Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (1->4)-beta-D-glucan | multiple interactions | ISO | Polr2e (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of POLR2E mRNA | CTD | PMID:36331819 | 1,2-dimethylhydrazine | increases expression | ISO | Polr2e (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of POLR2E mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | ISO | Polr2e (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of POLR2E mRNA] | CTD | PMID:22206623 | 1-nitropyrene | decreases expression | ISO | POLR2E (Homo sapiens) | 6480464 | 1-nitropyrene results in decreased expression of POLR2E mRNA | CTD | PMID:19041380 | 17alpha-ethynylestradiol | increases expression | ISO | Polr2e (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of POLR2E mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | multiple interactions | ISO | Polr2e (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POLR2E mRNA | CTD | PMID:17942748 | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | ISO | Polr2e (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:30294300 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | POLR2E (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | ISO | Polr2e (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:31388691 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Polr2e (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POLR2E mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of POLR2E mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Polr2e (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of POLR2E mRNA | CTD | PMID:21570461 | 2,4,6-tribromophenol | decreases expression | ISO | POLR2E (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:19954255 | 2-hydroxypropanoic acid | decreases expression | ISO | POLR2E (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of POLR2E mRNA | CTD | PMID:30851411 | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | POLR2E (Homo sapiens) | 6480464 | tetrabromobisphenol A results in decreased expression of POLR2E protein | CTD | PMID:31675489 | arsenous acid | increases expression | ISO | POLR2E (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of POLR2E protein | CTD | PMID:25419056 | benzo[a]pyrene | increases expression | ISO | POLR2E (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of POLR2E protein | CTD | PMID:33278487 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of POLR2E mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of POLR2E mRNA | CTD | PMID:34947998 | bisphenol A | decreases expression | ISO | POLR2E (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of POLR2E protein | CTD | PMID:31675489 more ... | bisphenol A | decreases expression | ISO | Polr2e (Mus musculus) | 6480464 | bisphenol A results in decreased expression of POLR2E mRNA | CTD | PMID:33221593 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of POLR2E mRNA | CTD | PMID:30816183 | bisphenol A | affects expression | ISO | POLR2E (Homo sapiens) | 6480464 | bisphenol A affects the expression of POLR2E mRNA | CTD | PMID:30903817 | butanal | decreases expression | ISO | POLR2E (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of POLR2E mRNA | CTD | PMID:26079696 | carmustine | decreases expression | ISO | POLR2E (Homo sapiens) | 6480464 | Carmustine results in decreased expression of POLR2E mRNA | CTD | PMID:15980968 | chlorpyrifos | increases expression | ISO | Polr2e (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of POLR2E mRNA | CTD | PMID:37019170 | choline | multiple interactions | ISO | Polr2e (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of POLR2E gene | CTD | PMID:20938992 | chromium(6+) | affects expression | ISO | Polr2e (Mus musculus) | 6480464 | chromium hexavalent ion affects the expression of POLR2E mRNA | CTD | PMID:28472532 | cobalt dichloride | decreases expression | ISO | POLR2E (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of POLR2E mRNA | CTD | PMID:19376846 | coumestrol | increases expression | ISO | POLR2E (Homo sapiens) | 6480464 | Coumestrol results in increased expression of POLR2E mRNA | CTD | PMID:19167446 | cyclosporin A | decreases expression | ISO | POLR2E (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of POLR2E mRNA | CTD | PMID:20106945 and PMID:25562108 | decabromodiphenyl ether | decreases expression | ISO | POLR2E (Homo sapiens) | 6480464 | decabromobiphenyl ether results in decreased expression of POLR2E protein | CTD | PMID:31675489 | deguelin | decreases expression | ISO | POLR2E (Homo sapiens) | 6480464 | deguelin results in decreased expression of POLR2E mRNA | CTD | PMID:33512557 | diarsenic trioxide | increases expression | ISO | POLR2E (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of POLR2E protein | CTD | PMID:25419056 | dioxygen | increases expression | ISO | Polr2e (Mus musculus) | 6480464 | Oxygen deficiency results in increased expression of POLR2E mRNA | CTD | PMID:24205000 | epoxiconazole | decreases expression | ISO | Polr2e (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of POLR2E mRNA | CTD | PMID:35436446 | folic acid | multiple interactions | ISO | Polr2e (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of POLR2E gene more ... | CTD | PMID:20938992 and PMID:22206623 | folic acid | decreases expression | ISO | Polr2e (Mus musculus) | 6480464 | Folic Acid results in decreased expression of POLR2E mRNA | CTD | PMID:25629700 | ivermectin | decreases expression | ISO | POLR2E (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of POLR2E protein | CTD | PMID:32959892 | L-methionine | multiple interactions | ISO | Polr2e (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of POLR2E gene | CTD | PMID:20938992 | oxaliplatin | decreases expression | ISO | POLR2E (Homo sapiens) | 6480464 | oxaliplatin results in decreased expression of POLR2E mRNA | CTD | PMID:17762391 | paracetamol | decreases expression | ISO | POLR2E (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of POLR2E mRNA | CTD | PMID:22230336 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Polr2e (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of POLR2E mRNA | CTD | PMID:36331819 | pirinixic acid | increases expression | ISO | Polr2e (Mus musculus) | 6480464 | pirinixic acid results in increased expression of POLR2E mRNA | CTD | PMID:23811191 | rac-lactic acid | decreases expression | ISO | POLR2E (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of POLR2E mRNA | CTD | PMID:30851411 | resveratrol | increases expression | ISO | Polr2e (Mus musculus) | 6480464 | resveratrol results in increased expression of POLR2E mRNA | CTD | PMID:22610192 | rotenone | decreases expression | ISO | POLR2E (Homo sapiens) | 6480464 | Rotenone results in decreased expression of POLR2E mRNA | CTD | PMID:33512557 | sodium arsenate | decreases expression | ISO | POLR2E (Homo sapiens) | 6480464 | sodium arsenate results in decreased expression of POLR2E mRNA | CTD | PMID:12727804 | sodium arsenite | decreases expression | ISO | POLR2E (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of POLR2E mRNA | CTD | PMID:12727804 | sodium arsenite | multiple interactions | ISO | POLR2E (Homo sapiens) | 6480464 | sodium arsenite promotes the reaction [POLR2E protein binds to CAPRIN1 protein] | CTD | PMID:33939924 | sodium arsenite | increases expression | ISO | POLR2E (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of POLR2E mRNA | CTD | PMID:34032870 | T-2 toxin | increases expression | ISO | POLR2E (Homo sapiens) | 6480464 | T-2 Toxin results in increased expression of POLR2E mRNA | CTD | PMID:34581912 | tert-butyl hydroperoxide | decreases expression | ISO | POLR2E (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in decreased expression of POLR2E mRNA | CTD | PMID:15336504 | |