Map3k3 (mitogen-activated protein kinase kinase kinase 3) - Rat Genome Database

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Pathways
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Gene: Map3k3 (mitogen-activated protein kinase kinase kinase 3) Mus musculus
Analyze
Symbol: Map3k3
Name: mitogen-activated protein kinase kinase kinase 3
RGD ID: 1312093
MGI Page MGI
Description: Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within blood vessel development and positive regulation of p38MAPK cascade. Predicted to be active in cytoplasm. Is expressed in several structures, including early conceptus; heart; and metanephros. Orthologous to human MAP3K3 (mitogen-activated protein kinase kinase kinase 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW548911; KIAA4031; MAPK/ERK kinase kinase 3; MAPKK; MAPKKK3; MEK kinase 3; MEKK 3; Mekk3; mitogen activated protein kinase kinase kinase 3; mKIAA4031
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm7103  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911105,975,358 - 106,047,482 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11105,975,439 - 106,046,272 (+)EnsemblGRCm39 Ensembl
GRCm3811106,084,587 - 106,156,656 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11106,084,613 - 106,155,446 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711105,946,216 - 106,016,760 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611105,900,992 - 105,971,536 (+)NCBIMGSCv36mm8
Celera11117,815,382 - 117,885,664 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1168.89NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mechanisms and functions of p38 MAPK signalling. Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
2. p38 MAP-kinases pathway regulation, function and role in human diseases. Cuenda A and Rousseau S, Biochim Biophys Acta. 2007 Aug;1773(8):1358-75. Epub 2007 Mar 24.
3. MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42. Fanger GR, etal., EMBO J. 1997 Aug 15;16(16):4961-72.
4. The c-jun kinase/stress-activated pathway: regulation, function and role in human disease. Johnson GL and Nakamura K, Biochim Biophys Acta. 2007 Aug;1773(8):1341-8. Epub 2007 Jan 4.
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Regulation of cellular functions by the ERK5 signalling pathway. Wang X and Tournier C, Cell Signal. 2006 Jun;18(6):753-60. Epub 2006 Jan 6.
Additional References at PubMed
PMID:8621389   PMID:9452471   PMID:10349636   PMID:10593883   PMID:10700190   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11429546   PMID:11544199   PMID:12391307  
PMID:12466851   PMID:12477932   PMID:12650640   PMID:12912994   PMID:14634666   PMID:14636585   PMID:14661019   PMID:15001576   PMID:15102471   PMID:15489334   PMID:15964803   PMID:16126726  
PMID:16141072   PMID:16141073   PMID:16362041   PMID:16737960   PMID:17116170   PMID:17197697   PMID:17214902   PMID:17687003   PMID:17699753   PMID:18206350   PMID:18308725   PMID:18799693  
PMID:18855897   PMID:19008476   PMID:19223432   PMID:19224984   PMID:19265138   PMID:19465115   PMID:20124484   PMID:20720201   PMID:21333552   PMID:21471448   PMID:21873635   PMID:25043814  
PMID:25625206   PMID:26235885   PMID:27027284   PMID:27513872   PMID:27671672   PMID:29329581   PMID:29941457   PMID:30566428   PMID:32325033   PMID:33812250   PMID:36719480   PMID:36995941  
PMID:37583551  


Genomics

Comparative Map Data
Map3k3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911105,975,358 - 106,047,482 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11105,975,439 - 106,046,272 (+)EnsemblGRCm39 Ensembl
GRCm3811106,084,587 - 106,156,656 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11106,084,613 - 106,155,446 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711105,946,216 - 106,016,760 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611105,900,992 - 105,971,536 (+)NCBIMGSCv36mm8
Celera11117,815,382 - 117,885,664 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1168.89NCBI
MAP3K3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381763,622,417 - 63,696,305 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1763,622,415 - 63,696,305 (+)EnsemblGRCh38hg38GRCh38
GRCh371761,699,777 - 61,773,665 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361759,053,533 - 59,127,402 (+)NCBINCBI36Build 36hg18NCBI36
Build 341759,053,532 - 59,127,401NCBI
Celera1756,087,919 - 56,161,790 (+)NCBICelera
Cytogenetic Map17q23.3NCBI
HuRef1757,077,975 - 57,141,816 (+)NCBIHuRef
CHM1_11761,764,216 - 61,838,082 (+)NCBICHM1_1
T2T-CHM13v2.01764,493,028 - 64,567,209 (+)NCBIT2T-CHM13v2.0
Map3k3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81091,519,976 - 91,588,651 (+)NCBIGRCr8
mRatBN7.21091,020,174 - 91,088,852 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1091,020,174 - 91,088,848 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1096,075,116 - 96,143,482 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01095,538,287 - 95,606,652 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01090,949,010 - 91,017,411 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01094,280,703 - 94,349,372 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1094,280,703 - 94,349,368 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01094,029,306 - 94,098,042 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41095,482,303 - 95,551,065 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11095,496,690 - 95,565,451 (+)NCBI
Celera1089,696,294 - 89,764,939 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
Map3k3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554788,125,436 - 8,199,253 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554788,122,999 - 8,185,138 (-)NCBIChiLan1.0ChiLan1.0
MAP3K3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21979,794,119 - 79,868,489 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11784,611,585 - 84,685,943 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01757,702,242 - 57,776,601 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11762,858,655 - 62,922,874 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1762,858,635 - 62,922,874 (+)Ensemblpanpan1.1panPan2
MAP3K3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1911,612,527 - 11,678,407 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl911,612,994 - 11,675,838 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha912,572,499 - 12,638,395 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0913,276,493 - 13,339,186 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl913,276,310 - 13,338,713 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1912,220,815 - 12,286,279 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0915,245,905 - 15,311,520 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0915,248,794 - 15,314,683 (-)NCBIUU_Cfam_GSD_1.0
Map3k3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560214,849,361 - 14,918,227 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365414,276,371 - 4,344,008 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365414,276,371 - 4,345,239 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP3K3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1215,230,182 - 15,298,784 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11215,228,979 - 15,298,784 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21215,215,673 - 15,285,409 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP3K3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11657,594,770 - 57,670,047 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1657,597,288 - 57,669,720 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607728,205,915 - 28,279,700 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map3k3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248491,118,492 - 1,185,777 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248491,118,275 - 1,186,244 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Map3k3
1874 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:901
Count of miRNA genes:469
Interacting mature miRNAs:577
Transcripts:ENSMUST00000002044, ENSMUST00000124449, ENSMUST00000129793
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100254186120887165Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101022590121973369Mouse
14700693Ppiq12_mprepulse inhibition QTL 12 (mouse)11101504820114472363Mouse
14700694Ppiq13_mprepulse inhibition QTL 13 (mouse)11101504820114472363Mouse
14700695Ppiq14_mprepulse inhibition QTL 14 (mouse)11101504820114472363Mouse
14700696Ppiq15_mprepulse inhibition QTL 15 (mouse)11101504820114472363Mouse
1300957Pbd1_mpeak bone density 1 (mouse)Not determined11102344123112384123Mouse
4141612Cia40_mcollagen induced arthritis 40 (mouse)Not determined11103273992115021444Mouse

Markers in Region
RH133214  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811106,150,100 - 106,150,284UniSTSGRCm38
MGSCv3711106,011,414 - 106,011,598UniSTSGRCm37
Celera11117,880,318 - 117,880,502UniSTS
Cytogenetic Map11E1UniSTS
AW548911  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811106,154,604 - 106,154,699UniSTSGRCm38
MGSCv3711106,015,918 - 106,016,013UniSTSGRCm37
Celera11117,884,822 - 117,884,917UniSTS
Cytogenetic Map11E1UniSTS
Whitehead/MRC_RH111424.0UniSTS
U43187  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811106,154,308 - 106,154,496UniSTSGRCm38
MGSCv3711106,015,622 - 106,015,810UniSTSGRCm37
Celera11117,884,526 - 117,884,714UniSTS
Cytogenetic Map11E1UniSTS
Whitehead/MRC_RH111427.02UniSTS
Whitehead_YAC11 UniSTS
D11Mit147  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811106,140,852 - 106,140,945UniSTSGRCm38
MGSCv3711106,002,166 - 106,002,259UniSTSGRCm37
Celera11117,871,078 - 117,871,171UniSTS
Cytogenetic Map11E1UniSTS
cM Map1165.0UniSTS
Whitehead Genetic1165.6UniSTS
Whitehead_YAC11 UniSTS
Map3k3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11E1UniSTS
cM Map11 UniSTS
UniSTS:236758  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811106,137,815 - 106,138,045UniSTSGRCm38
MGSCv3711105,999,129 - 105,999,359UniSTSGRCm37
Celera11117,868,039 - 117,868,269UniSTS
Cytogenetic Map11E1UniSTS
AU022928  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811106,097,551 - 106,097,778UniSTSGRCm38
MGSCv3711105,958,865 - 105,959,092UniSTSGRCm37
Celera11117,828,035 - 117,828,262UniSTS
Cytogenetic Map11E1UniSTS
Whitehead/MRC_RH1856.53UniSTS
U43187  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811106,155,135 - 106,155,219UniSTSGRCm38
MGSCv3711106,016,449 - 106,016,533UniSTSGRCm37
Celera11117,885,353 - 117,885,437UniSTS
Cytogenetic Map11E1UniSTS
Whitehead/MRC_RH111427.02UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000002044   ⟹   ENSMUSP00000002044
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11105,975,439 - 106,046,272 (+)Ensembl
GRCm38.p6 Ensembl11106,084,613 - 106,155,446 (+)Ensembl
RefSeq Acc Id: ENSMUST00000124449
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11106,042,890 - 106,044,966 (+)Ensembl
GRCm38.p6 Ensembl11106,152,064 - 106,154,140 (+)Ensembl
RefSeq Acc Id: ENSMUST00000129793
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11106,042,038 - 106,043,204 (+)Ensembl
GRCm38.p6 Ensembl11106,151,212 - 106,152,378 (+)Ensembl
RefSeq Acc Id: NM_011947   ⟹   NP_036077
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911105,975,413 - 106,047,482 (+)NCBI
GRCm3811106,084,587 - 106,156,656 (+)NCBI
MGSCv3711105,946,216 - 106,016,760 (+)RGD
Celera11117,815,382 - 117,885,664 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011249037   ⟹   XP_011247339
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911105,975,792 - 106,047,476 (+)NCBI
GRCm3811106,084,962 - 106,156,650 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036156710   ⟹   XP_036012603
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911105,978,341 - 106,047,476 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036156711   ⟹   XP_036012604
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911105,975,360 - 106,047,476 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004936967
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911105,975,358 - 106,047,476 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_036077   ⟸   NM_011947
- UniProtKB: Q61084 (UniProtKB/Swiss-Prot),   Q3UVM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011247339   ⟸   XM_011249037
- Peptide Label: isoform X1
- UniProtKB: Q3UVM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000002044   ⟸   ENSMUST00000002044
RefSeq Acc Id: XP_036012604   ⟸   XM_036156711
- Peptide Label: isoform X2
- UniProtKB: Q3UVM5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036012603   ⟸   XM_036156710
- Peptide Label: isoform X1
- UniProtKB: Q3UVM5 (UniProtKB/TrEMBL)
Protein Domains
PB1   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61084-F1-model_v2 AlphaFold Q61084 1-626 view protein structure

Promoters
RGD ID:6821227
Promoter ID:MM_KWN:10214
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000006328
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611105,945,311 - 105,946,387 (+)MPROMDB
RGD ID:6821226
Promoter ID:MM_KWN:10217
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain,   Lung,   Spleen
Transcripts:OTTMUST00000006660,   OTTMUST00000006661
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611106,011,941 - 106,013,552 (+)MPROMDB
RGD ID:8677056
Promoter ID:EPDNEW_M16559
Type:initiation region
Name:Map3k3_1
Description:Mus musculus mitogen-activated protein kinase kinase kinase 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811106,085,000 - 106,085,060EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1346874 AgrOrtholog
Ensembl Genes ENSMUSG00000020700 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000002044 ENTREZGENE
  ENSMUST00000002044.10 UniProtKB/Swiss-Prot
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PB1_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PB1_MEKK2/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:26406 UniProtKB/Swiss-Prot
MGD MGI:1346874 ENTREZGENE
NCBI Gene 26406 ENTREZGENE
PANTHER MAP KINASE KINASE KINASE SSK2-RELATED-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Map3k3 PhenoGen
PROSITE PB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP CAD & PB1 domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt M3K3_MOUSE UniProtKB/Swiss-Prot
  Q3UVM5 ENTREZGENE, UniProtKB/TrEMBL
  Q5DTS0_MOUSE UniProtKB/TrEMBL
  Q61084 ENTREZGENE