Usp7 (ubiquitin specific peptidase 7) - Rat Genome Database

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Gene: Usp7 (ubiquitin specific peptidase 7) Rattus norvegicus
Analyze
Symbol: Usp7
Name: ubiquitin specific peptidase 7
RGD ID: 1306915
Description: Enables cysteine-type deubiquitinase activity and identical protein binding activity. Involved in positive regulation of apoptotic process; protein deubiquitination; and regulation of protein stability. Predicted to be located in XY body and cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in PML body and cytosol. Orthologous to human USP7 (ubiquitin specific peptidase 7); PARTICIPATES IN p53 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: deubiquitinating enzyme 7; Hausp; herpes-virus-associated ubiquitin-specific protease; herpesvirus-associated ubiquitin-specific protease; LOC360471; rHAUSP; ubiquitin carboxyl-terminal hydrolase 7; ubiquitin specific peptidase 7 (herpes virus-associated); ubiquitin specific protease 7 (herpes virus-associated); ubiquitin thioesterase 7; ubiquitin-specific-processing protease 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8107,335,508 - 7,432,018 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl107,367,604 - 7,432,013 (+)EnsemblGRCr8
mRatBN7.2106,880,684 - 6,925,355 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl106,828,795 - 6,925,355 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1011,588,325 - 11,631,578 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01011,084,682 - 11,128,048 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0106,735,783 - 6,779,154 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0106,930,462 - 7,019,910 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl106,975,244 - 7,018,930 (+)Ensemblrn6Rnor6.0
Rnor_5.0105,752,834 - 5,822,229 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4106,917,612 - 6,963,452 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera105,876,459 - 5,919,649 (+)NCBICelera
RGSC_v3.1106,917,611 - 6,963,451 (+)NCBI
Cytogenetic Map10q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
ABT-737  (ISO)
aflatoxin B1  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
chloroprene  (EXP)
chloroquine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cocaine  (EXP)
Cuprizon  (ISO)
cycloheximide  (ISO)
cytarabine  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
doxorubicin  (EXP,ISO)
enzyme inhibitor  (ISO)
esculin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (EXP)
gentamycin  (EXP)
haloperidol  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
methidathion  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nefazodone  (EXP)
oxaliplatin  (EXP)
paracetamol  (EXP)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (ISO)
phlorizin  (ISO)
picoxystrobin  (ISO)
pinosylvin  (ISO)
pyrimidifen  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sirolimus  (ISO)
sirtinol  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
topotecan  (EXP)
trans-pinosylvin  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IEA)
cytoplasm  (IEA,ISO)
cytosol  (IBA,IEA,ISO)
nuclear body  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO,ISS)
PML body  (IEA,ISO)
protein-containing complex  (IEA,ISO)
XY body  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Molecular cloning of rHAUSP encoding a deubiquitinating enzyme in rat testis. Baek KH, etal., Oncol Rep. 2006 Jan;15(1):173-7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Modes of p53 regulation. Kruse JP and Gu W, Cell. 2009 May 15;137(4):609-22. doi: 10.1016/j.cell.2009.04.050.
5. HAUSP, a deubiquitinating enzyme for p53, is polyubiquitinated, polyneddylated, and dimerized. Lee HJ, etal., FEBS Lett. 2005 Aug 29;579(21):4867-72.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:11279055   PMID:11923872   PMID:12093161   PMID:16791210   PMID:16964248   PMID:18410486   PMID:18566590   PMID:19182904   PMID:20096447   PMID:21258371   PMID:21268065   PMID:21745816  
PMID:22466612   PMID:25172512   PMID:25634095   PMID:25944111   PMID:26280536   PMID:26678539   PMID:27123980   PMID:27863226   PMID:28655758   PMID:33157209   PMID:33170804   PMID:33241864  
PMID:35538032   PMID:37257587  


Genomics

Comparative Map Data
Usp7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8107,335,508 - 7,432,018 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl107,367,604 - 7,432,013 (+)EnsemblGRCr8
mRatBN7.2106,880,684 - 6,925,355 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl106,828,795 - 6,925,355 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1011,588,325 - 11,631,578 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01011,084,682 - 11,128,048 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0106,735,783 - 6,779,154 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0106,930,462 - 7,019,910 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl106,975,244 - 7,018,930 (+)Ensemblrn6Rnor6.0
Rnor_5.0105,752,834 - 5,822,229 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4106,917,612 - 6,963,452 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera105,876,459 - 5,919,649 (+)NCBICelera
RGSC_v3.1106,917,611 - 6,963,451 (+)NCBI
Cytogenetic Map10q12NCBI
USP7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38168,892,097 - 8,963,906 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl168,892,097 - 8,975,328 (-)Ensemblhg38GRCh38
GRCh37168,985,954 - 9,057,763 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36168,893,452 - 8,964,842 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34168,894,850 - 8,964,842NCBI
Celera169,152,724 - 9,223,882 (-)NCBICelera
Cytogenetic Map16p13.2NCBI
HuRef168,907,081 - 8,945,418 (-)NCBIHuRef
CHM1_1168,985,936 - 9,057,340 (-)NCBICHM1_1
T2T-CHM13v2.0168,924,836 - 8,996,578 (-)NCBIT2T-CHM13v2.0
Usp7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39168,506,586 - 8,574,931 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl168,507,459 - 8,610,172 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38168,688,722 - 8,757,067 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl168,689,595 - 8,792,308 (-)Ensemblmm10GRCm38
MGSCv37168,688,815 - 8,738,435 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36168,606,101 - 8,653,606 (-)NCBIMGSCv36mm8
Celera169,334,440 - 9,362,384 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map164.28NCBI
Usp7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554429,315,225 - 9,356,393 (+)Ensembl
ChiLan1.0NW_0049554429,316,022 - 9,355,751 (+)NCBIChiLan1.0ChiLan1.0
USP7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2189,431,901 - 9,501,001 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11613,210,502 - 13,278,888 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0167,825,332 - 7,895,095 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1169,065,366 - 9,106,406 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl169,065,858 - 9,106,146 (-)EnsemblpanPan2panpan1.1
USP7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1633,277,328 - 33,315,601 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl633,277,444 - 33,314,491 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha634,641,327 - 34,706,509 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0633,449,047 - 33,514,314 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl633,448,218 - 33,514,312 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1633,251,796 - 33,316,926 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0633,121,375 - 33,186,820 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0633,570,486 - 33,608,545 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Usp7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344109,848,236 - 109,882,862 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365307,694,379 - 7,724,684 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365307,693,681 - 7,724,215 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USP7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl333,775,829 - 33,810,465 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1333,754,357 - 33,810,480 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2334,686,115 - 34,742,973 (-)NCBISscrofa10.2Sscrofa10.2susScr3
USP7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.158,470,137 - 8,540,736 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl58,469,230 - 8,540,770 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606821,677,314 - 21,749,766 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Usp7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248246,276,354 - 6,338,227 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248246,277,111 - 6,338,051 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Usp7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1913,297,811 - 13,341,813 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Usp7
840 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:32
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000046232
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat

Markers in Region
RH143229  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8107,428,098 - 7,428,295 (+)Marker Load Pipeline
mRatBN7.2106,921,435 - 6,921,632 (+)MAPPERmRatBN7.2
Rnor_6.0107,015,988 - 7,016,184NCBIRnor6.0
Rnor_5.0105,818,307 - 5,818,503UniSTSRnor5.0
RGSC_v3.4106,960,708 - 6,960,904UniSTSRGSC3.4
Celera105,916,898 - 5,917,094UniSTS
RH 3.4 Map1067.21UniSTS
Cytogenetic Map10q12UniSTS
RH140275  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8107,430,391 - 7,430,857 (+)Marker Load Pipeline
mRatBN7.2106,923,728 - 6,924,194 (+)MAPPERmRatBN7.2
Rnor_6.0107,018,281 - 7,018,746NCBIRnor6.0
Rnor_5.0105,820,600 - 5,821,065UniSTSRnor5.0
RGSC_v3.4106,963,001 - 6,963,466UniSTSRGSC3.4
Celera105,919,198 - 5,919,663UniSTS
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000046232   ⟹   ENSRNOP00000041134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl107,403,358 - 7,432,013 (+)Ensembl
mRatBN7.2 Ensembl106,896,691 - 6,925,355 (+)Ensembl
Rnor_6.0 Ensembl106,975,244 - 7,018,930 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094143   ⟹   ENSRNOP00000093874
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl107,399,238 - 7,432,013 (+)Ensembl
mRatBN7.2 Ensembl106,892,557 - 6,925,355 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095866   ⟹   ENSRNOP00000081458
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl106,895,653 - 6,925,355 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100242   ⟹   ENSRNOP00000096267
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl107,387,014 - 7,432,013 (+)Ensembl
mRatBN7.2 Ensembl106,880,020 - 6,925,355 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112945   ⟹   ENSRNOP00000088505
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl106,894,589 - 6,925,355 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117646   ⟹   ENSRNOP00000083535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl107,367,604 - 7,431,663 (+)Ensembl
mRatBN7.2 Ensembl106,828,795 - 6,925,355 (+)Ensembl
RefSeq Acc Id: NM_001024790   ⟹   NP_001019961
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8107,387,353 - 7,432,018 (+)NCBI
mRatBN7.2106,880,684 - 6,925,355 (+)NCBI
Rnor_6.0106,975,289 - 7,018,732 (+)NCBI
Rnor_5.0105,752,834 - 5,822,229 (+)NCBI
RGSC_v3.4106,917,612 - 6,963,452 (+)RGD
Celera105,876,459 - 5,919,649 (+)RGD
Sequence:
RefSeq Acc Id: XM_006245757   ⟹   XP_006245819
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8107,396,481 - 7,432,018 (+)NCBI
mRatBN7.2106,891,946 - 6,925,033 (+)NCBI
Rnor_6.0106,986,082 - 7,019,910 (+)NCBI
Rnor_5.0105,752,834 - 5,822,229 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063269283   ⟹   XP_063125353
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8107,335,508 - 7,432,018 (+)NCBI
RefSeq Acc Id: XM_063269284   ⟹   XP_063125354
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8107,367,617 - 7,432,018 (+)NCBI
RefSeq Acc Id: XM_063269285   ⟹   XP_063125355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8107,367,599 - 7,432,018 (+)NCBI
RefSeq Acc Id: XM_063269286   ⟹   XP_063125356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8107,335,508 - 7,432,018 (+)NCBI
RefSeq Acc Id: XM_063269287   ⟹   XP_063125357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8107,386,737 - 7,432,018 (+)NCBI
RefSeq Acc Id: XM_063269288   ⟹   XP_063125358
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8107,396,481 - 7,432,018 (+)NCBI
RefSeq Acc Id: XM_063269289   ⟹   XP_063125359
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8107,404,604 - 7,432,018 (+)NCBI
RefSeq Acc Id: XM_063269290   ⟹   XP_063125360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8107,415,812 - 7,432,018 (+)NCBI
RefSeq Acc Id: NP_001019961   ⟸   NM_001024790
- UniProtKB: Q4VSI4 (UniProtKB/Swiss-Prot),   A0A8I6AP58 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245819   ⟸   XM_006245757
- Peptide Label: isoform X5
- UniProtKB: A0A8I6AKU3 (UniProtKB/TrEMBL),   A0A8I5ZSA1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000041134   ⟸   ENSRNOT00000046232
Ensembl Acc Id: ENSRNOP00000083535   ⟸   ENSRNOT00000117646
Ensembl Acc Id: ENSRNOP00000088505   ⟸   ENSRNOT00000112945
Ensembl Acc Id: ENSRNOP00000081458   ⟸   ENSRNOT00000095866
Ensembl Acc Id: ENSRNOP00000096267   ⟸   ENSRNOT00000100242
Ensembl Acc Id: ENSRNOP00000093874   ⟸   ENSRNOT00000094143
RefSeq Acc Id: XP_063125353   ⟸   XM_063269283
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZSA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125356   ⟸   XM_063269286
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZSA1 (UniProtKB/TrEMBL),   A0A8I5ZZJ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125355   ⟸   XM_063269285
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZSA1 (UniProtKB/TrEMBL),   A0A8I5ZZJ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125354   ⟸   XM_063269284
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZSA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125357   ⟸   XM_063269287
- Peptide Label: isoform X3
- UniProtKB: Q4VSI4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063125358   ⟸   XM_063269288
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZSA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125359   ⟸   XM_063269289
- Peptide Label: isoform X6
- UniProtKB: A0A8I6A6B9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125360   ⟸   XM_063269290
- Peptide Label: isoform X7
Protein Domains
MATH   USP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4VSI4-F1-model_v2 AlphaFold Q4VSI4 1-1103 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696950
Promoter ID:EPDNEW_R7475
Type:single initiation site
Name:Usp7_1
Description:ubiquitin specific peptidase 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0106,975,333 - 6,975,393EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306915 AgrOrtholog
BioCyc Gene G2FUF-26099 BioCyc
Ensembl Genes ENSRNOG00000025496 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000094143 ENTREZGENE
  ENSRNOT00000100242 ENTREZGENE
  ENSRNOT00000117646 ENTREZGENE
Gene3D-CATH Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A UniProtKB/Swiss-Prot
  Cysteine proteinases UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
InterPro MATH/TRAF_dom UniProtKB/Swiss-Prot
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot
  Peptidase_C19 UniProtKB/Swiss-Prot
  Peptidase_C19_UCH UniProtKB/Swiss-Prot
  TRAF-like UniProtKB/Swiss-Prot
  USP7_ICP0-binding_dom UniProtKB/Swiss-Prot
  USP_C UniProtKB/Swiss-Prot
  USP_CS UniProtKB/Swiss-Prot
  USP_dom UniProtKB/Swiss-Prot
KEGG Report rno:360471 UniProtKB/Swiss-Prot
NCBI Gene 360471 ENTREZGENE
PANTHER UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UniProtKB/Swiss-Prot
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7 UniProtKB/Swiss-Prot
Pfam MATH_2 UniProtKB/Swiss-Prot
  UCH UniProtKB/Swiss-Prot
  USP7_C2 UniProtKB/Swiss-Prot
  USP7_ICP0_bdg UniProtKB/Swiss-Prot
PhenoGen Usp7 PhenoGen
PROSITE MATH UniProtKB/Swiss-Prot
  USP_1 UniProtKB/Swiss-Prot
  USP_2 UniProtKB/Swiss-Prot
  USP_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000025496 RatGTEx
SMART MATH UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot
  TRAF domain-like UniProtKB/Swiss-Prot
UniProt A0A8I5ZSA1 ENTREZGENE
  A0A8I5ZZJ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A6B9 ENTREZGENE
  A0A8I6AKU3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AP58 ENTREZGENE, UniProtKB/TrEMBL
  A6K4L6_RAT UniProtKB/TrEMBL
  F1LM09_RAT UniProtKB/TrEMBL
  Q4VSI4 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-18 Usp7  ubiquitin specific peptidase 7  Usp7  ubiquitin specific peptidase 7 (herpes virus-associated)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Usp7  ubiquitin specific peptidase 7 (herpes virus-associated)  Usp7  ubiquitin specific peptidase 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Usp7  ubiquitin specific peptidase 7  Usp7  ubiquitin specific protease 7 (herpes virus-associated)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Usp7  ubiquitin specific protease 7 (herpes virus-associated)  Usp7_predicted  ubiquitin specific protease 7 (herpes virus-associated) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Usp7_predicted  ubiquitin specific protease 7 (herpes virus-associated) (predicted)      Symbol and Name status set to approved 70820 APPROVED