GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Usp7 | affects methylation | ISO | USP7 (Homo sapiens) | 6480464 | CTD | Arsenic affects the methylation of USP7 gene | PMID:25304211 | Usp7 | decreases activity | ISO | USP7 (Homo sapiens) | 6480464 | CTD | Arsenic results in decreased activity of USP7 protein | PMID:35821281 | Usp7 | increases ubiquitination | ISO | USP7 (Homo sapiens) | 6480464 | CTD | Arsenic results in increased ubiquitination of USP7 protein | PMID:35821281 | Usp7 | multiple interactions | ISO | USP7 (Homo sapiens) | 6480464 | CTD | [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of USP7 protein; [Arsenic results in decreased activity of USP7 protein] which results in decreased ubiquitination of HMOX1 protein; Arsenic inhibits the reaction [[USP7 protein mutant form co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of HMOX1 protein]; Arsenic inhibits the reaction [USP7 protein results in increased ubiquitination of HMOX1 protein]; Arsenic promotes the reaction [[USP7 protein co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of HMOX1 protein]; Arsenic promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [HMOX1 protein binds to USP7 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Sirolimus inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of USP7 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [USP7 protein affects the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of MCL1 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of USP7 protein]]; Sirolimus inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of USP7 protein]; USP7 protein affects the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]; USP7 protein affects the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]; USP7 protein affects the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of and results in decreased ubiquitination of MCL1 protein]; USP7 protein affects the reaction [Arsenic inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of HMOX1 protein]]; USP7 protein affects the reaction [Arsenic results in increased expression of H2AX protein]; USP7 protein affects the reaction [Arsenic results in increased expression of HMOX1 protein]; USP7 protein affects the reaction [Arsenic results in increased expression of MDM2 protein]; USP7 protein mutant form affects the reaction [USP7 protein affects the reaction [Arsenic results in increased expression of H2AX protein]]; USP7 protein mutant form inhibits the reaction [Arsenic results in decreased ubiquitination of HMOX1 protein]; Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of USP7 protein] | PMID:32802178 PMID:35821281 | | ||||||||||||||||||||||
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