Tollip (toll interacting protein) - Rat Genome Database

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Gene: Tollip (toll interacting protein) Rattus norvegicus
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Symbol: Tollip
Name: toll interacting protein
RGD ID: 1304676
Description: Enables SUMO binding activity; enzyme binding activity; and interleukin-1, type I receptor binding activity. Involved in positive regulation of protein sumoylation. Located in nuclear body and perinuclear region of cytoplasm. Orthologous to human TOLLIP (toll interacting protein); PARTICIPATES IN interleukin-1 signaling pathway; Toll-like receptor signaling pathway; INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 4,4'-sulfonyldiphenol; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC361677; toll-interacting protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81206,391,120 - 206,413,809 (-)NCBIGRCr8
mRatBN7.21196,961,585 - 196,984,252 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,950,771 - 196,983,625 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1205,305,293 - 205,326,118 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,423,637 - 212,444,459 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01205,097,793 - 205,118,619 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01214,823,993 - 214,844,861 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,823,978 - 214,844,858 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,737,397 - 221,758,265 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41202,008,799 - 202,029,669 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11202,170,336 - 202,189,385 (-)NCBI
Celera1194,590,002 - 194,610,866 (-)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 11 of 11 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TollipRatBeckwith-Wiedemann syndrome  ISOTOLLIP (Homo sapiens)8554872ClinVar Annotator: match by term: Beckwith-Wiedemann syndromeClinVarPMID:21910219 more ...
TollipRatchronic obstructive pulmonary disease  ISOTOLLIP (Homo sapiens)8554872ClinVar Annotator: match by term: Chronic obstructive pulmonary diseaseClinVar 
TollipRatCOVID-19  ISOTOLLIP (Homo sapiens)8554872ClinVar Annotator: match by term: Susceptibility to severe coronavirus disease (COVID-19)ClinVar 
TollipRatdelta beta-thalassemia  ISOTOLLIP (Homo sapiens)8554872ClinVar Annotator: match by term: Thalassemia and gamma-delta-betaClinVarPMID:2798417
TollipRatdevelopmental and epileptic encephalopathy  ISOTOLLIP (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathyClinVarPMID:28492532
TollipRatearly infantile epileptic encephalopathy  ISOTOLLIP (Homo sapiens)8554872ClinVar Annotator: match by term: Early infantile epileptic encephalopathyClinVarPMID:28492532
TollipRatidiopathic pulmonary fibrosis  ISOTOLLIP (Homo sapiens)8554872ClinVar Annotator: match by term: Fibrocystic pulmonary dysplasiaClinVar 
TollipRatimmunodeficiency 39  ISOTOLLIP (Homo sapiens)8554872ClinVar Annotator: match by term: Immunodeficiency 39ClinVarPMID:28492532
TollipRatinterstitial lung disease 2  ISOTOLLIP (Homo sapiens)8554872ClinVar Annotator: match by term: Interstitial lung disease 2ClinVar 
TollipRatneuronal ceroid lipofuscinosis  ISOTOLLIP (Homo sapiens)8554872ClinVar Annotator: match by term: Neuronal ceroid lipofuscinosisClinVarPMID:28492532
TollipRatSegawa Syndrome, Autosomal Recessive  ISOTOLLIP (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal recessive DOPA responsive dystoniaClinVarPMID:28492532
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1 to 20 of 102 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TollipRat(1->4)-beta-D-glucan multiple interactionsISOTollip (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of TOLLIP mRNACTDPMID:36331819
TollipRat1,2-dimethylhydrazine decreases expressionISOTollip (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of TOLLIP mRNACTDPMID:22206623
TollipRat17beta-estradiol decreases expressionISOTollip (Mus musculus)6480464Estradiol results in decreased expression of TOLLIP mRNACTDPMID:39298647
TollipRat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOTOLLIP (Homo sapiens)64804642 more ...CTDPMID:31675489
TollipRat2,2',4,4'-Tetrabromodiphenyl ether multiple interactionsISOTollip (Mus musculus)6480464[Flame Retardants results in increased abundance of 2 more ...CTDPMID:38995820
TollipRat2,2',5,5'-tetrachlorobiphenyl decreases expressionEXP 64804642 more ...CTDPMID:23829299
TollipRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOTollip (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of TOLLIP mRNACTDPMID:21570461
TollipRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOTollip (Mus musculus)6480464[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of TOLLIP mRNACTDPMID:25975270
TollipRat2,4,6-tribromophenol decreases expressionISOTOLLIP (Homo sapiens)64804642 more ...CTDPMID:31675489
TollipRat2,6-dimethoxyphenol multiple interactionsISOTOLLIP (Homo sapiens)6480464[Furaldehyde co-treated with pyrogallol 1 more ...CTDPMID:38598786
TollipRat3,3',5,5'-tetrabromobisphenol A decreases expressionISOTOLLIP (Homo sapiens)6480464tetrabromobisphenol A results in decreased expression of TOLLIP proteinCTDPMID:31675489
TollipRat3,4-methylenedioxymethamphetamine increases expressionISOTollip (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of TOLLIP mRNACTDPMID:20188158
TollipRat4,4'-diaminodiphenylmethane increases expressionISOTollip (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in increased expression of TOLLIP mRNACTDPMID:18648102
TollipRat4,4'-sulfonyldiphenol decreases expressionISOTollip (Mus musculus)6480464bisphenol S results in decreased expression of TOLLIP mRNACTDPMID:39298647
TollipRat4,4'-sulfonyldiphenol multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of TOLLIP mRNACTDPMID:36041667
TollipRatacrylamide increases expressionISOTOLLIP (Homo sapiens)6480464Acrylamide results in increased expression of TOLLIP mRNACTDPMID:32763439
TollipRataflatoxin B1 increases methylationISOTOLLIP (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of TOLLIP promoterCTDPMID:30157460
TollipRataristolochic acid A increases expressionISOTOLLIP (Homo sapiens)6480464aristolochic acid I results in increased expression of TOLLIP mRNACTDPMID:33212167
TollipRatarsane affects methylationISOTOLLIP (Homo sapiens)6480464Arsenic affects the methylation of TOLLIP geneCTDPMID:25304211
TollipRatarsane multiple interactionsISOTOLLIP (Homo sapiens)6480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of TOLLIP mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TOLLIP mRNACTDPMID:39836092

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Biological Process
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Original Reference(s)
TollipRatautophagy involved_inIEAUniProtKB-KW:KW-00721600115GO_REF:0000043UniProtGO_REF:0000043
TollipRatepithelial cell differentiation involved_inISOTOLLIP (Homo sapiens)1624291 PMID:21492153RGDPMID:21492153
TollipRatepithelial cell differentiation involved_inIEAUniProtKB:Q9H0E2 and ensembl:ENSP000003147331600115GO_REF:0000107EnsemblGO_REF:0000107
TollipRatimmune system process involved_inIEAUniProtKB-KW:KW-03911600115GO_REF:0000043UniProtGO_REF:0000043
TollipRatinflammatory response involved_inIEAUniProtKB-KW:KW-03951600115GO_REF:0000043UniProtGO_REF:0000043
TollipRatinnate immune response involved_inIEAUniProtKB-KW:KW-03991600115GO_REF:0000043UniProtGO_REF:0000043
TollipRatinterleukin-1-mediated signaling pathway involved_inISOTOLLIP (Homo sapiens)1624291 PMID:10854325RGDPMID:10854325
TollipRatinterleukin-1-mediated signaling pathway involved_inIEAUniProtKB:Q9QZ06 and ensembl:ENSMUSP000000019501600115GO_REF:0000107EnsemblGO_REF:0000107
TollipRatinterleukin-1-mediated signaling pathway involved_inIEAUniProtKB:Q9H0E2 and ensembl:ENSP000003147331600115GO_REF:0000107EnsemblGO_REF:0000107
TollipRatinterleukin-1-mediated signaling pathway involved_inISOTollip (Mus musculus)1624291 PMID:10854325RGDPMID:10854325
TollipRatphosphorylation involved_inISSUniProtKB:Q9H0E21600115GO_REF:0000024UniProtGO_REF:0000024
TollipRatphosphorylation involved_inISOTOLLIP (Homo sapiens)1624291 PMID:1085432RGDPMID:1085432
TollipRatpositive regulation of protein sumoylation  IDA 5508208 RGD 
TollipRatprotein localization to endosome involved_inISOTOLLIP (Homo sapiens)1624291 PMID:16412388RGDPMID:16412388
TollipRatprotein localization to endosome involved_inIEAUniProtKB:Q9H0E2 and ensembl:ENSP000003147331600115GO_REF:0000107EnsemblGO_REF:0000107
TollipRatsignal transduction involved_inISOTOLLIP (Homo sapiens)1624291UniProtKB:O60603 and PMID:11441107RGDPMID:11441107
TollipRatsignal transduction involved_inIEAUniProtKB:Q9H0E2 and ensembl:ENSP000003147331600115GO_REF:0000107EnsemblGO_REF:0000107
TollipRatubiquitin-dependent protein catabolic process involved_inIBAPANTHER:PTN002314087 and SGD:S0000055681600115GO_REF:0000033GO_CentralGO_REF:0000033
1 to 18 of 18 rows

Cellular Component
1 to 12 of 12 rows

  
Object Symbol
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Evidence
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Reference
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Original Reference(s)
TollipRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
TollipRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
TollipRatcytoplasm is_active_inIBAPANTHER:PTN002314087 and Tollip (Rattus norvegicus)1600115GO_REF:0000033GO_CentralGO_REF:0000033
TollipRatearly endosome located_inIEAUniProtKB-SubCell:SL-00941600115GO_REF:0000044UniProtGO_REF:0000044
TollipRatendosome located_inIEAUniProtKB-SubCell:SL-01011600115GO_REF:0000044UniProtGO_REF:0000044
TollipRatendosome located_inIEAUniProtKB-KW:KW-09671600115GO_REF:0000043UniProtGO_REF:0000043
TollipRatnuclear body  IDA 5508208 RGD 
TollipRatperinuclear region of cytoplasm  IDA 5508208 RGD 
TollipRatprotein-containing complex part_ofISOTOLLIP (Homo sapiens)1624291 PMID:10854325RGDPMID:10854325
TollipRatprotein-containing complex part_ofIEAUniProtKB:Q9H0E2 and ensembl:ENSP000003147331600115GO_REF:0000107EnsemblGO_REF:0000107
TollipRatprotein-containing complex part_ofIEAUniProtKB:Q9QZ06 and ensembl:ENSMUSP000000019501600115GO_REF:0000107EnsemblGO_REF:0000107
TollipRatprotein-containing complex part_ofISOTollip (Mus musculus)1624291 PMID:10854325RGDPMID:10854325
1 to 12 of 12 rows

Molecular Function
1 to 18 of 18 rows

  
Object Symbol
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Reference
Notes
Source
Original Reference(s)
TollipRatinterleukin-1, type I receptor binding  IPIIl1r1 (Rattus norvegicus)5508208 RGD 
TollipRatkinase binding enablesISOTOLLIP (Homo sapiens)1624291UniProtKB:P51617 and PMID:10854325RGDPMID:10854325
TollipRatkinase binding enablesIEAUniProtKB:Q9H0E2 and ensembl:ENSP000003147331600115GO_REF:0000107EnsemblGO_REF:0000107
TollipRatmolecular adaptor activity enablesISOTOLLIP (Homo sapiens)1624291 PMID:10854325 and PMID:27368102RGDPMID:10854325 and PMID:27368102
TollipRatmolecular adaptor activity enablesIEAUniProtKB:Q9H0E2 and ensembl:ENSP000003147331600115GO_REF:0000107EnsemblGO_REF:0000107
TollipRatprotein binding  IPIRANGAP1 (Homo sapiens)5508208 RGD 
TollipRatprotein binding enablesISOTOLLIP (Homo sapiens) and UniProtKB:Q9H0E2-11624291UniProtKB:O60784 and PMID:26320582RGDPMID:26320582
TollipRatprotein binding enablesISOTOLLIP (Homo sapiens)1624291UniProtKB:A8MTA8-2 more ...RGDPMID:11397809 more ...
TollipRatprotein binding enablesISOTollip (Mus musculus)1624291UniProtKB:O88746 more ...RGDPMID:10854325 and PMID:14563850
TollipRatSUMO binding  IPISumo1 (Rattus norvegicus)5508208 RGD 
TollipRatToll-like receptor binding enablesISOTOLLIP (Homo sapiens)1624291UniProtKB:O00206 more ...RGDPMID:11441107
TollipRatToll-like receptor binding enablesIEAUniProtKB:Q9H0E2 and ensembl:ENSP000003147331600115GO_REF:0000107EnsemblGO_REF:0000107
TollipRatubiquitin binding enablesIEAInterPro:IPR0038921600115GO_REF:0000002InterProGO_REF:0000002
TollipRatubiquitin binding enablesIBAPANTHER:PTN002314087 and SGD:S0000055681600115GO_REF:0000033GO_CentralGO_REF:0000033
TollipRatubiquitin conjugating enzyme binding  IPIUbe2i (Rattus norvegicus)5508208 RGD 
TollipRatubiquitin conjugating enzyme binding enablesIBAPANTHER:PTN002314087 and Tollip (Rattus norvegicus)1600115GO_REF:0000033GO_CentralGO_REF:0000033
TollipRatubiquitin protein ligase binding  IPIPias1 (Rattus norvegicus)5508208 RGD 
TollipRatubiquitin protein ligase binding  IPIPias2 (Rattus norvegicus)5508208 RGD 
1 to 18 of 18 rows

RGD Manual Annotations


  
Object Symbol
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Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
TollipRatinterleukin-1 signaling pathway   ISOTOLLIP (Homo sapiens)5490218 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TollipRatToll-like receptor signaling pathway   IEA 6907045 KEGGrno:04620

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TollipRatinterleukin-1 signaling pathway   ISOTOLLIP (Homo sapiens)6484113 PIDPID:200089

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#
Reference Title
Reference Citation
1. Tollip is a mediator of protein sumoylation. Ciarrocchi A, etal., PLoS One. 2009;4(2):e4404. Epub 2009 Feb 9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme. Verstrepen L, etal., Cell Mol Life Sci. 2008 Oct;65(19):2964-78.
1 to 9 of 9 rows
PMID:1085432   PMID:10854325   PMID:11441107   PMID:12477932   PMID:16412388   PMID:16903783   PMID:19056867   PMID:21492153   PMID:23376485   PMID:23533145   PMID:23656243   PMID:25269519  
PMID:26011492   PMID:28056921   PMID:29142263   PMID:30053369   PMID:32357304   PMID:35164650  



Tollip
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81206,391,120 - 206,413,809 (-)NCBIGRCr8
mRatBN7.21196,961,585 - 196,984,252 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,950,771 - 196,983,625 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1205,305,293 - 205,326,118 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,423,637 - 212,444,459 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01205,097,793 - 205,118,619 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01214,823,993 - 214,844,861 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,823,978 - 214,844,858 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,737,397 - 221,758,265 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41202,008,799 - 202,029,669 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11202,170,336 - 202,189,385 (-)NCBI
Celera1194,590,002 - 194,610,866 (-)NCBICelera
Cytogenetic Map1q41NCBI
TOLLIP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,274,371 - 1,309,632 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,274,371 - 1,309,654 (-)EnsemblGRCh38hg38GRCh38
GRCh37111,295,601 - 1,330,862 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,252,177 - 1,287,415 (-)NCBINCBI36Build 36hg18NCBI36
Build 34111,252,176 - 1,287,415NCBI
Celera111,332,006 - 1,366,839 (-)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef111,087,157 - 1,122,196 (-)NCBIHuRef
CHM1_1111,294,507 - 1,328,900 (-)NCBICHM1_1
T2T-CHM13v2.0111,345,549 - 1,381,261 (-)NCBIT2T-CHM13v2.0
Tollip
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397141,435,317 - 141,456,198 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7141,428,550 - 141,472,244 (-)EnsemblGRCm39 Ensembl
GRCm387141,881,580 - 141,902,461 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,874,813 - 141,918,507 (-)EnsemblGRCm38mm10GRCm38
MGSCv377149,067,490 - 149,088,311 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367141,690,975 - 141,711,796 (-)NCBIMGSCv36mm8
Celera7141,635,280 - 141,656,101 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map787.34NCBI
Tollip
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547610,987,223 - 11,010,808 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547610,987,223 - 11,009,134 (+)NCBIChiLan1.0ChiLan1.0
TOLLIP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v293,691,091 - 3,727,594 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,903,417 - 2,940,145 (-)NCBINHGRI_mPanPan1
TOLLIP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11845,559,385 - 45,578,467 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1845,560,681 - 45,578,449 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1844,170,829 - 44,189,892 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01846,240,952 - 46,260,016 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1846,240,952 - 46,308,721 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11845,688,932 - 45,707,995 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01845,269,721 - 45,288,788 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01846,007,629 - 46,026,693 (-)NCBIUU_Cfam_GSD_1.0
Tollip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947962,528 - 991,542 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936816216,546 - 245,606 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936816216,542 - 245,545 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOLLIP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2851,512 - 864,483 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12852,198 - 864,337 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TOLLIP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111,094,535 - 1,127,342 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11,094,582 - 1,125,045 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603898,226,602 - 98,258,983 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tollip
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476621,365,680 - 21,388,471 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476621,365,659 - 21,388,366 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Tollip
111 total Variants

Predicted Target Of
Summary Value
Count of predictions:773
Count of miRNA genes:309
Interacting mature miRNAs:409
Transcripts:ENSRNOT00000046344
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 91 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat

1 to 10 of 91 rows
RH133412  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21196,961,583 - 196,961,771 (+)MAPPERmRatBN7.2
Rnor_6.01214,823,994 - 214,824,181NCBIRnor6.0
Rnor_5.01221,737,398 - 221,737,585UniSTSRnor5.0
RGSC_v3.41202,008,798 - 202,008,985UniSTSRGSC3.4
Celera1194,590,001 - 194,590,188UniSTS
RH 3.4 Map11436.9UniSTS
Cytogenetic Map1q41UniSTS
BE112982  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21196,962,916 - 196,963,083 (+)MAPPERmRatBN7.2
Rnor_6.01214,825,327 - 214,825,493NCBIRnor6.0
Rnor_5.01221,738,731 - 221,738,897UniSTSRnor5.0
RGSC_v3.41202,010,131 - 202,010,297UniSTSRGSC3.4
Celera1194,591,334 - 194,591,500UniSTS
RH 3.4 Map11437.51UniSTS
Cytogenetic Map1q41UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000046344   ⟹   ENSRNOP00000049498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1196,961,585 - 196,982,451 (-)Ensembl
Rnor_6.0 Ensembl1214,823,978 - 214,844,858 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103130   ⟹   ENSRNOP00000087930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1196,961,580 - 196,983,625 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112102   ⟹   ENSRNOP00000089844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1196,950,771 - 196,982,451 (-)Ensembl
RefSeq Acc Id: NM_001109668   ⟹   NP_001103138
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81206,391,122 - 206,411,988 (-)NCBI
mRatBN7.21196,961,585 - 196,982,451 (-)NCBI
Rnor_6.01214,823,995 - 214,844,861 (-)NCBI
Rnor_5.01221,737,397 - 221,758,265 (-)NCBI
RGSC_v3.41202,008,799 - 202,029,669 (-)RGD
Celera1194,590,002 - 194,610,866 (-)RGD
Sequence:
RefSeq Acc Id: XM_039083484   ⟹   XP_038939412
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81206,391,120 - 206,411,975 (-)NCBI
mRatBN7.21196,961,586 - 196,982,447 (-)NCBI
RefSeq Acc Id: XM_039083487   ⟹   XP_038939415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81206,391,120 - 206,413,809 (-)NCBI
mRatBN7.21196,961,586 - 196,984,252 (-)NCBI
1 to 11 of 11 rows
Protein RefSeqs NP_001103138 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939412 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939415 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A2RUW1 (Get FASTA)   NCBI Sequence Viewer  
  AAI33068 (Get FASTA)   NCBI Sequence Viewer  
  BAI44639 (Get FASTA)   NCBI Sequence Viewer  
  EDM12107 (Get FASTA)   NCBI Sequence Viewer  
  EDM12108 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000049498
  ENSRNOP00000049498.2
  ENSRNOP00000087930
1 to 11 of 11 rows
RefSeq Acc Id: NP_001103138   ⟸   NM_001109668
- UniProtKB: A2RUW1 (UniProtKB/Swiss-Prot),   A6HY26 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000049498   ⟸   ENSRNOT00000046344
RefSeq Acc Id: XP_038939415   ⟸   XM_039083487
- Peptide Label: isoform X2
- UniProtKB: A6HY27 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939412   ⟸   XM_039083484
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A889 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000089844   ⟸   ENSRNOT00000112102
C2   CUE

Name Modeler Protein Id AA Range Protein Structure
AF-A2RUW1-F1-model_v2 AlphaFold A2RUW1 1-274 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690555
Promoter ID:EPDNEW_R1080
Type:initiation region
Name:Tollip_1
Description:toll interacting protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01214,844,783 - 214,844,843EPDNEW


1 to 36 of 36 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-56931 BioCyc
Ensembl Genes ENSRNOG00000019861 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000046344 ENTREZGENE
  ENSRNOT00000046344.4 UniProtKB/Swiss-Prot
  ENSRNOT00000103130 ENTREZGENE
Gene3D-CATH 2.60.40.150 UniProtKB/Swiss-Prot
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7193007 IMAGE-MGC_LOAD
InterPro C2_dom UniProtKB/Swiss-Prot
  C2_domain_sf UniProtKB/Swiss-Prot
  CUE UniProtKB/Swiss-Prot
  TOLIP_CUE UniProtKB/Swiss-Prot
  Tollip_C2 UniProtKB/Swiss-Prot
  UBA-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:361677 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156818 IMAGE-MGC_LOAD
NCBI Gene 361677 ENTREZGENE
PANTHER TOLL-INTERACTING PROTEIN UniProtKB/Swiss-Prot
  TOLL-INTERACTING PROTEIN UniProtKB/Swiss-Prot
Pfam CUE UniProtKB/Swiss-Prot
  PF00168 UniProtKB/Swiss-Prot
PhenoGen Tollip PhenoGen
PROSITE CUE UniProtKB/Swiss-Prot
  PS50004 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019861 RatGTEx
SMART CUE UniProtKB/Swiss-Prot
  SM00239 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46934 UniProtKB/Swiss-Prot
  SSF49562 UniProtKB/Swiss-Prot
UniProt A0A8I6A889 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ACI3_RAT UniProtKB/TrEMBL
  A2RUW1 ENTREZGENE
  A6HY26 ENTREZGENE, UniProtKB/TrEMBL
  A6HY27 ENTREZGENE, UniProtKB/TrEMBL
  C9K104_RAT UniProtKB/TrEMBL
  TOLIP_RAT UniProtKB/Swiss-Prot
1 to 36 of 36 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Tollip  toll interacting protein   Tollip_predicted  toll interacting protein (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tollip_predicted  toll interacting protein (predicted)      Symbol and Name status set to approved 70820 APPROVED