E2f3 (E2F transcription factor 3) - Rat Genome Database

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Gene: E2f3 (E2F transcription factor 3) Rattus norvegicus
Analyze
Symbol: E2f3
Name: E2F transcription factor 3
RGD ID: 1561600
Description: Predicted to enable DNA-binding transcription activator activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to contribute to DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; positive regulation of vascular associated smooth muscle cell apoptotic process; and protein import into nucleus. Predicted to act upstream of or within positive regulation of DNA-templated transcription and positive regulation of cell population proliferation. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and prostate cancer. Orthologous to human E2F3 (E2F transcription factor 3); PARTICIPATES IN cell cycle pathway, mitotic; ceramide signaling pathway; chronic myeloid leukemia pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E2F transcription factor 3-like; LOC100361421; LOC291105; RGD1561600; similar to E2f3 protein; similar to Transcription factor E2F3 (E2F-3); transcription factor E2F3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81734,810,355 - 34,887,725 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1734,809,998 - 34,887,725 (+)EnsemblGRCr8
mRatBN7.21734,601,756 - 34,679,139 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1734,601,830 - 34,676,253 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1734,421,885 - 34,499,059 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01736,025,759 - 36,102,934 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01734,417,688 - 34,494,867 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01736,334,136 - 36,408,831 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1736,334,147 - 36,408,831 (+)Ensemblrn6Rnor6.0
Rnor_5.01737,641,855 - 37,716,592 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41741,079,346 - 41,145,568 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1734,130,042 - 34,203,210 (+)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-palmitoylglycerol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
adenosine  (EXP)
alpha-pinene  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium dichloride  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
eugenol  (ISO)
formaldehyde  (ISO)
furan  (EXP)
geldanamycin  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
GW 3965  (ISO)
hexadecanoic acid  (ISO)
hexane  (EXP)
indometacin  (ISO)
inulin  (ISO)
kojic acid  (ISO)
Lasiocarpine  (ISO)
leptomycin B  (ISO)
lidocaine  (EXP,ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methylparaben  (ISO)
monosodium L-glutamate  (ISO)
motexafin gadolinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
propylparaben  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
retinyl acetate  (ISO)
ritonavir  (ISO)
silver(1+) nitrate  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
valproic acid  (ISO)
zinc acetate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Nuclear overexpression of the E2F3 transcription factor in human lung cancer. Cooper CS, etal., Lung Cancer. 2006 Nov;54(2):155-62. doi: 10.1016/j.lungcan.2006.07.005. Epub 2006 Aug 30.
2. Transcription factor E2F3 overexpressed in prostate cancer independently predicts clinical outcome. Foster CS, etal., Oncogene. 2004 Aug 5;23(35):5871-9. doi: 10.1038/sj.onc.1207800.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. Measurement of blood E2F3 mRNA in prostate cancer by quantitative RT-PCR: a preliminary study. Pipinikas CP, etal., Biomarkers. 2007 Sep-Oct;12(5):541-57. doi: 10.1080/13547500701391353 .
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Knockdown of E2F3 Inhibits Proliferation, Migration, and Invasion and Increases Apoptosis in Glioma Cells. Shen ZG, etal., Oncol Res. 2017 Nov 2;25(9):1555-1566. doi: 10.3727/096504017X14897158009178. Epub 2017 Mar 23.
8. Autoregulatory feedback loop of EZH2/miR-200c/E2F3 as a driving force for prostate cancer development. Tao T, etal., Biochim Biophys Acta. 2014 Sep;1839(9):858-65. doi: 10.1016/j.bbagrm.2014.07.001. Epub 2014 Jul 10.
9. Genetic variants of genes in the Notch signaling pathway predict overall survival of non-small cell lung cancer patients in the PLCO study. Xu Y, etal., Oncotarget. 2016 Sep 20;7(38):61716-61727. doi: 10.18632/oncotarget.11436.
Additional References at PubMed
PMID:7739537   PMID:11980909   PMID:12893818   PMID:15158336   PMID:15574595   PMID:15722552   PMID:15735762   PMID:17062573   PMID:17102628   PMID:18541936   PMID:20176812   PMID:22886504  
PMID:23332764   PMID:33058540   PMID:34666672   PMID:35616132  


Genomics

Comparative Map Data
E2f3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81734,810,355 - 34,887,725 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1734,809,998 - 34,887,725 (+)EnsemblGRCr8
mRatBN7.21734,601,756 - 34,679,139 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1734,601,830 - 34,676,253 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1734,421,885 - 34,499,059 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01736,025,759 - 36,102,934 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01734,417,688 - 34,494,867 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01736,334,136 - 36,408,831 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1736,334,147 - 36,408,831 (+)Ensemblrn6Rnor6.0
Rnor_5.01737,641,855 - 37,716,592 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41741,079,346 - 41,145,568 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1734,130,042 - 34,203,210 (+)NCBICelera
Cytogenetic Map17p12NCBI
E2F3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38620,401,879 - 20,493,714 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl620,401,847 - 20,493,714 (+)Ensemblhg38GRCh38
GRCh37620,402,110 - 20,493,945 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36620,510,377 - 20,601,921 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34620,510,376 - 20,601,921NCBI
Celera621,635,267 - 21,727,062 (+)NCBICelera
Cytogenetic Map6p22.3NCBI
HuRef620,346,529 - 20,438,219 (+)NCBIHuRef
CHM1_1620,404,479 - 20,496,262 (+)NCBICHM1_1
T2T-CHM13v2.0620,273,917 - 20,365,731 (+)NCBIT2T-CHM13v2.0
E2f3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391330,090,558 - 30,171,172 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1330,090,558 - 30,170,046 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381329,906,575 - 29,986,064 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1329,906,575 - 29,986,063 (-)Ensemblmm10GRCm38
MGSCv371329,998,444 - 30,077,932 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361329,917,237 - 29,993,528 (-)NCBIMGSCv36mm8
Celera1330,125,315 - 30,204,809 (-)NCBICelera
Cytogenetic Map13A3.2NCBI
cM Map1313.09NCBI
E2f3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554836,042,863 - 6,117,479 (-)Ensembl
ChiLan1.0NW_0049554836,039,569 - 6,116,000 (-)NCBIChiLan1.0ChiLan1.0
E2F3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2535,036,930 - 35,128,398 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1631,036,391 - 31,127,855 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0620,225,471 - 20,317,199 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1620,574,244 - 20,665,785 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl620,574,898 - 20,665,785 (+)EnsemblpanPan2panpan1.1
E2F3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13519,012,646 - 19,086,674 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3519,012,324 - 19,083,634 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3518,971,644 - 19,045,676 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03519,123,558 - 19,197,676 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3519,122,042 - 19,194,624 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13518,931,701 - 19,005,696 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03518,996,668 - 19,070,695 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03520,416,008 - 20,490,009 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
E2f3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049465,947,295 - 6,019,002 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365525,711,923 - 5,783,694 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365525,712,247 - 5,783,643 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
E2F3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl715,794,178 - 15,870,204 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1715,793,519 - 15,870,213 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2716,704,641 - 16,779,074 (+)NCBISscrofa10.2Sscrofa10.2susScr3
E2F3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11751,714,052 - 51,805,827 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604420,694,985 - 20,787,283 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
E2f3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247566,185,366 - 6,266,000 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247566,182,087 - 6,266,097 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
E2f3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11448,953,675 - 49,027,254 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in E2f3
525 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir34arno-miR-34a-5pMirtarbaseexternal_infoWestern blotFunctional MTI18942116

Predicted Target Of
Summary Value
Count of predictions:516
Count of miRNA genes:247
Interacting mature miRNAs:286
Transcripts:ENSRNOT00000050261
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173219953449497050Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172149899450592236Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173219953455604694Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat

Markers in Region
PMC85656P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21734,601,707 - 34,601,817 (+)MAPPERmRatBN7.2
Rnor_6.01736,334,025 - 36,334,134NCBIRnor6.0
Rnor_5.01737,641,744 - 37,641,853UniSTSRnor5.0
RGSC_v3.41741,079,235 - 41,079,344UniSTSRGSC3.4
Celera1734,129,931 - 34,130,040UniSTS
Cytogenetic Map17p12UniSTS
PMC85656P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21734,601,100 - 34,601,275 (+)MAPPERmRatBN7.2
Rnor_6.01736,333,418 - 36,333,592NCBIRnor6.0
Rnor_5.01737,641,137 - 37,641,311UniSTSRnor5.0
RGSC_v3.41741,078,628 - 41,078,802UniSTSRGSC3.4
Celera1734,129,324 - 34,129,498UniSTS
Cytogenetic Map17p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 13 71 189 91 90 59 140 59 6 429 249 17 171 97 95 31 24 24

Sequence


Ensembl Acc Id: ENSRNOT00000050261   ⟹   ENSRNOP00000040345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1734,601,830 - 34,676,253 (+)Ensembl
Rnor_6.0 Ensembl1736,334,147 - 36,408,831 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081368   ⟹   ENSRNOP00000071597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1734,809,998 - 34,887,725 (+)Ensembl
mRatBN7.2 Ensembl1734,601,830 - 34,676,253 (+)Ensembl
Rnor_6.0 Ensembl1736,334,589 - 36,408,486 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091334   ⟹   ENSRNOP00000068682
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1734,812,089 - 34,884,491 (+)Ensembl
mRatBN7.2 Ensembl1734,603,273 - 34,675,825 (+)Ensembl
Rnor_6.0 Ensembl1736,335,804 - 36,408,401 (+)Ensembl
RefSeq Acc Id: NM_001137626   ⟹   NP_001131098
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81734,810,416 - 34,887,725 (+)NCBI
mRatBN7.21734,601,819 - 34,679,139 (+)NCBI
Rnor_6.01736,334,136 - 36,408,831 (+)NCBI
Rnor_5.01737,641,855 - 37,716,592 (+)NCBI
RGSC_v3.41741,079,346 - 41,145,568 (+)RGD
Celera1734,130,042 - 34,203,210 (+)RGD
Sequence:
RefSeq Acc Id: XM_039095500   ⟹   XP_038951428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81734,810,365 - 34,887,722 (+)NCBI
mRatBN7.21734,601,761 - 34,679,139 (+)NCBI
RefSeq Acc Id: XM_039095503   ⟹   XP_038951431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81734,860,557 - 34,887,722 (+)NCBI
mRatBN7.21734,648,520 - 34,679,139 (+)NCBI
RefSeq Acc Id: XM_039095504   ⟹   XP_038951432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81734,860,557 - 34,887,722 (+)NCBI
mRatBN7.21734,648,519 - 34,679,139 (+)NCBI
RefSeq Acc Id: XM_039095505   ⟹   XP_038951433
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81734,811,491 - 34,887,722 (+)NCBI
mRatBN7.21734,603,550 - 34,679,136 (+)NCBI
RefSeq Acc Id: XM_039095506   ⟹   XP_038951434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81734,811,490 - 34,887,722 (+)NCBI
mRatBN7.21734,603,550 - 34,679,136 (+)NCBI
RefSeq Acc Id: XM_039095507   ⟹   XP_038951435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81734,810,355 - 34,883,073 (+)NCBI
mRatBN7.21734,601,756 - 34,674,486 (+)NCBI
RefSeq Acc Id: NP_001131098   ⟸   NM_001137626
- UniProtKB: A0A0G2K0V6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071597   ⟸   ENSRNOT00000081368
Ensembl Acc Id: ENSRNOP00000068682   ⟸   ENSRNOT00000091334
Ensembl Acc Id: ENSRNOP00000040345   ⟸   ENSRNOT00000050261
RefSeq Acc Id: XP_038951435   ⟸   XM_039095507
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038951428   ⟸   XM_039095500
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038951433   ⟸   XM_039095505
- Peptide Label: isoform X4
- UniProtKB: A0A0G2JTE8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951434   ⟸   XM_039095506
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038951432   ⟸   XM_039095504
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038951431   ⟸   XM_039095503
- Peptide Label: isoform X2
Protein Domains
E2F/DP family winged-helix DNA-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K0V6-F1-model_v2 AlphaFold A0A0G2K0V6 1-426 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700430
Promoter ID:EPDNEW_R10954
Type:initiation region
Name:E2f3_2
Description:E2F transcription factor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10955  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01736,334,111 - 36,334,171EPDNEW
RGD ID:13700433
Promoter ID:EPDNEW_R10955
Type:single initiation site
Name:E2f3_1
Description:E2F transcription factor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10954  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01736,335,864 - 36,335,924EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561600 AgrOrtholog
BioCyc Gene G2FUF-9524 BioCyc
Ensembl Genes ENSRNOG00000029273 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000081368.3 UniProtKB/TrEMBL
  ENSRNOT00000091334 ENTREZGENE
  ENSRNOT00000091334.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  6.10.250.540 UniProtKB/TrEMBL
InterPro E2F UniProtKB/TrEMBL
  E2F-DP_heterodim UniProtKB/TrEMBL
  E2F_CC-MB UniProtKB/TrEMBL
  E2F_TDP UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:291105 UniProtKB/TrEMBL
NCBI Gene 291105 ENTREZGENE
PANTHER E2F UniProtKB/TrEMBL
  TRANSCRIPTION FACTOR E2F3 UniProtKB/TrEMBL
Pfam E2F_CC-MB UniProtKB/TrEMBL
  E2F_TDP UniProtKB/TrEMBL
PhenoGen E2f3 PhenoGen
RatGTEx ENSRNOG00000029273 RatGTEx
SMART E2F_TDP UniProtKB/TrEMBL
Superfamily-SCOP SSF144074 UniProtKB/TrEMBL
  SSF46785 UniProtKB/TrEMBL
UniProt A0A0G2JTE8 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K0V6 ENTREZGENE, UniProtKB/TrEMBL
  A6J7N1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 E2f3  E2F transcription factor 3  LOC100361421  E2F transcription factor 3-like  Data merged from RGD:2320144 737654 PROVISIONAL
2013-05-24 E2f3  E2F transcription factor 3  LOC691420  similar to Transcription factor E2F3 (E2F-3)  Data merged from RGD:1583953 1643240 APPROVED
2010-05-05 LOC100361421  E2F transcription factor 3-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-02-29 E2f3  E2F transcription factor 3  RGD1561600_predicted  similar to E2f3 protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC691420  similar to Transcription factor E2F3 (E2F-3)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1561600_predicted  similar to E2f3 protein (predicted)  LOC291105  similar to E2f3 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC291105  similar to E2f3 protein      Symbol and Name status set to provisional 70820 PROVISIONAL