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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2018
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acly
Name: ATP citrate lyase
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aclydecreases expressionISOACLY (Homo sapiens)6480464CTDGenistein results in decreased expression of ACLY proteinPMID:20884965
Aclyincreases expressionISOACLY (Homo sapiens)6480464CTDGenistein results in increased expression of ACLY mRNAPMID:20706672
Aclymultiple interactionsISOACLY (Homo sapiens)6480464CTDESR2 promotes the reaction [Genistein results in decreased expression of ACLY protein]PMID:20884965
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