RGD Reference Report - Nuclear protein dysregulation in lymphoplasmacytic lymphoma/waldenstrom macroglobulinemia. - Rat Genome Database

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Nuclear protein dysregulation in lymphoplasmacytic lymphoma/waldenstrom macroglobulinemia.

Authors: Roberts, MJ  Chadburn, A  Ma, S  Hyjek, E  Peterson, LC 
Citation: Roberts MJ, etal., Am J Clin Pathol. 2013 Feb;139(2):210-9. doi: 10.1309/AJCP0YGM8BLFYHJY.
RGD ID: 11530052
Pubmed: PMID:23355206   (View Abstract at PubMed)
DOI: DOI:10.1309/AJCP0YGM8BLFYHJY   (Journal Full-text)

Waldenstrom macroglobulinemia (WM) is characterized by monoclonal gammopathy, usually IgM, in association with lymphoplasmacytic lymphoma (LPL). Little is known of the expression of nuclear proteins involved in B-cell development in LPL/WM. In this study, the expression patterns of PAX5/BSAP, MUM1/IRF4, and PRDM1/BLIMP1 were analyzed in plasma cells and lymphocytes in 29 cases of newly diagnosed LPL/WM by double immunohistochemical staining with CD138 and CD22. These patterns were compared with the expression profiles seen in normal bone marrow samples, reactive tonsils, and cases of plasma cell myeloma and marginal zone lymphoma. The median percentage of plasma cells coexpressing CD138 and PAX5 was significantly higher in LPL/WM compared with benign tissues (P = .001), marginal zone lymphoma (P = .002), and plasma cell myeloma (P < .0001), whereas the median percentage of plasma cells coexpressing CD138 and MUM1 was lower in LPL/WM than plasma cells in benign tissues (P = .02), marginal zone lymphoma (P = .001), and plasma cell myeloma (P = .0002). These findings show that a subset of plasma cells in LPL/WM demonstrates a nuclear protein expression pattern characteristic of the B-cell developmental program. Thus, the results better define the immunophenotypic profile of the neoplastic cells in LPL/WM.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
lymphoplasmacytic lymphoma  IEP 11530052 RGD 
lymphoplasmacytic lymphoma  ISOIRF4 (Homo sapiens)11530052; 11530052 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Irf4  (interferon regulatory factor 4)

Genes (Mus musculus)
Irf4  (interferon regulatory factor 4)

Genes (Homo sapiens)
IRF4  (interferon regulatory factor 4)


Additional Information