The RGD Strain records may be accessed in two different ways:
- Search by Keyword - Search the strain records for strain entries containing a particular keyword, for example to find strains documented as being associated with hypertension. The search returns a list of hits with a short sample of text around the keyword to indicate the context in which is was used.
- View specific strain record - Select a known strain from the list of RGD Strain records to view the strain record directly.
The rat strain data presented here is based on the Rat Strain List collected by Dr. M. Festing plus new strain data collected as part of the RGD curation effort. At the present time not all of the original Rat Strain List entries are loaded, work is underway to curate these remaining records during the summer of 2001.
This is a table showing the number of heterozygotic allele sizes detected when
48 strains were screened with 4000+ SSLPs. A completely inbred strain would
be expected to have very few (ideally zero) heterozygotic markers, higher numbers
of heterozygotic markers would suggest a less inbred strain.
Based on the ACP data, this table indicates the percentage of polymorphic markers detected between two given strains. Two tables are presented, calculated using different criteria to define when two allele sizes are polymorphic between two strains. At its simplest, a marker is polymorphic between strain A and strain B if its allele size in Strain A is different to that in Strain B. These percentages are give in Table 1. However, this does not take into account the potential inaccuracies brought about by polyacrylamide gel electrophoresis, both at the gel running and gel reading stages. To account for this, we have recalculated the polymorphism percentages based upon saying that a marker is polymorphic between Strain A and Strain B if the difference in marker size between the two strains is greater than 2bp (Table 2). This results in a lower polymorphism rate between the strains but is perhaps a more accurate value.
- Table 1 - Basic Strain Polymorphism Percentage table, markers were considered polymorphic if they were not identical in size.
- Table 2 - Recalculated percentages based on polymorphism being a size difference greater than 2 base pairs.
NB These are both large HTML tables.