TOLLIP (toll interacting protein) - Rat Genome Database

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Gene: TOLLIP (toll interacting protein) Sus scrofa
Analyze
Symbol: TOLLIP
Name: toll interacting protein
RGD ID: 14148206
Description: ENCODES a protein that exhibits interleukin-1, type I receptor binding (ortholog); SUMO binding (ortholog); ubiquitin conjugating enzyme binding (ortholog); INVOLVED IN positive regulation of protein sumoylation (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog); delta beta-thalassemia (ortholog); developmental and epileptic encephalopathy (ortholog); FOUND IN nuclear body (ortholog); perinuclear region of cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: toll-interacting protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2851,512 - 864,483 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12852,198 - 864,337 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22083706   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TOLLIP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2851,512 - 864,483 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12852,198 - 864,337 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TOLLIP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,274,371 - 1,309,632 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,274,371 - 1,309,654 (-)EnsemblGRCh38hg38GRCh38
GRCh37111,295,601 - 1,330,862 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,252,177 - 1,287,415 (-)NCBINCBI36Build 36hg18NCBI36
Build 34111,252,176 - 1,287,415NCBI
Celera111,332,006 - 1,366,839 (-)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef111,087,157 - 1,122,196 (-)NCBIHuRef
CHM1_1111,294,507 - 1,328,900 (-)NCBICHM1_1
T2T-CHM13v2.0111,345,549 - 1,381,261 (-)NCBIT2T-CHM13v2.0
Tollip
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397141,435,317 - 141,456,198 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7141,428,550 - 141,472,244 (-)EnsemblGRCm39 Ensembl
GRCm387141,881,580 - 141,902,461 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,874,813 - 141,918,507 (-)EnsemblGRCm38mm10GRCm38
MGSCv377149,067,490 - 149,088,311 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367141,690,975 - 141,711,796 (-)NCBIMGSCv36mm8
Celera7141,635,280 - 141,656,101 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map787.34NCBI
Tollip
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81206,391,120 - 206,413,809 (-)NCBIGRCr8
mRatBN7.21196,961,585 - 196,984,252 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,950,771 - 196,983,625 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1205,305,293 - 205,326,118 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,423,637 - 212,444,459 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01205,097,793 - 205,118,619 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01214,823,993 - 214,844,861 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,823,978 - 214,844,858 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,737,397 - 221,758,265 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41202,008,799 - 202,029,669 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11202,170,336 - 202,189,385 (-)NCBI
Celera1194,590,002 - 194,610,866 (-)NCBICelera
Cytogenetic Map1q41NCBI
Tollip
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547610,987,223 - 11,010,808 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547610,987,223 - 11,009,134 (+)NCBIChiLan1.0ChiLan1.0
TOLLIP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v293,691,091 - 3,727,594 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,903,417 - 2,940,145 (-)NCBINHGRI_mPanPan1
TOLLIP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11845,559,385 - 45,578,467 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1845,560,681 - 45,578,449 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1844,170,829 - 44,189,892 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01846,240,952 - 46,260,016 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1846,240,952 - 46,308,721 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11845,688,932 - 45,707,995 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01845,269,721 - 45,288,788 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01846,007,629 - 46,026,693 (-)NCBIUU_Cfam_GSD_1.0
Tollip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947962,528 - 991,542 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936816216,546 - 245,606 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936816216,542 - 245,545 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOLLIP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111,094,535 - 1,127,342 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11,094,582 - 1,125,045 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603898,226,602 - 98,258,983 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tollip
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476621,365,680 - 21,388,471 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476621,365,659 - 21,388,366 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TOLLIP
221 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 2 2 7 2 2
Low 9 3 3 3 16 3 1
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000045167   ⟹   ENSSSCP00000038545
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2851,517 - 864,479 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000078281   ⟹   ENSSSCP00000060576
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2851,517 - 864,479 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000084334   ⟹   ENSSSCP00000061661
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2851,512 - 858,045 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000090394   ⟹   ENSSSCP00000065248
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2852,353 - 864,483 (-)Ensembl
RefSeq Acc Id: NM_001315800   ⟹   NP_001302729
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12852,198 - 864,337 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001302729   ⟸   NM_001315800
- UniProtKB: G9M4N3 (UniProtKB/TrEMBL),   A0A4X1UEU5 (UniProtKB/TrEMBL),   A0A287A3T1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000060576   ⟸   ENSSSCT00000078281
RefSeq Acc Id: ENSSSCP00000065248   ⟸   ENSSSCT00000090394
RefSeq Acc Id: ENSSSCP00000061661   ⟸   ENSSSCT00000084334
RefSeq Acc Id: ENSSSCP00000038545   ⟸   ENSSSCT00000045167
Protein Domains
C2   CUE


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000033033 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025039403 UniProtKB/TrEMBL
  ENSSSCG00030074981 UniProtKB/TrEMBL
  ENSSSCG00035027611 UniProtKB/TrEMBL
  ENSSSCG00040017355 UniProtKB/TrEMBL
  ENSSSCG00045025093 UniProtKB/TrEMBL
  ENSSSCG00050006273 UniProtKB/TrEMBL
  ENSSSCG00055018215 UniProtKB/TrEMBL
  ENSSSCG00060077149 UniProtKB/TrEMBL
  ENSSSCG00065055622 UniProtKB/TrEMBL
  ENSSSCG00070016356 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000045167 ENTREZGENE
  ENSSSCT00000045167.2 UniProtKB/TrEMBL
  ENSSSCT00000078281.1 UniProtKB/TrEMBL
  ENSSSCT00000084334.2 UniProtKB/TrEMBL
  ENSSSCT00000090394.2 UniProtKB/TrEMBL
  ENSSSCT00025053495.1 UniProtKB/TrEMBL
  ENSSSCT00025053684.1 UniProtKB/TrEMBL
  ENSSSCT00025053772.1 UniProtKB/TrEMBL
  ENSSSCT00025053872.1 UniProtKB/TrEMBL
  ENSSSCT00030105406.1 UniProtKB/TrEMBL
  ENSSSCT00030105410.1 UniProtKB/TrEMBL
  ENSSSCT00030105411.1 UniProtKB/TrEMBL
  ENSSSCT00035036523.1 UniProtKB/TrEMBL
  ENSSSCT00040023397.1 UniProtKB/TrEMBL
  ENSSSCT00040023452.1 UniProtKB/TrEMBL
  ENSSSCT00040023460.1 UniProtKB/TrEMBL
  ENSSSCT00040023506.1 UniProtKB/TrEMBL
  ENSSSCT00045042898.1 UniProtKB/TrEMBL
  ENSSSCT00045043185.1 UniProtKB/TrEMBL
  ENSSSCT00045043285.1 UniProtKB/TrEMBL
  ENSSSCT00050008563.1 UniProtKB/TrEMBL
  ENSSSCT00050008595.1 UniProtKB/TrEMBL
  ENSSSCT00050008597.1 UniProtKB/TrEMBL
  ENSSSCT00050008606.1 UniProtKB/TrEMBL
  ENSSSCT00055035805.1 UniProtKB/TrEMBL
  ENSSSCT00055035864.1 UniProtKB/TrEMBL
  ENSSSCT00055036117.1 UniProtKB/TrEMBL
  ENSSSCT00060106102.1 UniProtKB/TrEMBL
  ENSSSCT00060106144.1 UniProtKB/TrEMBL
  ENSSSCT00060106155.1 UniProtKB/TrEMBL
  ENSSSCT00060106208.1 UniProtKB/TrEMBL
  ENSSSCT00065076133.1 UniProtKB/TrEMBL
  ENSSSCT00065076152.1 UniProtKB/TrEMBL
  ENSSSCT00065076155.1 UniProtKB/TrEMBL
  ENSSSCT00065076166.1 UniProtKB/TrEMBL
  ENSSSCT00070032223.1 UniProtKB/TrEMBL
  ENSSSCT00070032245.1 UniProtKB/TrEMBL
  ENSSSCT00070032257.1 UniProtKB/TrEMBL
  ENSSSCT00070032277.1 UniProtKB/TrEMBL
  ENSSSCT00070032280.1 UniProtKB/TrEMBL
  ENSSSCT00070032284.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.150 UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  CUE UniProtKB/TrEMBL
  TOLIP_CUE UniProtKB/TrEMBL
  Tollip_C2 UniProtKB/TrEMBL
  UBA-like_sf UniProtKB/TrEMBL
KEGG Report ssc:100625123 UniProtKB/TrEMBL
NCBI Gene TOLLIP ENTREZGENE
PANTHER TOLL-INTERACTING PROTEIN UniProtKB/TrEMBL
  TOLL-INTERACTING PROTEIN UniProtKB/TrEMBL
Pfam CUE UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
PROSITE CUE UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
SMART CUE UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
Superfamily-SCOP SSF46934 UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
UniProt A0A287A3T1 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UAK8_PIG UniProtKB/TrEMBL
  A0A4X1UD12_PIG UniProtKB/TrEMBL
  A0A4X1UEU5 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UEW0_PIG UniProtKB/TrEMBL
  A0A4X1UFM3_PIG UniProtKB/TrEMBL
  A0A4X1UG48_PIG UniProtKB/TrEMBL
  A0A5G2QDG4_PIG UniProtKB/TrEMBL
  A0A5G2QEX3_PIG UniProtKB/TrEMBL
  A0A5G2QKA7_PIG UniProtKB/TrEMBL
  G9M4N3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:94301 ENTREZGENE