PhysGen Knockouts

The PhysGen Knockout program ("Mechanistic Characterization of Genes for Hypertension and Renal Disease") aims to knock out a large number of genes nominated by genome wide association studies, combine these gene knockouts (KO) with hypertensive and normotensive strains, and phenotypically characterize them.

We invite the scientific community to nominate genes involved in the development of hypertension and renal disease. To do so, please contact Mindy Dwinell, Ph.D. (mrdwinel@mcw.edu).   

Key Personnel   Role  Contact email
Howard Jacob, Ph.D.  Principal Investigator  jacob@mcw.edu 
Allen Cowley, Jr., Ph.D.  Co-Investigator  cowley@mcw.edu
Melinda Dwinell, Ph.D. Co-Investigator  mrdwinel@mcw.edu  
Aron Geurts, Ph.D.  Co-Investigator  ageurts@mcw.edu 
Andrew Greene, Ph.D.  Co-Investigator  agreene@mcw.edu 
Jozef Lazar, MD, Ph.D.  Co-Investigator  jlazar@mcw.edu 
Julian Lombard, Ph.D.  Co-Investigator  jlombard@mcw.edu 
David Mattson, Ph.D.  Co-Investigator  dmattson@mcw.edu 
Carol Moreno Quinn, MD, Ph.D.  Co-Investigator  quinn@mcw.edu 
  
The National Heart, Lung, and Blood Institute (NHLBI) has awarded Howard Jacob, PhD and the Medical College of Wisconsin an R24 Resource grant to make ~200 genetically modified rat strains over the next five years. Click here for more information.

Genome view of PhysGen Knockout genes targeted using zinc finger nucleases.  Each targeted gene is represented by a blue bar.  Click on any bar to see a more detailed view. 

Strain Development Progress

Gene 

Symbol 

Allele 

Strain

Received 

Injected

 Hit 

Backcrossing  Intercrossing  In Phenoytping  Data available in PhenoMiner  Strain available for distribution Strain cryopreserved 

Apolipoprotein E 

 Apoe

Apoeem7Mcwi

SS-Apoeem7Mcwi

Yes

Yes

Yes

Yes 

 Yes

 Yes

Yes  Yes No 
Apoe Apoeem8Mcwi SS-Apoeem8Mcwi Yes Yes Yes Yes Yes Yes Yes Yes No

cytochrome P450, family 4, subfamily A, polypeptide 2 

Cyp4a2 Cyp4a2em1Mcwi SS-Chr 5BN-Cyp4a2em1Mcwi

Yes

Yes

 Yes 

Yes 

 Yes  Yes  No Yes  No
cytochrome P450, family 4, subfamily a, polypeptide 3 Cyp4a3 Cyp4a3em3Mcwi SS-Chr 5 BN-Cyp4a3em3Mcwi Yes Yes Yes Yes Yes Yes No Yes Yes

 regulated endocrine-specific protein 18

Resp18

Resp18em2mcwi

SS-Resp18em2Mcwi

Yes

Yes

Yes

 Yes  Yes  No No   Yes Yes
Resp18 Resp18em3Mcwi SS-Resp18em3Mcwi Yes Yes Yes Yes Yes No No Yes Yes

 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)

 Ets1

Ets1em1Mcwi

SS-Ets1em1Mcwi

Yes

Yes

 Yes

 Yes

 Yes

 Yes

 Yes Yes  Yes

nuclear receptor subfamily 2, group F, member 2

Nr2f2

Nr2f2em1Mcwi

SS-Nr2f2em1Mcwi

Yes

Yes

Yes  Yes  Yes No  No  Yes Yes

uromodulin 

 Umod

Umodem1Mcwi

SS-Umodem1Mcwi

Yes

Yes

 Yes  Yes No  No  No  No  No 

 low density lipoprotein receptor

 Ldlr

Ldlrem1Mcwi

SS-Ldlrem1Mcwi

Yes

Yes

 Yes

Yes 

 Yes

 No No Yes Yes 
Ldlr Ldlrem2Mcwi SS-Ldlrem2Mcwi Yes Yes Yes Yes Yes No No No No
Ldlr Ldlrem3Mcwi SS-Ldlrem3Mcwi Yes Yes Yes Yes Yes No No No No
Ldlr Ldlrem4Mcwi SS-Ldlrem4Mcwi Yes Yes Yes Yes Yes No No Yes Yes

SH2B adaptor protein 3 

 Sh2b3

Sh2b3em1Mcwi

SS-Sh2b3em1Mcwi

Yes

Yes

 Yes

Yes 

 Yes

 Yes

Yes Yes Yes 
Sh2b3 Sh2b3em2Mcwi SS-Sh2b3em2Mcwi Yes Yes Yes Yes Yes Yes Yes Yes Yes

 MAS1 oncogene

 Mas1

Mas1em1Mcwi

SS-Mas1em1Mcwi

Yes

Yes

 Yes

Yes 

Yes

 Yes

Yes Yes Yes 

Agouti signaling protein

Asip

Asipem1Mcwi 

ACI.FHH-(D1Mit18-D1Rat90)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/EurMcwi-Asipem1Mcwi

Yes

Yes

Yes

Yes

Yes

Yes

No

Yes 

Yes

sortilin-related VPS10 domain containing receptor 1 

Sorcs1 

Sorcs1em1Mcwi 

FHH-Chr 1BN-Sorcs1em1Mcwi

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes 

Yes

interleukin 1 receptor 1 

Il1r1 

Il1r1em3Mcwi BBDR.BBDP-(D4Mit6-D4Mit7)/RhwMcwi-Il1r1em3Mcwi

Yes

Yes

 Yes

Yes 

 Yes

No

No

No

No

recombinant activating gene 1 

Rag1 

Rag1em1Mcwi 

SS-Rag1em1Mcwi

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes 

Yes

Rag1 Rag1em2Mcwi SS-Rag1em2Mcwi Yes Yes Yes Yes Yes Yes Yes Yes Yes

sortilin-related VPS10 domain containing receptor 3 

Sorcs3 

Sorcs3em1Mcwi

FHH-Chr1BN-Sorcs3em1Mcwi

Yes

Yes

Yes

Yes 

Yes 

 Yes

No

Yes

Yes

Nck-associated protein 5 

Nckap5 

Nckap5em1Mcwi 

SS-Nckap5em1Mcwi

Yes

Yes

Yes

Yes

Yes

Yes

Yes

No

No

Nckap5 Nckap5em2Mcwi SS-Nckap5em2Mcwi Yes Yes Yes Yes Yes Yes Yes Yes Yes
Nckap5 Nckap5em3Mcwi SS-Nckap5em3Mcwi Yes Yes Yes Yes Yes Yes Yes Yes Yes

Associated Ras oncogene family member (Rab38) 

Rab38 

Rab38em1Mcwi 

FHH.BN-Rab38em1Mcwi

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Renin 

Ren 

Renem1Mcwi

SS-Renem1Mcwi

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes 

Yes

natriuretic peptide precursor A

Nppa 

Nppaem4Mcwi

SS-Nppaem4Mcwi

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes 

Yes

acyl-CoA dehydrogenase family, member 10 Acad10 Acad10em2Mcwi SS-Acad10em2Mcwi Yes Yes Yes Yes Yes Yes Yes Yes Yes

angiotensin II receptor-associated protein 

Agtrap 

Agtrapem4Mcwi

SS-Agtrapem4Mcwi

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes 

Agrap Agtrapem8Mcwi SS-Agtrapem8Mcwi Yes Yes Yes Yes Yes Yes Yes Yes Yes

leptin 

Lep 

Lepem5Mcwi

SS-Lepem5Mcwi

Yes

Yes

Yes

 Yes

Yes

No

No

Yes

Yes

potassium inwardly rectifying channel, subfamily J, member 11 

Kcnj11 

Kcnj11em5Mcwi SS-Kcnj11em5Mcwi

Yes

Yes

Yes

Yes

 Yes

No

No

Yes

Yes

natriuretic peptide precursor B 

Nppb 

Nppbem2Mcwi 

SS-Nppbem2Mcwi

Yes

Yes

Yes

Yes 

Yes 

Yes

Yes

 Yes

Yes

Nppb Nppbem4Mcwi SS-Nppbem4Mcwi Yes Yes Yes Yes Yes Yes Yes Yes Yes

aldehyde dehydrogenase 2 family (mitochondrial) 

Aldh2 

Aldh2em2Mcwi 

SS-Aldh2em2Mcwi

Yes

Yes

Yes

Yes 

Yes 

Yes 

Yes

Yes

Yes

peroxisome proliferator-activated receptor gamma

Pparg 

Ppargem1Mcwi SS-Ppargem1Mcwi

Yes

Yes

Yes

Yes

 Yes

No

No

Yes

Yes

hexamthylene bis-acetamide inducible 2 

Hexim2

Hexim2em4Mcwi SS-Hexim2em4Mcwi

Yes

Yes

Yes 

Yes 

Yes 

 Yes

Yes

Yes 

Yes

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 

Prex1 

Prex1em2Mcwi

SS-Prex1em2Mcwi

Yes

Yes

 Yes

Yes 

Yes 

No

No

Yes 

Yes

5,10-methylenetetrahydrofolate reducatase (NADPH) 

Mthfr 

Mthfrem1Mcwi 

SS-Mthfrem1Mcwi

Yes

Yes

Yes

Yes

Yes

Yes 

Yes

Yes 

Yes

serine/threonine kinase 39, STE20/SPS1 homolog (yeast) 

Stk39 

Stke39em2Mcwi

SS-Stk39em2Mcwi

Yes

Yes

Yes

Yes

Yes 

Yes 

Yes

No

No

methionine sulfoxide reductase A 

Msra 

Msraem3Mcwi 

SS-Msraem3Mcwi

Yes

Yes

Yes

Yes

Yes 

Yes 

Yes

Yes 

Yes 

Msra Msraem4Mcwi SS-Msraem4Mcwi Yes Yes Yes Yes Yes Yes Yes Yes Yes

pleckstrin homology domain containing, family A member 7 

Plekha7 

Plekha7em1Mcwi 

SS-Plekha7em1Mcwi

Yes

Yes

Yes

Yes

Yes

Yes 

Yes

Yes 

Yes 

Plekha7 Plekha7em4Mcwi SS-Plekha7em4Mcwi Yes Yes Yes Yes Yes Yes Yes Yes Yes

ATPase, Ca++ transporting, plasma membrane 1 

Atp2b1 

Atp2b1em2Mcwi

SS-Atp2b1em2Mcwi

Yes

Yes

 Yes

 Yes

Yes 

No

No

Yes

Yes

TRAF type zinc finger domain containing 1 

Trafd1 

Trafd1em1Mcwi 

SS-Trafd1em1Mcwi

Yes

Yes

Yes

Yes 

Yes 

No

No

Yes

Yes 

 unc-51-like kinase 3 (C. elegans)

Ulk3 

Ulk3em1Mcwi 

SS-Ulk3em1Mcwi

Yes

Yes

Yes

Yes

Yes

Yes 

Yes

Yes

Yes 

Ulk3 Ulk3em4Mcwi SS-Ulk3em4Mcwi Yes Yes Yes Yes Yes Yes Yes Yes Yes

 solute carrier family 30 (zinc transporter), member 8

Slc30a8 

Slc30a8em1Mcwi 

SS-Slc30a8em1Mcwi

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes 

Slc30a8 Slc30a8em2Mcwi SS-Slc30a8em2Mcwi Yes Yes Yes Yes Yes Yes Yes Yes Yes

 potassium voltage-gated channel, KQT-like subfamily, member 1

Kcnq1 

Kcnq1em14Mcwi 

SS-Kcnq1em14Mcwi

Yes

Yes

Yes

Yes 

Yes 

Yes 

Yes

Yes

Yes 

 cytochrome P450, family 1, subfamily a, polypeptide 1

Cyp1a1 

Cyp1a1em1Mcwi 

SS-Cyp1a1em1Mcwi

Yes

Yes

Yes

Yes 

Yes 

 Yes

Yes

Yes 

Yes

Cyp1a1 Cyp1a1em2Mcwi SS-Cyp1a1em2Mcwi Yes Yes Yes Yes Yes Yes Yes Yes Yes
Cyp1a1 Cyp1a1em5Mcwi SS-Cyp1a1em5Mcwi Yes Yes Yes Yes Yes Yes Yes Yes Yes

 cadherin 13

Cdh13 

Cdh13em1Mcwi

SS-Cdh13em1Mcwi

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

 phospholipase C, delta 3

Plcd3 

Plcd3em4Mcwi 

SS-Plcd3em4Mcwi

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes 

Yes 

Plcd3 Plcd3em7Mcwi SS-Plcd3em7Mcwi Yes Yes Yes Yes Yes Yes Yes Yes Yes

prokineticin receptor 1

Prokr1 

Prokr1em1Mcwi 

SS-Prokr1em1Mcwi

Yes

Yes

Yes

Yes

Yes

 Yes 

Yes

Yes

 Yes

Prokr1 Prokr1em2Mcwi SS-Prokr1em2Mcwi Yes Yes Yes Yes Yes Yes Yes Yes Yes

chloride channel 6 

Clcn6 

Clcn6em2Mcwi 

SS-Clcn6em2Mcwi

Yes

Yes

Yes

Yes

 Yes

Yes 

No

Yes

Yes

 RAS guanyl releasing protein 3 (calcium and DAG-regulated)

Rasgrp3 

Rasgrp3em1Mcwi

SS-Rasgrp3em1Mcwi

Yes

Yes

Yes

Yes

Yes 

 Yes

Yes

Yes 

Yes 

Rasgrp3 Rasgrp3em3Mcwi SS-Rasgrp3em3Mcwi Yes Yes Yes Yes Yes Yes Yes Yes Yes

 unc-51-like kinase 4

Ulk4 

Ulk4em3Mcwi 

SS-Ulk4em3Mcwi

Yes

Yes

Yes

Yes 

Yes 

Yes 

Yes

Yes

Yes 

 integrin, alpha 9

Itga9 

Itga9em1Mcwi 

SS-Itga9em1Mcwi

Yes

Yes

Yes

Yes 

Yes 

Yes 

Yes

Yes

Yes

 protein tyrosine phosphatase, non-receptor type

Ptpn11 

Ptpn11em1Mcwi 

SS-Ptpn11em1Mcwi

Yes

Yes

Yes

Yes

Yes

No

No

Yes

Yes 

Ptpn11 Ptpn11em4Mcwi SS-Ptpn11em4Mcwi Yes Yes Yes Yes Yes No No Yes Yes

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 

Plod1 

 Plod1em1Mcwi

SS-Plod1em1Mcwi

Yes

Yes

Yes

Yes

Yes

Yes 

 Yes

Yes 

Yes

myostatin 

 Mstn

 Mstnem1Mcwi

SS-Mstnem1Mcwi

Yes

Yes

Yes

Yes

Yes

Yes 

 Yes

Yes

Yes 

Mstn Mstnem3Mcwi SS-Mstnem3Mcwi Yes Yes Yes Yes Yes Yes Yes Yes Yes

 transcription factor 7-like 2 (T-cell specific, HMG-box)

 Tcf7l2

 Tcf7l2em1Mcwi

SS-Tcf7l2em1Mcwi

Yes

Yes

Yes

Yes

Yes 

Yes 

 Yes

Yes 

Yes

 angiotensin II receptor, type 1a

 Agtr1a

 Agtr1aem1Mcwi

SS-Agtr1aem1Mcwi  Yes  Yes  Yes  Yes Yes  Yes  Yes Yes  Yes
Agtr1a Agtr1aem5Mcwi SS-Agtr1aem5Mcwi Yes Yes Yes Yes Yes Yes Yes Yes Yes

 cubilin (intrinsic factor-cobalamin receptor)

 Cubn

Cubnem1Mcwi

SS-Cubnem1Mcwi

 Yes

Yes 

Yes  Yes Yes  No No Yes   Yes

 breast carcinoma amplified sequence 3

 Bcas3

 Bcasem4Mcwi SS-Bcasem4Mcwi

 Yes

 Yes Yes  Yes Yes  Yes Yes Yes Yes 

 N-acetyltransferase 8

 Nat8

Nat8em4Mcwi  SS-Nat8em4Mcwi

 Yes

 Yes  Yes  Yes Yes  No No Yes  Yes 

 guanylate cyclase 1, soluble, alpha 3

 Gucy1a3

 Gucy1a3em1Mcwi

SS-Gucy1a3em1Mcwi

 Yes

Yes 

 Yes  Yes  Yes  Yes No No  No 

 WD repeat domain 72

 Wdr72

 Wdr72em1Mcwi

SS-Wdr72em1Mcwi

 Yes

 Yes

Yes   Yes  Yes  Yes Yes Yes Yes
Wdr72 Wdr72em2Mcwi SS-Wdr72em2Mcwi Yes Yes Yes Yes Yes Yes Yes Yes Yes

 Alstrom syndrome 1 homolog (human)

 Alms1

Alms1em1Mcwi

SS-Alms1em1Mcwi

 Yes

 Yes

 Yes  Yes  Yes  Yes Yes Yes  Yes 

 prune homolog (Drosophila)

 Prune

 Pruneem1Mcwi

SS-Pruneem1Mcwi

 Yes

 Yes

Yes   Yes  Yes No No Yes  Yes
Prune Pruneem3Mcwi SS-Pruneem3Mcwi Yes Yes Yes Yes Yes No No Yes Yes

 solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12

 Slc6a12

 Slc6a12em1Mcwi

SS-Slc6a12em1Mcwi

 Yes

Yes 

 Yes  Yes  Yes No No  Yes Yes 

 stanniocalcin 1

 Stc1

 Stc1em2Mcwi

SS-Stc1em2Mcwi

 Yes

 Yes Yes   Yes  Yes  No No  Yes   Yes

 transcription factor Dp-2 (E2F dimerization partner 2)

 Tfdp2

 Tfdp2em2Mcwi

SS-Tfdp2em2Mcwi

 Yes

 Yes Yes   Yes  Yes Yes Yes Yes Yes
Tfdp2 Tfdp2em6Mcwi SS-Tfdp2em6Mcwi Yes Yes Yes Yes Yes No No Yes Yes

 ubiquitin-conjugating enzyme E2Q family member 2

 Ube2q2

 Ube2q2em3Mcwi

SS-Ube2q2em3Mcwi  Yes Yes   Yes  Yes  Yes Yes Yes Yes  Yes 

fibroblast growth factor 5

Fgf5 

 Fgf5em1Mcwi

SS-Fgf5em1Mcwi

 Yes

Yes 

Yes 

 Yes 

 Yes

No

No

Yes

Yes

Fgf5 Fgf5em5Mcwi SS-Fgf5em5Mcwi Yes Yes Yes Yes Yes No No Yes Yes

cystatin C

 Cst3

Cst3em3Mcwi 

SS-Cst3em3Mcwi

 Yes

Yes 

 Yes

Yes 

Yes 

No

No

Yes 

Yes

adiponectin, C1Q and collagen domain containing

Adipoq 

 Adipoqem1Mcwi

SS-Adipoqem1Mcwi

 Yes

 Yes

 Yes

 Yes

Yes

Yes

No

Yes 

Yes

Apipoq Adipoqem2Mcwi SS-Adipoqem2Mcwi Yes Yes Yes Yes Yes Yes No Yes Yes

angiotensin II receptor, type 1b

 Agtr1b


 Yes

 Yes

No

No

No

No

No

No

No

adrenergic receptor, alpha 2a

Adra2a 

 Adra2aem1Mcwi

SS-Adra2aem1Mcwi

 Yes

 Yes

Yes 

Yes 

Yes 

Yes 

Yes 

Yes 

Yes

solute carrier family 7 (cationic amino acid transporter, y+ system), member 9

Slc7a9 

 Slc7a9em2Mcwi

SS-Slc7a9em2Mcwi

 Yes

 Yes

Yes 

Yes

Yes 

No

No

Yes 

Yes

angiotensin I converting enzyme (peptidyl-dipeptidase A) 1

 Ace

Aceem1Mcwi

SS-Aceem1Mcwi

 Yes

 Yes

Yes 

Yes 

Yes

No

No

Yes

Yes

Ace Aceem2Mcwi SS-Aceem2Mcwi Yes Yes Yes Yes Yes No No Yes Yes

solute carrier family 34 (sodium phosphate), member 1

 Slc34a1

 Slc34a1em1Mcwi

SS-Slc34a1em1Mcwi

 Yes

 Yes

Yes

No

No

No

No

No

No

myeloid-associated differentiation marker-like 2

 Myadml2

 Myadml2em1Mcwi

SS-Myadml2em1Mcwi

Yes 

 Yes

Yes 

 Yes

 Yes

No

No

 Yes

Yes 

Myadml2 Myadml2em5Mcwi SS-Myadml2em5Mcwi Yes Yes Yes Yes Yes No No Yes Yes
adducin 2 (beta) Add2  Yes  Yes No  No  No  No No No  No 
branched chain aminotransferase 1, cytosolic Bcat1 Bcat1em2Mcwi SS-Bcat1em2Mcwi  Yes  Yes  Yes Yes  Yes No No Yes  Yes 
calcium channel, voltage-dependent, T type, alpha 1H subunit Cacna1h Cacna1hem2Mcwi SS-Cacna1hem2Mcwi  Yes  Yes  Yes  Yes Yes  No No Yes Yes 
CD247 Cd247 Cd247em1Mcwi SS-Cd247em1Mcwi  Yes  Yes  Yes  Yes Yes  No No  Yes Yes 

Cd247

Cd247em3Mcwi SS-Cd247em3Mcwi Yes Yes Yes Yes Yes No No Yes Yes
Cd247 Cd247em5Mcwi SS-Cd247em5Mcwi Yes Yes Yes Yes Yes No No No No
catechol-O-methyltransferase Comt Comtem1Mcwi SS-Comtem1Mcwi  Yes  Yes Yes   Yes  Yes No No Yes  Yes 
fibroblast growth factor 1 Fgf1 Fgf1em2Mcwi SS-Fgf1em2Mcwi  Yes  Yes  Yes Yes   Yes No No Yes  Yes 
Fyn oncogene related to Src, Fgr, Yes Fyn Fynem6Mcwi SS-Fynem6Mcwi  Yes  Yes  Yes Yes Yes  No No Yes  Yes
guanine nucleotide binding protein (G protein), beta polypeptide 3 Gnb3 Gnb3em1Mcwi SS-Gnb3em1Mcwi  Yes  Yes  Yes  Yes Yes  No No Yes  Yes
glutamate receptor, metabotropic 7 Grm7 Grm7em2Mcwi SS-Grm7em2Mcwi  Yes  Yes  Yes Yes  Yes  No No  Yes  Yes
potassium inwardly-rectifying channel, subfamily J, member 16 Kcnj16 Kcnj16em1Mcwi SS-Kcnj16em1Mcwi  Yes  Yes  Yes Yes   Yes No No  Yes  Yes
lipin 1 Lpin1 Lpin1em1Mcwi SS-Lpinem1Mcwi  Yes  Yes  Yes  Yes Yes No No Yes  Yes 
myosin regulatory light chain interacting protein Mylip Mylipem1Mcwi SS-Mylipem1Mcwi  Yes  Yes  Yes Yes  Yes No No Yes  Yes
Mylip Mylipem2Mcwi SS-Mylipem2Mcwi Yes Yes Yes Yes Yes No No Yes Yes
Mylip Mylipem3Mcwi SS-Mylipem3Mcwi Yes Yes Yes Yes Yes No No Yes Yes
nitric oxide synthase 3, endothelial cell Nos3 Nos3em8Mcwi SS-Nos3em8Mcwi  Yes  Yes Yes  Yes  Yes  No No Yes  Yes
Phosducin Pdc Pdcem2Mcwi SS-Pdcem2Mcwi  Yes  Yes Yes Yes  Yes  No No Yes  Yes 
Pdc Pdcem3Mcwi SS-Pdcem3Mcwi Yes Yes Yes Yes Yes No No Yes Yes
SPARC related molecular calcium binding 2 Smoc2  Yes  Yes No  No  No  No  No No  No 
Sortilin-related VPS10 domain containing receptor 2 Sorcs2 Sorcs2em4Mcwi SS-Sorcs2em4Mcwi  Yes  Yes  Yes Yes Yes No No Yes  Yes 
adenosine A2B receptor Adora2b Adora2bem1Mcwi SS-Adora2bem1Mcwi Yes Yes Yes Yes Yes No No Yes Yes
leptin receptor Lepr Leprem2Mcwi SS-Leprem2Mcwi Yes Yes Yes Yes Yes No No Yes Yes
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) Lss Lssem2Mcwi SS-Lssem2Mcwi Yes Yes Yes Yes Yes No No Yes Yes
ATP-binding cassette, sub-family B (MDR/TAP), member 1B Abcb1b Abcb1bem2Mcwi SS-Abcb1bem2Mcwi Yes Yes Yes Yes Yes No No Yes Yes
potassium large conductance calcium-activated, subfamily M, beta member 1 Kcnmb1 Kcnmb1em3Mcwi SS-Kcnmb1em3Mcwi Yes Yes Yes Yes Yes No No Yes Yes

Last updated 9/12/2012

Funding

This project is funded by the National Heart, Lung and Blood Institute of the NIH (5RC2HL101681-02).