USP7 (ubiquitin specific peptidase 7) - Rat Genome Database

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Pathways
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Gene: USP7 (ubiquitin specific peptidase 7) Chlorocebus sabaeus
Analyze
Symbol: USP7
Name: ubiquitin specific peptidase 7
RGD ID: 18593436
Description: ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); identical protein binding (ortholog); INVOLVED IN monoubiquitinated protein deubiquitination (ortholog); positive regulation of apoptotic process (ortholog); protein deubiquitination (ortholog); PARTICIPATES IN p53 signaling pathway; ASSOCIATED WITH Charcot-Marie-Tooth disease type 1C (ortholog); GABA aminotransferase deficiency (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (ortholog); PML body (ortholog); XY body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ubiquitin carboxyl-terminal hydrolase 7
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.158,470,137 - 8,540,736 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl58,469,230 - 8,540,770 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606821,677,314 - 21,749,766 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
cytosol  (IEA)
nucleus  (IEA)
PML body  (IEA,ISO)
protein-containing complex  (IEA)
XY body  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
USP7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.158,470,137 - 8,540,736 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl58,469,230 - 8,540,770 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606821,677,314 - 21,749,766 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
USP7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38168,892,097 - 8,963,906 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl168,892,097 - 8,975,328 (-)EnsemblGRCh38hg38GRCh38
GRCh37168,985,954 - 9,057,763 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36168,893,452 - 8,964,842 (-)NCBINCBI36Build 36hg18NCBI36
Build 34168,894,850 - 8,964,842NCBI
Celera169,152,724 - 9,223,882 (-)NCBICelera
Cytogenetic Map16p13.2NCBI
HuRef168,907,081 - 8,945,418 (-)NCBIHuRef
CHM1_1168,985,936 - 9,057,340 (-)NCBICHM1_1
T2T-CHM13v2.0168,924,836 - 8,996,578 (-)NCBIT2T-CHM13v2.0
Usp7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39168,506,586 - 8,574,931 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl168,507,459 - 8,610,172 (-)EnsemblGRCm39 Ensembl
GRCm38168,688,722 - 8,757,067 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl168,689,595 - 8,792,308 (-)EnsemblGRCm38mm10GRCm38
MGSCv37168,688,815 - 8,738,435 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36168,606,101 - 8,653,606 (-)NCBIMGSCv36mm8
Celera169,334,440 - 9,362,384 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map164.28NCBI
Usp7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8107,335,508 - 7,432,018 (+)NCBIGRCr8
mRatBN7.2106,880,684 - 6,925,355 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl106,828,795 - 6,925,355 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1011,588,325 - 11,631,578 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01011,084,682 - 11,128,048 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0106,735,783 - 6,779,154 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0106,930,462 - 7,019,910 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl106,975,244 - 7,018,930 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0105,752,834 - 5,822,229 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4106,917,612 - 6,963,452 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1106,917,611 - 6,963,451 (+)NCBI
Celera105,876,459 - 5,919,649 (+)NCBICelera
Cytogenetic Map10q12NCBI
Usp7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554429,315,225 - 9,356,393 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554429,316,022 - 9,355,751 (+)NCBIChiLan1.0ChiLan1.0
USP7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2189,431,901 - 9,501,001 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11613,210,502 - 13,278,888 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0167,825,332 - 7,895,095 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1169,065,366 - 9,106,406 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl169,065,858 - 9,106,146 (-)Ensemblpanpan1.1panPan2
USP7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1633,277,328 - 33,315,601 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl633,277,444 - 33,314,491 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha634,641,327 - 34,706,509 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0633,449,047 - 33,514,314 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl633,448,218 - 33,514,312 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1633,251,796 - 33,316,926 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0633,121,375 - 33,186,820 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0633,570,486 - 33,608,545 (+)NCBIUU_Cfam_GSD_1.0
Usp7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344109,848,236 - 109,882,862 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365307,694,379 - 7,724,684 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365307,693,681 - 7,724,215 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USP7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl333,775,829 - 33,810,465 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1333,754,357 - 33,810,480 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2334,686,115 - 34,742,973 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Usp7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248246,276,354 - 6,338,227 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248246,277,111 - 6,338,051 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 18 60
Low 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000006742   ⟹   ENSCSAP00000004939
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl58,469,230 - 8,540,770 (-)Ensembl
RefSeq Acc Id: XM_007985309   ⟹   XP_007983500
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.158,470,137 - 8,540,736 (-)NCBI
Vero_WHO_p1.0NW_02366606821,677,314 - 21,749,766 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007985323   ⟹   XP_007983514
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.158,470,137 - 8,507,381 (-)NCBI
Vero_WHO_p1.0NW_02366606821,711,908 - 21,749,766 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007983500 (Get FASTA)   NCBI Sequence Viewer  
  XP_007983514 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000004939
  ENSCSAP00000004939.1
Reference Protein Sequences
RefSeq Acc Id: XP_007983500   ⟸   XM_007985309
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R8K0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007983514   ⟸   XM_007985323
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCSAP00000004939   ⟸   ENSCSAT00000006742


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000008682 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000006742.1 UniProtKB/TrEMBL
Gene3D-CATH Cysteine proteinases UniProtKB/TrEMBL
InterPro MATH/TRAF_dom UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/TrEMBL
  Peptidase_C19_UCH UniProtKB/TrEMBL
  TRAF-like UniProtKB/TrEMBL
  USP7_ICP0-binding_dom UniProtKB/TrEMBL
  USP_C UniProtKB/TrEMBL
  USP_CS UniProtKB/TrEMBL
  USP_dom UniProtKB/TrEMBL
KEGG Report csab:103228044 UniProtKB/TrEMBL
NCBI Gene USP7 ENTREZGENE
PANTHER UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UniProtKB/TrEMBL
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7 UniProtKB/TrEMBL
Pfam MATH UniProtKB/TrEMBL
  UCH UniProtKB/TrEMBL
  USP7_C2 UniProtKB/TrEMBL
  USP7_ICP0_bdg UniProtKB/TrEMBL
PROSITE MATH UniProtKB/TrEMBL
  USP_1 UniProtKB/TrEMBL
  USP_2 UniProtKB/TrEMBL
  USP_3 UniProtKB/TrEMBL
SMART MATH UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
  TRAF domain-like UniProtKB/TrEMBL
UniProt A0A0D9R8K0 ENTREZGENE, UniProtKB/TrEMBL