Tprg1 (tumor protein p63 regulated 1) - Rat Genome Database

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Gene: Tprg1 (tumor protein p63 regulated 1) Rattus norvegicus
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Symbol: Tprg1
Name: tumor protein p63 regulated 1
RGD ID: 1306226
Description: Predicted to be active in cytoplasm. Orthologous to human TPRG1 (tumor protein p63 regulated 1); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC360731; RGD1306226; similar to RIKEN cDNA 1200015A19; Svap30; synaptic vesicle associated protein of 30 kD; Tprg; transformation related protein 63 regulated; tumor protein p63-regulated gene 1 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81188,827,231 - 88,954,668 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1188,827,231 - 88,954,668 (-)EnsemblGRCr8
mRatBN7.21175,322,470 - 75,449,907 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1175,322,470 - 75,449,907 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1184,125,440 - 84,252,943 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01176,760,496 - 76,888,006 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01175,823,410 - 75,950,974 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01178,733,046 - 78,861,745 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1178,728,128 - 78,861,716 (-)Ensemblrn6Rnor6.0
Rnor_5.01181,863,279 - 81,991,056 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41177,477,085 - 77,601,486 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1174,224,150 - 74,351,014 (-)NCBICelera
RGSC_v3.11177,534,720 - 77,656,016 (-)NCBI
Cytogenetic Map11q22-q23NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
nucleoplasm  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18256694  


Genomics

Comparative Map Data
Tprg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81188,827,231 - 88,954,668 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1188,827,231 - 88,954,668 (-)EnsemblGRCr8
mRatBN7.21175,322,470 - 75,449,907 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1175,322,470 - 75,449,907 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1184,125,440 - 84,252,943 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01176,760,496 - 76,888,006 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01175,823,410 - 75,950,974 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01178,733,046 - 78,861,745 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1178,728,128 - 78,861,716 (-)Ensemblrn6Rnor6.0
Rnor_5.01181,863,279 - 81,991,056 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41177,477,085 - 77,601,486 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1174,224,150 - 74,351,014 (-)NCBICelera
RGSC_v3.11177,534,720 - 77,656,016 (-)NCBI
Cytogenetic Map11q22-q23NCBI
TPRG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383188,997,227 - 189,325,304 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3188,947,214 - 189,325,304 (+)Ensemblhg38GRCh38
GRCh373188,889,760 - 189,043,093 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363190,372,457 - 190,523,964 (+)NCBIBuild 36Build 36hg18NCBI36
Celera3187,324,428 - 187,475,904 (+)NCBICelera
Cytogenetic Map3q28NCBI
HuRef3186,294,129 - 186,445,298 (+)NCBIHuRef
CHM1_13188,852,675 - 189,004,217 (+)NCBICHM1_1
T2T-CHM13v2.03191,813,855 - 192,142,070 (+)NCBIT2T-CHM13v2.0
Tprg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391625,105,567 - 25,242,338 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1625,105,567 - 25,241,094 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381625,286,817 - 25,423,588 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1625,286,817 - 25,422,344 (+)Ensemblmm10GRCm38
MGSCv371625,286,903 - 25,422,430 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361625,202,166 - 25,337,693 (+)NCBIMGSCv36mm8
Celera1625,836,034 - 25,972,211 (+)NCBICelera
Cytogenetic Map16B1NCBI
cM Map1617.0NCBI
Tprg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542018,632,523 - 18,767,636 (-)Ensembl
ChiLan1.0NW_00495542018,632,583 - 18,853,032 (-)NCBIChiLan1.0ChiLan1.0
TPRG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22186,817,441 - 187,200,890 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13187,046,526 - 187,199,885 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03186,124,644 - 186,350,751 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13194,753,299 - 194,904,389 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3194,753,299 - 194,904,389 (+)EnsemblpanPan2panpan1.1
TPRG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13421,391,903 - 21,528,932 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3421,419,564 - 21,528,718 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3425,486,114 - 25,623,044 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03421,325,186 - 21,462,593 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3421,325,019 - 21,462,593 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13421,341,672 - 21,478,439 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03421,336,224 - 21,472,946 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03421,577,180 - 21,714,080 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tprg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602114,880,350 - 115,010,250 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936578972,010 - 1,102,077 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936578972,057 - 1,102,039 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPRG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13126,724,573 - 126,861,438 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113126,529,961 - 126,860,676 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213135,718,773 - 136,052,723 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TPRG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11583,408,942 - 83,566,246 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1583,455,741 - 83,566,220 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604157,002,079 - 57,150,830 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tprg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473067,725,466 - 67,841,980 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473067,719,765 - 67,871,369 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tprg1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1410,080,250 - 10,215,231 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:59
Count of miRNA genes:52
Interacting mature miRNAs:54
Transcripts:ENSRNOT00000002634
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)118295102896351019Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
13 8 9 42 47 45 15 28 15 6 112 58 23 19 57 30

Sequence


Ensembl Acc Id: ENSRNOT00000002634   ⟹   ENSRNOP00000002634
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1178,728,128 - 78,861,716 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108583   ⟹   ENSRNOP00000095870
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1188,827,231 - 88,954,668 (-)Ensembl
mRatBN7.2 Ensembl1175,322,470 - 75,449,907 (-)Ensembl
RefSeq Acc Id: NM_001108320   ⟹   NP_001101790
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81188,827,231 - 88,954,668 (-)NCBI
mRatBN7.21175,322,470 - 75,449,907 (-)NCBI
Rnor_6.01178,733,046 - 78,861,745 (-)NCBI
Rnor_5.01181,863,279 - 81,991,056 (+)NCBI
RGSC_v3.41177,477,085 - 77,601,486 (-)RGD
Celera1174,224,150 - 74,351,014 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101790 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL78106 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000095870
  ENSRNOP00000095870.1
RefSeq Acc Id: NP_001101790   ⟸   NM_001108320
- UniProtKB: D4A1Y2 (UniProtKB/TrEMBL),   A6JS01 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002634   ⟸   ENSRNOT00000002634
Ensembl Acc Id: ENSRNOP00000095870   ⟸   ENSRNOT00000108583
Protein Domains
hSac2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A1Y2-F1-model_v2 AlphaFold D4A1Y2 1-278 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306226 AgrOrtholog
BioCyc Gene G2FUF-20927 BioCyc
Ensembl Genes ENSRNOG00000001923 Ensembl
  ENSRNOG00000063970 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000108583 ENTREZGENE
  ENSRNOT00000108583.2 UniProtKB/TrEMBL
InterPro hSac2 UniProtKB/TrEMBL
  hSac2 UniProtKB/TrEMBL
  TPRG1-like UniProtKB/TrEMBL
KEGG Report rno:360731 UniProtKB/TrEMBL
NCBI Gene 360731 ENTREZGENE
PANTHER PTHR31108 UniProtKB/TrEMBL
  TUMOR PROTEIN P63-REGULATED GENE 1 PROTEIN UniProtKB/TrEMBL
Pfam hSac2 UniProtKB/TrEMBL
PhenoGen Tprg1 PhenoGen
PROSITE HSAC2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001923 RatGTEx
  ENSRNOG00000063970 RatGTEx
UniProt A6JS01 ENTREZGENE, UniProtKB/TrEMBL
  D4A1Y2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-07-29 Tprg1  tumor protein p63 regulated 1  Tprg  transformation related protein 63 regulated  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-12-28 Tprg  transformation related protein 63 regulated  RGD1306226_predicted  similar to RIKEN cDNA 1200015A19 (predicted)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1306226_predicted  similar to RIKEN cDNA 1200015A19 (predicted)  LOC360731_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC360731_predicted  similar to RIKEN cDNA 1200015A19 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL