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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359547 Species: Rattus norvegicus RGD Object: Gene Symbol: Arhgdia Name: Rho GDP dissociation inhibitor (GDI) alpha

Acc ID: CHEBI:44185 Term: methotrexate Definition: A pteridine that has formula C20H22N8O5. CasRN: 59-05-2 Chemical ID: MESH:D008727

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects response to substance	ISO	RGD:1354371	6480464	CTD	ARHGDIA protein affects the susceptibility to Methotrexate	PMID:16217747