Welcome to the MCW Gene Editing Rat Resource Center!
The National Heart, Lung, and Blood Institute (NHLBI) has awarded Melinda Dwinell, PhD and Aron Geurts, PhD at the Medical College of Wisconsin an R24 Resource grant to make ~200 genetically modified rat strains over a five year period (R24 HL114474). These models will be of interest and value to the mission of the NHLBI. The NHLBI promotes the prevention and treatment of heart, lung, and blood diseases through scientific discovery directed toward the causes of disease and translation of basic discoveries into clinical practice.
The rat strains will be made using several different gene editing technologies, making it feasible to genetically modify genes in rats in any desired background much faster than traditional technology.