Arhgdia (Rho GDP dissociation inhibitor alpha) - Rat Genome Database

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Gene: Arhgdia (Rho GDP dissociation inhibitor alpha) Rattus norvegicus
Analyze
Symbol: Arhgdia
Name: Rho GDP dissociation inhibitor alpha
RGD ID: 1359547
Description: Enables Hsp90 protein binding activity; enzyme binding activity; and fatty acid binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to redox state; and response to clozapine. Located in extracellular space. Is active in synapse. Biomarker of hypertension. Human ortholog(s) of this gene implicated in nephrotic syndrome type 8. Orthologous to human ARHGDIA (Rho GDP dissociation inhibitor alpha); PARTICIPATES IN platelet-derived growth factor signaling pathway; neurotrophic factor signaling pathway; vasopressin signaling pathway via receptor type 2; INTERACTS WITH (R,R,R)-alpha-tocopherol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Bles01; MGC94886; rho GDI 1; Rho GDP dissociation inhibitor (GDI) alpha; rho GDP-dissociation inhibitor 1; rho-GDI alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,352,858 - 106,356,347 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10106,353,491 - 106,356,347 (-)EnsemblGRCr8
mRatBN7.210105,854,526 - 105,858,020 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,854,533 - 105,858,023 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10110,958,544 - 110,962,033 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,421,572 - 110,425,061 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,774,979 - 105,778,468 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,754,012 - 109,757,506 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,754,004 - 109,757,550 (-)Ensemblrn6Rnor6.0
Rnor_5.010109,347,156 - 109,350,645 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410109,967,771 - 109,971,260NCBIRGSC_v3.4RGSC_v3.4rn4
Celera10104,397,938 - 104,401,427 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-naringenin  (ISO)
(Z)-3-butylidenephthalide  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
7,12-dimethyltetraphene  (ISO)
actinomycin D  (ISO)
all-trans-retinoic acid  (ISO)
ampicillin  (ISO)
arachidonic acid  (ISO)
bathocuproine disulfonic acid  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
busulfan  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
chlorpyrifos  (ISO)
choline  (EXP,ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
daidzein  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
desferrioxamine B  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
estriol  (ISO)
estrone  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ferric ammonium citrate  (ISO)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (EXP,ISO)
FR900359  (ISO)
fumonisin B1  (ISO)
furfural  (ISO)
genistein  (ISO)
glycitein  (ISO)
glyphosate  (ISO)
heparin  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
inulin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (EXP,ISO)
L-glutamic acid  (EXP)
L-methionine  (EXP,ISO)
lead(0)  (ISO)
lovastatin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (EXP)
methotrexate  (ISO)
Muconic dialdehyde  (ISO)
nickel atom  (ISO)
nitrates  (ISO)
Nonylphenol  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraoxon  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
progesterone  (ISO)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triacsin C  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
warfarin  (ISO)
WIN 55212-2  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Uterine secretome and its modulation in rat (Rattus norvegicus). Bhutada S, etal., Reproduction. 2013 Jun 14;146(1):13-26. doi: 10.1530/REP-12-0461. Print 2013 Jul.
2. Capturing proteins that bind polyunsaturated fatty acids: demonstration using arachidonic acid and eicosanoids. Brock TG Lipids. 2008 Feb;43(2):161-9. Epub 2007 Dec 15.
3. Two-dimensional gel electrophoresis revealed antipsychotic drugs induced protein expression modulations in C6 glioma cells. Chen ML Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jan 10;40:1-11. doi: 10.1016/j.pnpbp.2012.08.013. Epub 2012 Aug 31.
4. Modulation of GDP-dissociation inhibitor protein membrane retention by the cellular redox state in adipocytes. Chinni SR, etal., Exp Cell Res. 1998 Jul 10;242(1):373-80.
5. Cellular function of RhoGDI-alpha mediates the cycling of Rac1 and the regulation of pancreatic beta cell death. Cho Y, etal., Transplant Proc. 2012 May;44(4):1083-5. doi: 10.1016/j.transproceed.2012.03.021.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. KANK deficiency leads to podocyte dysfunction and nephrotic syndrome. Gee HY, etal., J Clin Invest. 2015 Jun;125(6):2375-84. doi: 10.1172/JCI79504. Epub 2015 May 11.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase. Li X and Lee AY, J Biol Chem. 2010 Oct 15;285(42):32436-45. doi: 10.1074/jbc.M110.120451. Epub 2010 Aug 9.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Regulation of RhoA signaling by the cAMP-dependent phosphorylation of RhoGDIalpha. Oishi A, etal., J Biol Chem. 2012 Nov 9;287(46):38705-15. doi: 10.1074/jbc.M112.401547. Epub 2012 Sep 25.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. Cellular regulation of basal tone in internal anal sphincter smooth muscle by RhoA/ROCK. Patel CA and Rattan S, Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1747-56. Epub 2007 Mar 22.
14. Role of Rho GDP dissociation inhibitor alpha in control of epithelial sodium channel (ENaC)-mediated sodium reabsorption. Pavlov TS, etal., J Biol Chem. 2014 Oct 10;289(41):28651-9. doi: 10.1074/jbc.M114.558262. Epub 2014 Aug 27.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. Role of Rac and Rho-GDI alpha in the frequency-dependent expression of h1-calponin in vascular smooth muscle cells under cyclic mechanical strain. Qu MJ, etal., Ann Biomed Eng. 2008 Sep;36(9):1481-8. doi: 10.1007/s10439-008-9521-0. Epub 2008 Jun 20.
18. Hsp90 Co-localizes with Rab-GDI-1 and regulates agonist-induced amylase release in AR42J cells. Raffaniello R, etal., Cell Physiol Biochem. 2009;24(5-6):369-78. doi: 10.1159/000257429. Epub 2009 Nov 4.
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
23. Characterization of a Rac1- and RhoGDI-associated lipid kinase signaling complex. Tolias KF, etal., Mol Cell Biol. 1998 Feb;18(2):762-70.
24. Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation. Wei L, etal., Development 2002 Apr;129(7):1705-14.
25. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
26. Identification of potential therapeutic targets in hypertension-associated bladder dysfunction. Yono M, etal., BJU Int. 2010 Mar;105(6):877-83. doi: 10.1111/j.1464-410X.2009.08809.x. Epub 2009 Aug 18.
Additional References at PubMed
PMID:8262133   PMID:8939998   PMID:11728336   PMID:15093731   PMID:16854843   PMID:17506542   PMID:17963997   PMID:18540023   PMID:19056867   PMID:19103160   PMID:19575003   PMID:19581409  
PMID:20069557   PMID:20458337   PMID:20696841   PMID:21572420   PMID:22082260   PMID:22871113   PMID:23376485   PMID:23533145   PMID:24129566   PMID:24815167   PMID:25074804   PMID:25367882  
PMID:26593060   PMID:26971292   PMID:27841340   PMID:31029634   PMID:35080740  


Genomics

Comparative Map Data
Arhgdia
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,352,858 - 106,356,347 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10106,353,491 - 106,356,347 (-)EnsemblGRCr8
mRatBN7.210105,854,526 - 105,858,020 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,854,533 - 105,858,023 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10110,958,544 - 110,962,033 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,421,572 - 110,425,061 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,774,979 - 105,778,468 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,754,012 - 109,757,506 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,754,004 - 109,757,550 (-)Ensemblrn6Rnor6.0
Rnor_5.010109,347,156 - 109,350,645 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410109,967,771 - 109,971,260NCBIRGSC_v3.4RGSC_v3.4rn4
Celera10104,397,938 - 104,401,427 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
ARHGDIA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381781,867,721 - 81,871,337 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1781,867,719 - 81,871,378 (-)Ensemblhg38GRCh38
GRCh371779,825,597 - 79,829,213 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361777,418,886 - 77,422,527 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341777,418,886 - 77,422,527NCBI
Celera1776,429,063 - 76,432,256 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1775,227,385 - 75,230,633 (-)NCBIHuRef
CHM1_11779,911,833 - 79,915,499 (-)NCBICHM1_1
T2T-CHM13v2.01782,734,886 - 82,738,502 (-)NCBIT2T-CHM13v2.0
Arhgdia
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911120,468,925 - 120,472,450 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11120,468,930 - 120,472,450 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3811120,578,099 - 120,581,624 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,578,104 - 120,581,624 (-)Ensemblmm10GRCm38
MGSCv3711120,438,549 - 120,442,934 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611120,394,202 - 120,397,337 (-)NCBIMGSCv36mm8
Celera11132,312,595 - 132,316,911 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.29NCBI
Arhgdia
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555061,297,956 - 1,300,072 (+)Ensembl
ChiLan1.0NW_0049555061,297,604 - 1,300,072 (+)NCBIChiLan1.0ChiLan1.0
ARHGDIA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21998,403,714 - 98,407,602 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117103,304,488 - 103,308,215 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01776,273,196 - 76,276,942 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11781,975,340 - 81,978,447 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1781,975,340 - 81,978,447 (-)EnsemblpanPan2panpan1.1
ARHGDIA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.19419,350 - 422,284 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl9419,413 - 423,252 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha91,021,510 - 1,024,385 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.091,012,711 - 1,015,586 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl91,012,165 - 1,078,415 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.191,037,876 - 1,040,773 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.091,164,453 - 1,167,349 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.091,243,370 - 1,246,265 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Arhgdia
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056021,025,305 - 1,027,650 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365945,383,380 - 5,386,494 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365945,383,370 - 5,386,618 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGDIA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl121,113,379 - 1,119,315 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1121,113,358 - 1,117,319 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ARHGDIA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11673,741,402 - 73,745,079 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1673,740,944 - 73,745,062 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607745,193,459 - 45,197,177 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgdia
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480110,717,133 - 10,722,840 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462480110,719,987 - 10,723,263 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Arhgdia
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1963,441,216 - 63,444,762 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Arhgdia
11 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:187
Count of miRNA genes:120
Interacting mature miRNAs:149
Transcripts:ENSRNOT00000054957
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093723381107556066Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1097202388107556066Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1097202388107556066Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000054957   ⟹   ENSRNOP00000051840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10106,353,491 - 106,356,347 (-)Ensembl
mRatBN7.2 Ensembl10105,854,561 - 105,858,023 (-)Ensembl
Rnor_6.0 Ensembl10109,754,004 - 109,757,550 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114464   ⟹   ENSRNOP00000080561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10105,854,533 - 105,857,651 (-)Ensembl
RefSeq Acc Id: NM_001007005   ⟹   NP_001007006
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,352,858 - 106,356,347 (-)NCBI
mRatBN7.210105,854,531 - 105,858,020 (-)NCBI
Rnor_6.010109,754,017 - 109,757,506 (-)NCBI
Rnor_5.010109,347,156 - 109,350,645 (-)NCBI
RGSC_v3.410109,967,771 - 109,971,260 (-)RGD
Celera10104,397,938 - 104,401,427 (-)RGD
Sequence:
RefSeq Acc Id: XM_006247897   ⟹   XP_006247959
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,352,858 - 106,356,207 (-)NCBI
mRatBN7.210105,854,526 - 105,857,645 (-)NCBI
Rnor_6.010109,754,012 - 109,757,110 (-)NCBI
Rnor_5.010109,347,156 - 109,350,645 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247898   ⟹   XP_006247960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,352,858 - 106,356,173 (-)NCBI
mRatBN7.210105,854,526 - 105,857,661 (-)NCBI
Rnor_6.010109,754,012 - 109,757,116 (-)NCBI
Rnor_5.010109,347,156 - 109,350,645 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001007006   ⟸   NM_001007005
- UniProtKB: Q5XI73 (UniProtKB/Swiss-Prot),   A6HLF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247960   ⟸   XM_006247898
- Peptide Label: isoform X1
- UniProtKB: Q5XI73 (UniProtKB/Swiss-Prot),   A6HLF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247959   ⟸   XM_006247897
- Peptide Label: isoform X1
- UniProtKB: Q5XI73 (UniProtKB/Swiss-Prot),   A6HLF5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000051840   ⟸   ENSRNOT00000054957
Ensembl Acc Id: ENSRNOP00000080561   ⟸   ENSRNOT00000114464

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XI73-F1-model_v2 AlphaFold Q5XI73 1-204 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697965
Promoter ID:EPDNEW_R8489
Type:initiation region
Name:Arhgdia_1
Description:Rho GDP dissociation inhibitor alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010109,757,495 - 109,757,555EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359547 AgrOrtholog
BioCyc Gene G2FUF-22407 BioCyc
Ensembl Genes ENSRNOG00000036688 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000114464.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.70.50.30 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7110945 IMAGE-MGC_LOAD
InterPro Ig_E-set UniProtKB/Swiss-Prot
  Rho_GDI UniProtKB/Swiss-Prot
  RhoGDI_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:360678 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94886 IMAGE-MGC_LOAD
NCBI Gene 360678 ENTREZGENE
PANTHER PTHR10980 UniProtKB/Swiss-Prot
  RHO GDP-DISSOCIATION INHIBITOR 1 UniProtKB/Swiss-Prot
Pfam Rho_GDI UniProtKB/Swiss-Prot
PhenoGen Arhgdia PhenoGen
PRINTS RHOGDI UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000036688 RatGTEx
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot
UniProt A0A8L2QPB4_RAT UniProtKB/TrEMBL
  A6HLF1_RAT UniProtKB/TrEMBL
  A6HLF5 ENTREZGENE, UniProtKB/TrEMBL
  GDIR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Arhgdia  Rho GDP dissociation inhibitor alpha  Arhgdia  Rho GDP dissociation inhibitor (GDI) alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Arhgdia  Rho GDP dissociation inhibitor (GDI) alpha      Symbol and Name status set to approved 1299863 APPROVED
2005-07-29 Arhgdia  Rho GDP dissociation inhibitor (GDI) alpha      Symbol and Name status set to provisional 70820 PROVISIONAL