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Gene:
Acly ( Rattus norvegicus )
ATP citrate lyase
Description:catalyzes the synthesis of cytosolic acetyl-CoA; plays a role in lipid and cholesterol metabolism
Synonyms:Clatp; MGC124629; ACL;  (details...)
ArrayIDs:6351546; 6374422; 6149299; L27075_g_at; 6740536; 6570402; 6729647; 6673045; 6023905; 1367854_at; L27075_at; 6420196; 6544844; 6463876; 5910853; 6282761; 6164783; GE20258; 6371532; 6137003; J05210_at; J05210_g_at; 6460168; 6436623; 6219506; 6487334; 5918039; A_44_P1004037; 5644229; 5969948; 5961110; 5948548; 6036638; 6245752; 5870302; A_43_P11761; 5727335; 5993578;  (details...)
Gene Type:protein-coding
 
Additional Data
Markers: D10Arb16 D10Wox19
primer pair: 70094
 
Homologs
Homo sapiens: ACLY     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Acly     See the Mouse gene in context in:     UCSC     NCBI MapViewer
 
Comparative Map Data
SpeciesSymbolMap NameChr.Position
Rattus norvegicusAclygenome assembly 3.11089435312 - 89485719
  Rat Celera Assembly1084129406 - 84179897
  RGSC genome assembly v3.41089420941 - 89471349
  Cytogenetic10q32.1
Mus musculusAclyMouse genome assembly build 36.111100337670 - 100389215
  Cytogenetic1111 D
Homo sapiensACLYhuman genome assembly1737276706 - 37328798
  Human genome assembly build 36.21737276705 - 37328798
  Cytogenetic17q12-q21
 
View comparative maps:      NCBI MapViewer
 
 Genome
View:
 
Browsers:
 
Other Map Data:
Associated SSLP Map Locations
No mapping information currently available in RGD for D10Arb16
STSD10Wox19genome assembly 3.11089435945 - 89436174
  RH 3.410857.8
  RH 2.0 10966.3
  RGSC genome assembly v3.41089421575 - 89421804
 
 Annotation
Molecular Function
NoteReference
substrate for protein kinase B in adipocytes631762
catalyzes the synthesis of cytosolic acetyl-CoA631747
Gene Ontology
protein binding,  citrate (pro-3S)-lyase activity,  ATP citrate synthase activity (details...)
Biological Process
NoteReference
plays a role in lipid and cholesterol metabolism631747
Gene Ontology
acetyl-CoA biosynthetic process,  lipid metabolic process (details...)
Cellular Component
Gene Ontology
mitochondrion,  cytosol (details...)
Disease
Ontology
Dentin Dysplasia (details...)
Phenotype
Ontology
abnormal avoidance learning behavior (details...)
Expression
NoteReference
protein detected in adipocytes631762
mRNA and active enzyme detected in liver631747
mRNA expression in liver is high at birth, decreases during suckling, and is higher in adults631747
Transcript structure
NoteReference
mRNA is 4.3 kb in size631747
Regulation
NoteReference
phosphorylated at Ser454 by protein kinase B in adipocytes631762
increased mRNA expression is detected in rats fed a low fat, high carbohydrate diet631747
 
 External Links
Databases
DATABASEIDSOURCE
PROSITE:SUCCINYL_COA_LIG_3IPI
PROSITE:SUCCINYL_COA_LIG_1IPI
PROSITE:SUCCINYL_COA_LIG_2IPI
UNIPARC:UPI00001252A8IPI
UNIPARC:UPI000019C017IPI
UNIPARC:UPI000153BF96IPI
KEGG Report:rno:24159ENTREZGENE
HomoloGene Group ID:854ENTREZGENE
Germonline:2018
Pfam:Ligase_CoAIPI
Pfam:CoA_bindingIPI
KEGG Pathway:00720ENTREZGENE
KEGG Pathway:00020ENTREZGENE
InterPro:Succinyl-CoA_synth-like.IPI
InterPro:Succ-CoA_synthase_bsu_CS.IPI
InterPro:NAD(P)-bd_dom.IPI
InterPro:CoA_ligase.IPI
InterPro:CoA_lig_alpha.IPI
InterPro:CoA_bd.IPI
InterPro:Citrate_synthase-like_core.IPI
InterPro:Citrate_synth-like_sm_a-sub.IPI
InterPro:Cit_synth/succinyl-CoA_lig_AS.IPI
InterPro:ATP_grasp_subdomain_2.IPI
InterPro:ATP-citrate_synthase.IPI
Ensembl Protein:ENSRNOP00000063103IPI
Ensembl Protein:ENSRNOP00000023447IPI
Ensembl Protein:ENSRNOP00000046597IPI
IPI:IPI00951134IPI
IPI:IPI00214665IPI
IPI:IPI00214801IPI
Gene3D-CATH:NAD(P)-bdIPI
Gene3D-CATH:Succinyl-CoA_synth-likeIPI
Gene3D-CATH:ATP_grasp_subdomain_2IPI
Gene3D-CATH:Citrate_synthase_sm_a-subIPI
Entrez Gene:AclyENTREZGENE
PIRSF:ATP_citrt_synIPI
IMAGE_CLONE:IMAGE:7934668IMAGE-MGC_LOAD
MGC_CLONE:MGC:124629IMAGE-MGC_LOAD
UniProt:ACLY_RATIPI
UniProt:Q9Z2G3_RATIPI
UniProt:ACLY_RATIPI
Ensembl Genes:ENSRNOG00000016924IPI
RatMap:15ENTREZGENE
Superfamily-SCOP:NAD(P)-bdIPI
Superfamily-SCOP:Citrate_synthase_coreIPI
Superfamily-SCOP:CoA_ligaseIPI
Sequences
Nucleotide:L47317Get FASTASearch GEO Profiles
Nucleotide:L47316Get FASTASearch GEO Profiles
Nucleotide:L47315Get FASTASearch GEO Profiles
Nucleotide:L47314Get FASTASearch GEO Profiles
Nucleotide:L47313Get FASTASearch GEO Profiles
Nucleotide:NM_016987Get FASTASearch GEO Profiles
Nucleotide:L47312Get FASTASearch GEO Profiles
Nucleotide:L47311Get FASTASearch GEO Profiles
Nucleotide:L47310Get FASTASearch GEO Profiles
Nucleotide:L47309Get FASTASearch GEO Profiles
Nucleotide:L47308Get FASTASearch GEO Profiles
Nucleotide:L47307Get FASTASearch GEO Profiles
Nucleotide:L47306Get FASTASearch GEO Profiles
Nucleotide:L47305Get FASTASearch GEO Profiles
Nucleotide:L47304Get FASTASearch GEO Profiles
Nucleotide:L47303Get FASTASearch GEO Profiles
Nucleotide:L47302Get FASTASearch GEO Profiles
Nucleotide:L47301Get FASTASearch GEO Profiles
Nucleotide:L47300Get FASTASearch GEO Profiles
Nucleotide:CH473948Get FASTASearch GEO Profiles
Nucleotide:AF063905Get FASTASearch GEO Profiles
Nucleotide:NM_001111095Get FASTASearch GEO Profiles
Nucleotide:J05210Get FASTASearch GEO Profiles
Nucleotide:DY473160Get FASTASearch GEO Profiles
Nucleotide:CR471829Get FASTASearch GEO Profiles
Nucleotide:CB800173Get FASTASearch GEO Profiles
Nucleotide:BC100618Get FASTASearch GEO Profiles
Nucleotide:L47319Get FASTASearch GEO Profiles
Nucleotide:L47320Get FASTASearch GEO Profiles
Nucleotide:L47318Get FASTASearch GEO Profiles
(View all 30 Nucleotide Accessions)
Protein:AAL34316Get FASTA
Protein:EDM06045Get FASTA
Protein:EDM06044Get FASTA
Protein:EDM06043Get FASTA
Protein:EDM06042Get FASTA
Protein:AAC95334Get FASTA
Protein:NP_001104565Get FASTA
Protein:NP_058683Get FASTA
Protein:Q9Z2G3Get FASTA
Protein:P16638Get FASTA
Protein:AAA74463Get FASTA
Protein:AAI00619Get FASTA
(View all 12 Protein Accessions)
Clusters
UniGene:29771
 
 References
Curated References
9 references in RGD related to Acly
Other References
11 other references at PubMed related to Acly
 
 Database Information
RGD ID2018
History
Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference
10-JUN-02: Acly ATP citrate lyase APPROVED Symbol and Name status set to approved 70586

       

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