Map2k7 (mitogen activated protein kinase kinase 7) - Rat Genome Database

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Gene: Map2k7 (mitogen activated protein kinase kinase 7) Rattus norvegicus
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Symbol: Map2k7
Name: mitogen activated protein kinase kinase 7
RGD ID: 1560043
Description: Enables several functions, including ATP binding activity; JUN kinase kinase activity; and magnesium ion binding activity. Involved in several processes, including MAPK cascade; cellular response to sorbitol; and positive regulation of JNK cascade. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colon adenocarcinoma; lung adenocarcinoma; lung carcinoma; and lung non-small cell carcinoma. Orthologous to human MAP2K7 (mitogen-activated protein kinase kinase 7); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; adenosine signaling pathway; FasL mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cadmium atom.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: c-Jun N-terminal kinase kinase 2; dual specificity mitogen-activated protein kinase kinase 7; JNK kinase 2; JNK-activating kinase 2; JNKK; JNKK 2; Jnkk2; MAP kinase kinase 7; MAPK/ERK kinase 7; MAPKK 7; Mapkk7; MEK 7; Mek7; Mkk7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8127,389,032 - 7,398,377 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl127,389,155 - 7,398,377 (+)EnsemblGRCr8
mRatBN7.2122,591,312 - 2,600,534 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl122,591,219 - 2,604,222 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx123,239,383 - 3,248,497 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0123,862,974 - 3,872,088 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0122,626,083 - 2,635,208 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,546,278 - 2,555,310 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,548,218 - 2,555,164 (-)Ensemblrn6Rnor6.0
Rnor_5.0124,698,912 - 4,708,078 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4121,545,407 - 1,552,353 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera124,407,043 - 4,413,990 (+)NCBICelera
Cytogenetic Map12p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
5-fluorouracil  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
alpha-Chaconine  (ISO)
andrographolide  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bufalin  (ISO)
butanal  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
Cuprizon  (EXP)
DDE  (ISO)
deguelin  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
hydrogen peroxide  (ISO)
isoniazide  (ISO)
L-gamma-glutamyl-L-cysteine  (EXP)
methamphetamine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP)
nicotine  (ISO)
nitrates  (ISO)
obeticholic acid  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
phlorizin  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
sodium arsenite  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO,ISS)
nucleus  (IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Stress- and cell type-dependent regulation of transfected c-Jun N-terminal kinase and mitogen-activated protein kinase kinase isoforms. Butterfield L, etal., Biochem J. 1999 Mar 15;338 ( Pt 3):681-6.
2. Combined high energy of extracorporeal shock wave and 5-FU effectively suppressed the proliferation and growth of tongue squamous cell carcinoma. Chang CL, etal., Biomed Pharmacother. 2021 Oct;142:112036. doi: 10.1016/j.biopha.2021.112036. Epub 2021 Aug 16.
3. Prognostic significance of autophagy-related genes within esophageal carcinoma. Chen C, etal., BMC Cancer. 2020 Aug 24;20(1):797. doi: 10.1186/s12885-020-07303-4.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Activation of ASK1, downstream MAPKK and MAPK isoforms during cardiac ischaemia. Harding SJ, etal., Biochim Biophys Acta. 2010 Sep;1802(9):733-40. doi: 10.1016/j.bbadis.2010.06.005. Epub 2010 Jun 13.
6. The p38 kinases MKK4 and MKK6 suppress metastatic colonization in human ovarian carcinoma. Hickson JA, etal., Cancer Res. 2006 Feb 15;66(4):2264-70.
7. Genetic variants of JNK and p38α pathways and risk of non-small cell lung cancer in an Eastern Chinese population. Jia M, etal., Int J Cancer. 2017 Feb 15;140(4):807-817. doi: 10.1002/ijc.30508. Epub 2016 Nov 16.
8. The c-jun kinase/stress-activated pathway: regulation, function and role in human disease. Johnson GL and Nakamura K, Biochim Biophys Acta. 2007 Aug;1773(8):1341-8. Epub 2007 Jan 4.
9. Activated mitogen-activated protein kinase kinase 7 redistributes to the cytosol and binds to Jun N-terminal kinase-interacting protein 1 involving oxidative stress during early reperfusion in rat hippocampal CA1 region. Li CH, etal., J Neurochem. 2005 Apr;93(2):290-8.
10. JNK1/2 represses Lkb1-deficiency-induced lung squamous cell carcinoma progression. Liu J, etal., Nat Commun. 2019 May 14;10(1):2148. doi: 10.1038/s41467-019-09843-1.
11. Up-regulation of MKK4, MKK6 and MKK7 during prostate cancer progression: an important role for SAPK signalling in prostatic neoplasia. Lotan TL, etal., J Pathol. 2007 Aug;212(4):386-94.
12. An autophagy-related model of 4 key genes for predicting prognosis of patients with laryngeal cancer. Luo MS, etal., Medicine (Baltimore). 2020 Jul 24;99(30):e21163. doi: 10.1097/MD.0000000000021163.
13. The neuroprotective effects of K252a through inhibiting MLK3/MKK7/JNK3 signaling pathway on ischemic brain injury in rat hippocampal CA1 region. Pan J, etal., Neuroscience. 2005;131(1):147-59.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. The MKK7 p.Glu116Lys Rare Variant Serves as a Predictor for Lung Cancer Risk and Prognosis in Chinese. Qiu F, etal., PLoS Genet. 2016 Mar 30;12(3):e1005955. doi: 10.1371/journal.pgen.1005955. eCollection 2016 Mar.
18. A tumor-associated splice-isoform of MAP2K7 drives dedifferentiation in MBNL1-low cancers via JNK activation. Ray D, etal., Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16391-16400. doi: 10.1073/pnas.2002499117. Epub 2020 Jun 29.
19. GOA pipeline RGD automated data pipeline
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer. Ruiz EJ, etal., JCI Insight. 2021 Jul 8;6(13). pii: e124985. doi: 10.1172/jci.insight.124985.
22. MKK7 mediates miR-493-dependent suppression of liver metastasis of colon cancer cells. Sakai H, etal., Cancer Sci. 2014 Apr;105(4):425-30. doi: 10.1111/cas.12380. Epub 2014 Mar 24.
23. The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression. Schramek D, etal., Nat Genet. 2011 Mar;43(3):212-9. doi: 10.1038/ng.767. Epub 2011 Feb 13.
24. Mitogen-activated protein kinase kinase 7 is activated during low potassium-induced apoptosis in rat cerebellar granule neurons. Trotter L, etal., Neurosci Lett. 2002 Mar 1;320(1-2):29-32.
25. Suppression of metastatic colonization by the context-dependent activation of the c-Jun NH2-terminal kinase kinases JNKK1/MKK4 and MKK7. Vander Griend DJ, etal., Cancer Res. 2005 Dec 1;65(23):10984-91.
26. Disruption of signaling through SEK1 and MKK7 yields differential responses in hypoxic colon cancer cells treated with oxaliplatin. Vasilevskaya IA, etal., Mol Pharmacol. 2008 Jul;74(1):246-54. doi: 10.1124/mol.107.044644. Epub 2008 Apr 24.
27. MEKK1 controls neurite regrowth after experimental injury by balancing ERK1/2 and JNK2 signaling. Waetzig V and Herdegen T, Mol Cell Neurosci. 2005 Sep;30(1):67-78.
28. Inhibition of MLK3-MKK4/7-JNK1/2 pathway by Akt1 in exogenous estrogen-induced neuroprotection against transient global cerebral ischemia by a non-genomic mechanism in male rats. Wang R, etal., J Neurochem. 2006 Dec;99(6):1543-54. Epub 2006 Oct 25.
29. POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis. Xu Z, etal., EMBO J. 2003 Jan 15;22(2):252-61.
30. Delayed activation and regulation of MKK7 in hippocampal CA1 region following global cerebral ischemia in rats. Zhang Q, etal., Life Sci. 2003 Nov 21;74(1):37-45.
31. Crosstalk between PSD-95 and JIP1-mediated signaling modules: the mechanism of MLK3 activation in cerebral ischemia. Zhang QX, etal., Biochemistry. 2007 Apr 3;46(13):4006-16. Epub 2007 Mar 10.
Additional References at PubMed
PMID:9405446   PMID:9535930   PMID:9891090   PMID:11959862   PMID:14615289   PMID:14697235   PMID:20633641   PMID:21406225   PMID:21531765   PMID:22088537   PMID:25100604   PMID:26270349  
PMID:28111074  


Genomics

Comparative Map Data
Map2k7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8127,389,032 - 7,398,377 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl127,389,155 - 7,398,377 (+)EnsemblGRCr8
mRatBN7.2122,591,312 - 2,600,534 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl122,591,219 - 2,604,222 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx123,239,383 - 3,248,497 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0123,862,974 - 3,872,088 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0122,626,083 - 2,635,208 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,546,278 - 2,555,310 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,548,218 - 2,555,164 (-)Ensemblrn6Rnor6.0
Rnor_5.0124,698,912 - 4,708,078 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4121,545,407 - 1,552,353 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera124,407,043 - 4,413,990 (+)NCBICelera
Cytogenetic Map12p12NCBI
MAP2K7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38197,903,877 - 7,914,478 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl197,903,843 - 7,914,480 (+)Ensemblhg38GRCh38
GRCh37197,968,762 - 7,979,363 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,874,765 - 7,885,363 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34197,874,764 - 7,885,362NCBI
Celera197,839,967 - 7,850,565 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef197,639,009 - 7,649,623 (+)NCBIHuRef
CHM1_1197,968,237 - 7,978,836 (+)NCBICHM1_1
T2T-CHM13v2.0197,904,832 - 7,915,433 (+)NCBIT2T-CHM13v2.0
Map2k7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3984,288,740 - 4,297,897 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl84,288,865 - 4,301,423 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm39 Ensembl84,288,740 - 4,297,897 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3884,238,740 - 4,247,897 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl84,238,865 - 4,251,423 (+)Ensemblmm10GRCm38
GRCm38.p6 Ensembl84,238,740 - 4,247,897 (+)Ensemblmm10GRCm38
MGSCv3784,238,740 - 4,247,897 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3684,238,990 - 4,246,173 (+)NCBIMGSCv36mm8
Celera84,439,329 - 4,448,486 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map81.99NCBI
Map2k7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555631,352,638 - 1,361,598 (-)Ensembl
ChiLan1.0NW_0049555631,352,638 - 1,361,598 (-)NCBIChiLan1.0ChiLan1.0
MAP2K7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22012,586,639 - 12,597,308 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11911,702,668 - 11,714,508 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0197,205,124 - 7,215,776 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1198,058,431 - 8,068,555 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl198,057,598 - 8,066,512 (+)EnsemblpanPan2panpan1.1
MAP2K7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12052,594,450 - 52,604,236 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2052,594,536 - 52,602,150 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2052,396,989 - 52,406,782 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02053,122,659 - 53,132,453 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2053,122,690 - 53,132,448 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12052,325,934 - 52,335,725 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02052,770,533 - 52,780,328 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02053,001,904 - 53,011,707 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Map2k7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118212,942,983 - 212,952,496 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365884,882,184 - 4,892,071 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365884,882,191 - 4,891,807 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP2K7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl271,298,325 - 71,308,124 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1271,299,010 - 71,308,432 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2271,699,410 - 71,708,529 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP2K7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.167,355,387 - 7,365,944 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl67,355,434 - 7,364,398 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666081448,367 - 458,990 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map2k7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624828869,425 - 878,231 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624828869,424 - 878,358 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Map2k7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1162,371,589 - 2,380,894 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Map2k7
70 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:83
Count of miRNA genes:75
Interacting mature miRNAs:82
Transcripts:ENSRNOT00000061821
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12592191825247790Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12115486827Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)12124849755Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1357337Gluco3Glucose level QTL 30.0004adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)12116966671Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
61334Gluco17Glucose level QTL 176.3adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)12116966671Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12111869600Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000061821   ⟹   ENSRNOP00000058535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl127,389,155 - 7,398,239 (+)Ensembl
mRatBN7.2 Ensembl122,591,219 - 2,600,396 (+)Ensembl
Rnor_6.0 Ensembl122,548,218 - 2,555,164 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084460   ⟹   ENSRNOP00000072160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl127,389,267 - 7,398,377 (+)Ensembl
mRatBN7.2 Ensembl122,591,478 - 2,604,222 (+)Ensembl
Rnor_6.0 Ensembl122,548,218 - 2,555,164 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104881   ⟹   ENSRNOP00000086269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl127,389,155 - 7,398,375 (+)Ensembl
mRatBN7.2 Ensembl122,591,219 - 2,604,222 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000145942   ⟹   ENSRNOP00000106236
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl127,389,734 - 7,398,377 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000150250   ⟹   ENSRNOP00000101298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl127,389,867 - 7,398,377 (+)Ensembl
RefSeq Acc Id: NM_001025425   ⟹   NP_001020596
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8127,389,267 - 7,398,377 (+)NCBI
mRatBN7.2122,591,424 - 2,600,534 (+)NCBI
Rnor_6.0122,548,218 - 2,555,164 (-)NCBI
Rnor_5.0124,698,912 - 4,708,078 (-)NCBI
RGSC_v3.4121,545,407 - 1,552,353 (-)RGD
Celera124,407,043 - 4,413,990 (+)RGD
Sequence:
RefSeq Acc Id: NM_001401207   ⟹   NP_001388136
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8127,389,267 - 7,398,377 (+)NCBI
mRatBN7.2122,591,424 - 2,600,534 (+)NCBI
RefSeq Acc Id: XM_006248769   ⟹   XP_006248831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8127,389,032 - 7,398,377 (+)NCBI
mRatBN7.2122,591,312 - 2,600,534 (+)NCBI
Rnor_6.0122,546,278 - 2,555,310 (-)NCBI
Rnor_5.0124,698,912 - 4,708,078 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008768985   ⟹   XP_008767207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8127,389,032 - 7,398,377 (+)NCBI
mRatBN7.2122,591,313 - 2,600,534 (+)NCBI
Rnor_6.0122,546,278 - 2,555,308 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001020596   ⟸   NM_001025425
- Peptide Label: isoform 1
- UniProtKB: Q4KSH7 (UniProtKB/Swiss-Prot),   A6KQ65 (UniProtKB/TrEMBL),   A6KQ61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248831   ⟸   XM_006248769
- Peptide Label: isoform X1
- UniProtKB: A6KQ62 (UniProtKB/TrEMBL),   A6KQ61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767207   ⟸   XM_008768985
- Peptide Label: isoform X2
- UniProtKB: A0A8L2UMW0 (UniProtKB/TrEMBL),   A6KQ63 (UniProtKB/TrEMBL),   A6KQ61 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072160   ⟸   ENSRNOT00000084460
Ensembl Acc Id: ENSRNOP00000058535   ⟸   ENSRNOT00000061821
Ensembl Acc Id: ENSRNOP00000086269   ⟸   ENSRNOT00000104881
RefSeq Acc Id: NP_001388136   ⟸   NM_001401207
- Peptide Label: isoform 2
- UniProtKB: D3XAM6 (UniProtKB/TrEMBL),   A6KQ64 (UniProtKB/TrEMBL),   A0A0G2K2A1 (UniProtKB/TrEMBL),   A6KQ61 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000101298   ⟸   ENSRNOT00000150250
Ensembl Acc Id: ENSRNOP00000106236   ⟸   ENSRNOT00000145942
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4KSH7-F1-model_v2 AlphaFold Q4KSH7 1-419 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698383
Promoter ID:EPDNEW_R8907
Type:initiation region
Name:Map2k7_1
Description:mitogen activated protein kinase kinase 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0122,555,234 - 2,555,294EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560043 AgrOrtholog
BioCyc Gene G2FUF-20352 BioCyc
Ensembl Genes ENSRNOG00000001047 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000061821 ENTREZGENE
  ENSRNOT00000084460 ENTREZGENE
  ENSRNOT00000104881 ENTREZGENE
  ENSRNOT00000104881.1 UniProtKB/Swiss-Prot
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Dual_spec_MAPK_kinase UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:363855 UniProtKB/Swiss-Prot
NCBI Gene 363855 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5 UniProtKB/Swiss-Prot
  PROTEIN KINASE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PharmGKB MAP2K7 RGD
PhenoGen Map2k7 PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001047 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A0G2K2A1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UMW0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L930_RAT UniProtKB/TrEMBL
  A0ABK0LVX7_RAT UniProtKB/TrEMBL
  A6KQ61 ENTREZGENE, UniProtKB/TrEMBL
  A6KQ62 ENTREZGENE, UniProtKB/TrEMBL
  A6KQ63 ENTREZGENE, UniProtKB/TrEMBL
  A6KQ64 ENTREZGENE, UniProtKB/TrEMBL
  A6KQ65 ENTREZGENE, UniProtKB/TrEMBL
  A6KQ66_RAT UniProtKB/TrEMBL
  A6KQ67_RAT UniProtKB/TrEMBL
  D3XAM6 ENTREZGENE
  MP2K7_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-02-09 Map2k7  mitogen activated protein kinase kinase 7      Symbol and Name status set to provisional 70820 PROVISIONAL