Acly (ATP citrate lyase) - Rat Genome Database

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Gene: Acly (ATP citrate lyase) Rattus norvegicus
Analyze
Symbol: Acly
Name: ATP citrate lyase
RGD ID: 2018
Description: Enables ATP citrate synthase activity. Involved in acetyl-CoA metabolic process and carboxylic acid metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human ACLY (ATP citrate lyase); PARTICIPATES IN fatty acid biosynthetic pathway; citric acid cycle pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ACL; ATP-citrate (pro-S-)-lyase; ATP-citrate synthase; citrate cleavage enzyme; Clatp; MGC124629
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81085,912,402 - 85,964,605 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1085,912,402 - 85,963,631 (-)EnsemblGRCr8
mRatBN7.21085,412,045 - 85,464,253 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,412,049 - 85,463,320 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1090,448,266 - 90,499,722 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01089,927,528 - 89,978,548 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,320,315 - 85,371,541 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,392,248 - 88,442,845 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,392,248 - 88,442,845 (-)Ensemblrn6Rnor6.0
Rnor_5.01088,185,495 - 88,237,133 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41089,420,934 - 89,471,398 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1084,129,399 - 84,179,946 (-)NCBICelera
RGSC_v3.11089,435,312 - 89,485,719 (-)NCBI
Cytogenetic Map10q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-beta-thujone  (ISO)
(-)-acanthoic acid  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-camphor  (ISO)
(R)-linalyl acetate  (ISO)
1,2-dimethylhydrazine  (ISO)
1,8-cineole  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dimethoxyphenol  (ISO)
2-chloroethanol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetyl-CoA  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldrin  (ISO)
alpha-linolenic acid  (EXP)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amiodarone  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
benzene  (EXP)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
benzylpenicillin  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
brexpiprazole  (ISO)
Brodifacoum  (EXP)
bromobenzene  (EXP)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calyculin A  (ISO)
camphor  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
chloroethene  (ISO)
chlorogenic acid  (ISO)
chloropicrin  (ISO)
chlorothalonil  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cis-caffeic acid  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corn oil  (EXP)
corticosterone  (EXP)
cortisol  (ISO)
coumarin  (EXP)
coumestrol  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cyproconazole  (EXP)
D-glucose  (EXP,ISO)
D-mannitol  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP,ISO)
erythromycin A  (ISO)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
ferrostatin-1  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fructose  (EXP)
furan  (EXP)
furfural  (ISO)
gamma-hexachlorocyclohexane  (EXP)
Ganoderic acid A  (ISO)
genistein  (ISO)
glucose  (EXP,ISO)
glyphosate  (ISO)
guggulsterone  (ISO)
GW 3965  (ISO)
GW 4064  (ISO)
hexadecanoic acid  (ISO)
Honokiol  (EXP)
hydrogen cyanide  (ISO)
indometacin  (ISO)
inulin  (ISO)
isoniazide  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
josamycin  (ISO)
L-methionine  (ISO)
linalool  (ISO)
linalyl acetate  (ISO)
linoleic acid  (EXP)
metformin  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (EXP)
methyl methanesulfonate  (ISO)
miconazole  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (ISO)
N-methyl-N-nitrosourea  (EXP)
n-propyl gallate  (EXP)
naloxone  (EXP)
nefazodone  (EXP)
nickel dichloride  (EXP)
nimesulide  (EXP)
Nivalenol  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
Oleacein  (ISO)
oleic acid  (ISO)
orotic acid  (EXP)
Osajin  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
Pomiferin  (ISO)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
procymidone  (ISO)
propamocarb  (ISO)
propiconazole  (EXP)
Propiverine  (EXP)
puerarin  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
Rosavin  (ISO)
rotenone  (EXP,ISO)
rutin  (ISO)
sabinene  (ISO)
sarin  (ISO)
SB 431542  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
spathulenol  (ISO)
sucrose  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (EXP)
sulindac  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
toosendanin  (ISO)
trametinib  (ISO)
trans-caffeic acid  (ISO)
Tributyltin oxide  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vemurafenib  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IEA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes. Berwick DC, etal., J Biol Chem. 2002 Sep 13;277(37):33895-900. Epub 2002 Jul 09.
2. [Biological-molecular trend in psychiatry] Bilikiewicz A Pol Tyg Lek 1978 Jun 26;33(26):1046-50.
3. Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat. Deng AY and Rapp JP, J Clin Invest 1995 May;95(5):2170-7
4. [Sanitary and hygienic evaluation of a technological line for removing manure]. Dolgov VS, Veterinariia. 1978 Dec;(12):61-3.
5. Rat ATP citrate-lyase. Molecular cloning and sequence analysis of a full-length cDNA and mRNA abundance as a function of diet, organ, and age. Elshourbagy NA, etal., J Biol Chem 1990 Jan 25;265(3):1430-5.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Dietary lipoic acid-dependent changes in the activity and mRNA levels of hepatic lipogenic enzymes in rats. Huong DT and Ide T, Br J Nutr. 2008 Jul;100(1):79-87. Epub 2007 Dec 7.
9. Regulation of glucose- and mitochondrial fuel-induced insulin secretion by a cytosolic protein histidine phosphatase in pancreatic beta-cells. Kamath V, etal., Am J Physiol Endocrinol Metab. 2010 Aug;299(2):E276-86. doi: 10.1152/ajpendo.00091.2010. Epub 2010 May 25.
10. Variant cDNA sequences of human ATP:citrate lyase: cloning, expression, and purification from baculovirus-infected insect cells. Lord KA, etal., Protein Expr Purif. 1997 Feb;9(1):133-41. doi: 10.1006/prep.1996.0668.
11. Activity of adenosine deaminase in the sleep regulatory areas of the rat CNS. Mackiewicz M, etal., Brain Res Mol Brain Res 2000 Sep 15;80(2):252-5.
12. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Menendez JA and Lupu R, Nat Rev Cancer. 2007 Oct;7(10):763-77.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Effect of cold acclimation on brown adipose tissue fatty acid synthesis in rats adapted to a high-protein, carbohydrate-free diet. Moura MA, etal., Metabolism. 2001 Dec;50(12):1493-8.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. The kinetic properties of citrate synthase from rat liver mitochondria. Shepherd D and Garland PB, Biochem J. 1969 Sep;114(3):597-610.
Additional References at PubMed
PMID:1371749   PMID:2176822   PMID:8688462   PMID:10653665   PMID:11989980   PMID:12086928   PMID:12477932   PMID:16396499   PMID:16854843   PMID:17823126   PMID:18614015   PMID:19056867  
PMID:19286649   PMID:19946888   PMID:20458337   PMID:20460097   PMID:21454710   PMID:23225248   PMID:23533145   PMID:23932781   PMID:24625528   PMID:25450640   PMID:26296893   PMID:32357304  
PMID:33450132  


Genomics

Comparative Map Data
Acly
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81085,912,402 - 85,964,605 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1085,912,402 - 85,963,631 (-)EnsemblGRCr8
mRatBN7.21085,412,045 - 85,464,253 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,412,049 - 85,463,320 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1090,448,266 - 90,499,722 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01089,927,528 - 89,978,548 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,320,315 - 85,371,541 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,392,248 - 88,442,845 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,392,248 - 88,442,845 (-)Ensemblrn6Rnor6.0
Rnor_5.01088,185,495 - 88,237,133 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41089,420,934 - 89,471,398 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1084,129,399 - 84,179,946 (-)NCBICelera
RGSC_v3.11089,435,312 - 89,485,719 (-)NCBI
Cytogenetic Map10q31NCBI
ACLY
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381741,866,917 - 41,930,545 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1741,866,916 - 41,930,545 (-)Ensemblhg38GRCh38
GRCh371740,023,170 - 40,075,275 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,276,705 - 37,328,798 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341737,276,706 - 37,328,798NCBI
Celera1736,674,340 - 36,725,809 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1735,785,140 - 35,836,956 (-)NCBIHuRef
CHM1_11740,258,594 - 40,311,000 (-)NCBICHM1_1
T2T-CHM13v2.01742,723,421 - 42,775,531 (-)NCBIT2T-CHM13v2.0
Acly
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,367,178 - 100,418,826 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,367,179 - 100,418,826 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3811100,476,352 - 100,528,000 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,476,353 - 100,528,000 (-)Ensemblmm10GRCm38
MGSCv3711100,337,670 - 100,389,215 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611100,292,446 - 100,343,991 (-)NCBIMGSCv36mm8
Celera11111,095,710 - 111,147,350 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.47NCBI
Acly
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,058,727 - 16,092,589 (-)Ensembl
ChiLan1.0NW_00495545116,058,916 - 16,091,831 (-)NCBIChiLan1.0ChiLan1.0
ACLY
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21923,053,400 - 23,115,308 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,943,541 - 25,005,482 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01715,385,335 - 15,447,269 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11715,615,957 - 15,665,692 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,615,994 - 15,664,800 (+)EnsemblpanPan2panpan1.1
ACLY
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,929,530 - 20,974,200 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,929,614 - 20,973,663 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha920,390,153 - 20,434,737 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0921,648,350 - 21,693,226 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,648,295 - 21,693,224 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1920,433,791 - 20,478,844 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,700,516 - 20,745,189 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,803,776 - 20,849,064 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Acly
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560220,276,950 - 20,317,138 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649016,757,985 - 16,798,237 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649016,758,001 - 16,798,152 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACLY
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,796,749 - 20,841,298 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11220,796,678 - 20,841,301 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21221,082,937 - 21,106,727 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACLY
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11664,343,175 - 64,392,011 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607735,156,831 - 35,219,899 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acly
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,872,454 - 1,911,004 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247951,872,413 - 1,910,495 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Acly
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1959,780,983 - 59,823,393 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Acly
437 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:452
Count of miRNA genes:197
Interacting mature miRNAs:227
Transcripts:ENSRNOT00000023447, ENSRNOT00000043172
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108101207791729860Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108306123692869129Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108450348796432422Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108450348796432422Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
D10Wox19  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,412,685 - 85,412,915 (+)MAPPERmRatBN7.2
Rnor_6.01088,392,889 - 88,393,118NCBIRnor6.0
Rnor_5.01088,186,136 - 88,186,365UniSTSRnor5.0
RGSC_v3.41089,421,575 - 89,421,804RGDRGSC3.4
RGSC_v3.41089,421,575 - 89,421,804UniSTSRGSC3.4
Celera1084,130,040 - 84,130,269UniSTS
RGSC_v3.11089,435,945 - 89,436,174RGD
RH 3.4 Map10857.8UniSTS
RH 3.4 Map10857.8RGD
RH 2.0 Map10966.3RGD
Cytogenetic Map10q32.1UniSTS
D10Arb16   No map positions available.
D10Mco75  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81085,930,592 - 85,930,855 (+)Marker Load Pipeline
mRatBN7.21085,430,237 - 85,430,500 (+)MAPPERmRatBN7.2
Rnor_6.01088,410,439 - 88,410,701NCBIRnor6.0
Rnor_5.01088,203,686 - 88,203,948UniSTSRnor5.0
RGSC_v3.41089,439,125 - 89,439,388RGDRGSC3.4
RGSC_v3.41089,439,126 - 89,439,388UniSTSRGSC3.4
Celera1084,147,582 - 84,147,844UniSTS
RGSC_v3.11089,453,495 - 89,453,758RGD
Cytogenetic Map10q32.1UniSTS
D10Wox48  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,430,237 - 85,430,498 (+)MAPPERmRatBN7.2
Rnor_6.01088,410,439 - 88,410,699NCBIRnor6.0
Rnor_5.01088,203,686 - 88,203,946UniSTSRnor5.0
RGSC_v3.41089,439,126 - 89,439,386UniSTSRGSC3.4
Celera1084,147,582 - 84,147,842UniSTS
Cytogenetic Map10q32.1UniSTS
AW526881  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,412,474 - 85,412,567 (+)MAPPERmRatBN7.2
Rnor_6.01088,392,678 - 88,392,770NCBIRnor6.0
Rnor_5.01088,185,925 - 88,186,017UniSTSRnor5.0
RGSC_v3.41089,421,364 - 89,421,456UniSTSRGSC3.4
Celera1084,129,829 - 84,129,921UniSTS
RH 3.4 Map10858.6UniSTS
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000023447   ⟹   ENSRNOP00000023447
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1085,912,402 - 85,963,631 (-)Ensembl
mRatBN7.2 Ensembl1085,412,049 - 85,463,310 (-)Ensembl
Rnor_6.0 Ensembl1088,392,248 - 88,442,845 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000043172   ⟹   ENSRNOP00000046597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1085,912,402 - 85,963,631 (-)Ensembl
mRatBN7.2 Ensembl1085,412,049 - 85,463,320 (-)Ensembl
Rnor_6.0 Ensembl1088,392,248 - 88,442,845 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077579   ⟹   ENSRNOP00000073397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1085,912,402 - 85,963,631 (-)Ensembl
mRatBN7.2 Ensembl1085,412,049 - 85,463,298 (-)Ensembl
Rnor_6.0 Ensembl1088,392,257 - 88,442,796 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114571   ⟹   ENSRNOP00000093648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1085,912,402 - 85,963,631 (-)Ensembl
mRatBN7.2 Ensembl1085,412,049 - 85,463,310 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119580   ⟹   ENSRNOP00000084652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1085,935,765 - 85,963,631 (-)Ensembl
mRatBN7.2 Ensembl1085,435,410 - 85,463,310 (-)Ensembl
RefSeq Acc Id: NM_001111095   ⟹   NP_001104565
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81085,912,402 - 85,963,631 (-)NCBI
mRatBN7.21085,412,045 - 85,463,279 (-)NCBI
Rnor_6.01088,392,248 - 88,442,845 (-)NCBI
Rnor_5.01088,185,495 - 88,237,133 (-)NCBI
RGSC_v3.41089,420,934 - 89,471,398 (-)RGD
Celera1084,129,399 - 84,179,946 (-)RGD
Sequence:
RefSeq Acc Id: NM_016987   ⟹   NP_058683
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81085,912,402 - 85,963,631 (-)NCBI
mRatBN7.21085,412,045 - 85,463,279 (-)NCBI
Rnor_6.01088,392,248 - 88,442,845 (-)NCBI
Rnor_5.01088,185,495 - 88,237,133 (-)NCBI
RGSC_v3.41089,420,934 - 89,471,398 (-)RGD
Celera1084,129,399 - 84,179,946 (-)RGD
Sequence:
RefSeq Acc Id: XM_039085164   ⟹   XP_038941092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81085,912,406 - 85,964,605 (-)NCBI
mRatBN7.21085,412,053 - 85,464,253 (-)NCBI
RefSeq Acc Id: NP_058683   ⟸   NM_016987
- Peptide Label: isoform 1
- UniProtKB: Q8VIQ1 (UniProtKB/Swiss-Prot),   Q497C7 (UniProtKB/Swiss-Prot),   P16638 (UniProtKB/Swiss-Prot),   G3V888 (UniProtKB/TrEMBL),   A6HJ39 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001104565   ⟸   NM_001111095
- Peptide Label: isoform 2
- UniProtKB: Q8VIQ1 (UniProtKB/Swiss-Prot),   Q497C7 (UniProtKB/Swiss-Prot),   P16638 (UniProtKB/Swiss-Prot),   G3V9G4 (UniProtKB/TrEMBL),   A6HJ38 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000046597   ⟸   ENSRNOT00000043172
Ensembl Acc Id: ENSRNOP00000023447   ⟸   ENSRNOT00000023447
Ensembl Acc Id: ENSRNOP00000073397   ⟸   ENSRNOT00000077579
RefSeq Acc Id: XP_038941092   ⟸   XM_039085164
- Peptide Label: isoform X1
- UniProtKB: Q8VIQ1 (UniProtKB/Swiss-Prot),   Q497C7 (UniProtKB/Swiss-Prot),   P16638 (UniProtKB/Swiss-Prot),   G3V888 (UniProtKB/TrEMBL),   A6HJ39 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084652   ⟸   ENSRNOT00000119580
Ensembl Acc Id: ENSRNOP00000093648   ⟸   ENSRNOT00000114571
Protein Domains
ATP-citrate synthase ATP-grasp   ATP-citrate synthase citrate-binding   ATP-grasp   CoA-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P16638-F1-model_v2 AlphaFold P16638 1-1100 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697727
Promoter ID:EPDNEW_R8248
Type:multiple initiation site
Name:Acly_1
Description:ATP citrate lyase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01088,442,822 - 88,442,882EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2018 AgrOrtholog
BioCyc Gene G2FUF-23232 BioCyc
BioCyc Pathway PWY-5172 [acetyl-CoA biosynthesis from citrate] BioCyc
BioCyc Pathway Image PWY-5172 BioCyc
Ensembl Genes ENSRNOG00000016924 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000023447 ENTREZGENE
  ENSRNOT00000043172 ENTREZGENE
Gene3D-CATH 1.10.230.10 UniProtKB/Swiss-Prot
  1.10.580.10 UniProtKB/Swiss-Prot
  3.30.470.110 UniProtKB/Swiss-Prot
  3.40.50.261 UniProtKB/Swiss-Prot
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7934668 IMAGE-MGC_LOAD
InterPro ATP-citrate_synthase UniProtKB/Swiss-Prot
  Cit_synth/succinyl-CoA_lig_AS UniProtKB/Swiss-Prot
  Citrate-bd UniProtKB/Swiss-Prot
  Citrate_synth-like_lrg_a-sub UniProtKB/Swiss-Prot
  Citrate_synth-like_sm_a-sub UniProtKB/Swiss-Prot
  Citrate_synth_N UniProtKB/Swiss-Prot
  Citrate_synthase UniProtKB/Swiss-Prot
  Citrate_synthase_sf UniProtKB/Swiss-Prot
  Citrt_syn/SCS-alpha_CS UniProtKB/Swiss-Prot
  CoA-bd UniProtKB/Swiss-Prot
  CoA_ligase UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
  Succ-CoA_synthase_bsu_CS UniProtKB/Swiss-Prot
  Succinyl-CoA_synth-like UniProtKB/Swiss-Prot
KEGG Report rno:24159 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124629 IMAGE-MGC_LOAD
NCBI Gene 24159 ENTREZGENE
PANTHER ATP-CITRATE SYNTHASE UniProtKB/Swiss-Prot
  ATP-CITRATE SYNTHASE UniProtKB/Swiss-Prot
Pfam Citrate_bind UniProtKB/Swiss-Prot
  Citrate_synt UniProtKB/Swiss-Prot
  Citrate_synth_N UniProtKB/Swiss-Prot
  CoA_binding UniProtKB/Swiss-Prot
  Ligase_CoA UniProtKB/Swiss-Prot
PhenoGen Acly PhenoGen
PIRSF ATP_citrt_syn UniProtKB/Swiss-Prot
PROSITE SUCCINYL_COA_LIG_1 UniProtKB/Swiss-Prot
  SUCCINYL_COA_LIG_2 UniProtKB/Swiss-Prot
  SUCCINYL_COA_LIG_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016924 RatGTEx
SMART CoA_binding UniProtKB/Swiss-Prot
Superfamily-SCOP Glutathione synthetase ATP-binding domain-like UniProtKB/Swiss-Prot
  SSF48256 UniProtKB/Swiss-Prot
  SSF51735 UniProtKB/Swiss-Prot
  SSF52210 UniProtKB/Swiss-Prot
UniProt A0A0G2K5E7_RAT UniProtKB/TrEMBL
  A0A8I6AM81_RAT UniProtKB/TrEMBL
  A0A8I6GAT1_RAT UniProtKB/TrEMBL
  A6HJ37_RAT UniProtKB/TrEMBL
  A6HJ38 ENTREZGENE, UniProtKB/TrEMBL
  A6HJ39 ENTREZGENE, UniProtKB/TrEMBL
  A6HJ40_RAT UniProtKB/TrEMBL
  ACLY_RAT UniProtKB/Swiss-Prot
  G3V888 ENTREZGENE, UniProtKB/TrEMBL
  G3V9G4 ENTREZGENE, UniProtKB/TrEMBL
  P16638 ENTREZGENE
  Q497C7 ENTREZGENE
  Q8VIQ1 ENTREZGENE
UniProt Secondary Q497C7 UniProtKB/Swiss-Prot
  Q8VIQ1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Acly  ATP citrate lyase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression protein detected in adipocytes 631762
gene_expression mRNA and active enzyme detected in liver 631747
gene_expression mRNA expression in liver is high at birth, decreases during suckling, and is higher in adults 631747
gene_function substrate for protein kinase B in adipocytes 631762
gene_function catalyzes the synthesis of cytosolic acetyl-CoA 631747
gene_process plays a role in lipid and cholesterol metabolism 631747
gene_regulation phosphorylated at Ser454 by protein kinase B in adipocytes 631762
gene_regulation increased mRNA expression is detected in rats fed a low fat, high carbohydrate diet 631747
gene_transcript mRNA is 4.3 kb in size 631747