RNA POLYMERASE II TRANSCRIPTION PATHWAY (PW:0000127)
Description
The three eukaryotic RNA polymerases (RNAPs)- Pol I, II and III, transcribe different sets of genes and require distinct sets of factors to assemble a specific initiation complex which recruits them on gene promoters. The multi-subunit enzymes are composed of 14 (RNAPI), 12 (RNAPII) and 17 (RNAPIII) subunits of which some are shared and others are unique, yet converging on an overall similar structural topology. Complexes specific to each of the three systems share the universal transcription factor 'TATA-box binding protein' (TBP) regardless of whether the promoters have a TATA box or not. In addition, modules and domains present in general transcription factors (GTFs) specific for RNAPII are found in subunits of RNAPI and RNAPIII and/or RNAPI and RNAPIII specific factors. The initiation, elongation and termination of transcription are steps shared by all systems, albeit with differing details and/or degrees of complexity. Beyond the shared or related elements, specific factors confer unique topological and functional features to the particular initiation complex associated with the three polymerases and account for the differences in promoter recognition and the class or category of transcribed genes. Pol I transcribes ribosomal RNA, all protein-coding and many non-coding genes are transcribed by pol II, while transfer RNA, the small 5S ribosomal RNA and a subset of small non-coding genes are the realm of pol III-mediated transcription. Transcription by RNA pol II is described here.
RNA polymerase II transcription pathway
Transcription Initiation
Pol II transcribes all protein-coding genes and many non-coding genes classes. Assembly of the pre-initiation complex (PIC) sets the stage for the recruitment of pol II, transcription start site selection and initiation of transcription. PIC involves the sequential assembly of TBP-containing TFIID complex, TFIIA and TFIIB, Pol II and TFIIF, TFIIE and TFIIH. TFIID complex is composed of TATA-box binding protein (TBP) and TBP associated factors (TAFs); it constitutes a scaffold for the assembly of other transcription factors. Topologically, it has a horse-shoe structure consisting of three lobes with TFIIA and TFIIB bound on opposite sides of the central cavity. TBP bends DNA by ~90 degrees which wraps DNA around the polymerase and probably accounts for its universal requirement. ~80% of the protein-coding genes do not have a TATA box and the transcription start site (TSS) may be spread over tens of base pairs. Promoter elements include the Initiator (Inr) surrounding the start site on both TATA and TATA-less promoters, the downstream promoter element (DPE) and downstream core element (DCE) on TATA-less and TATA-containing promoters, respectively. The presence of numerous TBP-associated factors (TAFs) allows for recognition of other regulatory elements. TAFs interact with GTFs, with activators, or transcription and signaling factors. They can form dimers and heterodimers, the latter among histone domain-containing TAFs. TFIIA binds the TBP-DNA complex, stabilizes it and blocks certain regulators. TFIIB bridges TBP and pol II; all its four functional domains interact with pol II. Pol II, in complex with TFIIF, assembles at the promoter, followed by TFIIE which recruits the TFIIH complex. TFIIH consists of a core with 3'-5' and 5'-3' helicase activities linked to a kinase module; ERCC5 known as XPG with 3'-endonuclase activity is also considered part of the complex. TFIIH plays essential roles in both pol II transcription and in DNA nucleotide excision repair (NER) pathways. In pol II transcription, it promotes ATP-dependent unwinding of ~10 base pairs of promoter DNA and phosphorylation of Ser5 within the carboxyl-terminal domain (CTD) of pol II. Pol II is unique among the three polymerases in its requirement for ATP-dependent promoter melting and the presence of CTD in its largest subunit [see CTD entry further down]. Unwinding of ~15 bases within the promoter forms the 'transcription bubble' and marks the transition of PIC from a closed to an open conformation (OC) state. Once OC is formed, TSS selection occurs followed by RNA synthesis. The Mediator complex, a coactivator required for transcription of most protein-coding genes that bridges regulatory and promoter complexes, likely stabilizes PIC via interactions with many of its components. It interacts with CTD and the rest of pol II subunits; in both yeast and human, pol II contacts the same region of Mediator. SAGA, a multisubunit coactivator, better characterized in yeast, may have functions redundant with TFIID, particularly at TATA promoters [see Mediator and SAGA in Complexes entry, further down].
Transcription Elongation
Transcription elongation is a reiterative process whereby pre-mRNA is 5' extended by 1 nucleotide (nt) and the polymerase translocates 1 nt along DNA. It involves a condensation reaction, thought to occur via a general two-metal-ion mechanism. Nascent RNA is annealed to the template strand forming an RNA-DNA hybrid of ~8-9 nts whose size is maintained throughout elongation; as RNA is 3' extended by 1 nt, the 5' end of the hybrid peels off the template and is threaded to the exit channel. Transition from promoter escape to full productive elongation is often accompanied by an intermediate promoter-proximal pausing. Once the initial transcript reaches 20-60 nucleotides, pol II pauses between the promoter and the 1+ nt, backtracks and is also prone to arrest. Paused pol II is recognized by pausing factors such as DSIF (DRB sensitivity-inducing factor) and NELF (negative elongation factor) complex. Arrested or paused pol II is rescued by TFIIS; TFIIF which acts as an elongation factor, may synergize with TFIIS. DSIF and NELF interact with RNA and pol II, Once elongation starts, some GTFs, TFIIB in particular, dissociate; others, such as TFIIF, remain associated with pol II. Productive elongation is promoted by the 5' capping of nascent RNA and phosphorylation of pol II. Capping consists of three enzymatic reactions of which the triphosphatase and guanylyltransferase reside on the same polypeptide in higher eukaryotes, the Rngtt gene product; a guanine-7-methyltransferase (Rnmt) adds the methyl group. Rngtt interacts with DSIF and the methyl transferase complex. Nuclear cap-binding complex (CBC), binds 5'-capped RNA, stimulates elongation and is involved in a range of other events, including splicing where it may act as a recruitment platform. Elongation-related entities are shown. Phosphorylation at Ser2 of CTD is carried out by P-TEFb (positive elongation factor b), whose kinase activity also targets DSIF and NELF. P-TEFb is a heterodimer composed of cyclin-dependent kinase 9 (CDK9) and cyclin T or, in humans, cyclin K. Several factors contribute to the recruitment of the P-TEFb complex, including CBC or the Med26 subunit of the Mediator complex. In the latter case, P-TEFb is a component of SECs (Super Elongation Complexes). Paf1 and FACT complexes among others, promote pol II transcription through nucleosomes and the gene body. Paf1 recruits SEC, FACT and histone- modifying enzymes. Chromatin and co-activator components are readers of modified CTD. Splicing occurs co-transcriptionally and the coupling between the splicing machinery and the elongating Pol II is likely mediated by the CTD domain [see Mediator and SEC in Complexes entry, and CTD entry, further down].
Transcription Termination
The termination step of pol II is mechanistically, probably the least understood one. Transcription termination occurs when the polymerase stops synthesizing RNA and both the enzyme and the nascent RNA are released, and it is coupled with pre-mRNA 3' end processing which consists of 3'-end cleavage and subsequent polyadenylation. 3'-end processing is at the crossroads of gene expression connecting transcription, splicing, mRNA biogenesis and mRNA export, and translation. Cleavage entities and events are presented/shown. The highly conserved A(A/U)UAAA element is a primary poly(A) signal located ~10-30 nts upstream of the cleavage site, followed by the U/GU-rich region ~30 nts downstream; the upstream UGUA rich motifs also play a role. The processing machinery consists of several complexes that include the cleavage and polyadenylation specificity factor (CPSF), the cleavage stimulation factor (CstF), the cleavage factors I and II (CF Im and CF IIm), and the poly(A) polymerases (PAPs) and associated proteins. CPSF recognizes the primary poly(A) element, recruits other complexes and catalyzes the cleavage reaction. CstF binds the downstream U/GU element and requires cooperative binding of CPSF to the upstream poly(A) signal. In addition to CPSF, CstF interacts with pol II CTD and CF IIm. CF Im binds the upstream UGUA motif and plays a role in the cleavage step. CF IIm interacts with pol II CTD and CstF, its exact function is not well known. The uncapped 5' downstream sequence generated by cleavage is a substrate for the exoribonuclease Xrn2, which in complex with Dxo, known as Dom3z, carries out its 5'-3' digestion. This activity is proposed to promote termination and is described as the 'torpedo' model. Alternatively, pol II-bound CF IIm may also promote termination in the 'allosteric' or 'anti-terminator' model. Released pol II needs to revert to its hypo-phosphorylated form in order to initiate another round of transcription. Terminal and promoter regions can interact via gene looping, enabling contacts between GTFs and 3'-end processing factors and leading to rapid pol II recycling and re-initiation of transcription.
Pol II carboxyl-terminal domain (CTD)
The CTD domain of Polr2a, the largest pol II subunit, contains multiple tandem repeats of a heptapeptide, with the consensus YSPTSPS sequence. The number of repeats appears to correlate with the complexity of the system - there are 26 in yeast but 52 in mammals, of which 21 are consensus and 31 are non-consensus. Via its many interactions with modification readers, CTD is involved in all steps of pol II transcription and associated pre-mRNA processing, splicing and chromatin modulation. The serine, threonine and tyrosine residues can all be phosphorylated in vivo and may undergo other post-translational modifications; non-consensus repeats can also be modified (for instance arginine methylation). The phosphorylation of serines is the best characterized modification. Ser5-(P)hosphorylation is primarily associated with the initiation step, Ser2-P with elongation while Ser7-P appears to be throughout the transcription cycle. The enzymes involved include: Cdk7 and Cdk8 kinases for Ser5, Cdk9 and Cdk12 kinases for Ser2 and Cdk7 and Cdk9 kinases for Ser7. Cdk7 is a subunit of TFIIH; Cdk8 is a subunit of the kinase module of Mediator; Cdk9 is a subunit of P-TEFb. Ser5-P is a substrate for Rpap2, Ctdsp1, Cdc14 and Ssu72 phosphatases, Ser2-P is a substrate for Ctdp1 and Cdc14 phosphatases and Ser7-P is a substrate for Ssu72. The cis-trans isomerization of the two prolines has also been reported and is dependent upon Pin1 isomerase. Many protein domains have been identified as readers of the CTD code, particularly in yeast; the precise function of these interactions remains to be characterized. The existence of multiple modification marks within a repeat and of many repeats within CTD, render the number of possible combinations extraordinarily large. This, combined with the dynamic, yet highly orchestrated nature of changes, makes unraveling the complexity of the CTD code an indomitable task.
Complexes: Mediator, SAGA and SEC
The Mediator is a large ~30 subunit complex largely conserved throughout evolution. It consists of several modules described as the 'head', 'middle' and 'tail' and an additional kinase module; in some isoform complexes, the kinase module and/or certain subunits are not present. Mediator interacts with elements of the core pol II machinery or modifies them via the Cdk8 activity of the kinase module. It interacts with many transcriptional regulators via an activator-binding domain (ABD) and the transactivation domains (TADs) in regulators; in addition, it interacts with epigenetic regulators, long non-coding RNA, other factors and/or large complexes. It is associated with all phases of pol II transcription as well as with DNA loop formation, chromatin modulation, RNA processing. Subunits can undergo post-translational modifications that further regulate their function and some may function as individual entities. The structures of many subunits have been solved; a cryo-EM structure of the yeast complex is available but solving a more refined structure is challenging both by virtue of its size and by its high degree of flexibility, conferred by many disordered regions. Additional subunits, present in vertebrates, are duplicates of Cdk8. Their function has not been well studied, existing data suggest that their roles are not redundant.
The SAGA coactivator appears to have functions redundant to TFIID in PIC assembly, particularly at TATA-containing promoters; TFIID appears to be associated with the TATA-less and the more abundant of promoter types. The proteins that make up the complexes have been largely conserved from yeast to man and they include a subset of TAFs also present in TFIID. SAGA modules carry out distinct functions such as ubiquitination, histone acetyltransferase, transcription activation and TBP binding; non-transcriptional functions include mRNA transport, maintenance of DNA integrity. Mammalian systems exhibit four SAGA-like subcomplexes: SAGA itself or ATAC, both depending on the presence of either Kat2a (Gcn5) or the related Kat2b (Pcaf) histone lysine acetyltransferases and each present in two versions. The two depend on the presence of Tada2b (Ada2b), exclusively in SAGA or Tada2a (Ada2a), exclusively in ATAC type complexes. The yeast Ada2 in higher metazoans has been duplicated into TADA2A and TADA2B.
The Super Elongation Complex (SEC) is recruited by coactivators such as the Mediator complex and in this context, delivers the P-TEFb complex to the elongation complex. In mammals, several SEC complexes are present resulting from combinations of AF4/FMR2 (Aff1 or 4), ELL (elongation factor - Ell1, 2 or 3), EAF (ELL-associated factor - Eaf1 or 2) family members, and Mllt1, known as ENL (eleven-nineteen leukemia) or Mllt3, known as AF9. Aff4 acts as a scaffold for assembling SEC via interactions with Mllt1, Mllt3, Ell and P-TEFb.
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Pathway Diagram:
Genes in Pathway:
G
Ccnc
cyclin C
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584
G
Cdc14a
cell division cycle 14A
ISO
pol II carboxyl-terminal domain (CTD)
RGD
PMID:22622228 PMID:23837720
RGD:9681737 , RGD:9681738
NCBI chr 2:204,225,540...204,380,927
Ensembl chr 2:204,225,540...204,380,927
G
Cdc14b
cell division cycle 14B
ISO
pol II carboxyl-terminal domain (CTD)
RGD
PMID:22622228 PMID:23837720
RGD:9681737 , RGD:9681738
NCBI chr17:844,686...934,787
Ensembl chr17:844,685...933,235
G
Cdk12
cyclin-dependent kinase 12
ISO
pol II carboxyl-terminal domain (CTD)
RGD
PMID:22622228 PMID:23837720
RGD:9681737 , RGD:9681738
NCBI chr10:83,201,177...83,256,906
Ensembl chr10:83,201,211...83,280,888 Ensembl chr10:83,201,211...83,280,888
G
Cdk19
cyclin-dependent kinase 19
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr20:43,770,409...43,910,629
Ensembl chr20:43,770,409...43,910,628
G
Cdk7
cyclin-dependent kinase 7
ISO
pol II carboxyl-terminal domain (CTD)
RGD
PMID:22622228 PMID:23837720
RGD:9681737 , RGD:9681738
NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383
G
Cdk8
cyclin-dependent kinase 8
ISO
pol II carboxyl-terminal domain (CTD)
RGD
PMID:24088064 PMID:23837720 PMID:22622228
RGD:9681732 , RGD:9681738 , RGD:9681737
NCBI chr12:8,737,198...8,805,026
Ensembl chr12:8,737,262...8,804,177
G
Cdk9
cyclin-dependent kinase 9
ISO
pol II carboxyl-terminal domain (CTD)
RGD
PMID:22622228 PMID:23837720
RGD:9681737 , RGD:9681738
NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410
G
Ctdp1
CTD phosphatase subunit 1
ISO
pol II carboxyl-terminal domain (CTD)
RGD
PMID:22622228 PMID:23837720
RGD:9681737 , RGD:9681738
NCBI chr18:73,854,277...73,916,232
Ensembl chr18:73,854,282...73,916,457
G
Ctdsp1
CTD small phosphatase 1
ISO
pol II carboxyl-terminal domain (CTD)
RGD
PMID:22622228 PMID:23837720
RGD:9681737 , RGD:9681738
NCBI chr 9:75,973,694...75,979,298
Ensembl chr 9:75,973,962...75,979,297
G
Med1
mediator complex subunit 1
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299
G
Med10
mediator complex subunit 10
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr 1:33,470,064...33,481,698
Ensembl chr 1:33,470,066...33,475,767
G
Med11
mediator complex subunit 11
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr10:55,164,322...55,165,940
Ensembl chr10:55,164,326...55,166,533
G
Med12
mediator complex subunit 12
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr X:66,404,807...66,427,775
Ensembl chr X:66,404,760...66,428,387
G
Med12l
mediator complex subunit 12L
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr 2:143,253,048...143,576,507
Ensembl chr 2:143,252,139...143,573,741
G
Med13
mediator complex subunit 13
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr10:71,086,978...71,176,535
Ensembl chr10:71,090,516...71,177,242
G
Med13l
mediator complex subunit 13L
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr12:37,807,596...38,004,886
Ensembl chr12:37,808,285...38,004,473
G
Med14
mediator complex subunit 14
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr X:10,036,749...10,127,910
Ensembl chr X:10,036,805...10,126,240
G
Med15
mediator complex subunit 15
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr11:83,280,722...83,356,006
Ensembl chr11:83,280,762...83,355,362
G
Med16
mediator complex subunit 16
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr 7:9,798,641...9,811,172
Ensembl chr 7:9,798,668...9,811,172
G
Med17
mediator complex subunit 17
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr 8:12,101,594...12,120,592
Ensembl chr 8:12,101,594...12,120,592
G
Med18
mediator complex subunit 18
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr 5:144,663,316...144,668,652
Ensembl chr 5:144,663,252...144,668,635
G
Med19
mediator complex subunit 19
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr 3:69,762,138...69,772,661
Ensembl chr 3:69,762,166...69,772,036
G
Med20
mediator complex subunit 20
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr 9:13,370,146...13,382,756
Ensembl chr 9:13,370,146...13,382,476
G
Med21
mediator complex subunit 21
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr 4:179,560,509...179,583,811
Ensembl chr 4:179,560,579...179,567,548
G
Med22
mediator complex subunit 22
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr 3:10,233,754...10,238,836
Ensembl chr 3:10,233,754...10,238,836
G
Med23
mediator complex subunit 23
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr 1:20,490,315...20,558,461
Ensembl chr 1:20,490,315...20,537,463
G
Med24
mediator complex subunit 24
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr10:83,664,609...83,702,315
Ensembl chr10:83,664,609...83,690,123
G
Med25
mediator complex subunit 25
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr 1:95,359,961...95,375,827
Ensembl chr 1:95,360,284...95,375,877
G
Med26
mediator complex subunit 26
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr16:17,299,722...17,350,168
Ensembl chr16:17,299,722...17,349,543
G
Med27
mediator complex subunit 27
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr 3:12,629,593...12,803,340
Ensembl chr 3:12,629,603...12,803,339
G
Med28
mediator complex subunit 28
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr14:65,594,785...65,603,583
Ensembl chr14:65,594,647...65,603,583
G
Med29
mediator complex subunit 29
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr 1:83,677,961...83,683,365
Ensembl chr 1:83,677,961...83,683,365
G
Med30
mediator complex subunit 30
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr 7:84,004,735...84,026,474
Ensembl chr 7:84,004,722...84,026,595
G
Med31
mediator complex subunit 31
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr10:56,836,944...56,840,326
Ensembl chr10:56,836,944...56,840,326
G
Med4
mediator complex subunit 4
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr15:48,696,542...48,706,818
Ensembl chr15:48,696,511...48,706,820
G
Med6
mediator complex subunit 6
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr 6:101,270,410...101,283,929
Ensembl chr 6:101,270,410...101,283,876
G
Med7
mediator complex subunit 7
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr10:30,842,330...30,857,873
Ensembl chr10:30,842,292...30,859,220
G
Med8
mediator complex subunit 8
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr 5:131,948,632...131,949,516
Ensembl chr 5:131,943,982...131,950,305
G
Med9
mediator complex subunit 9
ISO
RGD
PMID:24088064
RGD:9681732
NCBI chr10:44,750,667...44,765,464
Ensembl chr10:44,750,698...44,765,464
G
Polr2a
RNA polymerase II subunit A
ISO
RGD
PMID:22960599
RGD:9588243
NCBI chr10:54,452,438...54,478,486
Ensembl chr10:54,452,441...54,478,455
G
Polr2b
RNA polymerase II subunit B
ISO
RGD
PMID:22960599
RGD:9588243
NCBI chr14:30,797,228...30,834,916
Ensembl chr14:30,797,228...30,834,916
G
Polr2c
RNA polymerase II subunit C
ISO
RGD
PMID:22960599
RGD:9588243
NCBI chr19:10,158,153...10,164,935
Ensembl chr19:10,157,823...10,164,945
G
Polr2d
RNA polymerase II subunit D
ISO
RGD
PMID:22960599
RGD:9588243
NCBI chr18:23,418,097...23,425,228
Ensembl chr18:23,418,097...23,425,228
G
Polr2e
RNA polymerase II, I and III subunit E
ISO
RGD
PMID:22960599
RGD:9588243
NCBI chr 7:9,666,695...9,670,638
Ensembl chr 7:9,666,716...9,670,643
G
Polr2f
RNA polymerase II, I and III subunit F
ISO
RGD
PMID:22960599
RGD:9588243
NCBI chr 7:110,712,528...110,724,234
Ensembl chr 7:110,712,572...110,724,234
G
Polr2g
RNA polymerase II subunit G
ISO
RGD
PMID:22960599
RGD:9588243
NCBI chr 1:205,689,160...205,692,537
Ensembl chr 1:205,689,160...205,692,686
G
Polr2h
RNA polymerase II, I and III subunit H
ISO
RGD
PMID:22960599
RGD:9588243
NCBI chr11:80,192,017...80,197,468
Ensembl chr11:80,192,032...80,197,515 Ensembl chr10:80,192,032...80,197,515
G
Polr2i
RNA polymerase II subunit I
ISO
RGD
PMID:22960599
RGD:9588243
NCBI chr 1:85,483,515...85,484,952
Ensembl chr 1:85,483,515...85,484,952
G
Polr2j
RNA polymerase II subunit J
ISO
RGD
PMID:22960599
RGD:9588243
NCBI chr12:20,543,038...20,548,590
Ensembl chr12:20,543,038...20,548,594
G
Polr2k
RNA polymerase II, I and III subunit K
ISO
RGD
PMID:22960599
RGD:9588243
NCBI chr 7:67,347,118...67,359,466
Ensembl chr 7:67,356,113...67,357,668
G
Polr2l
RNA polymerase II, I and III subunit L
ISO
RGD
PMID:22960599
RGD:9588243
NCBI chr 1:196,570,051...196,572,060
G
Rpap2
RNA polymerase II associated protein 2
ISO
pol II carboxyl-terminal domain (CTD)
RGD
PMID:22622228 PMID:23837720
RGD:9681737 , RGD:9681738
NCBI chr14:2,109,044...2,187,343
Ensembl chr14:2,109,053...2,187,350
G
Ssu72
SSU72 homolog, RNA polymerase II CTD phosphatase
ISO
pol II carboxyl-terminal domain (CTD)
RGD
PMID:22622228 PMID:23837720
RGD:9681737 , RGD:9681738
NCBI chr 5:166,312,267...166,343,432
Ensembl chr 5:166,313,650...166,343,429
G
Clp1
cleavage factor polyribonucleotide kinase subunit 1
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr 3:69,806,774...69,818,633
Ensembl chr 3:69,806,778...69,810,421
G
Cpsf1
cleavage and polyadenylation specific factor 1
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr 7:108,319,429...108,330,018
Ensembl chr 7:108,319,434...108,329,934
G
Cpsf2
cleavage and polyadenylation specific factor 2
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr 6:121,123,941...121,152,756
Ensembl chr 6:121,120,569...121,151,921
G
Cpsf3
cleavage and polyadenylation specific factor 3
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr 6:40,836,121...40,864,129
Ensembl chr 6:40,836,097...40,864,128
G
Cpsf4
cleavage and polyadenylation specific factor 4
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 RGD:9681742
NCBI chr12:9,429,765...9,445,586
Ensembl chr12:9,429,523...9,445,586
G
Cpsf6
cleavage and polyadenylation specific factor 6
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr 7:52,956,589...53,001,783
Ensembl chr 7:52,956,589...52,988,122
G
Cpsf7
cleavage and polyadenylation specific factor 7
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr 1:207,167,690...207,191,938
Ensembl chr 1:207,167,859...207,191,905
G
Cstf1
cleavage stimulation factor subunit 1
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr 3:161,144,522...161,156,294
Ensembl chr 3:161,144,548...161,156,300
G
Cstf2
cleavage stimulation factor subunit 2
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr X:97,253,559...97,279,476
Ensembl chr X:97,253,586...97,279,476
G
Cstf2t
cleavage stimulation factor subunit 2, tau variant
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr 1:228,952,617...228,956,183
Ensembl chr 1:228,952,504...228,955,873
G
Cstf3
cleavage stimulation factor subunit 3
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr 3:90,966,415...91,037,669
Ensembl chr 3:90,966,354...91,042,196
G
Dxo
decapping exoribonuclease
ISO
RGD
PMID:21957020
RGD:9681741
NCBI chr20:3,993,322...3,995,484
Ensembl chr20:3,993,327...3,995,494
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Fip1l1
factor interacting with PAPOLA and CPSF1
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr14:33,615,210...33,675,742
Ensembl chr14:33,617,720...33,675,708
G
Nudt21
nudix hydrolase 21
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr19:10,974,800...10,993,841
Ensembl chr19:10,974,241...10,991,682
G
Pabpn1
poly(A) binding protein, nuclear 1
ISO
RGD
PMID:24243805
RGD:9681742
NCBI chr15:28,368,100...28,372,712
Ensembl chr15:28,368,100...28,372,703
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Papola
poly (A) polymerase alpha
ISO
RGD
PMID:24243805
RGD:9681742
NCBI chr 6:124,682,015...124,734,706
Ensembl chr 6:124,682,105...124,734,468
G
Papolb
poly(A) polymerase beta
ISO
RGD
PMID:24243805
RGD:9681742
NCBI chr12:12,044,275...12,046,621
Ensembl chr12:12,044,480...12,046,656
G
Papolg
poly(A) polymerase gamma
ISO
RGD
PMID:24243805
RGD:9681742
NCBI chr14:97,827,712...97,861,024
Ensembl chr14:97,827,712...97,861,024
G
Pcf11
PCF11 cleavage and polyadenylation factor subunit
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr 1:146,694,045...146,724,030
Ensembl chr 1:146,697,646...146,724,124
G
Sympk
symplekin scaffold protein
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr 1:78,672,372...78,700,684
Ensembl chr 1:78,672,378...78,700,684
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Wdr33
WD repeat domain 33
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr18:23,432,233...23,535,460
Ensembl chr18:23,432,191...23,468,597
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Xrn2
5'-3' exoribonuclease 2
ISO
RGD
PMID:21957020
RGD:9681741
NCBI chr 3:134,436,916...134,509,308
Ensembl chr 3:134,437,109...134,509,306
G
Ncbp1
nuclear cap binding protein subunit 1
ISO
RGD
PMID:24354960
RGD:9684851
NCBI chr 5:60,416,023...60,449,004
Ensembl chr 5:60,415,982...60,449,089
G
Ncbp2
nuclear cap binding protein subunit 2
ISO
RGD
PMID:24354960
RGD:9684851
NCBI chr11:68,821,026...68,829,863
Ensembl chr11:68,817,740...68,851,885
G
Ramac
RNA guanine-7 methyltransferase activating subunit
ISO
RGD
PMID:24354960
RGD:9684851
NCBI chr 1:135,708,529...135,714,417
Ensembl chr 1:135,708,535...135,722,151
G
Rngtt
RNA guanylyltransferase and 5'-phosphatase
ISO
RGD
PMID:24354960
RGD:9684851
NCBI chr 5:47,706,929...47,913,297
Ensembl chr 5:47,706,799...47,913,295
G
Rnmt
RNA (guanine-7-) methyltransferase
ISO
RGD
PMID:24354960
RGD:9684851
NCBI chr18:61,886,230...61,909,775
Ensembl chr18:61,886,292...61,909,775
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Aff1
ALF transcription elongation factor 1
ISO
RGD
PMID:22895430
RGD:9681740
NCBI chr14:5,861,188...6,024,196
Ensembl chr14:5,863,961...6,024,729
G
Aff4
ALF transcription elongation factor 4
ISO
RGD
PMID:22895430
RGD:9681740
NCBI chr10:37,498,825...37,579,751
Ensembl chr10:37,498,825...37,579,751
G
Ccnk
cyclin K
ISO
RGD
PMID:24050178
RGD:9681735
NCBI chr 6:127,090,115...127,113,195
Ensembl chr 6:127,090,569...127,113,191
G
Ccnt1
cyclin T1
ISO
RGD
PMID:24050178
RGD:9681735
NCBI chr 7:129,687,146...129,718,080
Ensembl chr 7:129,691,209...129,717,871
G
Ccnt2
cyclin T2
ISO
RGD
PMID:24050178
RGD:9681735
NCBI chr13:39,251,573...39,293,172
Ensembl chr13:39,251,573...39,292,019
G
Cdc73
cell division cycle 73
ISO
RGD
PMID:20060942
RGD:9588246
NCBI chr13:55,357,226...55,449,690
Ensembl chr13:55,357,226...55,449,656
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Cdk9
cyclin-dependent kinase 9
ISO
RGD
PMID:24050178
RGD:9681735
NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410
G
Ctr9
CTR9 homolog, Paf1/RNA polymerase II complex component
ISO
RGD
PMID:20060942
RGD:9588246
NCBI chr 1:165,137,277...165,167,303
Ensembl chr 1:165,137,215...165,167,303
G
Eaf1
ELL associated factor 1
ISO
RGD
PMID:22895430
RGD:9681740
NCBI chr16:6,698,322...6,713,071
Ensembl chr16:6,698,322...6,713,071
G
Eaf2
ELL associated factor 2
ISO
RGD
PMID:22895430
RGD:9681740
NCBI chr11:63,960,200...64,004,610
Ensembl chr11:63,960,200...64,004,610
G
Ell
elongation factor for RNA polymerase II
ISO
RGD
PMID:22895430
RGD:9681740
NCBI chr16:18,843,775...18,891,484
Ensembl chr16:18,843,780...18,891,118
G
Ell2
elongation factor for RNA polymerase II 2
ISO
RGD
PMID:22895430
RGD:9681740
NCBI chr 2:5,189,375...5,258,781
Ensembl chr 2:5,189,971...5,258,781
G
Ell3
elongation factor for RNA polymerase II 3
ISO
RGD
PMID:22895430
RGD:9681740
NCBI chr 3:108,413,035...108,417,181
Ensembl chr 3:108,410,448...108,417,132
G
Gtf2f1
general transcription factor IIF subunit 1
ISO
RGD
PMID:24050178
RGD:9681735
NCBI chr 9:1,844,027...1,853,455
Ensembl chr 9:1,843,901...1,853,423
G
Gtf2f2
general transcription factor IIF subunit 2
ISO
RGD
PMID:24050178
RGD:9681735
NCBI chr15:51,206,027...51,327,166
Ensembl chr15:51,206,031...51,327,253
G
Leo1
LEO1 homolog, Paf1/RNA polymerase II complex component
ISO
RGD
PMID:20060942
RGD:9588246
NCBI chr 8:76,199,547...76,223,983
Ensembl chr 8:76,199,099...76,223,983
G
Mllt1
MLLT1, super elongation complex subunit
ISO
RGD
PMID:22895430
RGD:9681740
NCBI chr 9:1,731,077...1,775,985
Ensembl chr 9:1,731,080...1,775,970
G
Mllt3
MLLT3, super elongation complex subunit
ISO
RGD
PMID:22895430
RGD:9681740
NCBI chr 5:102,259,075...102,515,447
Ensembl chr 5:102,260,011...102,515,361
G
Ncbp1
nuclear cap binding protein subunit 1
ISO
RGD
PMID:24354960
RGD:9684851
NCBI chr 5:60,416,023...60,449,004
Ensembl chr 5:60,415,982...60,449,089
G
Ncbp2
nuclear cap binding protein subunit 2
ISO
RGD
PMID:24354960
RGD:9684851
NCBI chr11:68,821,026...68,829,863
Ensembl chr11:68,817,740...68,851,885
G
Nelfa
negative elongation factor complex member A
ISO
RGD
PMID:24050178
RGD:9681735
NCBI chr14:76,808,920...76,832,998
Ensembl chr14:76,808,870...76,832,994
G
Nelfb
negative elongation factor complex member B
ISO
RGD
PMID:24050178
RGD:9681735
NCBI chr 3:8,010,883...8,027,403
Ensembl chr 3:8,010,888...8,027,403
G
Nelfcd
negative elongation factor complex member C/D
ISO
RGD
PMID:24050178
RGD:9681735
NCBI chr 3:163,213,765...163,224,886
Ensembl chr 3:163,213,762...163,224,884
G
Nelfe
negative elongation factor complex member E
ISO
RGD
PMID:24050178
RGD:9681735
NCBI chr20:3,976,512...3,982,389
Ensembl chr20:3,976,518...3,982,355
G
Paf1
PAF1 homolog, Paf1/RNA polymerase II complex component
ISO
RGD
PMID:20060942
RGD:9588246
NCBI chr 1:83,683,654...83,689,233
Ensembl chr 1:83,668,813...83,689,237
G
Rngtt
RNA guanylyltransferase and 5'-phosphatase
ISO
RGD
PMID:24354960
RGD:9684851
NCBI chr 5:47,706,929...47,913,297
Ensembl chr 5:47,706,799...47,913,295
G
Rtf1
Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
ISO
RGD
PMID:20060942
RGD:9588246
NCBI chr 3:106,659,363...106,718,956
Ensembl chr 3:106,659,308...106,718,970
G
Skic8
SKI8 subunit of superkiller complex
ISO
RGD
PMID:20060942
RGD:9588246
NCBI chr 8:55,103,542...55,120,837
Ensembl chr 8:55,103,545...55,120,813
G
Ssrp1
structure specific recognition protein 1
ISO
RGD
PMID:24050178
RGD:9681735
NCBI chr 3:70,124,371...70,134,481
Ensembl chr 3:70,118,655...70,134,482
G
Supt16h
SPT16 homolog, facilitates chromatin remodeling subunit
ISO
RGD
PMID:24050178
RGD:9681735
NCBI chr15:24,867,697...24,904,818
Ensembl chr15:24,866,489...24,904,846
G
Supt4h1
SPT4 homolog, DSIF elongation factor subunit
ISO
RGD
PMID:24050178
RGD:9681735
NCBI chr10:72,539,323...72,545,582
Ensembl chr10:72,539,382...72,545,831
G
Supt5h
SPT5 homolog, DSIF elongation factor subunit
ISO
RGD
PMID:24050178
RGD:9681735
NCBI chr 1:83,586,713...83,616,971
Ensembl chr 1:83,586,718...83,616,892
G
Tcea1
transcription elongation factor A1
ISO
RGD
PMID:24050178
RGD:9681735
NCBI chr 5:14,631,454...14,668,769
Ensembl chr 5:14,631,454...14,668,745 Ensembl chr15:14,631,454...14,668,745
G
Tcea2
transcription elongation factor A2
ISO
RGD
PMID:24050178
RGD:9681735
NCBI chr 3:168,796,244...168,804,125
Ensembl chr 3:168,796,331...168,804,116
G
Tcea3
transcription elongation factor A3
ISO
RGD
PMID:24050178
RGD:9681735
NCBI chr 5:148,476,941...148,509,452
Ensembl chr 5:148,476,941...148,509,448
G
Atxn7
ataxin 7
ISO
RGD
PMID:22426530
RGD:9681728
NCBI chr15:11,117,360...11,262,818
Ensembl chr15:11,118,886...11,263,106
G
Atxn7l3
ataxin 7-like 3
ISO
RGD
PMID:22426530
RGD:9681728
NCBI chr10:87,242,843...87,250,186
Ensembl chr10:87,243,587...87,250,620
G
Ccnh
cyclin H
ISO
RGD
PMID:21592869
RGD:9681726
NCBI chr 2:15,835,064...15,855,648
Ensembl chr 2:15,834,833...15,855,819
G
Cdk7
cyclin-dependent kinase 7
ISO
RGD
PMID:21592869
RGD:9681726
NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383
G
Dr1
down-regulator of transcription 1
ISO
RGD
PMID:22426530
RGD:9681728
NCBI chr14:1,458,223...1,469,578
Ensembl chr14:1,458,223...1,469,638
G
Eny2
ENY2, transcription and export complex 2 subunit
ISO
RGD
PMID:22426530
RGD:9681728
NCBI chr 7:75,581,215...75,605,903
Ensembl chr 7:75,581,240...75,605,897
G
Ercc2
ERCC excision repair 2, TFIIH core complex helicase subunit
ISO
RGD
PMID:21592869
RGD:9681726
NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102
G
Ercc3
ERCC excision repair 3, TFIIH core complex helicase subunit
ISO
RGD
PMID:21592869
RGD:9681726
NCBI chr18:23,883,613...23,914,326
Ensembl chr18:23,883,580...23,914,329
G
Ercc5
ERCC excision repair 5, endonuclease
ISO
RGD
PMID:21592869
RGD:9681726
NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472
G
Gtf2a1
general transcription factor 2A subunit 1
ISO
RGD
PMID:24120742
RGD:9681721
NCBI chr 6:110,488,891...110,521,502
Ensembl chr 6:110,488,931...110,521,511
G
Gtf2a2
general transcription factor 2A subunit 2
ISO
RGD
PMID:24120742
RGD:9681721
NCBI chr 8:70,662,447...70,675,576
Ensembl chr 8:70,662,428...70,675,569
G
Gtf2b
general transcription factor IIB
ISO
RGD
PMID:24120742
RGD:9681721
NCBI chr 2:231,767,317...231,785,626
Ensembl chr 2:231,767,238...231,785,651
G
Gtf2e1
general transcription factor IIE subunit 1
ISO
RGD
PMID:24120742
RGD:9681721
NCBI chr11:63,182,073...63,215,349
Ensembl chr11:63,182,349...63,213,942
G
Gtf2e2
general transcription factor IIE subunit 2
ISO
RGD
PMID:24120742
RGD:9681721
NCBI chr16:58,399,307...58,449,467
Ensembl chr16:58,399,107...58,449,371
G
Gtf2f1
general transcription factor IIF subunit 1
ISO
RGD
PMID:24120742
RGD:9681721
NCBI chr 9:1,844,027...1,853,455
Ensembl chr 9:1,843,901...1,853,423
G
Gtf2f2
general transcription factor IIF subunit 2
ISO
RGD
PMID:24120742
RGD:9681721
NCBI chr15:51,206,027...51,327,166
Ensembl chr15:51,206,031...51,327,253
G
Gtf2h1
general transcription factor IIH subunit 1
ISO
RGD
PMID:21592869
RGD:9681726
NCBI chr 1:97,321,417...97,349,455
Ensembl chr 1:97,321,394...97,349,455
G
Gtf2h2
general transcription factor IIH subunit 2
ISO
RGD
PMID:21592869
RGD:9681726
NCBI chr 2:31,623,752...31,652,697
Ensembl chr 2:31,624,678...31,652,592
G
Gtf2h3
general transcription factor IIH subunit 3
ISO
RGD
PMID:21592869
RGD:9681726
NCBI chr12:32,009,010...32,025,484
Ensembl chr12:32,009,014...32,025,497
G
Gtf2h4
general transcription factor 2H subunit 4
ISO
RGD
PMID:21592869
RGD:9681726
NCBI chr20:3,071,328...3,076,990
Ensembl chr20:3,071,328...3,076,984
G
Gtf2h5
general transcription factor IIH subunit 5
ISO
RGD
PMID:21592869
RGD:9681726
NCBI chr 1:46,656,804...46,663,512
Ensembl chr 1:46,656,859...46,664,939
G
Hcfc2
host cell factor C2
ISO
RGD
PMID:22426530
RGD:9681728
NCBI chr 7:20,983,986...21,019,826
Ensembl chr 7:20,991,017...21,019,801
G
Kat14
lysine acetyltransferase 14
ISO
RGD
PMID:22426530
RGD:9681728
NCBI chr 3:131,736,430...131,781,732
Ensembl chr 3:131,736,549...131,781,706
G
Kat2a
lysine acetyltransferase 2A
ISO
RGD
PMID:22426530
RGD:9681728
NCBI chr10:85,632,216...85,640,561
Ensembl chr10:85,632,216...85,640,166
G
Kat2b
lysine acetyltransferase 2B
ISO
RGD
PMID:22426530
RGD:9681728
NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064
G
Mbip
MAP3K12 binding inhibitory protein 1
ISO
RGD
PMID:22426530
RGD:9681728
NCBI chr 6:73,808,133...73,825,394
Ensembl chr 6:73,808,133...73,825,374
G
Mnat1
MNAT1 component of CDK activating kinase
ISO
RGD
PMID:21592869
RGD:9681726
NCBI chr 6:91,814,703...91,971,945
Ensembl chr 6:91,814,749...91,970,744
G
Pole3
DNA polymerase epsilon 3, accessory subunit
ISO
RGD
PMID:22426530
RGD:9681728
NCBI chr 5:75,973,941...75,977,175
Ensembl chr 5:75,974,717...75,977,231 Ensembl chr 7:75,974,717...75,977,231
G
Sgf29
SAGA complex associated factor 29
ISO
RGD
PMID:22426530
RGD:9681728
NCBI chr 1:181,238,458...181,271,931
Ensembl chr 1:181,238,468...181,274,781
G
Supt20h
SPT20 homolog, SAGA complex component
ISO
RGD
PMID:22426530
RGD:9681728
NCBI chr 2:138,897,316...138,930,493
Ensembl chr 2:138,897,416...138,930,495
G
Supt3h
SPT3 homolog, SAGA and STAGA complex component
ISO
RGD
PMID:22426530
RGD:9681728
NCBI chr 9:15,878,296...16,206,768
Ensembl chr 9:15,868,287...16,206,706
G
Supt7l
SPT7 like, STAGA complex subunit gamma
ISO
RGD
PMID:22426530
RGD:9681728
NCBI chr 6:24,933,941...24,944,656
Ensembl chr 6:24,933,923...24,944,654
G
Tada1
transcriptional adaptor 1
ISO
RGD
PMID:22426530
RGD:9681728
NCBI chr13:78,632,908...78,646,863
Ensembl chr13:78,632,866...78,647,504
G
Tada2a
transcriptional adaptor 2A
ISO
RGD
PMID:22426530
RGD:9681728
NCBI chr10:68,966,502...69,014,149
Ensembl chr10:68,966,502...69,014,105
G
Tada2b
transcriptional adaptor 2B
ISO
RGD
PMID:22426530
RGD:9681728
NCBI chr14:74,279,286...74,290,758
Ensembl chr14:74,279,217...74,290,755
G
Tada3
transcriptional adaptor 3
ISO
RGD
PMID:22426530
RGD:9681728
NCBI chr 4:146,510,213...146,521,975
Ensembl chr 4:146,510,246...146,521,590
G
Taf1
TATA-box binding protein associated factor 1
ISO
RGD
PMID:23146842
RGD:9681723
NCBI chr X:66,640,915...66,716,543
Ensembl chr X:66,640,982...66,716,543
G
Taf10
TATA-box binding protein associated factor 10
ISO
RGD
PMID:23146842 PMID:22426530
RGD:9681723 , RGD:9681728
NCBI chr 1:160,095,108...160,096,401
Ensembl chr 1:160,095,108...160,096,376
G
Taf11
TATA-box binding protein associated factor 11
ISO
RGD
PMID:23146842
RGD:9681723
NCBI chr20:5,955,774...5,963,593
Ensembl chr20:5,955,777...5,961,905
G
Taf12
TATA-box binding protein associated factor 12
ISO
RGD
PMID:23146842 PMID:22426530
RGD:9681723 , RGD:9681728
NCBI chr 5:144,472,816...144,490,299
Ensembl chr 5:144,472,841...144,488,849
G
Taf13
TATA-box binding protein associated factor 13
ISO
RGD
PMID:23146842
RGD:9681723
NCBI chr 2:196,205,219...196,215,882
Ensembl chr 2:196,205,243...196,215,878
G
Taf15
TATA-box binding protein associated factor 15
ISO
RGD
PMID:23146842
RGD:9681723
NCBI chr10:68,272,921...68,304,951
Ensembl chr10:68,272,969...68,304,949
G
Taf2
TATA-box binding protein associated factor 2
ISO
RGD
PMID:23146842
RGD:9681723
NCBI chr 7:86,422,613...86,479,616
Ensembl chr 7:86,422,613...86,479,616
G
Taf3
TATA-box binding protein associated factor 3
ISO
RGD
PMID:23146842
RGD:9681723
NCBI chr17:68,455,389...68,608,367
Ensembl chr17:68,423,909...68,608,367
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Taf4
TATA-box binding protein associated factor 4
ISO
RGD
PMID:23146842
RGD:9681723
NCBI chr 3:167,017,992...167,083,413
Ensembl chr 3:167,017,993...167,083,356
G
Taf5
TATA-box binding protein associated factor 5
ISO
RGD
PMID:23146842
RGD:9681723
NCBI chr 1:245,958,428...245,973,914
Ensembl chr 1:245,958,428...245,973,914
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Taf5l1
TATA-box binding protein associated factor 5 like 1
ISO
RGD
PMID:22426530
RGD:9681728
NCBI chr19:51,991,704...52,011,001
Ensembl chr19:51,991,708...52,011,295
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Taf6
TATA-box binding protein associated factor 6
ISO
RGD
PMID:23146842
RGD:9681723
NCBI chr12:17,055,864...17,064,244
Ensembl chr12:17,055,873...17,064,247
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Taf6l
TATA-box binding protein associated factor 6 like
ISO
RGD
PMID:22426530
RGD:9681728
NCBI chr 1:205,672,147...205,684,721
Ensembl chr 1:205,672,149...205,684,655
G
Taf7
TATA-box binding protein associated factor 7
ISO
RGD
PMID:23146842
RGD:9681723
NCBI chr18:29,459,937...29,462,086
Ensembl chr18:29,452,943...29,462,134
G
Taf8
TATA-box binding protein associated factor 8
ISO
RGD
PMID:23146842
RGD:9681723
NCBI chr 9:13,491,892...13,511,713
Ensembl chr 9:13,491,937...13,511,717
G
Taf9
TATA-box binding protein associated factor 9
ISO
RGD
PMID:23146842 PMID:22426530
RGD:9681723 , RGD:9681728
NCBI chr 2:31,794,316...31,798,324
Ensembl chr 2:31,794,142...31,798,769
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Tbp
TATA box binding protein
ISO
RGD
PMID:24120742 PMID:23146842
RGD:9681721 , RGD:9681723
NCBI chr 1:56,463,330...56,480,430
Ensembl chr 1:56,463,618...56,510,016
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Trrap
transformation/transcription domain-associated protein
ISO
RGD
PMID:22426530
RGD:9681728
NCBI chr12:9,738,006...9,827,708
Ensembl chr12:9,738,006...9,827,674
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Usp22
ubiquitin specific peptidase 22
ISO
RGD
PMID:22426530
RGD:9681728
NCBI chr10:45,828,619...45,855,468
Ensembl chr10:45,828,622...45,855,497
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Wdr5
WD repeat domain 5
ISO
RGD
PMID:22426530
RGD:9681728
NCBI chr 3:10,836,964...10,856,682
Ensembl chr 3:10,837,025...10,856,671
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Yeats2
YEATS domain containing 2
ISO
RGD
PMID:22426530
RGD:9681728
NCBI chr11:80,743,134...80,829,253
Ensembl chr11:80,743,134...80,829,208
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Zzz3
zinc finger, ZZ-type containing 3
ISO
RGD
PMID:22426530
RGD:9681728
NCBI chr 2:241,330,366...241,397,308
Ensembl chr 2:241,331,022...241,397,307
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Clp1
cleavage factor polyribonucleotide kinase subunit 1
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr 3:69,806,774...69,818,633
Ensembl chr 3:69,806,778...69,810,421
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Cpsf1
cleavage and polyadenylation specific factor 1
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr 7:108,319,429...108,330,018
Ensembl chr 7:108,319,434...108,329,934
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Cpsf2
cleavage and polyadenylation specific factor 2
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr 6:121,123,941...121,152,756
Ensembl chr 6:121,120,569...121,151,921
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Cpsf3
cleavage and polyadenylation specific factor 3
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr 6:40,836,121...40,864,129
Ensembl chr 6:40,836,097...40,864,128
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Cpsf4
cleavage and polyadenylation specific factor 4
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 RGD:9681742
NCBI chr12:9,429,765...9,445,586
Ensembl chr12:9,429,523...9,445,586
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Cpsf6
cleavage and polyadenylation specific factor 6
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr 7:52,956,589...53,001,783
Ensembl chr 7:52,956,589...52,988,122
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Cpsf7
cleavage and polyadenylation specific factor 7
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr 1:207,167,690...207,191,938
Ensembl chr 1:207,167,859...207,191,905
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Cstf1
cleavage stimulation factor subunit 1
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr 3:161,144,522...161,156,294
Ensembl chr 3:161,144,548...161,156,300
G
Cstf2
cleavage stimulation factor subunit 2
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr X:97,253,559...97,279,476
Ensembl chr X:97,253,586...97,279,476
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Cstf2t
cleavage stimulation factor subunit 2, tau variant
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr 1:228,952,617...228,956,183
Ensembl chr 1:228,952,504...228,955,873
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Cstf3
cleavage stimulation factor subunit 3
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr 3:90,966,415...91,037,669
Ensembl chr 3:90,966,354...91,042,196
G
Dxo
decapping exoribonuclease
ISO
RGD
PMID:21957020
RGD:9681741
NCBI chr20:3,993,322...3,995,484
Ensembl chr20:3,993,327...3,995,494
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Fip1l1
factor interacting with PAPOLA and CPSF1
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr14:33,615,210...33,675,742
Ensembl chr14:33,617,720...33,675,708
G
Nudt21
nudix hydrolase 21
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr19:10,974,800...10,993,841
Ensembl chr19:10,974,241...10,991,682
G
Pcf11
PCF11 cleavage and polyadenylation factor subunit
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr 1:146,694,045...146,724,030
Ensembl chr 1:146,697,646...146,724,124
G
Sympk
symplekin scaffold protein
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr 1:78,672,372...78,700,684
Ensembl chr 1:78,672,378...78,700,684
G
Wdr33
WD repeat domain 33
ISO
RGD
PMID:21957020 PMID:24243805
RGD:9681741 , RGD:9681742
NCBI chr18:23,432,233...23,535,460
Ensembl chr18:23,432,191...23,468,597
G
Xrn2
5'-3' exoribonuclease 2
ISO
RGD
PMID:21957020
RGD:9681741
NCBI chr 3:134,436,916...134,509,308
Ensembl chr 3:134,437,109...134,509,306
G
Aar2
AAR2 splicing factor
ISO
RGD
PMID:23592432
RGD:9686090
NCBI chr 3:145,057,368...145,079,838
Ensembl chr 3:145,057,458...145,080,166
G
Acin1
apoptotic chromatin condensation inducer 1
IEA
KEGG
rno:03040
NCBI chr15:28,102,112...28,147,001
Ensembl chr15:28,102,112...28,147,001
G
Alyref
Aly/REF export factor
IEA
KEGG
rno:03040
NCBI chr10:105,871,424...105,875,076
Ensembl chr10:105,871,306...105,875,069
G
Aqr
aquarius intron-binding spliceosomal factor
IEA ISO
KEGG RGD
PMID:23742842
rno:03040, RGD:9686094
NCBI chr 3:100,874,987...100,945,026
Ensembl chr 3:100,874,987...100,945,044
G
Bcas2
BCAS2, pre-mRNA processing factor
IEA ISO
KEGG RGD
PMID:23742842
rno:03040, RGD:9686094
NCBI chr 2:190,692,503...190,700,386
Ensembl chr 2:190,692,461...190,700,389
G
Bud31
BUD31 homolog
IEA ISO
KEGG RGD
PMID:23742842
rno:03040, RGD:9686094
NCBI chr12:9,462,838...9,470,387
Ensembl chr12:9,462,441...9,470,509
G
Ccdc12
coiled-coil domain containing 12
IEA ISO
KEGG RGD
PMID:23742842
rno:03040, RGD:9686094
NCBI chr 8:110,635,276...110,686,417
Ensembl chr 8:110,635,710...110,686,417
G
Cdc40
cell division cycle 40
IEA
KEGG
rno:03040
NCBI chr20:44,273,080...44,325,605
Ensembl chr20:44,273,089...44,325,358
G
Cdc5l
cell division cycle 5-like
IEA ISO
KEGG RGD
PMID:23742842
rno:03040, RGD:9686094
NCBI chr 9:15,564,949...15,603,453
Ensembl chr 9:15,564,767...15,603,450
G
Cherp
calcium homeostasis endoplasmic reticulum protein
IEA
KEGG
rno:03040
NCBI chr16:17,367,455...17,380,507
Ensembl chr16:17,367,455...17,380,507
G
Crnkl1
crooked neck pre-mRNA splicing factor 1
IEA ISO
KEGG RGD
PMID:23742842
rno:03040, RGD:9686094
NCBI chr 3:133,338,593...133,354,329
Ensembl chr 3:133,337,039...133,354,302 Ensembl chr 6:133,337,039...133,354,302
G
Ctnnbl1
catenin, beta like 1
IEA ISO
KEGG RGD
PMID:23742842
rno:03040, RGD:9686094
NCBI chr 3:146,387,940...146,548,987
Ensembl chr 3:146,387,889...146,548,987
G
Cwc15
CWC15 spliceosome-associated protein
IEA ISO
KEGG RGD
PMID:23742842
rno:03040, RGD:9686094
NCBI chr 8:11,305,401...11,316,326
Ensembl chr 8:11,305,424...11,316,325
G
Ddx23
DEAD-box helicase 23
IEA ISO
KEGG RGD
PMID:19239890 PMID:23454554
rno:03040, RGD:9686089 , RGD:9686093
NCBI chr 7:129,797,620...129,814,909
Ensembl chr 7:129,797,614...129,814,949
G
Ddx39b
DExD-box helicase 39B
ISO
RGD
PMID:23454554
RGD:9686093
NCBI chr20:3,547,702...3,585,064
Ensembl chr20:3,572,056...3,584,996
G
Ddx42
DEAD-box helicase 42
IEA ISO
KEGG RGD
PMID:17537823
rno:03040, RGD:9686091
NCBI chr10:91,148,926...91,180,940
Ensembl chr10:91,148,254...91,180,939
G
Ddx46
DEAD-box helicase 46
IEA ISO
KEGG RGD
PMID:23454554
rno:03040, RGD:9686093
NCBI chr17:8,942,070...8,988,440
Ensembl chr17:8,944,454...8,988,439
G
Ddx5
DEAD-box helicase 5
IEA
KEGG
rno:03040
NCBI chr10:91,723,508...91,732,210
Ensembl chr10:91,723,508...91,732,283
G
Dhx15
DEAH-box helicase 15
IEA
KEGG
rno:03040
NCBI chr14:58,787,147...58,825,083
Ensembl chr14:58,787,127...58,825,088
G
Dhx16
DEAH-box helicase 16
IEA ISO
KEGG RGD
PMID:23454554
rno:03040, RGD:9686093
NCBI chr20:2,862,000...2,874,991
Ensembl chr20:2,862,000...2,874,948
G
Dhx38
DEAH-box helicase 38
IEA ISO
KEGG RGD
PMID:23454554
rno:03040, RGD:9686093
NCBI chr19:37,512,893...37,530,135
Ensembl chr19:37,512,891...37,530,140
G
Dhx8
DEAH-box helicase 8
IEA ISO
KEGG RGD
PMID:23454554
rno:03040, RGD:9686093
NCBI chr10:86,667,641...86,704,198
Ensembl chr10:86,667,834...86,705,137
G
Eftud2
elongation factor Tu GTP binding domain containing 2
IEA ISO
KEGG RGD
PMID:23454554 PMID:23592432
rno:03040, RGD:9686093 , RGD:9686090
NCBI chr10:87,804,893...87,852,181
Ensembl chr10:87,804,892...87,846,079
G
Eif4a3
eukaryotic translation initiation factor 4A3
IEA ISO
KEGG RGD
PMID:15145352
rno:03040, RGD:9686404
NCBI chr10:104,549,038...104,559,032
Ensembl chr10:104,549,038...104,559,057
G
Hnrnpa0
heterogeneous nuclear ribonucleoprotein A0
ISO
RGD
PMID:17537823
RGD:9686091
NCBI chr17:6,507,728...6,510,385
Ensembl chr17:6,507,275...6,509,375
G
Hnrnpa1
heterogeneous nuclear ribonucleoprotein A1
IEA ISO
KEGG RGD
PMID:17537823 PMID:19239890
rno:03040, RGD:9686091 , RGD:9686089
NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609
G
Hnrnpa2b1
heterogeneous nuclear ribonucleoprotein A2/B1
ISO
RGD
PMID:17537823
RGD:9686091
NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249
G
Hnrnpa3
heterogeneous nuclear ribonucleoprotein A3
IEA
KEGG
rno:03040
NCBI chr 3:60,578,574...60,588,755
Ensembl chr 3:60,578,673...60,588,306
G
Hnrnpab
heterogeneous nuclear ribonucleoprotein A/B
ISO
RGD
PMID:17537823
RGD:9686091
NCBI chr10:35,857,040...35,862,935
Ensembl chr10:35,857,041...35,863,344
G
Hnrnpc
heterogeneous nuclear ribonucleoprotein C
IEA ISO
KEGG RGD
PMID:17537823 PMID:19239890
rno:03040, RGD:9686091 , RGD:9686089
NCBI chr15:24,779,593...24,809,213
Ensembl chr15:24,779,450...24,809,183
G
Hnrnpd
heterogeneous nuclear ribonucleoprotein D
ISO
RGD
PMID:17537823
RGD:9686091
NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786
G
Hnrnph1
heterogeneous nuclear ribonucleoprotein H1
ISO
RGD
PMID:17537823
RGD:9686091
NCBI chr10:34,692,868...34,702,849
Ensembl chr10:34,693,555...34,702,846
G
Hnrnph3
heterogeneous nuclear ribonucleoprotein H3
ISO
RGD
PMID:17537823
RGD:9686091
NCBI chr20:25,616,400...25,625,814
Ensembl chr20:25,614,733...25,625,750
G
Hnrnpk
heterogeneous nuclear ribonucleoprotein K
IEA ISO
KEGG RGD
PMID:17537823 PMID:19239890
rno:03040, RGD:9686091 , RGD:9686089
NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997
G
Hnrnpl
heterogeneous nuclear ribonucleoprotein L
ISO
RGD
PMID:17537823
RGD:9686091
NCBI chr 1:84,098,558...84,111,568
Ensembl chr 1:84,100,879...84,111,553
G
Hnrnpm
heterogeneous nuclear ribonucleoprotein M
ISO
RGD
PMID:19239890 PMID:17537823
RGD:9686089 , RGD:9686091
NCBI chr 7:14,438,703...14,476,781
Ensembl chr 7:14,438,688...14,476,762
G
Hnrnpr
heterogeneous nuclear ribonucleoprotein R
ISO
RGD
PMID:17537823
RGD:9686091
NCBI chr 5:148,542,999...148,574,888
Ensembl chr 5:148,543,044...148,574,867
G
Hnrnpu
heterogeneous nuclear ribonucleoprotein U
IEA ISO
KEGG RGD
PMID:17537823 PMID:19239890
rno:03040, RGD:9686091 , RGD:9686089
NCBI chr13:90,069,058...90,086,905
Ensembl chr13:90,074,181...90,086,588
G
Hspa1a
heat shock protein family A (Hsp70) member 1A
IEA
KEGG
rno:03040
NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
G
Hspa1b
heat shock protein family A (Hsp70) member 1B
IEA
KEGG
rno:03040
NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 Ensembl chr20:3,856,006...3,873,240
G
Hspa1l
heat shock protein family A (Hsp70) member 1 like
IEA
KEGG
rno:03040
NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
G
Hspa2
heat shock protein family A (Hsp70) member 2
IEA
KEGG
rno:03040
NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287
G
Hspa8
heat shock protein family A (Hsp70) member 8
IEA ISO
KEGG RGD
PMID:23742842
rno:03040, RGD:9686094
NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
G
Isy1
ISY1 splicing factor homolog
ISO
RGD
PMID:23742842
RGD:9686094
NCBI chr 4:120,276,535...120,297,227
Ensembl chr 4:120,276,292...120,297,188
G
Lsm2
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
IEA ISO
KEGG RGD
PMID:17537823 PMID:19239890
rno:03040, RGD:9686091 , RGD:9686089
NCBI chr20:3,843,467...3,847,217
Ensembl chr20:3,843,466...3,847,266
G
Lsm3
LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
IEA ISO
KEGG RGD
PMID:17537823 PMID:19239890
rno:03040, RGD:9686091 , RGD:9686089
NCBI chr 4:124,021,023...124,027,269
Ensembl chr 4:124,021,023...124,027,269
G
Lsm4
LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
IEA ISO
KEGG RGD
PMID:17537823 PMID:19239890
rno:03040, RGD:9686091 , RGD:9686089
NCBI chr16:18,755,481...18,761,106
Ensembl chr16:18,755,484...18,760,926
G
Lsm5
LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
IEA
KEGG
rno:03040
NCBI chr 4:85,951,073...85,954,289
Ensembl chr 6:104,652,477...104,654,165 Ensembl chr 4:104,652,477...104,654,165
G
Lsm6
LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
IEA ISO
KEGG RGD
PMID:17537823 PMID:19239890
rno:03040, RGD:9686091 , RGD:9686089
NCBI chr19:29,098,254...29,112,858
Ensembl chr13:42,114,032...42,116,484 Ensembl chr19:42,114,032...42,116,484
G
Lsm7
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
IEA ISO
KEGG RGD
PMID:17537823 PMID:19239890
rno:03040, RGD:9686091 , RGD:9686089
NCBI chr 7:8,856,698...8,859,113
Ensembl chr 7:8,856,489...8,859,119
G
Lsm8
LSM8 homolog, U6 small nuclear RNA associated
ISO
RGD
PMID:19239890 PMID:17537823
RGD:9686089 , RGD:9686091
NCBI chr 4:47,306,259...47,312,125
Ensembl chr 4:47,306,295...47,314,293
G
Magoh
mago homolog, exon junction complex subunit
IEA
KEGG
rno:03040
NCBI chr 5:122,639,268...122,646,650
Ensembl chr 5:122,639,308...122,646,617
G
Magohb
mago homolog B, exon junction complex subunit
IEA ISO
KEGG RGD
PMID:15145352
rno:03040, RGD:9686404
NCBI chr 4:165,034,131...165,041,977
Ensembl chr 4:165,034,122...165,041,967
G
Mbnl1
muscleblind-like splicing regulator 1
ISO
RGD
PMID:23498935
RGD:9686382
NCBI chr 2:144,639,819...144,814,395
Ensembl chr 2:144,670,285...144,814,368
G
Ncbp1
nuclear cap binding protein subunit 1
IEA
KEGG
rno:03040
NCBI chr 5:60,416,023...60,449,004
Ensembl chr 5:60,415,982...60,449,089
G
Pcbp1
poly(rC) binding protein 1
IEA
KEGG
rno:03040
NCBI chr 4:118,972,698...118,974,705
Ensembl chr 4:118,972,661...118,976,500
G
Phf5a
PHD finger protein 5A
IEA
KEGG
rno:03040
NCBI chr 7:113,378,469...113,385,035
Ensembl chr 7:113,378,471...113,385,460
G
Pigz
phosphatidylinositol glycan anchor biosynthesis, class Z
IEA
KEGG
rno:03040
NCBI chr11:68,831,847...68,851,798
G
Plrg1
pleiotropic regulator 1
IEA ISO
KEGG RGD
PMID:23742842
rno:03040, RGD:9686094
NCBI chr 2:168,408,139...168,424,470
Ensembl chr 2:168,408,124...168,424,522
G
Pnn
pinin, desmosome associated protein
ISO
RGD
PMID:15145352
RGD:9686404
NCBI chr 6:76,758,138...76,766,451
Ensembl chr 6:76,758,117...76,766,889
G
Ppie
peptidylprolyl isomerase E
IEA ISO
KEGG RGD
PMID:18544344 PMID:23742842
rno:03040, RGD:9686376 , RGD:9686094
NCBI chr 5:135,406,172...135,419,332
Ensembl chr 5:135,406,176...135,419,235
G
Ppig
peptidylprolyl isomerase G
ISO
RGD
PMID:18544344
RGD:9686376
NCBI chr 3:54,484,023...54,512,929
Ensembl chr 3:54,484,023...54,512,926
G
Ppih
peptidylprolyl isomerase H
IEA ISO
KEGG RGD
PMID:18544344
rno:03040, RGD:9686376
NCBI chr 5:132,906,324...132,924,341
Ensembl chr 5:132,906,328...132,924,267
G
Ppil1
peptidylprolyl isomerase like 1
IEA ISO
KEGG RGD
PMID:18544344 PMID:23742842
rno:03040, RGD:9686376 , RGD:9686094
NCBI chr20:7,302,292...7,322,349
Ensembl chr20:7,302,621...7,322,354
G
Ppil2
peptidylprolyl isomerase like 2
ISO
RGD
PMID:18544344
RGD:9686376
NCBI chr11:83,897,719...83,920,970
Ensembl chr11:83,897,764...83,922,144
G
Ppil3
peptidylprolyl isomerase like 3
ISO
RGD
PMID:18544344
RGD:9686376
NCBI chr 9:59,966,405...59,980,147
Ensembl chr 9:59,964,919...59,979,886
G
Pqbp1
polyglutamine binding protein 1
IEA
KEGG
rno:03040
NCBI chr X:14,603,516...14,608,091
Ensembl chr X:14,603,539...14,608,087
G
Prpf18
pre-mRNA processing factor 18
IEA ISO
KEGG RGD
PMID:24452469
rno:03040, RGD:9686092
NCBI chr17:73,630,560...73,661,210
Ensembl chr17:73,630,571...73,690,979
G
Prpf19
pre-mRNA processing factor 19
IEA ISO
KEGG RGD
PMID:23742842
rno:03040, RGD:9686094
NCBI chr 1:207,541,582...207,552,664
Ensembl chr 1:207,541,595...207,552,662
G
Prpf3
pre-mRNA processing factor 3
IEA ISO
KEGG RGD
PMID:19239890
rno:03040, RGD:9686089
NCBI chr 2:183,379,041...183,403,526
Ensembl chr 2:183,378,718...183,403,489
G
Prpf31
pre-mRNA processing factor 31
IEA ISO
KEGG RGD
PMID:19239890
rno:03040, RGD:9686089
NCBI chr 1:65,575,887...65,587,561
Ensembl chr 1:65,575,887...65,587,873
G
Prpf38a
pre-mRNA processing factor 38A
IEA
KEGG
rno:03040
NCBI chr 5:123,312,461...123,324,160
Ensembl chr 5:123,311,482...123,323,972
G
Prpf38b
pre-mRNA processing factor 38B
IEA
KEGG
rno:03040
NCBI chr 2:196,553,224...196,562,271
Ensembl chr 2:196,553,225...196,562,250
G
Prpf4
pre-mRNA splicing tri-snRNP complex factor 4
IEA ISO
KEGG RGD
PMID:19239890
rno:03040, RGD:9686089
NCBI chr 5:75,859,934...75,873,924
Ensembl chr 5:75,859,924...75,873,919
G
Prpf40a
pre-mRNA processing factor 40 homolog A
IEA
KEGG
rno:03040
NCBI chr 3:37,625,585...37,689,859
Ensembl chr 3:37,627,690...37,690,886
G
Prpf6
pre-mRNA processing factor 6
IEA ISO
KEGG RGD
PMID:19239890
rno:03040, RGD:9686089
NCBI chr 3:168,706,952...168,771,191
Ensembl chr 3:168,704,299...168,774,991
G
Prpf8
pre-mRNA processing factor 8
IEA ISO
KEGG RGD
PMID:23592432
rno:03040, RGD:9686090
NCBI chr10:60,331,494...60,354,606
Ensembl chr10:60,331,494...60,354,606
G
Ptbp1
polypyrimidine tract binding protein 1
ISO
RGD
PMID:23385723
RGD:9686381
NCBI chr 7:9,842,574...9,852,332
Ensembl chr 7:9,842,574...9,852,397
G
Ptbp2
polypyrimidine tract binding protein 2
ISO
RGD
PMID:23498935
RGD:9686382
NCBI chr 2:207,812,659...207,874,019
Ensembl chr 2:207,812,920...207,873,506
G
Puf60
poly-U binding splicing factor 60
IEA
KEGG
rno:03040
NCBI chr 7:107,782,799...107,793,759
Ensembl chr 7:107,782,770...107,794,531
G
Qki
QKI, KH domain containing RNA binding
ISO
RGD
PMID:23385723
RGD:9686381
NCBI chr 1:50,387,716...50,501,568
Ensembl chr 1:50,387,698...50,498,831
G
Rbm17
RNA binding motif protein 17
IEA
KEGG
rno:03040
NCBI chr17:66,937,140...66,954,034
Ensembl chr17:66,937,140...66,954,014
G
Rbm22
RNA binding motif protein 22
IEA ISO
KEGG RGD
PMID:23742842
rno:03040, RGD:9686094
NCBI chr18:54,013,374...54,024,182
Ensembl chr18:54,013,351...54,024,569
G
Rbm25
RNA binding motif protein 25
IEA
KEGG
rno:03040
NCBI chr 6:103,271,775...103,319,090
Ensembl chr 6:103,271,801...103,317,854
G
Rbm25l1
RNA binding motif protein 25-like 1
IEA
KEGG
rno:03040
NCBI chr10:10,267,026...10,270,510
Ensembl chr10:10,267,260...10,269,710
G
Rbm8a
RNA binding motif protein 8A
IEA ISO
KEGG RGD
PMID:15145352
rno:03040, RGD:9686404
NCBI chr 2:184,165,189...184,167,959
Ensembl chr 2:184,165,193...184,167,959
G
Rbmx
RNA binding motif protein, X-linked
IEA ISO
KEGG RGD
PMID:17537823 PMID:19239890
rno:03040, RGD:9686091 , RGD:9686089
NCBI chr X:135,305,237...135,314,806
Ensembl chr X:135,305,325...135,314,743
G
Rbmxl1
Rbmx like 1
IEA
KEGG
rno:03040
NCBI chr19:29,407,902...29,411,519
Ensembl chr19:29,407,912...29,412,859
G
Rnps1
RNA binding protein with serine rich domain 1
ISO
RGD
PMID:15145352
RGD:9686404
NCBI chr10:13,445,516...13,455,858
Ensembl chr10:13,445,653...13,455,858
G
Sart1
spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
IEA
KEGG
rno:03040
NCBI chr 1:202,690,472...202,699,136
Ensembl chr 1:202,690,459...202,699,136
G
Sart3
spliceosome associated factor 3, U4/U6 recycling protein
ISO
RGD
PMID:23592432
RGD:9686090
NCBI chr12:42,859,026...42,887,041
Ensembl chr12:42,859,305...42,887,038
G
Sf1
splicing factor 1
ISO
RGD
PMID:19239890
RGD:9686089
NCBI chr 1:203,670,016...203,683,432
Ensembl chr 1:203,670,018...203,684,330
G
Sf3a1
splicing factor 3A subunit 1
IEA ISO
KEGG RGD
PMID:17537823
rno:03040, RGD:9686091
NCBI chr14:79,031,394...79,052,144
Ensembl chr14:79,031,394...79,052,144
G
Sf3a2
splicing factor 3A subunit 2
IEA ISO
KEGG RGD
PMID:17537823
rno:03040, RGD:9686091
NCBI chr 7:8,909,507...8,916,104
Ensembl chr 7:8,909,507...8,915,530
G
Sf3a3
splicing factor 3a, subunit 3
IEA ISO
KEGG RGD
PMID:17537823
rno:03040, RGD:9686091
NCBI chr 5:136,967,713...136,987,345
Ensembl chr 5:136,967,691...136,987,361
G
Sf3b1
splicing factor 3b, subunit 1
IEA ISO
KEGG RGD
PMID:17537823
rno:03040, RGD:9686091
NCBI chr 9:56,492,403...56,532,300
Ensembl chr 9:56,492,403...56,532,300
G
Sf3b2
splicing factor 3b, subunit 2
IEA ISO
KEGG RGD
PMID:17537823
rno:03040, RGD:9686091
NCBI chr 1:202,570,423...202,590,774
Ensembl chr 1:202,570,423...202,590,759
G
Sf3b3
splicing factor 3b, subunit 3
IEA ISO
KEGG RGD
PMID:17537823
rno:03040, RGD:9686091
NCBI chr19:38,782,749...38,820,271
Ensembl chr19:38,783,040...38,820,245
G
Sf3b4
splicing factor 3B subunit 4
IEA ISO
KEGG RGD
PMID:17537823
rno:03040, RGD:9686091
NCBI chr 2:183,732,791...183,737,545
Ensembl chr 2:183,732,754...183,737,959
G
Sf3b5
splicing factor 3b, subunit 5
IEA ISO
KEGG RGD
PMID:17537823
rno:03040, RGD:9686091
NCBI chr 1:7,357,040...7,357,752
Ensembl chr 1:7,350,731...7,357,839
G
Sf3b6
splicing factor 3B, subunit 6
ISO
RGD
PMID:17537823
RGD:9686091
NCBI chr 6:27,826,044...27,835,086
Ensembl chr 6:27,826,029...27,835,156
G
Slu7
SLU7 homolog, splicing factor
IEA ISO
KEGG RGD
PMID:24452469
rno:03040, RGD:9686092
NCBI chr10:27,908,325...27,923,784
Ensembl chr10:27,908,396...27,923,349
G
Smndc1
survival motor neuron domain containing 1
IEA
KEGG
rno:03040
NCBI chr 1:252,389,675...252,400,749
Ensembl chr 1:252,389,673...252,401,616
G
Snrnp200
small nuclear ribonucleoprotein U5 subunit 200
ISO
RGD
PMID:23592432 PMID:23454554
RGD:9686090 , RGD:9686093
NCBI chr 3:114,428,854...114,458,194
Ensembl chr 3:114,428,854...114,458,182
G
Snrnp27
small nuclear ribonucleoprotein U4/U6.U5 subunit 27
IEA
KEGG
rno:03040
NCBI chr 4:119,123,676...119,133,234
Ensembl chr 4:119,121,877...119,133,234
G
Snrnp40
small nuclear ribonucleoprotein U5 subunit 40
IEA
KEGG
rno:03040
NCBI chr 5:142,700,632...142,733,776
Ensembl chr 5:142,700,534...142,733,776
G
Snrnp70
small nuclear ribonucleoprotein U1 subunit 70
IEA ISO
KEGG RGD
PMID:23592432
rno:03040, RGD:9686090
NCBI chr 1:95,856,038...95,876,434
Ensembl chr 1:95,856,036...95,876,392
G
Snrpa
small nuclear ribonucleoprotein polypeptide A
IEA ISO
KEGG RGD
PMID:23592432
rno:03040, RGD:9686090
NCBI chr 1:82,481,770...82,490,540
Ensembl chr 1:82,481,770...82,490,538
G
Snrpa1
small nuclear ribonucleoprotein polypeptide A'
ISO
RGD
PMID:17537823
RGD:9686091
NCBI chr 1:119,641,402...119,654,653
Ensembl chr 1:119,638,481...119,654,653
G
Snrpb
small nuclear ribonucleoprotein polypeptides B and B1
IEA ISO
KEGG RGD
PMID:17537823 PMID:19239890
rno:03040, RGD:9686091 , RGD:9686089
NCBI chr 3:117,369,816...117,379,344
Ensembl chr 3:117,370,100...117,379,339
G
Snrpb2
small nuclear ribonucleoprotein polypeptide B2
IEA ISO
KEGG RGD
PMID:17537823
rno:03040, RGD:9686091
NCBI chr 3:130,399,239...130,408,821
Ensembl chr 3:130,399,248...130,408,812
G
Snrpc
small nuclear ribonucleoprotein polypeptide C
IEA ISO
KEGG RGD
PMID:23592432
rno:03040, RGD:9686090
NCBI chr20:5,888,453...5,906,638
Ensembl chr20:5,888,453...5,906,638
G
Snrpd1
small nuclear ribonucleoprotein D1 polypeptide
IEA ISO
KEGG RGD
PMID:17537823 PMID:19239890
rno:03040, RGD:9686091 , RGD:9686089
NCBI chr18:1,696,838...1,707,400
Ensembl chr18:1,696,852...1,708,256
G
Snrpd2
small nuclear ribonucleoprotein D2 polypeptide
IEA ISO
KEGG RGD
PMID:17537823 PMID:19239890
rno:03040, RGD:9686091 , RGD:9686089
NCBI chr 1:78,798,377...78,801,227
Ensembl chr 1:78,798,377...78,803,351
G
Snrpd3
small nuclear ribonucleoprotein D3 polypeptide
ISO
RGD
PMID:19239890 PMID:17537823
RGD:9686089 , RGD:9686091
NCBI chr20:13,130,112...13,145,947
Ensembl chr20:13,130,119...13,145,978
G
Snrpe
small nuclear ribonucleoprotein polypeptide E
IEA ISO
KEGG RGD
PMID:17537823 PMID:19239890
rno:03040, RGD:9686091 , RGD:9686089
NCBI chr13:45,050,986...45,057,231
Ensembl chr13:45,050,986...45,057,310 Ensembl chr 8:45,050,986...45,057,310
G
Snrpf
small nuclear ribonucleoprotein polypeptide F
IEA ISO
KEGG RGD
PMID:17537823 PMID:19239890
rno:03040, RGD:9686091 , RGD:9686089
NCBI chr 7:28,130,427...28,137,129
Ensembl chr 7:28,130,427...28,137,129
G
Snrpg
small nuclear ribonucleoprotein polypeptide G
ISO
RGD
PMID:19239890 PMID:17537823
RGD:9686089 , RGD:9686091
NCBI chr 4:118,812,278...118,819,827
Ensembl chr 4:118,812,252...118,819,826
G
Snu13
small nuclear ribonucleoprotein 13
IEA ISO
KEGG RGD
PMID:19239890
rno:03040, RGD:9686089
NCBI chr 7:113,565,293...113,570,887
Ensembl chr 7:113,565,295...113,570,872 Ensembl chr 1:113,565,295...113,570,872
G
Snu13l1
small nuclear ribonucleoprotein 13 like 1
IEA
KEGG
rno:03040
NCBI chr X:150,624,087...150,624,525
Ensembl chr X:150,624,087...150,624,473
G
Snw1
SNW domain containing 1
IEA ISO
KEGG RGD
PMID:23742842
rno:03040, RGD:9686094
NCBI chr 6:107,095,450...107,119,536
Ensembl chr 6:107,095,457...107,119,536
G
Srrm1
serine and arginine repetitive matrix 1
ISO
RGD
PMID:17537823 PMID:15145352
RGD:9686091 , RGD:9686404
NCBI chr 5:147,559,515...147,591,895
Ensembl chr 5:147,559,514...147,591,849
G
Srrm2
serine/arginine repetitive matrix 2
ISO
RGD
PMID:17537823
RGD:9686091
NCBI chr10:12,815,471...12,848,750
Ensembl chr10:12,815,471...12,848,751
G
Srrm4
serine/arginine repetitive matrix 4
ISO
RGD
PMID:23498935
RGD:9686382
NCBI chr12:39,998,975...40,158,897
Ensembl chr12:39,999,488...40,155,725
G
Srsf1
serine and arginine rich splicing factor 1
ISO
RGD
PMID:19239890 PMID:17537823
RGD:9686089 , RGD:9686091
NCBI chr10:72,838,926...72,859,066
Ensembl chr10:72,839,274...72,845,336
G
Srsf10
serine and arginine rich splicing factor 10
ISO
RGD
PMID:19239890 PMID:17537823
RGD:9686089 , RGD:9686091
NCBI chr 5:148,088,759...148,102,964
Ensembl chr 5:148,088,823...148,101,768
G
Srsf11
serine and arginine rich splicing factor 11
ISO
RGD
PMID:17537823
RGD:9686091
NCBI chr 2:247,074,623...247,101,460
Ensembl chr 2:247,074,631...247,101,425
G
Srsf12
serine and arginine rich splicing factor 12
ISO
RGD
PMID:17537823
RGD:9686091
NCBI chr 5:47,606,526...47,631,509
Ensembl chr 5:47,606,285...47,629,778
G
Srsf2
serine and arginine rich splicing factor 2
ISO
RGD
PMID:17537823
RGD:9686091
NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338
G
Srsf3
serine and arginine rich splicing factor 3
ISO
RGD
PMID:17537823 PMID:19239890
RGD:9686089 RGD:9686091
NCBI chr20:7,091,928...7,101,860
Ensembl chr20:7,091,910...7,101,078
G
Srsf4
serine and arginine rich splicing factor 4
ISO
RGD
PMID:19239890 PMID:17537823
RGD:9686089 , RGD:9686091
NCBI chr 5:144,060,981...144,090,798
Ensembl chr 5:144,061,463...144,089,229
G
Srsf5
serine and arginine rich splicing factor 5
ISO
RGD
PMID:19239890 PMID:17537823
RGD:9686089 , RGD:9686091
NCBI chr 6:100,605,165...100,610,192
Ensembl chr 6:100,605,456...100,610,177
G
Srsf6
serine and arginine rich splicing factor 6
ISO
RGD
PMID:19239890 PMID:17537823
RGD:9686089 , RGD:9686091
NCBI chr 3:151,589,546...151,594,869
Ensembl chr 3:151,589,535...151,594,860
G
Srsf7
serine and arginine rich splicing factor 7
ISO
RGD
PMID:19239890 PMID:17537823
RGD:9686089 , RGD:9686091
NCBI chr 6:14,811,775...14,818,968
Ensembl chr 6:14,811,808...14,818,965
G
Srsf9
serine and arginine rich splicing factor 9
ISO
RGD
PMID:19239890 PMID:17537823
RGD:9686089 , RGD:9686091
NCBI chr12:41,278,225...41,284,502
Ensembl chr12:41,275,687...41,284,499
G
Syf2
SYF2 pre-mRNA-splicing factor
IEA ISO
KEGG RGD
PMID:23742842
rno:03040, RGD:9686094
NCBI chr 5:147,156,492...147,164,416
Ensembl chr 5:147,156,480...147,164,414
G
Syncrip
synaptotagmin binding, cytoplasmic RNA interacting protein
ISO
RGD
PMID:17537823
RGD:9686091
NCBI chr 8:89,402,487...89,435,517
Ensembl chr 8:89,402,866...89,435,515
G
Tcerg1
transcription elongation regulator 1
IEA
KEGG
rno:03040
NCBI chr18:34,505,708...34,566,470
Ensembl chr18:34,505,751...34,566,470
G
Thoc1
THO complex subunit 1
IEA
KEGG
rno:03040
NCBI chr18:983,824...1,019,123
Ensembl chr18:983,824...1,019,114
G
Thoc2
THO complex subunit 2
IEA
KEGG
rno:03040
NCBI chr X:120,634,966...120,749,569
Ensembl chr X:120,634,968...120,749,513
G
Thoc3
THO complex subunit 3
IEA
KEGG
rno:03040
NCBI chr17:10,143,184...10,152,375
Ensembl chr17:10,143,139...10,152,370
G
Tial1
Tia1 cytotoxic granule-associated RNA binding protein-like 1
ISO
RGD
PMID:23385723
RGD:9686381
NCBI chr 1:183,008,358...183,045,092
Ensembl chr 1:183,009,253...183,031,637
G
Tra2a
transformer 2 alpha
IEA
KEGG
rno:03040
NCBI chr 4:78,220,838...78,239,737
Ensembl chr 4:78,220,883...78,239,712
G
Tra2b
transformer 2 beta
IEA
KEGG
rno:03040
NCBI chr11:78,788,880...78,807,252
Ensembl chr11:78,788,884...78,807,249
G
Txnl4a
thioredoxin-like 4A
ISO
RGD
PMID:19239890
RGD:9686089
NCBI chr18:73,659,107...73,674,893
Ensembl chr18:73,659,107...73,674,893
G
U2af1
U2 small nuclear RNA auxiliary factor 1
ISO
RGD
PMID:19239890
RGD:9686089
NCBI chr20:9,742,904...9,753,840
Ensembl chr20:9,742,905...9,753,832
G
U2af2
U2 small nuclear RNA auxiliary factor 2
IEA ISO
KEGG RGD
PMID:19239890
rno:03040, RGD:9686089
NCBI chr 1:68,760,911...68,779,730
Ensembl chr 1:68,760,924...68,778,492
G
U2surp
U2 snRNP-associated SURP domain containing
IEA
KEGG
rno:03040
NCBI chr 8:96,018,932...96,075,795
Ensembl chr 8:96,022,957...96,075,691
G
Usp39
ubiquitin specific peptidase 39
IEA
KEGG
rno:03040
NCBI chr 4:104,373,948...104,406,359
Ensembl chr 4:104,373,955...104,406,359
G
Wbp11
WW domain binding protein 11
IEA
KEGG
rno:03040
NCBI chr 4:169,680,984...169,694,431
Ensembl chr 4:169,680,983...169,694,443
G
Xab2
XPA binding protein 2
IEA ISO
KEGG RGD
PMID:23742842
rno:03040, RGD:9686094
NCBI chr12:1,667,672...1,679,702
Ensembl chr12:1,667,672...1,679,692
G
Zmat2
zinc finger, matrin type 2
IEA
KEGG
rno:03040
NCBI chr18:28,409,606...28,414,241
Ensembl chr18:28,398,795...28,414,747
Pathway Gene Annotations
Disease Annotations Associated with Genes in the RNA polymerase II transcription pathway
Ccnc Burns , genetic disease Cdc14a autosomal recessive nonsyndromic deafness 32 , Deafness , genetic disease , male infertility , maple syrup urine disease , oligospermia , sensorineural hearing loss Cdc14b genetic disease , intellectual disability , Premature Aging , renal cell carcinoma Cdk12 gastric adenocarcinoma , genetic disease , hepatocellular carcinoma , hereditary breast ovarian cancer syndrome , lung adenocarcinoma , Prostatic Neoplasms , stomach cancer Cdk19 developmental and epileptic encephalopathy 87 , genetic disease , microcephaly , Neurodevelopmental Disorders , Spinal Cord Injuries Cdk7 Alzheimer's disease , genetic disease , Neurodevelopmental Disorders Cdk8 dilated cardiomyopathy , Ebstein anomaly , genetic disease , INTELLECTUAL DEVELOPMENTAL DISORDER WITH HYPOTONIA AND BEHAVIORAL ABNORMALITIES Cdk9 congenital disorder of glycosylation Iu , congestive heart failure , developmental and epileptic encephalopathy , developmental and epileptic encephalopathy 31A , early infantile epileptic encephalopathy , Experimental Diabetes Mellitus , genetic disease , medulloblastoma , primary coenzyme Q10 deficiency 7 Ctdp1 Burn-McKeown syndrome , Charcot-Marie-Tooth disease , chromosome 18q deletion syndrome , Congenital Cataracts, Facial Dysmorphism, and Neuropathy , genetic disease , intestinal volvulus , Neurodevelopmental Disorders , Oculootofacial Dysplasia , pulmonary valve stenosis , Volvulus Of Midgut Ctdsp1 alacrima, achalasia, and impaired intellectual development syndrome , cerebrotendinous xanthomatosis , genetic disease , myofibrillar myopathy 1 , Neurodevelopmental Disorders , paroxysmal nonkinesigenic dyskinesia 1 Med1 Chemical and Drug Induced Liver Injury , congestive heart failure , dilated cardiomyopathy , endometriosis , genetic disease , hepatocellular carcinoma , intellectual disability , prostate cancer Med10 genetic disease Med11 genetic disease , NEURODEGENERATION WITH DEVELOPMENTAL DELAY, EARLY RESPIRATORY FAILURE, MYOCLONIC SEIZURES, AND BRAIN ABNORMALITIES Med12 adrenocortical carcinoma , Agenesis of Corpus Callosum , angiosarcoma , Anorectal Malformations , autistic disorder , Breast Neoplasms , Developmental Disabilities , dilated cardiomyopathy 1Y , Ehlers-Danlos syndrome classic type 1 , FG syndrome , FG Syndrome 1 , Fibroadenoma , gastric adenocarcinoma , genetic disease , glioblastoma , Hardikar Syndrome , imperforate anus , intellectual disability , leiomyosarcoma , lung squamous cell carcinoma , major depressive disorder , nephroblastoma , Ohdo syndrome , Ohdo Syndrome, X-Linked , pancreatic adenocarcinoma , phobic disorder , Phyllodes Tumor , prostate adenocarcinoma , Prostatic Neoplasms , Simpson-Golabi-Behmel syndrome type 1 , syndromic X-linked intellectual disability Lubs type , syndromic X-linked intellectual disorder Lujan-Fryns-type , thoracic aortic aneurysm , uterine fibroid , X-Linked Intellectual Developmental Disorders , X-linked severe combined immunodeficiency Med12l Developmental Disease , genetic disease , glycogen storage disease XV , hemorrhagic disease , intellectual disability , Neurodevelopmental Disorders , Nizon-Isidor Syndrome , platelet-type bleeding disorder 8 Med13 autism spectrum disorder , autistic disorder , Autosomal Dominant Intellectual Developmental Disorder 61 , Developmental Disease , epilepsy , genetic disease , intellectual disability , isolated growth hormone deficiency type II , megacolon , Neurodevelopmental Disorders , Right Ventricular Hypertrophy Med13l Au-Kline Syndrome , autism spectrum disorder , Developmental Disabilities , dextro-looped transposition of the great arteries , genetic disease , intellectual disability , Marfanoid Mental Retardation Syndrome, Autosomal , Mental Retardation and Distinctive Facial Features with or without Cardiac Defects , Neurodevelopmental Disorders , strabismus , vesicoureteral reflux Med14 autistic disorder , endometriosis , genetic disease , intellectual disability , Neurodevelopmental Disorders , ornithine carbamoyltransferase deficiency , syndromic X-linked intellectual disability Hedera type , syndromic X-linked intellectual disability Lubs type , syndromic X-linked intellectual disability Najm type Med15 autism spectrum disorder , autistic disorder , chromosome 22q11.2 deletion syndrome, distal , chromosome 22q11.2 microduplication syndrome , DiGeorge syndrome , epilepsy , genetic disease , hemorrhagic disease , Hirschsprung's disease , intellectual disability , megacolon , Neurodevelopmental Disorders , primary immunodeficiency disease , schizophrenia , velocardiofacial syndrome , Venous Thrombosis Med16 cerebral creatine deficiency syndrome , cyclic hematopoiesis , endometriosis , genetic disease , Peutz-Jeghers syndrome Med17 endometriosis , genetic disease , infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly , intellectual disability , microcephaly Med18 genetic disease Med19 genetic disease , intellectual disability Med20 genetic disease , infantile Refsum disease , Zellweger syndrome Med22 developmental and epileptic encephalopathy 14 , Ehlers-Danlos syndrome classic type 1 , genetic disease , Leigh disease , primary coenzyme Q10 deficiency 7 , Rafiq syndrome , tuberous sclerosis 1 Med23 autosomal recessive intellectual developmental disorder 18 , Fraser syndrome 3 , genetic disease , hyperargininemia , intellectual disability , Neurodevelopmental Disorders Med24 Dwarfism , genetic disease , hypertrophic cardiomyopathy 25 Med25 Basel-Vanagaite-Smirin-Yosef syndrome , Charcot-Marie-Tooth disease , Charcot-Marie-Tooth disease type 2 , Charcot-Marie-Tooth disease type 2B2 , developmental and epileptic encephalopathy 12 , Failure to Thrive , genetic disease , Neurodevelopmental Disorders , polyneuropathy Med26 genetic disease Med27 Ehlers-Danlos syndrome classic type 1 , genetic disease , intellectual disability , NEURODEVELOPMENTAL DISORDER WITH SPASTICITY, CATARACTS, AND CEREBELLAR HYPOPLASIA , primary coenzyme Q10 deficiency 7 Med28 Breast Neoplasms , genetic disease , hereditary breast ovarian cancer syndrome , Neoplasm Metastasis Med29 genetic disease , maturity-onset diabetes of the young type 1 , type 2 diabetes mellitus Med30 genetic disease , hereditary multiple exostoses , trichorhinophalangeal syndrome type I Med31 congenital myasthenic syndrome 2A , developmental and epileptic encephalopathy 25 , genetic disease , Leber congenital amaurosis 4 , very long chain acyl-CoA dehydrogenase deficiency Med4 cervical cancer , chromosome 13q14 deletion syndrome , endometriosis , genetic disease , intellectual disability , mitochondrial DNA depletion syndrome 5 , retinoblastoma Med6 genetic disease Med7 genetic disease , lymphoproliferative syndrome 1 Med8 Charcot-Marie-Tooth disease dominant intermediate C , genetic disease Med9 autistic disorder , Birt-Hogg-Dube syndrome , common variable immunodeficiency 2 , genetic disease , Joubert syndrome 1 , Potocki-Lupski syndrome Polr2a common variable immunodeficiency , congenital myasthenic syndrome 2A , Developmental Disease , dyskeratosis congenita , genetic disease , Huntington's disease , Infarction , intellectual disability , Li-Fraumeni syndrome , NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA AND VARIABLE INTELLECTUAL AND BEHAVIORAL ABNORMALITIES , Neurodevelopmental Disorders , very long chain acyl-CoA dehydrogenase deficiency , Weissenbacher-Zweymuller syndrome Polr2b genetic disease , Tracheoesophageal Fistula Polr2c Bardet-Biedl syndrome , Deafness , developmental and epileptic encephalopathy , early infantile epileptic encephalopathy , genetic disease , hereditary breast ovarian cancer syndrome , infertility , primary ovarian insufficiency 16 Polr2d autosomal dominant thrombophilia due to protein C deficiency , genetic disease Polr2e cerebral creatine deficiency syndrome , cyclic hematopoiesis , Dwarfism , genetic disease , Peutz-Jeghers syndrome Polr2f adenylosuccinase lyase deficiency , Anosmia , Charcot-Marie-Tooth disease , Deafness , Emery-Dreifuss muscular dystrophy , genetic disease , Hearing Loss , Hirschsprung Disease 1 , Hirschsprung's disease , intellectual disability , Kallmann syndrome , myoclonic dystonia 26 , neurodegeneration with brain iron accumulation 2A , Olfaction Disorders , PCWH syndrome , Van der Hoeve Halbertsma Waardenburg Gualdi Syndrome , Waardenburg syndrome , Waardenburg syndrome type 1 , Waardenburg syndrome type 2A , Waardenburg syndrome type 2E , Waardenburg syndrome type 4A , Waardenburg syndrome type 4C Polr2g Chemical and Drug Induced Liver Injury , intellectual disability , leukocyte adhesion deficiency 3 Polr2h 3-Methylcrotonyl-CoA carboxylase 1 deficiency , congenital disorder of glycosylation Id , Currarino syndrome , genetic disease Polr2i Brugada syndrome 5 , genetic disease , hereditary spastic paraplegia 75 Polr2j genetic disease , pleomorphic xanthoastrocytoma Polr2k Cohen syndrome , genetic disease , Kartagener syndrome , primary ciliary dyskinesia 28 Polr2l delta beta-thalassemia , developmental and epileptic encephalopathy , early infantile epileptic encephalopathy , genetic disease , immunodeficiency 39 , neuronal ceroid lipofuscinosis , Segawa Syndrome, Autosomal Recessive Rpap2 genetic disease Ssu72 chromosome 1p36 deletion syndrome , congenital myasthenic syndrome 8 , dilated cardiomyopathy 1LL , Ehlers-Danlos syndrome spondylodysplastic type 2 , genetic disease , Goldberg-Shprintzen syndrome , idiopathic generalized epilepsy , immunodeficiency 16 , immunodeficiency 38 , Joubert syndrome 25 , Neurodevelopmental Disorders , Peroxisome Biogenesis Disorder, Complementation Group 7 , Shprintzen-Goldberg Craniosynostosis
3-Methylcrotonyl-CoA carboxylase 1 deficiency Polr2h adenylosuccinase lyase deficiency Polr2f adrenocortical carcinoma Med12 Agenesis of Corpus Callosum Med12 alacrima, achalasia, and impaired intellectual development syndrome Ctdsp1 Alzheimer's disease Cdk7 angiosarcoma Med12 Anorectal Malformations Med12 Anosmia Polr2f Au-Kline Syndrome Med13l autism spectrum disorder Med13 , Med13l , Med15 autistic disorder Med12 , Med13 , Med14 , Med15 , Med9 Autosomal Dominant Intellectual Developmental Disorder 61 Med13 autosomal dominant thrombophilia due to protein C deficiency Polr2d autosomal recessive intellectual developmental disorder 18 Med23 autosomal recessive nonsyndromic deafness 32 Cdc14a Bardet-Biedl syndrome Polr2c Basel-Vanagaite-Smirin-Yosef syndrome Med25 Birt-Hogg-Dube syndrome Med9 Breast Neoplasms Med12 , Med28 Brugada syndrome 5 Polr2i Burn-McKeown syndrome Ctdp1 Burns Ccnc cerebral creatine deficiency syndrome Med16 , Polr2e cerebrotendinous xanthomatosis Ctdsp1 cervical cancer Med4 Charcot-Marie-Tooth disease Ctdp1 , Med25 , Polr2f Charcot-Marie-Tooth disease dominant intermediate C Med8 Charcot-Marie-Tooth disease type 2 Med25 Charcot-Marie-Tooth disease type 2B2 Med25 Chemical and Drug Induced Liver Injury Med1 , Polr2g chromosome 13q14 deletion syndrome Med4 chromosome 18q deletion syndrome Ctdp1 chromosome 1p36 deletion syndrome Ssu72 chromosome 22q11.2 deletion syndrome, distal Med15 chromosome 22q11.2 microduplication syndrome Med15 Cohen syndrome Polr2k common variable immunodeficiency Polr2a common variable immunodeficiency 2 Med9 Congenital Cataracts, Facial Dysmorphism, and Neuropathy Ctdp1 congenital disorder of glycosylation Id Polr2h congenital disorder of glycosylation Iu Cdk9 congenital myasthenic syndrome 2A Med31 , Polr2a congenital myasthenic syndrome 8 Ssu72 congestive heart failure Cdk9 , Med1 Currarino syndrome Polr2h cyclic hematopoiesis Med16 , Polr2e Deafness Cdc14a , Polr2c , Polr2f delta beta-thalassemia Polr2l developmental and epileptic encephalopathy Cdk9 , Polr2c , Polr2l developmental and epileptic encephalopathy 12 Med25 developmental and epileptic encephalopathy 14 Med22 developmental and epileptic encephalopathy 25 Med31 developmental and epileptic encephalopathy 31A Cdk9 developmental and epileptic encephalopathy 87 Cdk19 Developmental Disabilities Med12 , Med13l Developmental Disease Med12l , Med13 , Polr2a dextro-looped transposition of the great arteries Med13l DiGeorge syndrome Med15 dilated cardiomyopathy Cdk8 , Med1 dilated cardiomyopathy 1LL Ssu72 dilated cardiomyopathy 1Y Med12 Dwarfism Med24 , Polr2e dyskeratosis congenita Polr2a early infantile epileptic encephalopathy Cdk9 , Polr2c , Polr2l Ebstein anomaly Cdk8 Ehlers-Danlos syndrome classic type 1 Med12 , Med22 , Med27 Ehlers-Danlos syndrome spondylodysplastic type 2 Ssu72 Emery-Dreifuss muscular dystrophy Polr2f endometriosis Med1 , Med14 , Med16 , Med17 , Med4 epilepsy Med13 , Med15 Experimental Diabetes Mellitus Cdk9 Failure to Thrive Med25 FG syndrome Med12 FG Syndrome 1 Med12 Fibroadenoma Med12 Fraser syndrome 3 Med23 gastric adenocarcinoma Cdk12 , Med12 genetic disease Ccnc , Cdc14a , Cdc14b , Cdk12 , Cdk19 , Cdk7 , Cdk8 , Cdk9 , Ctdp1 , Ctdsp1 , Med1 , Med10 , Med11 , Med12 , Med12l , Med13 , Med13l , Med14 , Med15 , Med16 , Med17 , Med18 , Med19 , Med20 , Med22 , Med23 , Med24 , Med25 , Med26 , Med27 , Med28 , Med29 , Med30 , Med31 , Med4 , Med6 , Med7 , Med8 , Med9 , Polr2a , Polr2b , Polr2c , Polr2d , Polr2e , Polr2f , Polr2h , Polr2i , Polr2j , Polr2k , Polr2l , Rpap2 , Ssu72 glioblastoma Med12 glycogen storage disease XV Med12l Goldberg-Shprintzen syndrome Ssu72 Hardikar Syndrome Med12 Hearing Loss Polr2f hemorrhagic disease Med12l , Med15 hepatocellular carcinoma Cdk12 , Med1 hereditary breast ovarian cancer syndrome Cdk12 , Med28 , Polr2c hereditary multiple exostoses Med30 hereditary spastic paraplegia 75 Polr2i Hirschsprung Disease 1 Polr2f Hirschsprung's disease Med15 , Polr2f Huntington's disease Polr2a hyperargininemia Med23 hypertrophic cardiomyopathy 25 Med24 idiopathic generalized epilepsy Ssu72 immunodeficiency 16 Ssu72 immunodeficiency 38 Ssu72 immunodeficiency 39 Polr2l imperforate anus Med12 infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly Med17 infantile Refsum disease Med20 Infarction Polr2a infertility Polr2c INTELLECTUAL DEVELOPMENTAL DISORDER WITH HYPOTONIA AND BEHAVIORAL ABNORMALITIES Cdk8 intellectual disability Cdc14b , Med1 , Med12 , Med12l , Med13 , Med13l , Med14 , Med15 , Med17 , Med19 , Med23 , Med27 , Med4 , Polr2a , Polr2f , Polr2g intestinal volvulus Ctdp1 isolated growth hormone deficiency type II Med13 Joubert syndrome 1 Med9 Joubert syndrome 25 Ssu72 Kallmann syndrome Polr2f Kartagener syndrome Polr2k Leber congenital amaurosis 4 Med31 Leigh disease Med22 leiomyosarcoma Med12 leukocyte adhesion deficiency 3 Polr2g Li-Fraumeni syndrome Polr2a lung adenocarcinoma Cdk12 lung squamous cell carcinoma Med12 lymphoproliferative syndrome 1 Med7 major depressive disorder Med12 male infertility Cdc14a maple syrup urine disease Cdc14a Marfanoid Mental Retardation Syndrome, Autosomal Med13l maturity-onset diabetes of the young type 1 Med29 medulloblastoma Cdk9 megacolon Med13 , Med15 Mental Retardation and Distinctive Facial Features with or without Cardiac Defects Med13l microcephaly Cdk19 , Med17 mitochondrial DNA depletion syndrome 5 Med4 myoclonic dystonia 26 Polr2f myofibrillar myopathy 1 Ctdsp1 Neoplasm Metastasis Med28 nephroblastoma Med12 neurodegeneration with brain iron accumulation 2A Polr2f NEURODEGENERATION WITH DEVELOPMENTAL DELAY, EARLY RESPIRATORY FAILURE, MYOCLONIC SEIZURES, AND BRAIN ABNORMALITIES Med11 NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA AND VARIABLE INTELLECTUAL AND BEHAVIORAL ABNORMALITIES Polr2a NEURODEVELOPMENTAL DISORDER WITH SPASTICITY, CATARACTS, AND CEREBELLAR HYPOPLASIA Med27 Neurodevelopmental Disorders Cdk19 , Cdk7 , Ctdp1 , Ctdsp1 , Med12l , Med13 , Med13l , Med14 , Med15 , Med23 , Med25 , Polr2a , Ssu72 neuronal ceroid lipofuscinosis Polr2l Nizon-Isidor Syndrome Med12l Oculootofacial Dysplasia Ctdp1 Ohdo syndrome Med12 Ohdo Syndrome, X-Linked Med12 Olfaction Disorders Polr2f oligospermia Cdc14a ornithine carbamoyltransferase deficiency Med14 pancreatic adenocarcinoma Med12 paroxysmal nonkinesigenic dyskinesia 1 Ctdsp1 PCWH syndrome Polr2f Peroxisome Biogenesis Disorder, Complementation Group 7 Ssu72 Peutz-Jeghers syndrome Med16 , Polr2e phobic disorder Med12 Phyllodes Tumor Med12 platelet-type bleeding disorder 8 Med12l pleomorphic xanthoastrocytoma Polr2j polyneuropathy Med25 Potocki-Lupski syndrome Med9 Premature Aging Cdc14b primary ciliary dyskinesia 28 Polr2k primary coenzyme Q10 deficiency 7 Cdk9 , Med22 , Med27 primary immunodeficiency disease Med15 primary ovarian insufficiency 16 Polr2c prostate adenocarcinoma Med12 prostate cancer Med1 Prostatic Neoplasms Cdk12 , Med12 pulmonary valve stenosis Ctdp1 Rafiq syndrome Med22 renal cell carcinoma Cdc14b retinoblastoma Med4 Right Ventricular Hypertrophy Med13 schizophrenia Med15 Segawa Syndrome, Autosomal Recessive Polr2l sensorineural hearing loss Cdc14a Shprintzen-Goldberg Craniosynostosis Ssu72 Simpson-Golabi-Behmel syndrome type 1 Med12 Spinal Cord Injuries Cdk19 stomach cancer Cdk12 strabismus Med13l syndromic X-linked intellectual disability Hedera type Med14 syndromic X-linked intellectual disability Lubs type Med12 , Med14 syndromic X-linked intellectual disability Najm type Med14 syndromic X-linked intellectual disorder Lujan-Fryns-type Med12 thoracic aortic aneurysm Med12 Tracheoesophageal Fistula Polr2b trichorhinophalangeal syndrome type I Med30 tuberous sclerosis 1 Med22 type 2 diabetes mellitus Med29 uterine fibroid Med12 Van der Hoeve Halbertsma Waardenburg Gualdi Syndrome Polr2f velocardiofacial syndrome Med15 Venous Thrombosis Med15 very long chain acyl-CoA dehydrogenase deficiency Med31 , Polr2a vesicoureteral reflux Med13l Volvulus Of Midgut Ctdp1 Waardenburg syndrome Polr2f Waardenburg syndrome type 1 Polr2f Waardenburg syndrome type 2A Polr2f Waardenburg syndrome type 2E Polr2f Waardenburg syndrome type 4A Polr2f Waardenburg syndrome type 4C Polr2f Weissenbacher-Zweymuller syndrome Polr2a X-Linked Intellectual Developmental Disorders Med12 X-linked severe combined immunodeficiency Med12 Zellweger syndrome Med20