RNA POLYMERASE II TRANSCRIPTION PATHWAY (PW:0000127)

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Description

The three eukaryotic RNA polymerases (RNAPs)- Pol I, II and III, transcribe different sets of genes and require distinct sets of factors to assemble a specific initiation complex which recruits them on gene promoters. The multi-subunit enzymes are composed of 14 (RNAPI), 12 (RNAPII) and 17 (RNAPIII) subunits of which some are shared and others are unique, yet converging on an overall similar structural topology. Complexes specific to each of the three systems share the universal transcription f

Pathway Diagram:

Elsevier Inc. RNA polymerase II_term TFIIS TFIIF_elong CF Im CPSF complex Rngtt CBC complex P-TEFb complex DSIF NELF complex TFIIF Xrn2 Paf1 complex Mediator complex SEC complex TFIIE pol II CTD players ---> RNA polymerase II transcription termination pathway 3'-end pre-mRNA processing pathway <--> RNA polymerase II transcription termination pathway pol II CTD players ---> 5'-end pre-mRNA capping pathway pol II CTD players ---> RNA polymerase II transcription elongation pathway pol II CTD players ---> RNA polymerase II transcription initiation pathway RNA polymerase II transcription elongation pathway <--> spliceosome pathway RNA polymerase II_init ---- TFIIE Mediator complex ---> RNA polymerase II_term Mediator complex ---> 3'-end pre-mRNA processing pathway Mediator complex ---> spliceosome pathway Mediator complex ---> chromatin modification/remodeling pathway RNA polymerase II_elong ---- TFIIF_elong TFIIS ---> RNA polymerase II_elong Mediator complex ---> RNA polymerase II_elong P-TEFb complex ---- SEC complex Mediator complex ---- SEC complex DSIF ---- NELF complex P-TEFb complex ---> NELF complex FACT complex ---- Paf1 complex NELF complex ---- RNA polymerase II_elong CPSF complex ---- CstF complex CstF complex ---- RNA polymerase II_term SAGA complex ---> RNA polymerase II_init Gtf2b ---- RNA polymerase II_init Mediator complex ---> RNA polymerase II_init TFIIE ---- TFIIH complex TFIIH complex ---> RNA polymerase II_init RNA polymerase II_init ---- TFIIF P-TEFb complex ---> DSIF P-TEFb complex ---> RNA polymerase II_elong CF IIm ---- CstF complex Xrn2 ---> RNA polymerase II_term CF IIm ---- RNA polymerase II_term CstF complex SAGA complex TFIIH complex RNA polymerase II_elong CF IIm chromatin modification/remodeling pathway RNA polymerase II transcription elongation pathway RNA polymerase II transcription termination pathway RNA polymerase II transcription initiation pathway pol II CTD players FACT complex Paf1 complex ---- SEC complex DSIF ---- Rngtt spliceosome pathway RNA polymerase II_init Gtf2b TFIID complex Gtf2b ---- TFIID complex TFIIA ---- TFIID complex TFIIA Dxo pol II CTD players ---> 3'-end pre-mRNA processing pathway 5'-end pre-mRNA capping pathway 3'-end pre-mRNA processing pathway
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Genes in Pathway:

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RNA polymerase II transcription pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccnc cyclin C JBrowse link 5 35,865,598 35,883,732 RGD:9681732
G Cdc14a cell division cycle 14A JBrowse link 2 219,302,577 219,458,345 RGD:9681737
RGD:9681738
G Cdc14b cell division cycle 14B JBrowse link 17 1,709,703 1,797,732 RGD:9681737
RGD:9681738
G Cdk12 cyclin-dependent kinase 12 JBrowse link 10 86,157,186 86,210,657 RGD:9681737
RGD:9681738
G Cdk19 cyclin-dependent kinase 19 JBrowse link 20 45,458,499 45,598,799 RGD:9681732
G Cdk7 cyclin-dependent kinase 7 JBrowse link 2 30,710,642 30,735,522 RGD:9681737
RGD:9681738
G Cdk8 cyclin-dependent kinase 8 JBrowse link 12 10,496,273 10,561,335 RGD:9681732
RGD:9681737
RGD:9681738
G Cdk9 cyclin-dependent kinase 9 JBrowse link 3 11,742,269 11,747,117 RGD:9681737
RGD:9681738
G Ctdp1 CTD phosphatase subunit 1 JBrowse link 18 76,922,913 76,985,095 RGD:9681737
RGD:9681738
G Ctdsp1 CTD small phosphatase 1 JBrowse link 9 81,672,613 81,677,979 RGD:9681737
RGD:9681738
G Med1 mediator complex subunit 1 JBrowse link 10 86,101,560 86,145,271 RGD:9681732
G Med10 mediator complex subunit 10 JBrowse link 1 36,107,249 36,118,887 RGD:9681732
G Med11 mediator complex subunit 11 JBrowse link 10 57,057,272 57,059,415 RGD:9681732
G Med12 mediator complex subunit 12 JBrowse link X 71,174,653 71,197,812 RGD:9681732
G Med12l mediator complex subunit 12-like JBrowse link 2 149,213,134 149,316,569 RGD:9681732
G Med13 mediator complex subunit 13 JBrowse link 10 73,702,327 73,787,084 RGD:9681732
G Med13l mediator complex subunit 13-like JBrowse link 12 43,421,317 43,576,859 RGD:9681732
G Med14 mediator complex subunit 14 JBrowse link X 10,964,035 11,082,403 RGD:9681732
G Med15 mediator complex subunit 15 JBrowse link 11 87,553,868 87,628,631 RGD:9681732
G Med16 mediator complex subunit 16 JBrowse link 7 12,619,739 12,632,241 RGD:9681732
G Med17 mediator complex subunit 17 JBrowse link 8 13,522,257 13,835,302 RGD:9681732
G Med18 mediator complex subunit 18 JBrowse link 5 150,649,136 150,654,123 RGD:9681732
G Med19 mediator complex subunit 19 JBrowse link 3 72,080,630 72,091,150 RGD:9681732
G Med20 mediator complex subunit 20 JBrowse link 9 15,379,379 15,393,131 RGD:9681732
G Med21 mediator complex subunit 21 JBrowse link 4 180,961,194 180,968,155 RGD:9681732
G Med23 mediator complex subunit 23 JBrowse link 1 21,539,765 21,587,675 RGD:9681732
G Med24 mediator complex subunit 24 JBrowse link 10 86,620,166 86,658,014 RGD:9681732
G Med25 mediator complex subunit 25 JBrowse link 1 100,872,240 100,887,864 RGD:9681732
G Med26 mediator complex subunit 26 JBrowse link 16 19,001,061 19,050,874 RGD:9681732
G Med27 mediator complex subunit 27 JBrowse link 3 7,884,793 8,059,003 RGD:9681732
G Med28 mediator complex subunit 28 JBrowse link 14 70,089,225 70,098,021 RGD:9681732
G Med29 mediator complex subunit 29 JBrowse link 1 85,368,288 85,373,691 RGD:9681732
G Med30 mediator complex subunit 30 JBrowse link 7 92,234,584 92,260,019 RGD:9681732
G Med31 mediator complex subunit 31 JBrowse link 10 58,780,987 58,784,369 RGD:9681732
G Med4 mediator complex subunit 4 JBrowse link 15 55,406,543 55,416,816 RGD:9681732
G Med6 mediator complex subunit 6 JBrowse link 6 105,302,558 105,316,024 RGD:9681732
G Med7 mediator complex subunit 7 JBrowse link 10 31,532,190 31,536,405 RGD:9681732
G Med9 mediator complex subunit 9 JBrowse link 10 46,314,639 46,329,374 RGD:9681732
G Polr2a RNA polymerase II subunit A JBrowse link 10 56,339,277 56,364,888 RGD:9588243
G Polr2b RNA polymerase II subunit B JBrowse link 14 33,070,104 33,107,792 RGD:9588243
G Polr2c RNA polymerase II subunit C JBrowse link 19 10,575,060 10,581,842 RGD:9588243
G Polr2d RNA polymerase II subunit D JBrowse link 18 24,570,762 24,577,894 RGD:9588243
G Polr2e RNA polymerase II subunit E JBrowse link 7 12,532,785 12,536,797 RGD:9588243
G Polr2f RNA polymerase II subunit F JBrowse link 7 120,380,543 120,392,214 RGD:9588243
G Polr2g RNA polymerase II subunit G JBrowse link 1 224,991,250 224,998,355 RGD:9588243
G Polr2j RNA polymerase II subunit J JBrowse link 12 23,587,222 23,592,774 RGD:9588243
G Polr2k RNA polymerase II subunit K JBrowse link 7 74,939,010 74,992,594 RGD:9588243
G Rpap2 RNA polymerase II associated protein 2 JBrowse link 14 3,125,595 3,204,590 RGD:9681737
RGD:9681738
G Ssu72 SSU72 homolog, RNA polymerase II CTD phosphatase JBrowse link 5 173,152,964 173,182,720 RGD:9681737
RGD:9681738
3'-end pre-mRNA processing pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clp1 cleavage and polyadenylation factor I subunit 1 JBrowse link 3 72,125,269 72,137,122 RGD:9681741
RGD:9681742
G Cpsf1 cleavage and polyadenylation specific factor 1 JBrowse link 7 117,661,779 117,672,373 RGD:9681741
RGD:9681742
G Cpsf2 cleavage and polyadenylation specific factor 2 JBrowse link 6 125,870,372 125,898,039 RGD:9681741
RGD:9681742
G Cpsf3 cleavage and polyadenylation specific factor 3 JBrowse link 6 43,363,792 43,391,712 RGD:9681741
RGD:9681742
G Cpsf6 cleavage and polyadenylation specific factor 6 JBrowse link 7 60,385,688 60,417,661 RGD:9681741
RGD:9681742
G Cpsf7 cleavage and polyadenylation specific factor 7 JBrowse link 1 226,572,399 226,596,185 RGD:9681741
RGD:9681742
G Cstf1 cleavage stimulation factor subunit 1 JBrowse link 3 170,380,413 170,392,162 RGD:9681741
RGD:9681742
G Cstf2 cleavage stimulation factor subunit 2 JBrowse link X 104,882,726 104,909,746 RGD:9681741
RGD:9681742
G Cstf2t cleavage stimulation factor subunit 2, tau variant JBrowse link 1 249,574,954 249,578,520 RGD:9681741
RGD:9681742
G Cstf3 cleavage stimulation factor subunit 3 JBrowse link 3 94,530,586 94,603,378 RGD:9681741
RGD:9681742
G Dxo decapping exoribonuclease JBrowse link 20 4,517,307 4,519,391 RGD:9681741
G Fip1l1 factor interacting with PAPOLA and CPSF1 JBrowse link 14 36,150,381 36,208,395 RGD:9681741
RGD:9681742
G Nudt21 nudix hydrolase 21 JBrowse link 19 11,451,366 11,470,637 RGD:9681741
RGD:9681742
G Pabpn1 poly(A) binding protein, nuclear 1 JBrowse link 15 33,555,640 33,560,251 RGD:9681742
G Papola poly (A) polymerase alpha JBrowse link 6 129,609,068 129,662,002 RGD:9681742
G Papolb poly(A) polymerase beta JBrowse link 12 14,112,426 14,114,772 RGD:9681742
G Papolg poly(A) polymerase gamma JBrowse link 14 108,624,359 108,658,371 RGD:9681742
G Pcf11 PCF11 cleavage and polyadenylation factor subunit JBrowse link 1 157,463,014 157,494,134 RGD:9681741
RGD:9681742
G Sympk symplekin JBrowse link 1 79,931,097 79,959,461 RGD:9681741
RGD:9681742
G Wdr33 WD repeat domain 33 JBrowse link 18 24,584,832 24,689,681 RGD:9681741
RGD:9681742
G Xrn2 5'-3' exoribonuclease 2 JBrowse link 3 141,224,858 141,298,272 RGD:9681741
5'-end pre-mRNA capping pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fam103a1 family with sequence similarity 103, member A1 JBrowse link 1 143,583,675 143,589,563 RGD:9684851
G Ncbp1 nuclear cap binding protein subunit 1 JBrowse link 5 61,734,118 61,767,098 RGD:9684851
G Ncbp2 nuclear cap binding protein subunit 2 JBrowse link 11 72,071,838 72,103,087 RGD:9684851
G Rngtt RNA guanylyltransferase and 5'-phosphatase JBrowse link 5 48,561,325 48,779,214 RGD:9684851
G Rnmt RNA (guanine-7-) methyltransferase JBrowse link 18 64,084,746 64,108,246 RGD:9684851
RNA polymerase II transcription elongation pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aff1 AF4/FMR2 family, member 1 JBrowse link 14 7,222,883 7,384,916 RGD:9681740
G Aff4 AF4/FMR2 family, member 4 JBrowse link 10 38,692,167 38,773,021 RGD:9681740
G Ccnk cyclin K JBrowse link 6 132,090,235 132,113,560 RGD:9681735
G Ccnt1 cyclin T1 JBrowse link 7 140,215,052 140,245,958 RGD:9681735
G Ccnt2 cyclin T2 JBrowse link 13 44,475,959 44,516,892 RGD:9681735
G Cdc73 cell division cycle 73 JBrowse link 13 60,403,771 60,496,511 RGD:9588246
G Cdk9 cyclin-dependent kinase 9 JBrowse link 3 11,742,269 11,747,117 RGD:9681735
G Ctr9 CTR9 homolog, Paf1/RNA polymerase II complex component JBrowse link 1 175,839,140 175,869,167 RGD:9588246
G Eaf1 ELL associated factor 1 JBrowse link 16 7,588,217 7,602,966 RGD:9681740
G Eaf2 ELL associated factor 2 JBrowse link 11 66,878,658 66,923,092 RGD:9681740
G Ell elongation factor for RNA polymerase II JBrowse link 16 20,594,129 20,641,441 RGD:9681740
G Ell2 elongation factor for RNA polymerase II 2 JBrowse link 2 2,456,189 2,525,590 RGD:9681740
G Ell3 elongation factor for RNA polymerase II 3 JBrowse link 3 113,400,395 113,405,869 RGD:9681740
G Gtf2f1 general transcription factor IIF subunit 1 JBrowse link 9 10,032,806 10,042,392 RGD:9681735
G Gtf2f2 general transcription factor IIF subunit 2 JBrowse link 15 57,942,057 58,068,892 RGD:9681735
G Leo1 LEO1 homolog, Paf1/RNA polymerase II complex component JBrowse link 8 82,380,906 82,405,293 RGD:9588246
G Mllt1 MLLT1, super elongation complex subunit JBrowse link 9 10,110,389 10,155,305 RGD:9681740
G Mllt3 MLLT3, super elongation complex subunit JBrowse link 5 106,103,498 106,202,559 RGD:9681740
G Ncbp1 nuclear cap binding protein subunit 1 JBrowse link 5 61,734,118 61,767,098 RGD:9684851
G Ncbp2 nuclear cap binding protein subunit 2 JBrowse link 11 72,071,838 72,103,087 RGD:9684851
G Nelfa negative elongation factor complex member A JBrowse link 14 82,093,837 82,117,913 RGD:9681735
G Nelfb negative elongation factor complex member B JBrowse link 3 2,414,448 2,431,148 RGD:9681735
G Nelfcd negative elongation factor complex member C/D JBrowse link 3 172,510,840 172,527,118 RGD:9681735
G Nelfe negative elongation factor complex member E JBrowse link 20 4,530,328 4,536,085 RGD:9681735
G Paf1 PAF1 homolog, Paf1/RNA polymerase II complex component JBrowse link 1 85,362,421 85,367,999 RGD:9588246
G Rngtt RNA guanylyltransferase and 5'-phosphatase JBrowse link 5 48,561,325 48,779,214 RGD:9684851
G Rtf1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) JBrowse link 3 111,478,350 111,537,941 RGD:9588246
G Ssrp1 structure specific recognition protein 1 JBrowse link 3 72,447,516 72,457,621 RGD:9681735
G Supt16h SPT16 homolog, facilitates chromatin remodeling subunit JBrowse link 15 28,574,841 28,611,959 RGD:9681735
G Supt4h1 SPT4 homolog, DSIF elongation factor subunit JBrowse link 10 75,032,365 75,038,547 RGD:9681735
G Supt5h SPT5 homolog, DSIF elongation factor subunit JBrowse link 1 85,437,780 85,466,854 RGD:9681735
G Tcea1 transcription elongation factor A1 JBrowse link 5 14,511,183 14,548,494 RGD:9681735
G Tcea2 transcription elongation factor A2 JBrowse link 3 177,187,686 177,195,898 RGD:9681735
G Tcea3 transcription elongation factor A3 JBrowse link 5 154,598,765 154,634,687 RGD:9681735
G Wdr61 WD repeat domain 61 JBrowse link 8 59,296,339 59,313,663 RGD:9588246
RNA polymerase II transcription initiation pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atxn7 ataxin 7 JBrowse link 15 12,421,432 12,569,649 RGD:9681728
G Atxn7l3 ataxin 7-like 3 JBrowse link 10 90,234,749 90,241,757 RGD:9681728
G Ccnh cyclin H JBrowse link 2 13,593,100 13,613,910 RGD:9681726
G Cdk7 cyclin-dependent kinase 7 JBrowse link 2 30,710,642 30,735,522 RGD:9681726
G Dr1 down-regulator of transcription 1 JBrowse link 14 2,463,651 2,475,004 RGD:9681728
G Eny2 ENY2, transcription and export complex 2 subunit JBrowse link 7 83,348,656 83,358,430 RGD:9681728
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit JBrowse link 1 80,293,574 80,307,334 RGD:9681726
G Ercc3 ERCC excision repair 3, TFIIH core complex helicase subunit JBrowse link 18 25,037,668 25,068,380 RGD:9681726
G Ercc5 ERCC excision repair 5, endonuclease JBrowse link 9 50,928,847 50,970,962 RGD:9681726
G Gtf2a1 general transcription factor 2A subunit 1 JBrowse link 6 115,321,110 115,352,659 RGD:9681721
G Gtf2a2 general transcription factor 2A subunit 2 JBrowse link 8 76,422,341 76,435,587 RGD:9681721
G Gtf2b general transcription factor IIB JBrowse link 2 248,709,433 248,727,741 RGD:9681721
G Gtf2e1 general transcription factor IIE subunit 1 JBrowse link 11 66,078,786 66,111,394 RGD:9681721
G Gtf2e2 general transcription factor IIE subunit 2 JBrowse link 16 62,113,846 62,164,339 RGD:9681721
G Gtf2f1 general transcription factor IIF subunit 1 JBrowse link 9 10,032,806 10,042,392 RGD:9681721
G Gtf2f2 general transcription factor IIF subunit 2 JBrowse link 15 57,942,057 58,068,892 RGD:9681721
G Gtf2h1 general transcription factor IIH subunit 1 JBrowse link 1 102,849,618 102,877,939 RGD:9681726
G Gtf2h2 general transcription factor IIH subunit 2 JBrowse link 2 30,494,718 30,522,716 RGD:9681726
G Gtf2h3 general transcription factor IIH subunit 3 JBrowse link 12 37,427,556 37,444,027 RGD:9681726
G Gtf2h4 general transcription factor 2H subunit 4 JBrowse link 20 3,582,688 3,588,373 RGD:9681726
G Gtf2h5 general transcription factor IIH subunit 5 JBrowse link 1 46,978,345 46,985,032 RGD:9681726
G Hcfc2 host cell factor C2 JBrowse link 7 27,107,931 27,136,658 RGD:9681728
G Kat14 lysine acetyltransferase 14 JBrowse link 3 138,508,899 138,549,437 RGD:9681728
G Kat2a lysine acetyltransferase 2A JBrowse link 10 88,611,586 88,619,558 RGD:9681728
G Kat2b lysine acetyltransferase 2B JBrowse link 9 4,440,982 4,492,949 RGD:9681728
G Mbip MAP3K12 binding inhibitory protein 1 JBrowse link 6 77,226,439 77,243,696 RGD:9681728
G Mnat1 MNAT1, CDK activating kinase assembly factor JBrowse link 6 95,995,341 96,153,331 RGD:9681726
G Pole3 DNA polymerase epsilon 3, accessory subunit JBrowse link 5 78,380,813 78,384,047 RGD:9681728
G Sgf29 SAGA complex associated factor 29 JBrowse link 1 198,066,974 198,100,494 RGD:9681728
G Supt20h SPT20 homolog, SAGA complex component JBrowse link 2 143,892,609 143,925,733 RGD:9681728
G Supt3h SPT3 homolog, SAGA and STAGA complex component JBrowse link 9 18,249,565 18,604,814 RGD:9681728
G Supt7l SPT7-like STAGA complex gamma subunit JBrowse link 6 26,241,672 26,251,810 RGD:9681728
G Tada1 transcriptional adaptor 1 JBrowse link 13 84,588,587 84,602,542 RGD:9681728
G Tada2a transcriptional adaptor 2A JBrowse link 10 71,393,701 71,441,435 RGD:9681728
G Tada2b transcriptional adaptor 2B JBrowse link 14 79,446,057 79,457,341 RGD:9681728
G Tada3 transcriptional adaptor 3 JBrowse link 4 145,318,417 145,330,291 RGD:9681728
G Taf1 TATA-box binding protein associated factor 1 JBrowse link X 71,412,291 71,486,456 RGD:9681723
G Taf10 TATA-box binding protein associated factor 10 JBrowse link 1 170,585,160 170,586,428 RGD:9681723
RGD:9681728
G Taf11 TATA-box binding protein associated factor 11 JBrowse link 20 7,476,648 7,484,417 RGD:9681723
G Taf12 TATA-box binding protein associated factor 12 JBrowse link 5 150,459,701 150,476,521 RGD:9681723
RGD:9681728
G Taf13 TATA-box binding protein associated factor 13 JBrowse link 2 211,359,623 211,370,285 RGD:9681723
G Taf15 TATA-box binding protein associated factor 15 JBrowse link 10 70,689,863 70,721,892 RGD:9681723
G Taf2 TATA-box binding protein associated factor 2 JBrowse link 7 94,698,987 94,755,924 RGD:9681723
G Taf3 TATA-box binding protein associated factor 3 JBrowse link 17 72,240,785 72,393,448 RGD:9681723
G Taf4 TATA-box binding protein associated factor 4 JBrowse link 3 175,300,842 175,364,655 RGD:9681723
G Taf5 TATA-box binding protein associated factor 5 JBrowse link 1 266,844,480 266,859,965 RGD:9681723
G Taf5l TATA-box binding protein associated factor 5 like JBrowse link 19 56,781,854 56,801,005 RGD:9681728
G Taf6 TATA-box binding protein associated factor 6 JBrowse link 12 19,320,269 19,328,706 RGD:9681723
G Taf6l TATA-box binding protein associated factor 6 like JBrowse link 1 224,974,238 224,986,819 RGD:9681728
G Taf7 TATA-box binding protein associated factor 7 JBrowse link 18 30,779,149 30,781,297 RGD:9681723
G Taf8 TATA-box binding protein associated factor 8 JBrowse link 9 15,513,048 15,532,992 RGD:9681723
G Taf9 TATA-box binding protein associated factor 9 JBrowse link 2 30,664,407 30,668,414 RGD:9681723
RGD:9681728
G Tbp TATA box binding protein JBrowse link 1 57,491,381 57,509,335 RGD:9681721
RGD:9681723
G Trrap transformation/transcription domain-associated protein JBrowse link 12 11,537,950 11,627,563 RGD:9681728
G Usp22 ubiquitin specific peptidase 22 JBrowse link 10 47,429,201 47,453,298 RGD:9681728
G Wdr5 WD repeat domain 5 JBrowse link 3 6,061,892 6,080,724 RGD:9681728
G Yeats2 YEATS domain containing 2 JBrowse link 11 84,330,064 84,595,296 RGD:9681728
G Zzz3 zinc finger, ZZ-type containing 3 JBrowse link 2 257,602,924 257,671,783 RGD:9681728
RNA polymerase II transcription termination pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clp1 cleavage and polyadenylation factor I subunit 1 JBrowse link 3 72,125,269 72,137,122 RGD:9681741
RGD:9681742
G Cpsf1 cleavage and polyadenylation specific factor 1 JBrowse link 7 117,661,779 117,672,373 RGD:9681741
RGD:9681742
G Cpsf2 cleavage and polyadenylation specific factor 2 JBrowse link 6 125,870,372 125,898,039 RGD:9681741
RGD:9681742
G Cpsf3 cleavage and polyadenylation specific factor 3 JBrowse link 6 43,363,792 43,391,712 RGD:9681741
RGD:9681742
G Cpsf6 cleavage and polyadenylation specific factor 6 JBrowse link 7 60,385,688 60,417,661 RGD:9681741
RGD:9681742
G Cpsf7 cleavage and polyadenylation specific factor 7 JBrowse link 1 226,572,399 226,596,185 RGD:9681741
RGD:9681742
G Cstf1 cleavage stimulation factor subunit 1 JBrowse link 3 170,380,413 170,392,162 RGD:9681741
RGD:9681742
G Cstf2 cleavage stimulation factor subunit 2 JBrowse link X 104,882,726 104,909,746 RGD:9681741
RGD:9681742
G Cstf2t cleavage stimulation factor subunit 2, tau variant JBrowse link 1 249,574,954 249,578,520 RGD:9681741
RGD:9681742
G Cstf3 cleavage stimulation factor subunit 3 JBrowse link 3 94,530,586 94,603,378 RGD:9681741
RGD:9681742
G Dxo decapping exoribonuclease JBrowse link 20 4,517,307 4,519,391 RGD:9681741
G Fip1l1 factor interacting with PAPOLA and CPSF1 JBrowse link 14 36,150,381 36,208,395 RGD:9681741
RGD:9681742
G Nudt21 nudix hydrolase 21 JBrowse link 19 11,451,366 11,470,637 RGD:9681741
RGD:9681742
G Pcf11 PCF11 cleavage and polyadenylation factor subunit JBrowse link 1 157,463,014 157,494,134 RGD:9681741
RGD:9681742
G Sympk symplekin JBrowse link 1 79,931,097 79,959,461 RGD:9681741
RGD:9681742
G Wdr33 WD repeat domain 33 JBrowse link 18 24,584,832 24,689,681 RGD:9681741
RGD:9681742
G Xrn2 5'-3' exoribonuclease 2 JBrowse link 3 141,224,858 141,298,272 RGD:9681741
spliceosome pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aar2 AAR2 splicing factor homolog JBrowse link 3 152,626,738 152,648,365 RGD:9686090
G Acin1 apoptotic chromatin condensation inducer 1 JBrowse link 15 33,288,369 33,333,256 RGD:6907045
G Alyref Aly/REF export factor JBrowse link 10 109,768,593 109,774,639 RGD:6907045
G Aqr aquarius intron-binding spliceosomal factor JBrowse link 3 105,570,399 105,640,431 RGD:6907045
RGD:9686094
G Bcas2 BCAS2, pre-mRNA processing factor JBrowse link 2 205,662,633 205,670,514 RGD:6907045
RGD:9686094
G Bud31 BUD31 homolog JBrowse link 12 11,232,963 11,240,449 RGD:6907045
RGD:9686094
G Ccdc12 coiled-coil domain containing 12 JBrowse link 8 118,925,682 118,977,038 RGD:6907045
RGD:9686094
G Cdc40 cell division cycle 40 JBrowse link 20 48,503,973 48,574,546 RGD:6907045
G Cdc5l cell division cycle 5-like JBrowse link 9 17,949,764 17,988,514 RGD:6907045
RGD:9686094
G Cherp calcium homeostasis endoplasmic reticulum protein JBrowse link 16 19,068,783 19,081,837 RGD:6907045
G Crnkl1 crooked neck pre-mRNA splicing factor 1 JBrowse link 6 18,349,226 18,351,540 RGD:6907045
RGD:9686094
G Ctnnbl1 catenin, beta like 1 JBrowse link 3 154,212,245 154,373,170 RGD:6907045
RGD:9686094
G Cwc15 CWC15 spliceosome-associated protein JBrowse link 8 12,994,131 13,004,958 RGD:6907045
RGD:9686094
G Ddx23 DEAD-box helicase 23 JBrowse link 7 140,325,453 140,342,730 RGD:6907045
RGD:9686089
RGD:9686093
G Ddx39b DExD-box helicase 39B JBrowse link 20 4,806,103 4,818,600 RGD:9686093
G Ddx42 DEAD-box helicase 42 JBrowse link 10 94,407,094 94,439,052 RGD:6907045
RGD:9686091
G Ddx46 DEAD-box helicase 46 JBrowse link 17 9,475,275 9,519,545 RGD:6907045
RGD:9686093
G Ddx5 DEAD-box helicase 5 JBrowse link 10 94,979,759 94,988,461 RGD:6907045
G Dhx15 DEAH-box helicase 15 JBrowse link 14 61,136,740 61,174,880 RGD:6907045
G Dhx16 DEAH-box helicase 16 JBrowse link 20 3,368,971 3,386,087 RGD:6907045
RGD:9686093
G Dhx38 DEAH-box helicase 38 JBrowse link 19 42,110,291 42,127,540 RGD:6907045
RGD:9686093
G Dhx8 DEAH-box helicase 8 JBrowse link 10 89,645,979 89,683,839 RGD:6907045
RGD:9686093
G Eftud2 elongation factor Tu GTP binding domain containing 2 JBrowse link 10 90,932,071 90,983,971 RGD:6907045
RGD:9686090
RGD:9686093
G Eif4a3 eukaryotic translation initiation factor 4A3 JBrowse link 10 108,415,201 108,425,195 RGD:6907045
RGD:9686404
G Hnrnpa0 heterogeneous nuclear ribonucleoprotein A0 RGD:9686091
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 JBrowse link 7 144,865,302 144,871,592 RGD:6907045
RGD:9686089
RGD:9686091
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 JBrowse link 4 81,237,496 81,241,281 RGD:9686091
G Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 JBrowse link 3 62,481,222 62,491,356 RGD:6907045
G Hnrnpab heterogeneous nuclear ribonucleoprotein A/B JBrowse link 10 34,955,713 34,961,662 RGD:9686091
G Hnrnpc heterogeneous nuclear ribonucleoprotein C JBrowse link 15 28,486,605 28,517,353 RGD:6907045
RGD:9686089
RGD:9686091
G Hnrnpd heterogeneous nuclear ribonucleoprotein D JBrowse link 14 11,256,163 11,274,684 RGD:9686091
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 JBrowse link 10 35,872,619 35,879,911 RGD:9686091
G Hnrnpk heterogeneous nuclear ribonucleoprotein K JBrowse link 17 6,664,730 6,676,753 RGD:6907045
RGD:9686089
RGD:9686091
G Hnrnpl heterogeneous nuclear ribonucleoprotein L JBrowse link 1 86,994,090 87,006,776 RGD:9686091
G Hnrnpm heterogeneous nuclear ribonucleoprotein M JBrowse link 7 18,516,253 18,554,536 RGD:9686089
RGD:9686091
G Hnrnpr heterogeneous nuclear ribonucleoprotein R JBrowse link 5 154,668,194 154,699,967 RGD:9686091
G Hnrnpu heterogeneous nuclear ribonucleoprotein U JBrowse link 13 96,222,093 96,238,845 RGD:6907045
RGD:9686089
RGD:9686091
G Hspa1a heat shock protein family A (Hsp70) member 1A JBrowse link 20 4,875,834 4,881,751 RGD:6907045
G Hspa1b heat shock protein family A (Hsp70) member 1B JBrowse link 20 4,877,638 4,880,112 RGD:6907045
G Hspa1l heat shock protein family A (Hsp70) member 1 like JBrowse link 20 4,879,998 4,965,191 RGD:6907045
G Hspa2 heat shock protein family A member 2 JBrowse link 6 99,433,575 99,436,288 RGD:6907045
G Hspa8 heat shock protein family A (Hsp70) member 8 JBrowse link 8 44,989,401 44,993,261 RGD:6907045
RGD:9686094
G Isy1 ISY1 splicing factor homolog JBrowse link 4 119,721,659 119,742,349 RGD:9686094
G Lsm2 LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated JBrowse link 20 4,966,817 4,970,567 RGD:6907045
RGD:9686089
RGD:9686091
G Lsm3 LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated JBrowse link 4 123,162,086 123,168,330 RGD:6907045
RGD:9686089
RGD:9686091
G Lsm4 LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated JBrowse link 16 20,506,399 20,511,818 RGD:6907045
RGD:9686089
RGD:9686091
G Lsm5 LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated JBrowse link 4 87,016,003 87,019,219 RGD:6907045
G Lsm6 LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated JBrowse link 19 32,770,640 32,785,215 RGD:6907045
RGD:9686089
RGD:9686091
G Lsm7 LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated JBrowse link 7 11,724,932 11,732,020 RGD:6907045
RGD:9686089
RGD:9686091
G Lsm8 LSM8 homolog, U6 small nuclear RNA associated JBrowse link 4 45,555,077 45,560,943 RGD:9686089
RGD:9686091
G Magoh mago homolog, exon junction complex core component JBrowse link 5 127,480,465 127,487,617 RGD:6907045
G Magohb mago homolog B, exon junction complex core component JBrowse link 4 165,514,584 165,522,366 RGD:6907045
RGD:9686404
G Mbnl1 muscleblind-like splicing regulator 1 JBrowse link 2 150,698,248 150,867,791 RGD:9686382
G Ncbp1 nuclear cap binding protein subunit 1 JBrowse link 5 61,734,118 61,767,098 RGD:6907045
G Pcbp1 poly(rC) binding protein 1 JBrowse link 4 118,327,185 118,329,223 RGD:6907045
G Phf5a PHD finger protein 5A JBrowse link 7 123,095,286 123,101,851 RGD:6907045
G Pigz phosphatidylinositol glycan anchor biosynthesis, class Z JBrowse link 11 72,930,040 72,936,002 RGD:6907045
G Plrg1 pleiotropic regulator 1 JBrowse link 2 182,040,338 182,056,669 RGD:6907045
RGD:9686094
G Pnn pinin, desmosome associated protein JBrowse link 6 80,159,364 80,167,677 RGD:9686404
G Ppie peptidylprolyl isomerase E JBrowse link 5 140,822,141 140,835,244 RGD:6907045
RGD:9686094
RGD:9686376
G Ppig peptidylprolyl isomerase G JBrowse link 3 55,959,756 55,990,040 RGD:9686376
G Ppih peptidylprolyl isomerase H JBrowse link 5 138,343,934 138,361,743 RGD:6907045
RGD:9686376
G Ppil1 peptidylprolyl isomerase like 1 JBrowse link 20 6,515,638 6,864,571 RGD:6907045
RGD:9686094
RGD:9686376
G Ppil2 peptidylprolyl isomerase like 2 JBrowse link 11 88,147,342 88,169,968 RGD:9686376
G Ppil3 peptidylprolyl isomerase like 3 JBrowse link 9 65,315,407 65,329,145 RGD:9686376
G Pqbp1 polyglutamine binding protein 1 JBrowse link X 15,448,570 15,453,130 RGD:6907045
G Prpf18 pre-mRNA processing factor 18 JBrowse link 17 77,601,914 77,632,507 RGD:6907045
RGD:9686092
G Prpf19 pre-mRNA processing factor 19 JBrowse link 1 226,947,065 226,958,147 RGD:6907045
RGD:9686094
G Prpf3 pre-mRNA processing factor 3 JBrowse link 2 197,947,010 197,971,464 RGD:6907045
RGD:9686089
G Prpf31 pre-mRNA processing factor 31 JBrowse link 1 64,150,786 64,162,461 RGD:6907045
RGD:9686089
G Prpf38a pre-mRNA processing factor 38A JBrowse link 5 128,174,835 128,186,532 RGD:6907045
G Prpf38b pre-mRNA processing factor 38B JBrowse link 2 211,706,245 211,715,271 RGD:6907045
G Prpf4 pre-mRNA processing factor 4 JBrowse link 5 78,267,248 78,281,172 RGD:6907045
RGD:9686089
G Prpf40a pre-mRNA processing factor 40 homolog A JBrowse link 3 38,680,583 38,741,570 RGD:6907045
G Prpf6 pre-mRNA processing factor 6 JBrowse link 3 177,098,137 177,162,937 RGD:6907045
RGD:9686089
G Prpf8 pre-mRNA processing factor 8 JBrowse link 10 63,635,239 63,658,360 RGD:6907045
RGD:9686090
G Ptbp1 polypyrimidine tract binding protein 1 JBrowse link 7 12,663,965 12,673,723 RGD:9686381
G Ptbp2 polypyrimidine tract binding protein 2 JBrowse link 2 223,261,444 223,323,075 RGD:9686382
G Puf60 poly-U binding splicing factor 60 JBrowse link 7 117,129,237 117,140,234 RGD:6907045
G Qki QKI, KH domain containing, RNA binding JBrowse link 1 50,983,133 51,061,103 RGD:9686381
G Rbm17 RNA binding motif protein 17 JBrowse link 17 70,586,345 70,603,289 RGD:6907045
G Rbm22 RNA binding motif protein 22 JBrowse link 18 55,828,158 55,839,421 RGD:6907045
RGD:9686094
G Rbm25 RNA binding motif protein 25 JBrowse link 6 107,117,888 107,165,538 RGD:6907045
G Rbm25l1 RNA binding motif protein 25-like 1 JBrowse link 10 10,457,316 10,460,540 RGD:6907045
G Rbm8a RNA binding motif protein 8A JBrowse link 2 198,755,261 198,758,028 RGD:6907045
RGD:9686404
G Rbmx RNA binding motif protein, X-linked JBrowse link X 159,881,835 159,891,405 RGD:6907045
RGD:9686089
RGD:9686091
G Rbmxl1 RNA binding motif protein, X-linked-like 1 JBrowse link 19 33,081,473 33,084,988 RGD:6907045
G RGD1566078 similar to NHP2-like protein 1 (High mobility group-like nuclear protein 2 homolog 1) (Sperm specific antigen 1) JBrowse link X 152,781,177 152,781,621 RGD:6907045
G Rnps1 RNA binding protein with serine rich domain 1 JBrowse link 10 13,786,339 13,796,720 RGD:9686404
G Sart1 SART1, U4/U6.U5 tri-snRNP-associated protein 1 JBrowse link 1 220,762,496 220,771,158 RGD:6907045
G Sart3 squamous cell carcinoma antigen recognized by T-cells 3 JBrowse link 12 48,628,198 48,656,096 RGD:9686090
G Sf1 splicing factor 1 JBrowse link 1 221,735,512 221,749,216 RGD:9686089
G Sf3a1 splicing factor 3a, subunit 1 JBrowse link 14 84,393,182 84,413,931 RGD:6907045
RGD:9686091
G Sf3a2 splicing factor 3a, subunit 2 JBrowse link 7 11,777,826 11,784,373 RGD:6907045
RGD:9686091
G Sf3a3 splicing factor 3a, subunit 3 JBrowse link 5 142,702,721 142,722,350 RGD:6907045
RGD:9686091
G Sf3b1 splicing factor 3b, subunit 1 JBrowse link 9 61,594,620 61,634,510 RGD:6907045
RGD:9686091
G Sf3b2 splicing factor 3b, subunit 2 JBrowse link 1 220,645,685 220,665,611 RGD:6907045
RGD:9686091
G Sf3b3 splicing factor 3b, subunit 3 JBrowse link 19 43,392,071 43,429,582 RGD:6907045
RGD:9686091
G Sf3b4 splicing factor 3b, subunit 4 JBrowse link 2 198,312,428 198,317,180 RGD:6907045
RGD:9686091
G Sf3b5 splicing factor 3b, subunit 5 JBrowse link 1 7,101,715 7,102,427 RGD:6907045
RGD:9686091
G Sf3b6 splicing factor 3B, subunit 6 JBrowse link 6 29,991,232 29,999,668 RGD:9686091
G Slu7 SLU7 homolog, splicing factor JBrowse link 10 29,029,556 29,044,919 RGD:6907045
RGD:9686092
G Smndc1 survival motor neuron domain containing 1 JBrowse link 1 274,096,068 274,107,138 RGD:6907045
G Snrnp200 small nuclear ribonucleoprotein U5 subunit 200 JBrowse link 3 119,640,324 119,669,651 RGD:9686090
RGD:9686093
G Snrnp27 small nuclear ribonucleoprotein U4/U6.U5 subunit 27 JBrowse link 4 118,478,075 118,487,633 RGD:6907045
G Snrnp40 small nuclear ribonucleoprotein U5 subunit 40 JBrowse link 5 148,577,498 148,610,658 RGD:6907045
G Snrnp70 small nuclear ribonucleoprotein U1 subunit 70 JBrowse link 1 101,367,470 101,388,153 RGD:6907045
RGD:9686090
G Snrpa small nuclear ribonucleoprotein polypeptide A JBrowse link 1 83,999,670 84,008,429 RGD:6907045
RGD:9686090
G Snrpa1 small nuclear ribonucleoprotein polypeptide A' JBrowse link 1 126,961,389 126,974,453 RGD:9686091
G Snrpb small nuclear ribonucleoprotein polypeptides B and B1 JBrowse link 3 122,696,125 122,703,734 RGD:6907045
RGD:9686089
RGD:9686091
G Snrpb2 small nuclear ribonucleoprotein polypeptide B2 JBrowse link 3 137,138,082 137,147,575 RGD:6907045
RGD:9686091
G Snrpc small nuclear ribonucleoprotein polypeptide C JBrowse link 20 7,409,401 7,427,581 RGD:6907045
RGD:9686090
G Snrpd1 small nuclear ribonucleoprotein D1 polypeptide JBrowse link 18 1,866,066 1,876,613 RGD:6907045
RGD:9686089
RGD:9686091
G Snrpd2 small nuclear ribonucleoprotein D2 polypeptide JBrowse link 1 80,057,140 80,059,990 RGD:6907045
RGD:9686089
RGD:9686091
G Snrpd3 small nuclear ribonucleoprotein D3 polypeptide JBrowse link 20 14,080,562 14,095,644 RGD:9686089
RGD:9686091
G Snrpe small nuclear ribonucleoprotein polypeptide E JBrowse link 13 50,252,707 50,258,951 RGD:6907045
RGD:9686089
RGD:9686091
G Snrpf small nuclear ribonucleoprotein polypeptide F JBrowse link 7 34,478,331 34,485,034 RGD:6907045
RGD:9686089
RGD:9686091
G Snrpg small nuclear ribonucleoprotein polypeptide G JBrowse link 4 118,167,267 118,174,846 RGD:9686089
RGD:9686091
G Snu13 small nuclear ribonucleoprotein 13 JBrowse link 7 123,282,754 123,287,721 RGD:6907045
RGD:9686089
G Snw1 SNW domain containing 1 JBrowse link 6 111,483,698 111,507,782 RGD:6907045
RGD:9686094
G Srrm1 serine and arginine repetitive matrix 1 JBrowse link 5 153,675,619 153,708,187 RGD:9686091
RGD:9686404
G Srrm2 serine/arginine repetitive matrix 2 JBrowse link 10 13,128,820 13,162,956 RGD:9686091
G Srsf1 serine and arginine rich splicing factor 1 JBrowse link 10 75,334,200 75,341,197 RGD:9686089
RGD:9686091
G Srsf10 serine and arginine rich splicing factor 10 JBrowse link 5 154,205,358 154,219,550 RGD:9686089
RGD:9686091
G Srsf11 serine and arginine rich splicing factor 11 JBrowse link 2 264,837,463 264,864,296 RGD:9686091
G Srsf12 serine and arginine rich splicing factor 12 JBrowse link 5 48,456,777 48,484,017 RGD:9686091
G Srsf2 serine and arginine rich splicing factor 2 JBrowse link 10 105,792,779 105,795,986 RGD:9686091
G Srsf4 serine and arginine rich splicing factor 4 JBrowse link 5 150,032,999 150,060,769 RGD:9686089
RGD:9686091
G Srsf5 serine and arginine rich splicing factor 5 JBrowse link 6 104,611,026 104,640,033 RGD:9686089
RGD:9686091
G Srsf6 serine and arginine rich splicing factor 6 JBrowse link 3 159,305,345 159,310,668 RGD:9686089
RGD:9686091
G Srsf7 serine and arginine rich splicing factor 7 JBrowse link 6 2,879,312 2,886,505 RGD:9686089
RGD:9686091
G Srsf9 serine and arginine rich splicing factor 9 JBrowse link 12 47,039,714 47,046,022 RGD:9686089
RGD:9686091
G Syf2 SYF2 pre-mRNA-splicing factor JBrowse link 5 153,269,638 153,277,562 RGD:6907045
RGD:9686094
G Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein JBrowse link 8 96,100,692 96,266,342 RGD:9686091
G Tcerg1 transcription elongation regulator 1 JBrowse link 18 36,796,290 36,889,966 RGD:6907045
G Thoc1 THO complex 1 JBrowse link 18 1,142,540 1,177,084 RGD:6907045
G Thoc2 THO complex 2 JBrowse link X 128,153,824 128,268,327 RGD:6907045
G Thoc3 THO complex 3 JBrowse link 17 10,676,943 10,686,134 RGD:6907045
G Tial1 Tia1 cytotoxic granule-associated RNA binding protein-like 1 JBrowse link 1 199,844,854 199,865,843 RGD:9686381
G Tra2a transformer 2 alpha homolog JBrowse link 4 78,905,380 78,924,203 RGD:6907045
G Tra2b transformer 2 beta homolog JBrowse link 11 82,373,828 82,392,208 RGD:6907045
G U2af1 U2 small nuclear RNA auxiliary factor 1 JBrowse link 20 10,396,652 10,407,564 RGD:9686089
G U2af2 U2 small nuclear RNA auxiliary factor 2 JBrowse link 1 72,312,260 72,329,828 RGD:6907045
RGD:9686089
G U2surp U2 snRNP-associated SURP domain containing JBrowse link 8 103,242,095 103,299,082 RGD:6907045
G Usp39 ubiquitin specific peptidase 39 JBrowse link 4 100,181,408 100,211,425 RGD:6907045
G Wbp11 WW domain binding protein 11 JBrowse link 4 170,772,166 170,785,613 RGD:6907045
G Xab2 XPA binding protein 2 JBrowse link 12 2,158,391 2,170,397 RGD:6907045
RGD:9686094
G Zmat2 zinc finger, matrin type 2 JBrowse link 18 29,639,991 29,644,626 RGD:6907045

Pathway Gene Annotations

Disease Annotations Associated with Genes in the RNA polymerase II transcription pathway
Disease TermsGene Symbols
Adenocarcinoma of LungCdk12
ADENOCARCINOMA OF STOMACHMed12
Adenocarcinoma, ProstaticMed12
Adrenocortical CarcinomaMed12
Agenesis of Corpus CallosumMed12
Aging, PrematureCdc14b
Alzheimer DiseaseCdk7
Anus, ImperforateMed12
Autism Spectrum DisorderMed15
BASEL-VANAGAITE-SMIRIN-YOSEF SYNDROMEMed25
Bleeding Disorder, Platelet-Type, 8Med12l
Breast NeoplasmsMed12 , Med28
BurnsCcnc
Carcinoma, HepatocellularMed1
Carcinoma, Renal CellCdc14b
Charcot-Marie-Tooth DiseaseMed25
Charcot-Marie-Tooth Disease, Type 2B2Med25
Ciliary Dyskinesia, Primary, 28Polr2k
Congenital Cataracts, Facial Dysmorphism, and NeuropathyCtdp1
DEAFNESS, AUTOSOMAL RECESSIVE 105Cdc14a
Developmental DisabilitiesMed12
Diabetes Mellitus, ExperimentalCdk9
Drug-Induced Liver InjuryMed1
EndometriosisMed1 , Med14 , Med16 , Med17 , Med4
EpilepsyMed12
FibroadenomaMed12
Genetic Diseases, InbornMed12
Glomus vagale tumorsRpap2
Heart FailureCdk9
Hirschsprung Disease 1Polr2f
HydrocephalusMed12
HyperargininemiaMed23
Hypertrophy, Right VentricularMed13
InfarctionPolr2a
Intellectual DisabilityMed12 , Med13l
Kartagener SyndromePolr2k
LeiomyosarcomaMed12
Lujan Fryns SyndromeMed12
Mental retardation and distinctive facial features with or without cardiac defectsMed13l
Mental Retardation, Autosomal Recessive 18Med23
Mental Retardation, X-LinkedMed12
MicrocephalyMed12
Microcephaly, Postnatal Progressive, with Seizures and Brain AtrophyMed17
Neoplasm MetastasisMed28
Neurodevelopmental DisordersMed13l
Ohdo Syndrome, X-LinkedMed12
Opitz-Kaveggia SyndromeMed12
Pancreatic AdenocarcinomaMed12
Peripheral Demyelinating Neuropathy, Central Dysmyelination, Waardenburg Syndrome, and Hirschsprung DiseasePolr2f
Phyllodes TumorMed12
Pleomorphic Xanthoastrocytoma Polr2j
Prostatic NeoplasmsMed1 , Med12
SchizophreniaMed15
SeizuresMed12
Smith-Magenis SyndromeCdk12 , Med1 , Med13 , Med24
Spinal Cord InjuriesCdk19
Squamous Cell Carcinoma of the LungMed12
Transposition of Great VesselsMed13l
Transposition of the Great Arteries, Dextro-Looped 1Med13l
Uterine Cervical NeoplasmsMed4
Waardenburg SyndromePolr2f
Waardenburg Syndrome Type 2Polr2f
Waardenburg Syndrome, Type 4CPolr2f
Pathway Annotations Associated with Genes in the RNA polymerase II transcription pathway

References Associated with the RNA polymerase II transcription pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: