Irf4 (interferon regulatory factor 4) - Rat Genome Database

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Gene: Irf4 (interferon regulatory factor 4) Rattus norvegicus
Analyze
Symbol: Irf4
Name: interferon regulatory factor 4
RGD ID: 1308050
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including T-helper 17 cell lineage commitment; defense response to protozoan; and positive regulation of macromolecule biosynthetic process. Predicted to act upstream of or within several processes, including myeloid dendritic cell differentiation; negative regulation of toll-like receptor signaling pathway; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be part of nucleosome. Predicted to be active in nucleus. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in hematologic cancer (multiple) and pigmentation disease. Orthologous to human IRF4 (interferon regulatory factor 4); PARTICIPATES IN interleukin-4 signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC291100
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81733,930,460 - 33,948,842 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1733,930,471 - 33,948,730 (-)EnsemblGRCr8
mRatBN7.21733,721,800 - 33,742,570 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1733,721,811 - 33,740,070 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1733,560,168 - 33,578,389 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01735,164,039 - 35,182,262 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01733,555,976 - 33,574,191 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01734,886,746 - 34,905,191 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1734,886,739 - 34,905,117 (-)Ensemblrn6Rnor6.0
Rnor_5.01738,499,069 - 38,517,524 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41740,170,409 - 40,189,976 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1733,262,619 - 33,280,861 (-)NCBICelera
RGSC_v3.11740,176,635 - 40,190,951 (-)NCBI
Cytogenetic Map17p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
benzo[a]pyrene  (ISO)
benzoates  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
ethyl methanesulfonate  (ISO)
ethylparaben  (ISO)
ferroheme b  (ISO)
flavonoids  (ISO)
fluvastatin  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
glyphosate  (EXP)
heme b  (ISO)
hexadecanoic acid  (ISO)
hydroxychloroquine  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
ionomycin  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
metam  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
mevalonic acid  (ISO)
mevastatin  (ISO)
nickel atom  (ISO)
nitrates  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
pomalidomide  (ISO)
pyrrolidine dithiocarbamate  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
tenofovir disoproxil fumarate  (EXP)
testosterone  (EXP)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleosome  (IEA,ISO)
nucleus  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Implication of IRF4 aberrant gene expression in the acute leukemias of childhood. Adamaki M, etal., PLoS One. 2013 Aug 15;8(8):e72326. doi: 10.1371/journal.pone.0072326. eCollection 2013.
2. Variant IRF4/MUM1 associates with CD38 status and treatment-free survival in chronic lymphocytic leukaemia. Allan JM, etal., Leukemia. 2010 Apr;24(4):877-81. doi: 10.1038/leu.2009.298. Epub 2010 Jan 21.
3. Expression of MUM1/IRF4 correlates with clinical outcome in patients with B-cell chronic lymphocytic leukemia. Chang CC, etal., Blood. 2002 Dec 15;100(13):4671-5. Epub 2002 Aug 1.
4. Fine-scale mapping of the 6p25.3 chronic lymphocytic leukaemia susceptibility locus. Crowther-Swanepoel D, etal., Hum Mol Genet. 2010 May 1;19(9):1840-5. doi: 10.1093/hmg/ddq044. Epub 2010 Feb 1.
5. An intronic polymorphism of IRF4 gene influences gene transcription in vitro and shows a risk association with childhood acute lymphoblastic leukemia in males. Do TN, etal., Biochim Biophys Acta. 2010 Feb;1802(2):292-300. doi: 10.1016/j.bbadis.2009.10.015. Epub 2009 Nov 6.
6. Recurrent translocations involving the IRF4 oncogene locus in peripheral T-cell lymphomas. Feldman AL, etal., Leukemia. 2009 Mar;23(3):574-80. doi: 10.1038/leu.2008.320. Epub 2008 Nov 6.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. IRF4 mutations in chronic lymphocytic leukemia. Havelange V, etal., Blood. 2011 Sep 8;118(10):2827-9. doi: 10.1182/blood-2011-04-350579. Epub 2011 Jul 25.
10. Expression of MUM1/IRF4 mRNA as a prognostic marker in patients with multiple myeloma. Heintel D, etal., Leukemia. 2008 Feb;22(2):441-5. Epub 2007 Aug 9.
11. Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma. Iida S, etal., Nat Genet. 1997 Oct;17(2):226-30.
12. MUM1/IRF4 expression is an unfavorable prognostic factor in B-cell chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). Ito M, etal., Jpn J Cancer Res. 2002 Jun;93(6):685-94.
13. Role of interferon regulatory factor 4 in the regulation of pathological cardiac hypertrophy. Jiang DS, etal., Hypertension. 2013 Jun;61(6):1193-202. doi: 10.1161/HYPERTENSIONAHA.111.00614. Epub 2013 Apr 15.
14. Cooperation between deficiencies of IRF-4 and IRF-8 promotes both myeloid and lymphoid tumorigenesis. Jo SH, etal., Blood. 2010 Oct 14;116(15):2759-67. doi: 10.1182/blood-2009-07-234559. Epub 2010 Jun 28.
15. IRF4 is a key thermogenic transcriptional partner of PGC-1alpha. Kong X, etal., Cell. 2014 Jul 3;158(1):69-83. doi: 10.1016/j.cell.2014.04.049.
16. Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong. Lan Q, etal., Eur J Haematol. 2010 Dec;85(6):492-5. doi: 10.1111/j.1600-0609.2010.01518.x.
17. Expression of interleukin-9 and its upstream stimulating factors in rats with ischemic stroke. Lin Y, etal., Neurol Sci. 2015 Jun;36(6):913-20. doi: 10.1007/s10072-015-2096-2. Epub 2015 Feb 5.
18. Lenalidomide downregulates the cell survival factor, interferon regulatory factor-4, providing a potential mechanistic link for predicting response. Lopez-Girona A, etal., Br J Haematol. 2011 Aug;154(3):325-36. doi: 10.1111/j.1365-2141.2011.08689.x. Epub 2011 Jun 24.
19. Accelerated development of chronic lymphocytic leukemia in New Zealand Black mice expressing a low level of interferon regulatory factor 4. Ma S, etal., J Biol Chem. 2013 Sep 13;288(37):26430-40. doi: 10.1074/jbc.M113.475913. Epub 2013 Jul 29.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. MUM1 expression dichotomises follicular lymphoma into predominantly, MUM1-negative low-grade and MUM1-positive high-grade subtypes. Naresh KN Haematologica. 2007 Feb;92(2):267-8.
22. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
23. IRF4 is a suppressor of c-Myc induced B cell leukemia. Pathak S, etal., PLoS One. 2011;6(7):e22628. doi: 10.1371/journal.pone.0022628. Epub 2011 Jul 27.
24. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Comprehensive gene review and curation RGD comprehensive gene curation
27. Nuclear protein dysregulation in lymphoplasmacytic lymphoma/waldenstrom macroglobulinemia. Roberts MJ, etal., Am J Clin Pathol. 2013 Feb;139(2):210-9. doi: 10.1309/AJCP0YGM8BLFYHJY.
28. A role for IRF4 in the development of CLL. Shukla V, etal., Blood. 2013 Oct 17;122(16):2848-55. doi: 10.1182/blood-2013-03-492769. Epub 2013 Aug 7.
29. Dual mechanisms by which miR-125b represses IRF4 to induce myeloid and B-cell leukemias. So AY, etal., Blood. 2014 Aug 28;124(9):1502-12. doi: 10.1182/blood-2014-02-553842. Epub 2014 Jul 8.
30. Expression of the bcl-6 and MUM1/IRF4 proteins correlate with overall and disease-specific survival in patients with primary cutaneous large B-cell lymphoma: a tissue microarray study. Sundram U, etal., J Cutan Pathol. 2005 Mar;32(3):227-34.
31. Detection of MUM1/IRF4-IgH fusion in multiple myeloma. Yoshida S, etal., Leukemia. 1999 Nov;13(11):1812-6.
Additional References at PubMed
PMID:12374808   PMID:15184678   PMID:15959530   PMID:16236719   PMID:16428437   PMID:19946888   PMID:22948820   PMID:22983707   PMID:22992523   PMID:22992524   PMID:24627105   PMID:28851732  
PMID:34628795  


Genomics

Comparative Map Data
Irf4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81733,930,460 - 33,948,842 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1733,930,471 - 33,948,730 (-)EnsemblGRCr8
mRatBN7.21733,721,800 - 33,742,570 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1733,721,811 - 33,740,070 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1733,560,168 - 33,578,389 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01735,164,039 - 35,182,262 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01733,555,976 - 33,574,191 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01734,886,746 - 34,905,191 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1734,886,739 - 34,905,117 (-)Ensemblrn6Rnor6.0
Rnor_5.01738,499,069 - 38,517,524 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41740,170,409 - 40,189,976 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1733,262,619 - 33,280,861 (-)NCBICelera
RGSC_v3.11740,176,635 - 40,190,951 (-)NCBI
Cytogenetic Map17p12NCBI
IRF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386391,752 - 411,443 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6391,739 - 411,443 (+)Ensemblhg38GRCh38
GRCh376391,752 - 411,443 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366336,760 - 356,193 (+)NCBIBuild 36Build 36hg18NCBI36
Build 346336,759 - 356,193NCBI
Celera61,620,599 - 1,639,926 (+)NCBICelera
Cytogenetic Map6p25.3NCBI
HuRef6264,308 - 284,078 (+)NCBIHuRef
CHM1_16393,650 - 413,301 (+)NCBICHM1_1
T2T-CHM13v2.06250,136 - 269,771 (+)NCBIT2T-CHM13v2.0
Irf4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391330,933,191 - 30,950,965 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1330,933,209 - 30,950,959 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381330,749,233 - 30,766,981 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1330,749,226 - 30,766,976 (+)Ensemblmm10GRCm38
MGSCv371330,841,127 - 30,858,796 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361330,756,723 - 30,774,392 (+)NCBIMGSCv36mm8
Celera1330,963,334 - 30,981,003 (+)NCBICelera
Cytogenetic Map13A3.2NCBI
cM Map1313.28NCBI
Irf4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546512,497,462 - 12,513,106 (-)Ensembl
ChiLan1.0NW_00495546512,497,534 - 12,512,529 (-)NCBIChiLan1.0ChiLan1.0
IRF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2515,006,113 - 15,026,173 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1610,998,041 - 11,017,502 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06206,282 - 226,487 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16341,637 - 360,492 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6342,718 - 356,654 (+)EnsemblpanPan2panpan1.1
IRF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.135760,367 - 782,314 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl35767,011 - 781,339 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha35777,727 - 796,599 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.035714,152 - 737,540 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl35714,202 - 738,113 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.135700,365 - 719,274 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.035718,232 - 734,827 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0352,054,228 - 2,070,812 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Irf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494625,039,805 - 25,055,378 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366331,564,637 - 1,580,859 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366331,565,293 - 1,580,859 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7133,371 - 149,609 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.17133,358 - 149,609 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
IRF4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11771,739,920 - 71,758,811 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666044315,955 - 334,864 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Irf4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475623,918,323 - 23,931,501 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475623,917,111 - 23,931,482 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Irf4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11449,785,990 - 49,800,081 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Irf4
141 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:491
Count of miRNA genes:248
Interacting mature miRNAs:322
Transcripts:ENSRNOT00000024494
Prediction methods:Miranda, Pita, Pita,Targetscan, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173219953449497050Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172149899450592236Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173219953455604694Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 89 88 57 92 57 6 353 192 11 138 80 91 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000079332   ⟹   ENSRNOP00000070345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1733,721,811 - 33,739,449 (-)Ensembl
Rnor_6.0 Ensembl1734,886,739 - 34,903,862 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088931   ⟹   ENSRNOP00000074106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1733,930,471 - 33,948,730 (-)Ensembl
mRatBN7.2 Ensembl1733,721,811 - 33,740,070 (-)Ensembl
Rnor_6.0 Ensembl1734,886,746 - 34,905,117 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098421   ⟹   ENSRNOP00000086418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1733,930,471 - 33,948,730 (-)Ensembl
mRatBN7.2 Ensembl1733,721,811 - 33,739,449 (-)Ensembl
RefSeq Acc Id: NM_001106108   ⟹   NP_001099578
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81733,930,471 - 33,948,730 (-)NCBI
mRatBN7.21733,721,811 - 33,740,070 (-)NCBI
Rnor_6.01734,886,746 - 34,905,117 (-)NCBI
Rnor_5.01738,499,069 - 38,517,524 (+)NCBI
RGSC_v3.41740,170,409 - 40,189,976 (-)RGD
Celera1733,262,619 - 33,280,861 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253899   ⟹   XP_006253961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81733,930,460 - 33,948,842 (-)NCBI
mRatBN7.21733,721,800 - 33,742,570 (-)NCBI
Rnor_6.01734,889,379 - 34,905,190 (-)NCBI
Rnor_5.01738,499,069 - 38,517,524 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006253900   ⟹   XP_006253962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81733,930,460 - 33,948,842 (-)NCBI
mRatBN7.21733,721,800 - 33,742,569 (-)NCBI
Rnor_6.01734,889,379 - 34,905,191 (-)NCBI
Rnor_5.01738,499,069 - 38,517,524 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001099578 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253961 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253962 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL98364 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074106
  ENSRNOP00000074106.1
  ENSRNOP00000086418
  ENSRNOP00000086418.2
RefSeq Acc Id: NP_001099578   ⟸   NM_001106108
- UniProtKB: D3ZEX6 (UniProtKB/TrEMBL),   A6J7L4 (UniProtKB/TrEMBL),   A0A0G2JXN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253962   ⟸   XM_006253900
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A257 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253961   ⟸   XM_006253899
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JXN7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070345   ⟸   ENSRNOT00000079332
Ensembl Acc Id: ENSRNOP00000074106   ⟸   ENSRNOT00000088931
Ensembl Acc Id: ENSRNOP00000086418   ⟸   ENSRNOT00000098421
Protein Domains
IRF tryptophan pentad repeat

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZEX6-F1-model_v2 AlphaFold D3ZEX6 1-450 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700425
Promoter ID:EPDNEW_R10947
Type:single initiation site
Name:Irf4_1
Description:interferon regulatory factor 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01734,905,136 - 34,905,196EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308050 AgrOrtholog
BioCyc Gene G2FUF-9538 BioCyc
Ensembl Genes ENSRNOG00000061070 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000088931 ENTREZGENE
  ENSRNOT00000088931.3 UniProtKB/TrEMBL
  ENSRNOT00000098421 ENTREZGENE
  ENSRNOT00000098421.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  2.60.200.10 UniProtKB/TrEMBL
InterPro Interferon_reg_fac_CS UniProtKB/TrEMBL
  Interferon_reg_factor UniProtKB/TrEMBL
  Interferon_reg_factor-3 UniProtKB/TrEMBL
  SMAD_dom-like UniProtKB/TrEMBL
  SMAD_FHA_domain UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:291100 UniProtKB/TrEMBL
NCBI Gene 291100 ENTREZGENE
PANTHER INTERFERON REGULATORY FACTOR UniProtKB/TrEMBL
  INTERFERON REGULATORY FACTOR 4 UniProtKB/TrEMBL
Pfam IRF UniProtKB/TrEMBL
  IRF-3 UniProtKB/TrEMBL
PhenoGen Irf4 PhenoGen
PRINTS INTFRNREGFCT UniProtKB/TrEMBL
PROSITE IRF UniProtKB/TrEMBL
  IRF_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000061070 RatGTEx
SMART IRF UniProtKB/TrEMBL
  IRF-3 UniProtKB/TrEMBL
Superfamily-SCOP SMAD_FHA UniProtKB/TrEMBL
  SSF46785 UniProtKB/TrEMBL
UniProt A0A0G2JXN7 ENTREZGENE
  A0A8I6A257 ENTREZGENE, UniProtKB/TrEMBL
  A6J7L4 ENTREZGENE, UniProtKB/TrEMBL
  D3ZEX6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Irf4  interferon regulatory factor 4   Irf4_predicted  interferon regulatory factor 4 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Irf4_predicted  interferon regulatory factor 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED