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Gene: Map3k3 (mitogen activated protein kinase kinase kinase 3) Rattus norvegicus

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Symbol:

Map3k3

Name:

mitogen activated protein kinase kinase kinase 3

RGD ID:

1304575

Description:

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within blood vessel development; intracellular signal transduction; and positive regulation of p38MAPK cascade. Predicted to be active in cytoplasm. Orthologous to human MAP3K3 (mitogen-activated protein kinase kinase kinase 3); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; Erk5 MAPK signaling pathway; interleukin-1 signaling pathway; INTERACTS WITH 2,6-dinitrotoluene; amphetamine; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC303604; mitogen-activated protein kinase kinase kinase 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	91,519,976 - 91,588,651 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	91,519,888 - 91,588,651 (+)	Ensembl				GRCr8
mRatBN7.2	10	91,020,174 - 91,088,852 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	91,020,174 - 91,088,848 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	10	96,075,116 - 96,143,482 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	95,538,287 - 95,606,652 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	90,949,010 - 91,017,411 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	94,280,703 - 94,349,372 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	94,280,703 - 94,349,368 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	94,029,306 - 94,098,042 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	95,482,303 - 95,551,065 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	89,696,294 - 89,764,939 (+)	NCBI		Celera
RGSC_v3.1	10	95,496,690 - 95,565,451 (+)	NCBI
Cytogenetic Map	10	q32.1	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Cerebral Cavernous Malformation 5 (ISO)

Esophageal Neoplasms (ISO)

verrucous keratotic hemangioma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

2-palmitoylglycerol (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4-vinylcyclohexene dioxide (ISO)

5-aza-2'-deoxycytidine (ISO)

all-trans-retinoic acid (ISO)

amphetamine (EXP)

arsenite(3-) (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

bufalin (ISO)

C60 fullerene (EXP)

cadmium dichloride (EXP)

caffeine (ISO)

cannabidiol (ISO)

copper atom (ISO)

copper(0) (ISO)

decabromodiphenyl ether (EXP)

deguelin (ISO)

depsipeptide (ISO)

diallyl disulfide (ISO)

Diallyl sulfide (ISO)

diallyl trisulfide (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

diquat (ISO)

fenthion (ISO)

FR900359 (ISO)

gentamycin (EXP)

glyphosate (ISO)

hyaluronic acid (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

mercury dichloride (ISO)

methidathion (ISO)

methoxychlor (ISO)

mono(2-ethylhexyl) phthalate (ISO)

monosodium L-glutamate (EXP)

oxaliplatin (EXP)

ozone (ISO)

p-menthan-3-ol (ISO)

paracetamol (ISO)

pirinixic acid (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

retinyl acetate (ISO)

thimerosal (ISO)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (ISO)

triphenyl phosphate (ISO)

urethane (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

blood vessel development (ISO)

intracellular signal transduction (ISO)

positive regulation of canonical NF-kappaB signal transduction (IEA,ISO)

positive regulation of p38MAPK cascade (ISO)

protein autophosphorylation (ISO)

Molecular Function

ATP binding (IEA)

kinase activity (IEA)

metal ion binding (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase activity (IEA,ISO)

protein serine/threonine kinase activity (IEA)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

c-Jun N-terminal kinases MAPK signaling pathway (ISO)

Erk5 MAPK signaling pathway (ISO)

gonadotropin-releasing hormone signaling pathway (IEA)

interleukin-1 signaling pathway (ISO)

mitogen activated protein kinase signaling pathway (IEA)

neurotrophic factor signaling pathway (IEA)

p38 MAPK signaling pathway (ISO)

tumor necrosis factor mediated signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Mechanisms and functions of p38 MAPK signalling.	Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
2.	p38 MAP-kinases pathway regulation, function and role in human diseases.	Cuenda A and Rousseau S, Biochim Biophys Acta. 2007 Aug;1773(8):1358-75. Epub 2007 Mar 24.
3.	MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42.	Fanger GR, etal., EMBO J. 1997 Aug 15;16(16):4961-72.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	The c-jun kinase/stress-activated pathway: regulation, function and role in human disease.	Johnson GL and Nakamura K, Biochim Biophys Acta. 2007 Aug;1773(8):1341-8. Epub 2007 Jan 4.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10.	GOA pipeline	RGD automated data pipeline
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Comprehensive gene review and curation	RGD comprehensive gene curation
13.	Regulation of cellular functions by the ERK5 signalling pathway.	Wang X and Tournier C, Cell Signal. 2006 Jun;18(6):753-60. Epub 2006 Jan 6.

Additional References at PubMed

PMID:10700190	PMID:12477932	PMID:12650640	PMID:12761501	PMID:15001576

Genomics

Comparative Map Data

Map3k3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	91,519,976 - 91,588,651 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	91,519,888 - 91,588,651 (+)	Ensembl				GRCr8
mRatBN7.2	10	91,020,174 - 91,088,852 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	91,020,174 - 91,088,848 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	10	96,075,116 - 96,143,482 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	95,538,287 - 95,606,652 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	90,949,010 - 91,017,411 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	94,280,703 - 94,349,372 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	94,280,703 - 94,349,368 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	94,029,306 - 94,098,042 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	95,482,303 - 95,551,065 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	89,696,294 - 89,764,939 (+)	NCBI		Celera
RGSC_v3.1	10	95,496,690 - 95,565,451 (+)	NCBI
Cytogenetic Map	10	q32.1	NCBI

MAP3K3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	63,622,417 - 63,696,305 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	63,622,381 - 63,696,305 (+)	Ensembl			hg38	GRCh38
GRCh37	17	61,699,777 - 61,773,665 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	59,053,533 - 59,127,402 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	17	59,053,532 - 59,127,401	NCBI
Celera	17	56,087,919 - 56,161,790 (+)	NCBI		Celera
Cytogenetic Map	17	q23.3	NCBI
HuRef	17	57,077,975 - 57,141,816 (+)	NCBI		HuRef
CHM1_1	17	61,764,216 - 61,838,082 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	64,493,028 - 64,567,209 (+)	NCBI		T2T-CHM13v2.0

Map3k3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	105,975,358 - 106,047,482 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	105,975,439 - 106,046,272 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	11	106,084,587 - 106,156,656 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	106,084,613 - 106,155,446 (+)	Ensembl			mm10	GRCm38
MGSCv37	11	105,946,216 - 106,016,760 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	11	105,900,992 - 105,971,536 (+)	NCBI		MGSCv36	mm8
Celera	11	117,815,382 - 117,885,664 (+)	NCBI		Celera
Cytogenetic Map	11	E1	NCBI
cM Map	11	68.89	NCBI

Map3k3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955478	8,125,436 - 8,199,253 (-)	Ensembl
ChiLan1.0	NW_004955478	8,122,999 - 8,185,138 (-)	NCBI	ChiLan1.0	ChiLan1.0

MAP3K3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	79,794,119 - 79,868,489 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	84,611,585 - 84,685,943 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	57,702,242 - 57,776,601 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	62,858,655 - 62,922,874 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	62,858,635 - 62,922,874 (+)	Ensembl			panPan2	panpan1.1

MAP3K3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	11,612,527 - 11,678,407 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	11,612,994 - 11,675,838 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	12,572,499 - 12,638,395 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	13,276,493 - 13,339,186 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	13,276,310 - 13,338,713 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	12,220,815 - 12,286,279 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	15,245,905 - 15,311,520 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	15,248,794 - 15,314,683 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Map3k3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	14,849,361 - 14,918,227 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936541	4,276,371 - 4,344,008 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936541	4,276,371 - 4,345,239 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MAP3K3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	15,230,182 - 15,298,784 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	12	15,228,979 - 15,298,784 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	15,215,673 - 15,285,409 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MAP3K3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	57,594,770 - 57,670,047 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	57,597,288 - 57,669,720 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666077	28,205,915 - 28,279,700 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Map3k3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624849	1,118,492 - 1,185,777 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624849	1,118,275 - 1,186,244 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Map3k3
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	9	72,961,501 - 73,029,339 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Map3k3
856 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	369
Count of miRNA genes:	190
Interacting mature miRNAs:	257
Transcripts:	ENSRNOT00000011406
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1549846	Scl47	Serum cholesterol level QTL 47	3.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	10	51071897	96071897	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	27023535	98502431	Rat
8657410	Bp374	Blood pressure QTL 374			heart left ventricle size trait (VT:0002753)	heart left ventricle end-diastolic diameter (CMO:0000982)	10	67476608	107713808	Rat
61449	Ciaa2	CIA Autoantibody QTL 2	7.1		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	10	63719161	107713808	Rat
631555	Bp134	Blood pressure QTL 134		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	81012077	91729860	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
1298078	Stresp5	Stress response QTL 5	2.99	0.00025	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	42546145	107713808	Rat
1549831	Bss6	Bone structure and strength QTL 6	4		lumbar vertebra strength trait (VT:0010574)	vertebra ultimate force (CMO:0001678)	10	58073360	103073360	Rat
12903252	Cm113	Cardiac mass QTL 113		0.047	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	66817119	107713808	Rat
1579915	Bp280	Blood pressure QTL 280		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	90904245	95604677	Rat
70164	Bw21	Body weight QTL 21	4.36	0.00005	body mass (VT:0001259)	body weight (CMO:0000012)	10	54296336	99451733	Rat
4889948	Bss91	Bone structure and strength QTL 91	4		tibia area (VT:1000281)	tibia midshaft total cross-sectional area (CMO:0001715)	10	83061236	92869129	Rat
1579919	Bp281	Blood pressure QTL 281		0.01	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	50464802	95464802	Rat
2298548	Neuinf7	Neuroinflammation QTL 7	3.4		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	10	64939013	107713808	Rat
1302404	Cia27	Collagen induced arthritis QTL 27	2.6	0.0045	joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	10	76951790	107713808	Rat
1300107	Rf18	Renal function QTL 18	3.41		urine output (VT:0003620)	timed urine volume (CMO:0000260)	10	79272424	102982300	Rat
2300218	Hpcl2	Hepatic cholesterol level QTL 2			liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	45529164	96099749	Rat
70168	Eae12	Experimental allergic encephalomyelitis QTL 12		0.0009	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	73599825	107713808	Rat
70171	Cari1	Carrageenan-induced inflammation QTL 1	4.9	0.0005	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	10	54296227	107713808	Rat
10450495	Bp383	Blood pressure QTL 383		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	76743133	95464802	Rat
12903269	Am15	Aortic mass QTL 15		0.042	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	66817119	107713808	Rat
10450493	Bp382	Blood pressure QTL 382		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	50860288	95860288	Rat
2313856	Bp342	Blood pressure QTL 342	4.4	0.0001	life span trait (VT:0005372)	age at time of death (CMO:0001193)	10	87807758	96620484	Rat
12903266	Cm114	Cardiac mass QTL 114		0.02	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	10	66817119	107713808	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
2292617	Ept18	Estrogen-induced pituitary tumorigenesis QTL 18	3.9		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	10	73950353	96620293	Rat
2313103	Bss80	Bone structure and strength QTL 80	2	0.0001	tibia strength trait (VT:1000284)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	10	62556066	107556066	Rat
12880372	Am12	Aortic mass QTL 12		0.003	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	66817119	107713808	Rat
70193	Mcs7	Mammary carcinoma susceptibility QTL 7	2.38		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	72724423	107713808	Rat
2313105	Bss79	Bone structure and strength QTL 79	1.8	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	62556066	107556066	Rat
12880375	Kidm66	Kidney mass QTL 66		0.009	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	10	66817119	107713808	Rat
61363	Oia3	Oil induced arthritis QTL 3		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	87807758	107713808	Rat
1357344	Bp249	Blood pressure QTL 249		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	67241334	98502431	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14991535	107556066	Rat
12880370	Cm105	Cardiac mass QTL 105		0.008	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	10	66817119	107713808	Rat
12880371	Cm106	Cardiac mass QTL 106		0.007	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	66817119	107713808	Rat
2306970	Anxrr22	Anxiety related response QTL 22	5.95		fear/anxiety-related behavior trait (VT:1000241)	number of periods of voluntary immobility (CMO:0001045)	10	61843496	98710773	Rat
724530	Bp149	Blood pressure QTL 149		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	91127270	95604677	Rat
1300137	Bp186	Blood pressure QTL 186	3.57		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	10	91127270	107556066	Rat
11565453	Kidm58	Kidney mass QTL 58		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	10	66817119	107713808	Rat
1359017	Hrtrt21	Heart rate QTL 21	2.4		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	10	73695339	97272278	Rat
7387312	Bw125	Body weight QTL 125	3	0.0047	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight (CMO:0000356)	10	65390777	107713808	Rat
6893357	Bw102	Body weight QTL 102	0.5	0.36	body mass (VT:0001259)	body weight (CMO:0000012)	10	81012077	101828297	Rat
12880384	Cm107	Cardiac mass QTL 107		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)		90904245	95604677	Rat
12880385	Cm108	Cardiac mass QTL 108		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)		90904245	95604677	Rat
12880396	Am13	Aortic mass QTL 13		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	90904245	95604677	Rat
2306793	Ean5	Experimental allergic neuritis QTL 5	4.7		nervous system integrity trait (VT:0010566)	IFNG-secreting splenocyte count (CMO:0002122)	10	73049656	94495280	Rat
12880398	Kidm67	Kidney mass QTL 67		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	10	90904245	95604677	Rat
2306792	Ean4	Experimental allergic neuritis QTL 4	4		nervous system integrity trait (VT:0010566)	IFNG-secreting splenocyte count (CMO:0002122)	10	49495492	94495492	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	52269185	107713808	Rat
12880395	Cm109	Cardiac mass QTL 109		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	10	90904245	95604677	Rat
61396	Bp9	Blood pressure QTL 9	4.8	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	68920187	107713808	Rat
1358915	Stresp7	Stress response QTL 7	3.52		blood norepinephrine amount (VT:0005663)	plasma norepinephrine level (CMO:0001010)	10	65307813	107713808	Rat
634320	Niddm49	Non-insulin dependent diabetes mellitus QTL 49	4.41		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	10	89039175	107713808	Rat
70363	Bp71	Blood pressure QTL 71		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	61843496	106843496	Rat
70364	Bp72	Blood pressure QTL 72			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	88900501	96620484	Rat
6893366	Bw106	Body weight QTL 106	0.3	0.47	body mass (VT:0001259)	body weight (CMO:0000012)	10	70698731	107713808	Rat
631530	Tls3	T-lymphoma susceptibility QTL 3	0	0.0001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	10	27587226	96099902	Rat
1354608	Cm33	Cardiac mass QTL 33	2.8		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	10	55307972	93608131	Rat
1558643	Cm44	Cardiac mass QTL 44	4.8	0.0000368	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	61843496	100198886	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
631269	Cia22	Collagen induced arthritis QTL 22	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40535708	107713808	Rat
1576308	Schws1	Schwannoma susceptibility QTL 1		0.0041	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	40535708	107713808	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14991535	107713808	Rat
7207811	Bmd90	Bone mineral density QTL 90	5.2		femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	10	49943710	94943710	Rat
631270	Cia23	Collagen induced arthritis QTL 23	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40535708	107713808	Rat
1581559	Eae18	Experimental allergic encephalomyelitis QTL 18		0.00002	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	10	66108888	107555881	Rat
6893336	Cm75	Cardiac mass QTL 75	0.1	0.87	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	10	61843496	100198886	Rat
631547	Bp87	Blood pressure QTL 87	4.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	47869129	92869129	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6864618	96620484	Rat
12880055	Am11	Aortic mass QTL 11		0.004	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	84503487	96432422	Rat
2292438	Bp311	Blood pressure QTL 311			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	76743133	95604677	Rat
2301398	Kidm38	Kidney mass QTL 38		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	10	84503487	96432422	Rat
2292436	Bp310	Blood pressure QTL 310			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	50604677	95604677	Rat
1600367	Mcs15	Mammary carcinoma susceptibility QTL 15	4.5		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	72724423	107713808	Rat
1358188	Ept9	Estrogen-induced pituitary tumorigenesis QTL 9	3.9		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	10	73950353	96620293	Rat
631537	Oia4	Oil induced arthritis QTL 4			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	76128947	107713808	Rat
634354	Rends3	Renal damage susceptibility QTL 3		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	10	61997479	106997479	Rat
2301405	Cm69	Cardiac mass QTL 69		0.031	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	10	66817119	107713808	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	27023535	99451848	Rat

Markers in Region

RH129350

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	91,088,537 - 91,088,753 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	94,349,058 - 94,349,273	NCBI	Rnor6.0
Rnor_5.0	10	94,097,728 - 94,097,943	UniSTS	Rnor5.0
RGSC_v3.4	10	95,550,767 - 95,550,982	UniSTS	RGSC3.4
Celera	10	89,764,625 - 89,764,840	UniSTS
RH 3.4 Map	10	979.2	UniSTS
Cytogenetic Map	10	q32.1	UniSTS

RH133214

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	91,082,543 - 91,082,731 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	94,343,064 - 94,343,251	NCBI	Rnor6.0
Rnor_5.0	10	94,091,734 - 94,091,921	UniSTS	Rnor5.0
RGSC_v3.4	10	95,544,773 - 95,544,960	UniSTS	RGSC3.4
Celera	10	89,758,631 - 89,758,818	UniSTS
RH 3.4 Map	10	979.5	UniSTS
Cytogenetic Map	10	q32.1	UniSTS

AW548911

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	91,086,805 - 91,086,912 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	94,347,326 - 94,347,432	NCBI	Rnor6.0
Rnor_5.0	10	94,095,996 - 94,096,102	UniSTS	Rnor5.0
RGSC_v3.4	10	95,549,035 - 95,549,141	UniSTS	RGSC3.4
Celera	10	89,762,893 - 89,762,999	UniSTS
Cytogenetic Map	10	q32.1	UniSTS

RH124538

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	91,086,008 - 91,086,440 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	94,346,529 - 94,346,960	NCBI	Rnor6.0
Rnor_5.0	10	94,095,199 - 94,095,630	UniSTS	Rnor5.0
RGSC_v3.4	10	95,548,238 - 95,548,669	UniSTS	RGSC3.4
Celera	10	89,762,096 - 89,762,527	UniSTS
Cytogenetic Map	10	q32.1	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107058	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063269201	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC133055	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC168979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000088656 ⟹ ENSRNOP00000074780

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	91,519,888 - 91,587,436 (+)	Ensembl
mRatBN7.2 Ensembl	10	91,020,174 - 91,088,848 (+)	Ensembl
Rnor_6.0 Ensembl	10	94,280,703 - 94,349,368 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095570 ⟹ ENSRNOP00000085202

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	91,531,971 - 91,588,651 (+)	Ensembl
mRatBN7.2 Ensembl	10	91,032,107 - 91,088,848 (+)	Ensembl

RefSeq Acc Id:

NM_001107058 ⟹ NP_001100528

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	91,519,976 - 91,588,651 (+)	NCBI
mRatBN7.2	10	91,020,174 - 91,088,852 (+)	NCBI
Rnor_6.0	10	94,280,703 - 94,349,372 (+)	NCBI
Rnor_5.0	10	94,029,306 - 94,098,042 (+)	NCBI
RGSC_v3.4	10	95,482,303 - 95,551,065 (+)	RGD
Celera	10	89,696,294 - 89,764,939 (+)	NCBI

Sequence:

show sequence

CTTCTGGACTTCAAGACTGGCAGGCGGGCCAGCCGAGTGGCGCCGCCGAGGCCGGGTTGGGCCG
AGCCTGGGAGCGCCGGGGATGTAGCGGGCCACCCTGCTCATGCCACAGCGCCCGGCCCGGGCCG
GAGCCGGAGCCTGGGGAGGCGGCGGGGGCCCCGAGCGCAGCCCACGGCCCCCGCGCGGAGCCAG
GCCTGCCGCCGTCCCCGCCGCCTGCTCCCCCGGCATGCAGCCCCGGCTGCGGAGGTGACACTTC
TGGGCTGATACCGCTGCCGCCGCCATCGCCACCATGGATGAACAAGAGGCATTAGACTCAATCA
TGAAGGACCTGGTGGCCCTCCAGATGAGCCGACGTCCCCGGGTGTCTGGATATGAGACCATGAA
GAACAAGGACACAGGTCACCCAAACAGGCAGAGTGACGTCAGAATCAAGTTTGAACACAATGGG
GAGAGACGAATTATAGCATTCAGCCGGCCTGTGAGATATGAAGATGTGGAACACAAGGTGACAA
CGGTCTTTGGGCAGCCTCTTGATTTGCATTATATGAATAATGAGCTCTCCATCCTGTTGAAAAA
CCAAGATGATCTCGATAAAGCAATTGACATTTTGGATAGAAGCGCGAGTATGAAAAGCCTTAGG
ATACTACTGTTATCCCAAGACAGAAACCATACTAGTTCCTCTCCCCACTCTGGAGTGTCCAGGC
AGGTTCGGGTCAAGCCTTCCCAGTCTGCAGGGGATATAAATACCATCTACCAAGCTCCTGAGCC
CAGAAGCAGGCACCTCTCTGTCAGCTCCCAGAACCCTGGCCGAAGCTCTCCTCCCCCTGGTTAT
GTACCTGAGCGACAACAGCACATTGCCCGGCAGGGATCATATACGAGCATCAATAGTGAAGGTG
AATTCATCCCAGAGACCAGCGAGCAGTGCATGCTAGATCCCCTGAGCAGTGCCGAAAATTCCTT
GTCAGGAAGCTGCCAATCCTTGGACAGGTCAGCAGACAGCCCATCTTTCAGGAAATCACAAATG
TCCCGAGCCCGGAGCTTCCCAGACAACAGAAAGGAATGCTCGGATCGGGAGACCCAGCTCTATG
ATAAAGGAGTTAAAGGCGGAACCTATCCCAGGCGTTACCATGTATCTGTGCATCATAAAGACTA
CAATGATGGCAGAAGAACGTTTCCCCGAATACGACGGCACCAGGGCAACCTATTCACTCTGGTG
CCCTCAAGTCGCTCCTTGAGCACAAATGGCGAGAACATGGGTGCCGCTGTGCAGTACTTGGACC
CCCGCGGGCGCCTACGGAGTGCAGACAGTGAAAATGCCCTCACTGTGCAGGAAAGAAGTGTGCC
AACCAAGTCTCCTAGTGCTCCCATCAATTGGCGTCGGGGGAAGCTCCTGGGTCAAGGTGCCTTC
GGCAGGGTCTACTTATGCTATGATGTGGACACAGGACGTGAACTTGCTTCTAAGCAGGTTCAGT
TTGACCCAGATAGTCCTGAGACTAGCAAGGAGGTGAGTGCTCTGGAGTGCGAGATCCAGTTGCT
GAAGAACTTGCAGCATGAGCGCATCGTGCAGTACTATGGCTGCCTGCGGGACCGTGCTGAGAAG
ATCCTCACCATCTTTATGGAGTATATGCCAGGGGGCTCTGTAAAAGACCAGTTGAAGGCCTACG
GAGCTCTGACGGAGAGTGTGACCCGCAAGTATACACGGCAGATCCTGGAGGGCATGTCCTACCT
GCACAGCAACATGATCGTGCATCGTGACATCAAGGGAGCCAATATCCTCCGAGACTCGGCTGGG
AATGTGAAGCTTGGGGATTTTGGGGCCAGCAAACGCCTGCAAACCATCTGCATGTCAGGGACAG
GCATGCGCTCTGTCACTGGCACACCCTACTGGATGAGTCCTGAAGTCATCAGTGGCGAGGGCTA
TGGAAGAAAGGCAGATGTGTGGAGCCTGGGCTGTACCGTGGTGGAGATGCTGACAGAGAAACCA
CCTTGGGCAGAGTATGAAGCTATGGCTGCCATTTTCAAGATTGCCACCCAGCCTACCAATCCTC
AGCTGCCCTCTCACATCTCAGAACACGGCAGGGACTTCCTGAGGCGCATATTTGTGGAAGCTCG
TCAGAGACCCTCGGCTGAGGAGCTGCTCACACACCACTTTGCACAGCTAGTGTACTGAGCTCTC
AAGGCTATGCTGCTGCCAGCTGCCACCTGCTGAGCAGGCGAGGGGCTGCTGTCCGGCGCAGTGA
AGTTGCTGCTTCTCCCAGGCAAGGCTATGGACCAGTGGAGTGTCCCAGCCATTGTCTGTCTGTG
CCCCATCTGCCGCTGGGACTCAAAGCCAGGATCTGGCATCAAGACTGGGAGCTCCAGCCTGTAA
GACCCAAGAGCTTTGACATCCTAAGCTCAGTGTGGCAGGAAGGGCTGGGACCAGTATGTAAGAC
TGCCATGGGTCCTGCCTGCCCTCAGATGTGTCCTAACACTGCAGACAGCACTGAAGTCAAGAGG
GACTAGGCACAGGACCTACTCAAGGGTATGAATAGTGTTACTTCATCCAGAGTGTTACTTTGTT
TCTCTCCCAATGTTTGGAGACCACCAGAGAATCTCTGGGCTGCATGAGCCCACACAAGCCTGAG
GTAAAGCCCAGCGTCCCCCAGCAACAGGAGGTAGAGGTTTGGGCTGCCCCACTAAGCTTCCAGG
TATGCTGTGTCAGTCCTGTCTTACCAAAGATGAATGAAGCAAACGCTATGCTGCCTTATCCTGG
GAAGGAGGAGCTACCCCAATAAGCAGGGCCTGAGAAGCGGGGCTGCCTCCAGTAACTGGGGAGA
CCCAGTCTTGTCAATGCAATTGTCTCTGTTTTACAGGTTGGAGTCACTCTTATGCTGTTCCCAG
TTTTGAAACTGGAGACTTTGCCCTCTGAGCTCTGGAGACCCATGTGGGCTTAGGCCTTGGACTG
GATGGGAAAGAGCTGATGGCCTCCACCCCTGGCCTGCCATCTGTTCCCTCACTGGAGCAGAGAA
AGTAGACAACACAAGTTAGGGCACCTGGCTCTGGGCAACTCAGCAAAGTGCAGGGGGGTCTCTC
AGGCTATCTACATCTCAAATCTGTCAGGCCTGAGCCCACTCCATGGGGCAGAAAGTCCTTGTGC
TGCCACAACCATGTCCAAAACCACCAGCTGTGTTCCTTAGCCCTCCTTGTCCACTTGTCATCAG
CCTCATTTCCTTGTTCCTCCCACAGGGGAGGATGCCAGCAGGGGTTAGGGAAAAAGTTATCTCC
GAGCAGCTTAGAGTTGGCCATATTTACCTCAGCCTGGGTGCTGGTCCTTTCTTCCAGCCCCTTT
CTTCCCCTCCAAATGTGCCTATTGCTAGAGCTCCTCCCTCCTGATTCCCAAGTTTCTTGGGAAT
TATCATTAAAGAAAAAAAAAAAAAAAGCCAGTGCCCAGGTGGGCATCTCCAGGGAGCTGGGGAT
CAGTGCCAGGCATCTCTTTGCCAGCCATGCCCACGTCCCCATGGGCACAGAACAAGCCAAAGCC
TTCGTTGTCTGTTGACGATGCACTTTTATGAATGTAGTTCCTATCGCTGTTTTTAGCCTTTTCC
CATCATGTAATGTGAGGCCTTGTACTTGTTAATTTATATCTCAGATCCATATTTGATGGTTTTT
ATATATATCAATTCTAGACTGTTACCGGTGATGGACTCCTGAAGAGAGAACAGAAATTGAAAGC
AGCTGGTTTTGCAGATATGTGTGTTGCACGGTGCCAATTGGGCCTGGGCCCCTTTGTTTTATTT
CCTTTCCCTTGGGGGTCTGTTAGGCCACTCTCTAACTGCTCTGAAGCCAGTGAGCAAAGTCCTG
CTTCCACCTCAGCCTTTGCCCAAAGTAGGGACTGGCCCCCTCTTCTAGACCAAAGCTGCCAAAA
GGCAGCTCGGCCTCTCCATGACCCCATCCTGCTGGCTATGTAGCACCCCTTAGCCTATCCCTAT
CCACACCCCCAAACCTAGAGGAAATAGAGCTTGGTGGGCTGACAAGATGTTAGATGAGACAACT
CTGCTTGTCACAGGTTCAGGCTCTCACAGAGCTCCTCCCCCATTCCTCCCCTTGGGGGAGCTTA
TTACCTCATAGGGAATGTTTCTAAAGTGAACTTAAAAGTAAGTCAACAAATCCTGCACTCCAAA
GGAAAAAAAAAAAAGACCCTTTTTTTTTGTGCCAAAAACTGTGGACATGCTGGTTCAGCATCCT
CAGGACCAAAGCTATTAATTTATTTTCTCTTATTAACAAATTTAAAAGAGAATTGTGGGCCTCC
AGGATGGCCTGGACCCAAAGGTTATGAAGGACAGTTTCCTAGCAGCCCTTGGCTTGCTGTGCAA
AGATTCTGTGCCACCATTTGTTCTTCATTCCATGGGGTTTATCTGCCTTTGCCAACCCCATATG
GAAGGGCCAGGCCTGGGTCAGGTGCATGCCGCCCGCCACCCTCCTGCCCCTCCCACTCACCCAG
CTCTGTGTGCGTCTGAATTGTGGATTGTGCAGAAGAACCTGCAGGCATAGTTATTGACTATATC
GTGACTGAGGGCTTGCAGTGCAAAGCCAGGCCAGTGCATTACTTAACAATAAAAGGGATCATTT
ATATCAGAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063269201 ⟹ XP_063125271

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	91,520,334 - 91,588,651 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001100528	(Get FASTA)	NCBI Sequence Viewer
	XP_063125271	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI68979	(Get FASTA)	NCBI Sequence Viewer
	EDM06356	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000074780
	ENSRNOP00000074780.1
	ENSRNOP00000085202
	ENSRNOP00000085202.2

RefSeq Acc Id:

NP_001100528 ⟸ NM_001107058

- UniProtKB:

B5DF98 (UniProtKB/TrEMBL), A6HK01 (UniProtKB/TrEMBL), A0A8I6A3I3 (UniProtKB/TrEMBL), A0A0G2K8Y1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDEQEALDSIMKDLVALQMSRRPRVSGYETMKNKDTGHPNRQSDVRIKFEHNGERRIIAFSRPV
RYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSASMKSLRILLLSQDRNHT
SSSPHSGVSRQVRVKPSQSAGDINTIYQAPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQ
GSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSFRKSQMSRARSFPDNRK
ECSDRETQLYDKGVKGGTYPRRYHVSVHHKDYNDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGE
NMGAAVQYLDPRGRLRSADSENALTVQERSVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDT
GRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPG
GSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASK
RLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAI
FKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEELLTHHFAQLVY

hide sequence

Ensembl Acc Id:

ENSRNOP00000074780 ⟸ ENSRNOT00000088656

Ensembl Acc Id:

ENSRNOP00000085202 ⟸ ENSRNOT00000095570

RefSeq Acc Id:	XP_063125271 ⟸ XM_063269201
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A3I3 (UniProtKB/TrEMBL)

Protein Domains

PB1 Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B5DF98-F1-model_v2	AlphaFold	B5DF98	1-626	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697833

Promoter ID:

EPDNEW_R8358

Type:

multiple initiation site

Name:

Map3k3_1

Description:

mitogen activated protein kinase kinase kinase 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	94,280,662 - 94,280,722	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1304575	AgrOrtholog
BioCyc Gene	G2FUF-22964	BioCyc
Ensembl Genes	ENSRNOG00000061424	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000088656	ENTREZGENE
	ENSRNOT00000088656.3	UniProtKB/TrEMBL
	ENSRNOT00000095570	ENTREZGENE
	ENSRNOT00000095570.2	UniProtKB/TrEMBL
Gene3D-CATH	Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Kinase-like_dom	UniProtKB/TrEMBL
	OPR_PB1	UniProtKB/TrEMBL
	PB1-like	UniProtKB/TrEMBL
	PB1_MEKK2/3	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
KEGG Report	rno:303604	UniProtKB/TrEMBL
NCBI Gene	303604	ENTREZGENE
PANTHER	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3	UniProtKB/TrEMBL
	SERINE/THREONINE PROTEIN KINASE	UniProtKB/TrEMBL
Pfam	PB1	UniProtKB/TrEMBL
	Pkinase	UniProtKB/TrEMBL
PhenoGen	Map3k3	PhenoGen
PROSITE	PB1	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000061424	RatGTEx
SMART	PB1	UniProtKB/TrEMBL
	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	CAD & PB1 domains	UniProtKB/TrEMBL
	Kinase_like	UniProtKB/TrEMBL
UniProt	A0A0G2K8Y1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A3I3	ENTREZGENE, UniProtKB/TrEMBL
	A6HK01	ENTREZGENE, UniProtKB/TrEMBL
	B5DF98	ENTREZGENE
UniProt Secondary	B5DF98	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Map3k3	mitogen activated protein kinase kinase kinase 3	Map3k3_predicted	mitogen activated protein kinase kinase kinase 3 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Map3k3_predicted	mitogen activated protein kinase kinase kinase 3 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)