Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2018
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acly
Name: ATP citrate lyase
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aclyaffects expressionEXP 6480464CTDbisphenol A affects the expression of ACLY mRNAPMID:32145629
Aclydecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of ACLY mRNA; bisphenol A results in decreased expression of ACLY proteinPMID:30816183 PMID:32145629 PMID:32528016 PMID:34947998
Aclyincreases expressionEXP 6480464CTDbisphenol A results in increased expression of ACLY mRNAPMID:25181051 PMID:27178563
Aclyaffects expressionISOACLY (Homo sapiens)6480464CTDbisphenol A affects the expression of ACLY mRNAPMID:30903817
Aclyaffects methylationISOAcly (Mus musculus)6480464CTDbisphenol A affects the methylation of ACLY promoterPMID:27334623
Aclydecreases expressionISOACLY (Homo sapiens)6480464CTDbisphenol A results in decreased expression of ACLY proteinPMID:37567409
Aclyincreases expressionISOAcly (Mus musculus)6480464CTDbisphenol A results in increased expression of ACLY mRNA; bisphenol A results in increased expression of ACLY protein; bisphenol A results in increased expression of ACLY protein modified formPMID:21932408 PMID:37105096
Aclymultiple interactionsISOAcly (Mus musculus)6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in increased expression of ACLY mRNA; [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ACLY mRNAPMID:28433925 PMID:35739755
Go Back to source page   Continue to Ontology report