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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2018
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acly
Name: ATP citrate lyase
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aclydecreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of ACLY mRNAPMID:15084756 PMID:17522070
Aclyaffects expressionISOAcly (Mus musculus)6480464CTDAcetaminophen affects the expression of ACLY mRNAPMID:17562736
Aclyincreases expressionISOAcly (Mus musculus)6480464CTDAcetaminophen results in increased expression of ACLY mRNAPMID:29246445
Aclymultiple interactionsISOAcly (Mus musculus)6480464CTD[CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of ACLY protein; PANX1 gene mutant form inhibits the reaction [Acetaminophen results in increased expression of ACLY mRNA]PMID:25499718 PMID:29246445
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