBI
mRatBN7.27132,245,511 - 132,256,592 (+)NCBI
Rnor_6.07142,776,252 - 142,787,336 (+)NCBI
Rnor_5.07140,571,236 - 140,588,083 (+)NCBI
RGSC_v3.47139,873,596 - 139,884,675 (+)RGD
Celera7128,712,554 - 128,723,633 (+)RGD
Sequence:
RefSeq Acc Id: XM_006242303   ⟹   XP_006242365
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,117,917 - 134,135,306 (+)NCBI
mRatBN7.27132,239,200 - 132,256,592 (+)NCBI
Rnor_6.07142,769,942 - 142,787,336 (+)NCBI
Rnor_5.07140,571,236 - 140,588,083 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078441   ⟹   XP_038934369
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,117,953 - 134,135,306 (+)NCBI
mRatBN7.27132,239,236 - 132,256,592 (+)NCBI
RefSeq Acc Id: XM_039078443   ⟹   XP_038934371
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,117,917 - 134,135,306 (+)NCBI
mRatBN7.27132,239,236 - 132,256,592 (+)NCBI
RefSeq Acc Id: XM_039078444   ⟹   XP_038934372
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,117,917 - 134,135,306 (+)NCBI
mRatBN7.27132,239,236 - 132,256,592 (+)NCBI
RefSeq Acc Id: XM_039078445   ⟹   XP_038934373
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,117,953 - 134,135,306 (+)NCBI
mRatBN7.27132,239,236 - 132,256,592 (+)NCBI
RefSeq Acc Id: XM_039078446   ⟹   XP_038934374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,117,953 - 134,135,306 (+)NCBI
mRatBN7.27132,239,236 - 132,256,592 (+)NCBI
RefSeq Acc Id: XM_039078447   ⟹   XP_038934375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,117,954 - 134,135,306 (+)NCBI
mRatBN7.27132,239,236 - 132,256,592 (+)NCBI
RefSeq Acc Id: XM_039078448   ⟹   XP_038934376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,117,953 - 134,135,306 (+)NCBI
mRatBN7.27132,239,236 - 132,256,592 (+)NCBI
RefSeq Acc Id: XM_039078449   ⟹   XP_038934377
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,125,438 - 134,135,306 (+)NCBI
mRatBN7.27132,246,733 - 132,256,592 (+)NCBI
RefSeq Acc Id: XM_063263008   ⟹   XP_063119078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,117,954 - 134,135,306 (+)NCBI
RefSeq Acc Id: NP_071886   ⟸   NM_022441
- Peptide Label: precursor
- UniProtKB: Q63559 (UniProtKB/Swiss-Prot),   P80203 (UniProtKB/Swiss-Prot),   A6KCN1 (UniProtKB/TrEMBL),   A6KCM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242365   ⟸   XM_006242303
- Peptide Label: isoform X1
- UniProtKB: Q63559 (UniProtKB/Swiss-Prot),   P80203 (UniProtKB/Swiss-Prot),   A6KCN1 (UniProtKB/TrEMBL),   A6KCM9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008673   ⟸   ENSRNOT00000008673
Ensembl Acc Id: ENSRNOP00000072526   ⟸   ENSRNOT00000081047
RefSeq Acc Id: XP_038934375   ⟸   XM_039078447
- Peptide Label: isoform X1
- UniProtKB: P80203 (UniProtKB/Swiss-Prot),   Q63559 (UniProtKB/Swiss-Prot),   A6KCN1 (UniProtKB/TrEMBL),   A6KCM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934369   ⟸   XM_039078441
- Peptide Label: isoform X1
- UniProtKB: P80203 (UniProtKB/Swiss-Prot),   Q63559 (UniProtKB/Swiss-Prot),   A6KCN1 (UniProtKB/TrEMBL),   A6KCM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934371   ⟸   XM_039078443
- Peptide Label: isoform X1
- UniProtKB: P80203 (UniProtKB/Swiss-Prot),   Q63559 (UniProtKB/Swiss-Prot),   A6KCN1 (UniProtKB/TrEMBL),   A6KCM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934374   ⟸   XM_039078446
- Peptide Label: isoform X1
- UniProtKB: P80203 (UniProtKB/Swiss-Prot),   Q63559 (UniProtKB/Swiss-Prot),   A6KCN1 (UniProtKB/TrEMBL),   A6KCM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934373   ⟸   XM_039078445
- Peptide Label: isoform X1
- UniProtKB: P80203 (UniProtKB/Swiss-Prot),   Q63559 (UniProtKB/Swiss-Prot),   A6KCN1 (UniProtKB/TrEMBL),   A6KCM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934372   ⟸   XM_039078444
- Peptide Label: isoform X1
- UniProtKB: P80203 (UniProtKB/Swiss-Prot),   Q63559 (UniProtKB/Swiss-Prot),   A6KCN1 (UniProtKB/TrEMBL),   A6KCM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934376   ⟸   XM_039078448
- Peptide Label: isoform X1
- UniProtKB: P80203 (UniProtKB/Swiss-Prot),   Q63559 (UniProtKB/Swiss-Prot),   A6KCN1 (UniProtKB/TrEMBL),   A6KCM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934377   ⟸   XM_039078449
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063119078   ⟸   XM_063263008
- Peptide Label: isoform X1
- UniProtKB: Q63559 (UniProtKB/Swiss-Prot),   P80203 (UniProtKB/Swiss-Prot),   A6KCN1 (UniProtKB/TrEMBL),   A6KCM9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000104153   ⟸   ENSRNOT00000162298
Ensembl Acc Id: ENSRNOP00000109151   ⟸   ENSRNOT00000129074
Protein Domains
GS   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P80203-F1-model_v2 AlphaFold P80203 1-504 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2029 AgrOrtholog
BioCyc Gene G2FUF-31998 BioCyc
Ensembl Genes ENSRNOG00000028713 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008673 ENTREZGENE
  ENSRNOT00000008673.5 UniProtKB/Swiss-Prot
  ENSRNOT00000162298 ENTREZGENE
Gene3D-CATH 2.10.60.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7098096 IMAGE-MGC_LOAD
InterPro GS_dom UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  Snake_toxin-like_sf UniProtKB/Swiss-Prot
  TGFB_receptor UniProtKB/Swiss-Prot
KEGG Report rno:25237 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91691 IMAGE-MGC_LOAD
NCBI Gene 25237 ENTREZGENE
PANTHER PTHR23255 UniProtKB/Swiss-Prot
  SERINE/THREONINE-PROTEIN KINASE RECEPTOR R3 UniProtKB/Swiss-Prot
Pfam Pkinase_Tyr UniProtKB/Swiss-Prot
  TGF_beta_GS UniProtKB/Swiss-Prot
PhenoGen Acvrl1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
  PS51256 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000028713 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
  SM00467 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
  SSF57302 UniProtKB/Swiss-Prot
TIGR TC209468
UniProt A0ABK0L406_RAT UniProtKB/TrEMBL
  A0ABK0LVX4_RAT UniProtKB/TrEMBL
  A6KCM9 ENTREZGENE, UniProtKB/TrEMBL
  A6KCN1 ENTREZGENE, UniProtKB/TrEMBL
  ACVL1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63559 ENTREZGENE
UniProt Secondary Q63559 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Acvrl1  activin A receptor like type 1  Acvrl1  activin A receptor type IL  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-11 Acvrl1  activin A receptor type IL  Acvrl1  activin A receptor type II-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Acvrl1  activin A receptor type II-like 1    Activin receptor like kinase 1  Name updated 629478 APPROVED
2002-06-10 Acvrl1  Activin receptor like kinase 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in pulmonary and other blood vessel endothelium 631799
gene_expression expressed in macrophages and lymphoid tissues of spleen 631799
gene_expression expressed in fetal lung blood vessels 631799
gene_product member of the family of type I receptor serine-threonine kinases 631799