Htr1b (5-hydroxytryptamine receptor 1B) - Rat Genome Database

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Gene: Htr1b (5-hydroxytryptamine receptor 1B) Rattus norvegicus
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Symbol: Htr1b
Name: 5-hydroxytryptamine receptor 1B
RGD ID: 2846
Description: Enables G protein-coupled serotonin receptor activity; heterocyclic compound binding activity; and voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels. Involved in several processes, including drinking behavior; modulation of chemical synaptic transmission; and regulation of amine transport. Is active in calyx of Held. Used to study anxiety disorder. Biomarker of hypertension; ischemia; and obesity. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and substance abuse (multiple). Orthologous to human HTR1B (5-hydroxytryptamine receptor 1B); INTERACTS WITH (+)-pilocarpine; (6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5-HT-1B; 5-HT1B serotonin receptor; 5-hydroxytryptamine (serotonin ) receptor 1B; 5-hydroxytryptamine (serotonin) receptor 1B; 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled; Serotonin (5-hydroxytryptamine (5HT)) receptor type 1B; serotonin receptor 1B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SD  
Candidate Gene For: Alc20
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8891,395,405 - 91,414,815 (-)NCBIGRCr8
mRatBN7.2882,513,572 - 82,534,670 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl882,517,360 - 82,534,549 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx888,140,648 - 88,141,808 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0886,356,378 - 86,357,538 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0884,232,825 - 84,233,985 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0889,113,984 - 89,130,830 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl889,129,453 - 89,130,991 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0888,651,220 - 88,667,993 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4886,700,088 - 86,701,248 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1886,719,542 - 86,720,703 (-)NCBI
Celera882,222,051 - 82,223,211 (-)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
Species
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Reference
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Original Reference(s)
Htr1bRatalcohol dependence sexual_dimorphismISOHTR1B (Homo sapiens)405847401DNA:SNP: :861G>C (human)RGD 
Htr1bRatalcohol dependence susceptibilityISOHTR1B (Homo sapiens)405650694DNA:SNP:promoter:rs11568817 (human) RGD 
Htr1bRatalcohol dependence no_associationISOHTR1B (Homo sapiens)405818273DNA:SNP: :861G>C(human)RGD 
Htr1bRatalcohol dependence onsetISOHTR1B (Homo sapiens)405650698DNA:SNP and haplotype:promoter:161A>T (human)RGD 
Htr1bRatalcohol dependence susceptibilityISOHTR1B (Homo sapiens)405650693DNA:SNP:5'UTR:-161A>T (human)RGD 
Htr1bRatalcohol dependence onsetISOHTR1B (Homo sapiens)405847406 RGD 
Htr1bRatalcohol use disorder sexual_dimorphismISOHTR1B (Homo sapiens)405650695associated with attention deficit hyperactivity disorder and DNA:SNP: :rs11568817(human)RGD 
Htr1bRatalcohol use disorder onsetISOHTR1B (Homo sapiens)405847403DNA:SNP: :rs13212041 (human)RGD 
Htr1bRatalcohol use disorder no_associationISOHTR1B (Homo sapiens)405818272DNA:SNPs: :multiples (human)RGD 
Htr1bRatAnorexia  IEP 1626473associated with Sarcoma and protein:increased expression:hypothalamusRGD 
Htr1bRatantisocial personality disorder susceptibilityISOHTR1B (Homo sapiens)405847402associated with alcohol dependence more ...RGD 
Htr1bRatantisocial personality disorder no_associationISOHTR1B (Homo sapiens)405847405associated with alcohol dependence more ...RGD 
Htr1bRatantisocial personality disorder no_associationISOHTR1B (Homo sapiens)405847404associated with alcohol use disorder more ...RGD 
Htr1bRatanxiety disorder  IDA 625756 RGD 
Htr1bRatattention deficit hyperactivity disorder  ISOHTR1B (Homo sapiens)1358660 RGD 
Htr1bRatconduct disorder  ISOHTR1B (Homo sapiens)1358661associated with AlcoholismRGD 
Htr1bRatDyskinesias  IDA 1626453 RGD 
Htr1bRatgeneralized anxiety disorder sexual_dimorphismISOHTR1B (Homo sapiens)405650695associated with attention deficit hyperactivity disorder more ...RGD 
Htr1bRathypertension  IEP 1626447protein:increased expression:aortaRGD 
Htr1bRatischemia  IEP 1626445mRNA:increased expression:skeletal muscleRGD 
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Htr1bRatamphetamine abuse  ISOHTR1B (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:10780831
Htr1bRatautistic disorder  ISOHTR1B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19038234
Htr1bRatCocaine-Related Disorders  ISOHTR1B (Homo sapiens)11554173CTD more ...CTDPMID:9603521 and PMID:17509084
Htr1bRatHypotension  ISOHTR1B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9109356
Htr1bRatpsychotic disorder  ISOHTR1B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:14708030

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Original Reference(s)
Htr1bRat(+)-pilocarpine multiple interactionsEXP 6480464[cyanopindolol results in decreased activity of HTR1B protein] which results in decreased susceptibility to PilocarpineCTDPMID:2533336
Htr1bRat(6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide affects bindingEXP 6480464Methysergide binds to HTR1B proteinCTDPMID:11888550
Htr1bRat(S)-nicotine multiple interactionsEXP 6480464Nicotine results in increased activity of [HTR1B protein binds to HTR2A protein]CTDPMID:21316381
Htr1bRat1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactionsISOHtr1b (Mus musculus)6480464[2 more ...CTDPMID:25510870
Htr1bRat1,2-dimethylhydrazine multiple interactionsEXP 6480464[APC protein affects the susceptibility to 1 and 2-Dimethylhydrazine] which results in decreased expression of HTR1B mRNACTDPMID:27840820
Htr1bRat1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile decreases expressionEXP 6480464Citalopram results in decreased expression of HTR1B proteinCTDPMID:18157704
Htr1bRat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of HTR1B mRNACTDPMID:30723492
Htr1bRat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of HTR1B mRNACTDPMID:29097150
Htr1bRat17beta-estradiol affects expressionEXP 6480464Estradiol affects the expression of HTR1B mRNACTDPMID:12008023
Htr1bRat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of HTR1B mRNACTDPMID:26945725
Htr1bRat17beta-estradiol multiple interactionsEXP 6480464[Estradiol co-treated with Plant Preparations] results in decreased expression of HTR1B mRNACTDPMID:26945725
Htr1bRat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISOHtr1b (Mus musculus)6480464[2 more ...CTDPMID:25510870
Htr1bRat2,2',5,5'-tetrachlorobiphenyl multiple interactionsISOHtr1b (Mus musculus)6480464[2 more ...CTDPMID:25510870
Htr1bRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOHtr1b (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of HTR1B mRNACTDPMID:21570461 and PMID:24680724
Htr1bRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of HTR1B mRNACTDPMID:33387578
Htr1bRat2,4,4'-trichlorobiphenyl multiple interactionsISOHtr1b (Mus musculus)6480464[2 more ...CTDPMID:25510870
Htr1bRat3',5'-cyclic AMP multiple interactionsISOHTR1B (Homo sapiens)6480464HTR1B affects the reaction [almotriptan inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]CTDPMID:11134654
Htr1bRat4,4'-diaminodiphenylmethane decreases expressionISOHtr1b (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in decreased expression of HTR1B mRNACTDPMID:18648102
Htr1bRat4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline dimaleate affects bindingEXP 6480464CGS 12066B binds to HTR1B proteinCTDPMID:11888550
Htr1bRat4-nitrophenol decreases expressionISOHtr1b (Mus musculus)64804644-nitrophenol results in decreased expression of HTR1B mRNACTDPMID:34673133

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Biological Process
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Htr1bRatadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway acts_upstream_of_or_withinISOHtr1b (Mus musculus)1624291 RGDMGI:64075
Htr1bRatadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway involved_inISOHTR1B (Homo sapiens)1624291 PMID:8882600RGDPMID:8882600
Htr1bRatadenylate cyclase-inhibiting serotonin receptor signaling pathway involved_inISSUniProtKB:P282221600115GO_REF:0000024UniProtGO_REF:0000024
Htr1bRatadenylate cyclase-inhibiting serotonin receptor signaling pathway involved_inIBAPANTHER:PTN008398546 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Htr1bRatadenylate cyclase-inhibiting serotonin receptor signaling pathway involved_inISOHTR1B (Homo sapiens)1624291 PMID:1315531 more ...RGDPMID:1315531 more ...
Htr1bRatbone remodeling involved_inIEAInterPro:IPR0021471600115GO_REF:0000002InterProGO_REF:0000002
Htr1bRatbone remodeling acts_upstream_of_or_withinISOHtr1b (Mus musculus)1624291MGI:1278315 more ...RGDPMID:19041748
Htr1bRatcellular response to alkaloid involved_inISSUniProtKB:P282221600115GO_REF:0000024UniProtGO_REF:0000024
Htr1bRatcellular response to alkaloid involved_inISOHTR1B (Homo sapiens)1624291 PMID:1315531RGDPMID:1315531
Htr1bRatcellular response to xenobiotic stimulus involved_inISSUniProtKB:P282221600115GO_REF:0000024UniProtGO_REF:0000024
Htr1bRatcellular response to xenobiotic stimulus involved_inISOHTR1B (Homo sapiens)1624291 PMID:1315531RGDPMID:1315531
Htr1bRatchemical synaptic transmission  IDA 1358659 RGD 
Htr1bRatchemical synaptic transmission involved_inIEAInterPro:IPR0021471600115GO_REF:0000002InterProGO_REF:0000002
Htr1bRatchemical synaptic transmission involved_inIBAMGI:88398 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Htr1bRatdrinking behavior  IMP 1626464 RGD 
Htr1bRatfeeding behavior  IMP 1626446 RGD 
Htr1bRatG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000276 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Htr1bRatG protein-coupled receptor signaling pathway involved_inIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Htr1bRatG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger involved_inIBAPANTHER:PTN000664111 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Htr1bRatnegative regulation of gamma-aminobutyric acid secretion involved_inIDA 15023474PMID:30217553CACAO 
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Cellular Component
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Original Reference(s)
Htr1bRatcalyx of Held is_active_inEXP 13702319PMID:17067296SynGO 
Htr1bRatcalyx of Held is_active_inIDA 13702319PMID:17067296SynGO 
Htr1bRatcytoplasm located_inISOHtr1b (Mus musculus)1624291 PMID:17325130RGDPMID:17325130
Htr1bRatdendrite is_active_inIBAPANTHER:PTN000664111 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Htr1bRatendoplasmic reticulum located_inISOHTR1B (Homo sapiens)1624291 RGDGO_REF:0000052
Htr1bRatG protein-coupled serotonin receptor complex part_ofISOHtr1b (Mus musculus)1624291 PMID:17325130RGDPMID:17325130
Htr1bRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Htr1bRatmembrane located_inIEAInterPro:IPR000276 and InterPro:IPR0174521600115GO_REF:0000002InterProGO_REF:0000002
Htr1bRatplasma membrane located_inISOHtr1b (Mus musculus)1624291 PMID:17325130RGDPMID:17325130
Htr1bRatplasma membrane located_inIEAInterPro:IPR002147 and InterPro:IPR0022311600115GO_REF:0000002InterProGO_REF:0000002
Htr1bRatplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
Htr1bRatplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
Htr1bRatplasma membrane is_active_inIBAFB:FBgn0000037 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Htr1bRatplasma membrane located_inISOHTR1B (Homo sapiens)1624291 PMID:1315531RGDGO_REF:0000052 and PMID:1315531
Htr1bRatplasma membrane located_inISSUniProtKB:P282221600115GO_REF:0000024UniProtGO_REF:0000024
Htr1bRatplasma membrane is_active_inISOHTR1B (Homo sapiens)1624291 PMID:1652050RGDPMID:1652050
Htr1bRatpresynaptic membrane is_active_inISOHtr1b (Mus musculus)1624291 PMID:10234032RGDPMID:10234032
Htr1bRatserotonergic synapse is_active_inISOHtr1b (Mus musculus)1624291 PMID:10234032RGDPMID:10234032
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Molecular Function
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Htr1bRatG protein-coupled receptor activity enablesIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Htr1bRatG protein-coupled receptor activity enablesIEAInterPro:IPR0002761600115GO_REF:0000002InterProGO_REF:0000002
Htr1bRatG protein-coupled serotonin receptor activity  IDA 1358659 RGD 
Htr1bRatG protein-coupled serotonin receptor activity enablesISOHtr1b (Mus musculus)1624291 PMID:17325130RGDMGI:64075 and PMID:17325130
Htr1bRatG protein-coupled serotonin receptor activity enablesIBAFB:FBgn0004168 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Htr1bRatG protein-coupled serotonin receptor activity enablesIEAInterPro:IPR002147 and InterPro:IPR0022311600115GO_REF:0000002InterProGO_REF:0000002
Htr1bRatG protein-coupled serotonin receptor activity enablesISOHTR1B (Homo sapiens)1624291 PMID:1315531RGDPMID:1315531
Htr1bRatGi/o-coupled serotonin receptor activity enablesISOHTR1B (Homo sapiens)1624291 PMID:1348246 and PMID:29925951RGDPMID:1348246 and PMID:29925951
Htr1bRatheterocyclic compound binding  IDA 1626467Htr1b antagonist SB-616234-ARGD 
Htr1bRatneurotransmitter receptor activity enablesIBAFB:FBgn0000037 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Htr1bRatprotein binding enablesISOHTR1B (Homo sapiens)1624291UniProtKB:P35609 more ...RGDPMID:24722188 more ...
Htr1bRatserotonin binding enablesISOHtr1b (Mus musculus)1624291 PMID:17325130RGDPMID:17325130
Htr1bRatserotonin receptor activity enablesISOHTR1B (Homo sapiens)1624291 PMID:29925951RGDPMID:29925951
Htr1bRatvoltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels enablesEXP 13702319PMID:17067296SynGO 
Htr1bRatvoltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels enablesIDA 13702319PMID:17067296SynGO 
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Htr1bRatabnormal fear/anxiety-related behavior  IDA 625756 RGD 

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#
Reference Title
Reference Citation
1. Analysis of the role of the 5-HT1B receptor in spatial and aversive learning in the rat. Ahlander-Luttgen M, etal., Neuropsychopharmacology 2003 Sep;28(9):1642-55.
2. Prior exposure to chronic stress and MDMA potentiates mesoaccumbens dopamine release mediated by the 5-HT(1B) receptor. Amato JL, etal., Neuropsychopharmacology. 2007 Apr;32(4):946-54. Epub 2006 Aug 2.
3. Neurokinin-1 receptor antagonism in a rat model of subarachnoid hemorrhage: prevention of upregulation of contractile ETB and 5-HT1B receptors and cerebral blood flow reduction. Ansar S, etal., J Neurosurg. 2007 May;106(5):881-6.
4. Upregulation of arterial serotonin 1B and 2B receptors in deoxycorticosterone acetate-salt hypertension. Banes AK and Watts SW, Hypertension. 2002 Feb;39(2 Pt 2):394-8.
5. 5-HT(1B) receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaine. Barot SK, etal., Eur J Neurosci. 2007 May;25(10):3125-31. Epub 2007 May 17.
6. Contribution of 5-hydroxytryptamine1B receptors and 20-hydroxyeiscosatetraenoic acid to fall in cerebral blood flow after subarachnoid hemorrhage. Cambj-Sapunar L, etal., Stroke 2003 May;34(5):1269-75. Epub 2003 Apr 3.
7. Association between the 5-HTR1B gene polymorphisms and alcohol dependence in a Han Chinese population. Cao JX, etal., Brain Res. 2011 Feb 28;1376:1-9. doi: 10.1016/j.brainres.2010.12.039. Epub 2010 Dec 21.
8. Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats. Carta M, etal., Brain. 2007 Jul;130(Pt 7):1819-33. Epub 2007 Apr 23.
9. Different phenotypic and genotypic presentations in alcohol dependence: age at onset matters. Chen YC, etal., J Stud Alcohol Drugs. 2011 Sep;72(5):752-62. doi: 10.15288/jsad.2011.72.752.
10. Ginsenoside Rg1 mitigates morphine dependence via regulation of gut microbiota, tryptophan metabolism, and serotonergic system function. Chen Z, etal., Biomed Pharmacother. 2022 Jun;150:112935. doi: 10.1016/j.biopha.2022.112935. Epub 2022 Apr 18.
11. The effects of long-term adrenalectomy on 5-HT1B receptors mRNA expression in cerebellum, striatum, frontal cortex and hippocampus of rats. Chennaoui M, etal., Neurosci Lett 2003 Apr 10;340(2):131-4.
12. Novel and previously reported single-nucleotide polymorphisms in the human 5-HT(1B) receptor gene: no association with cocaine or alcohol abuse or dependence. Cigler T, etal., Am J Med Genet. 2001 Aug 8;105(6):489-97. doi: 10.1002/ajmg.1473.
13. Overexpression of 5-HT1B receptor in dorsal raphe nucleus using Herpes Simplex Virus gene transfer increases anxiety behavior after inescapable stress. Clark MS, etal., J Neurosci 2002 Jun 1;22(11):4550-62.
14. A haplotype analysis is consistent with the role of functional HTR1B variants in alcohol dependence. Contini V, etal., Drug Alcohol Depend. 2012 Apr 1;122(1-2):100-4. doi: 10.1016/j.drugalcdep.2011.09.020. Epub 2011 Oct 17.
15. CB1 receptors in the paraventricular nucleus of the hypothalamus modulate the release of 5-HT and GABA to stimulate food intake in rats. Cruz-Martínez AM, etal., Eur Neuropsychopharmacol. 2018 Nov;28(11):1247-1259. doi: 10.1016/j.euroneuro.2018.08.002. Epub 2018 Sep 11.
16. The HTR1B 861G>C receptor polymorphism among patients suffering from alcoholism, major depression, anxiety disorders and narcolepsy. Fehr C, etal., Psychiatry Res. 2000 Dec 4;97(1):1-10. doi: 10.1016/s0165-1781(00)00215-8.
17. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
19. Reappraisal of the serotonin 5-HT(1B) receptor gene in alcoholism: of mice and men. Gorwood P, etal., Brain Res Bull. 2002 Jan 1;57(1):103-7. doi: 10.1016/s0361-9230(01)00641-4.
20. Stimulation of the lateral hypothalamus produces antinociception mediated by 5-HT1A, 5-HT1B and 5-HT3 receptors in the rat spinal cord dorsal horn. Holden JE, etal., Neuroscience. 2005;135(4):1255-68. Epub 2005 Sep 13.
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PMID:1315531   PMID:1836757   PMID:8882600   PMID:9349547   PMID:10234032   PMID:12957218   PMID:16310183   PMID:17074068   PMID:17325130   PMID:17873013   PMID:18207350   PMID:18502320  
PMID:18638459   PMID:18793415   PMID:19041748   PMID:19121358   PMID:19556691   PMID:19819310   PMID:19963045   PMID:20226766   PMID:20385119   PMID:20510890   PMID:20833155   PMID:20843634  
PMID:21047499   PMID:21107539   PMID:21653728   PMID:21681557   PMID:21718722   PMID:21801291   PMID:21982809   PMID:22585122   PMID:22659115   PMID:22848635   PMID:22883081   PMID:23155193  
PMID:23583574   PMID:23609771   PMID:23988741   PMID:24269608   PMID:25871906   PMID:26547948   PMID:28720013   PMID:31468338   PMID:32574671   PMID:34061415   PMID:38750961  



Htr1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8891,395,405 - 91,414,815 (-)NCBIGRCr8
mRatBN7.2882,513,572 - 82,534,670 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl882,517,360 - 82,534,549 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx888,140,648 - 88,141,808 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0886,356,378 - 86,357,538 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0884,232,825 - 84,233,985 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0889,113,984 - 89,130,830 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl889,129,453 - 89,130,991 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0888,651,220 - 88,667,993 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4886,700,088 - 86,701,248 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1886,719,542 - 86,720,703 (-)NCBI
Celera882,222,051 - 82,223,211 (-)NCBICelera
Cytogenetic Map8q31NCBI
HTR1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38677,460,924 - 77,463,491 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl677,460,924 - 77,463,491 (-)EnsemblGRCh38hg38GRCh38
GRCh37678,170,641 - 78,173,208 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36678,228,667 - 78,229,839 (-)NCBINCBI36Build 36hg18NCBI36
Build 34678,228,666 - 78,229,839NCBI
Celera678,559,593 - 78,560,765 (-)NCBICelera
Cytogenetic Map6q14.1NCBI
HuRef675,364,405 - 75,365,577 (-)NCBIHuRef
CHM1_1678,338,190 - 78,339,362 (-)NCBICHM1_1
T2T-CHM13v2.0678,638,386 - 78,640,951 (-)NCBIT2T-CHM13v2.0
Htr1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39981,510,344 - 81,515,885 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl981,510,344 - 81,515,881 (-)EnsemblGRCm39 Ensembl
GRCm38981,628,291 - 81,633,832 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl981,628,291 - 81,633,828 (-)EnsemblGRCm38mm10GRCm38
MGSCv37981,524,999 - 81,526,159 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36981,428,110 - 81,429,270 (-)NCBIMGSCv36mm8
Celera978,725,698 - 78,726,858 (-)NCBICelera
Cytogenetic Map9E1NCBI
cM Map944.61NCBI
Htr1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555025,645,644 - 5,646,816 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555025,640,919 - 5,646,899 (-)NCBIChiLan1.0ChiLan1.0
HTR1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2597,481,591 - 97,517,530 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1695,362,194 - 95,398,144 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0675,309,078 - 75,313,747 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1678,594,870 - 78,598,204 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl678,596,408 - 78,597,580 (-)Ensemblpanpan1.1panPan2
HTR1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11238,659,088 - 38,659,546 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1238,541,798 - 38,542,967 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01239,430,205 - 39,431,374 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1239,430,205 - 39,431,374 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11238,755,029 - 38,756,198 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01238,739,892 - 38,741,061 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01238,869,413 - 38,870,583 (-)NCBIUU_Cfam_GSD_1.0
Htr1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494674,024,237 - 74,029,424 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936890155,233 - 156,408 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936890154,252 - 157,044 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTR1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl188,596,237 - 88,601,757 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1188,597,510 - 88,598,682 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2199,465,592 - 99,466,764 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HTR1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1132,143,646 - 2,145,943 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl132,144,313 - 2,145,485 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040178,365,080 - 178,420,109 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Htr1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248194,427,827 - 4,428,999 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248194,425,271 - 4,429,165 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Htr1b
166 total Variants

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:38
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000017411
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 49 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat

1 to 10 of 49 rows
PMC166422P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2882,533,078 - 82,533,410 (+)MAPPERmRatBN7.2
Rnor_6.0889,130,477 - 89,130,808NCBIRnor6.0
Rnor_5.0888,667,644 - 88,667,975UniSTSRnor5.0
RGSC_v3.4886,700,913 - 86,701,244UniSTSRGSC3.4
Celera882,222,876 - 82,223,207UniSTS
Cytogenetic Map8q31UniSTS
GDB:580614  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2882,532,623 - 82,532,824 (+)MAPPERmRatBN7.2
Rnor_6.0889,130,022 - 89,130,222NCBIRnor6.0
Rnor_5.0888,667,189 - 88,667,389UniSTSRnor5.0
RGSC_v3.4886,700,458 - 86,700,658UniSTSRGSC3.4
Celera882,222,421 - 82,222,621UniSTS
Cytogenetic Map8q31UniSTS
UniSTS:491331  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2882,532,198 - 82,533,477 (+)MAPPERmRatBN7.2
Rnor_6.0889,129,597 - 89,130,875NCBIRnor6.0
Rnor_5.0888,666,764 - 88,668,042UniSTSRnor5.0
RGSC_v3.4886,700,033 - 86,701,311UniSTSRGSC3.4
Celera882,221,996 - 82,223,274UniSTS
Cytogenetic Map8q31UniSTS


The following Strains have been annotated to Htr1b
SD    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 46 113 56 55 24 22 24 6 175 91 93 43 60 31



Ensembl Acc Id: ENSRNOT00000017411   ⟹   ENSRNOP00000017411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl882,517,360 - 82,534,549 (-)Ensembl
Rnor_6.0 Ensembl889,129,453 - 89,130,991 (-)Ensembl
RefSeq Acc Id: NM_022225   ⟹   NP_071561
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8891,409,291 - 91,414,815 (-)NCBI
mRatBN7.2882,529,144 - 82,534,670 (-)NCBI
Rnor_6.0889,129,652 - 89,130,812 (-)NCBI
Rnor_5.0888,651,220 - 88,667,993 (-)NCBI
RGSC_v3.4886,700,088 - 86,701,248 (-)RGD
Celera882,222,051 - 82,223,211 (-)RGD
Sequence:
RefSeq Acc Id: XM_063264941   ⟹   XP_063121011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8891,409,291 - 91,414,782 (-)NCBI
RefSeq Acc Id: XR_356450
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8891,395,405 - 91,414,516 (-)NCBI
mRatBN7.2882,513,572 - 82,534,386 (-)NCBI
Rnor_6.0889,113,984 - 89,130,830 (-)NCBI
Rnor_5.0888,651,220 - 88,667,993 (-)NCBI
Sequence:
Protein RefSeqs NP_071561 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121011 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40613 (Get FASTA)   NCBI Sequence Viewer  
  EDL77686 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017411
  ENSRNOP00000017411.1
GenBank Protein P28564 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_071561   ⟸   NM_022225
- UniProtKB: P28564 (UniProtKB/Swiss-Prot),   A6I1P1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017411   ⟸   ENSRNOT00000017411
RefSeq Acc Id: XP_063121011   ⟸   XM_063264941
- Peptide Label: isoform X1
- UniProtKB: P28564 (UniProtKB/Swiss-Prot),   A6I1P1 (UniProtKB/TrEMBL)
G-protein coupled receptors family 1 profile

Name Modeler Protein Id AA Range Protein Structure
AF-P28564-F1-model_v2 AlphaFold P28564 1-386 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 27 of 27 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-29731 BioCyc
Ensembl Genes ENSRNOG00000013042 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017411 ENTREZGENE
  ENSRNOT00000017411.4 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro 5HT1B_rcpt UniProtKB/Swiss-Prot
  5HT_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:25075 UniProtKB/Swiss-Prot
NCBI Gene 25075 ENTREZGENE
PANTHER 5-HYDROXYTRYPTAMINE RECEPTOR 1B UniProtKB/Swiss-Prot
  ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB HTR1B RGD
PhenoGen Htr1b PhenoGen
PRINTS 5HT1BRECEPTR UniProtKB/Swiss-Prot
  5HTRECEPTOR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013042 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt 5HT1B_RAT UniProtKB/Swiss-Prot
  A6I1P1 ENTREZGENE, UniProtKB/TrEMBL
  P28564 ENTREZGENE
1 to 27 of 27 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Htr1b  5-hydroxytryptamine receptor 1B  Htr1b  5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-17 Htr1b  5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled  Htr1b  5-hydroxytryptamine (serotonin) receptor 1B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-07-23 Htr1b  5-hydroxytryptamine (serotonin) receptor 1B      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED
2001-07-23 Htr1b  5-hydroxytryptamine (serotonin ) receptor 1B      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED
2001-07-23 Htr1b  Serotonin (5-hydroxytryptamine (5HT)) receptor, type 1B      Name withdrawn 67952 WITHDRAWN

Note Type Note Reference
gene_disease associated with stress, depression and anxiety behaviors 625756
gene_drugs antidepressants downregulate the receptor activity and normalize serotonergic neurotransmission; fluoxetine or paroxetine acts on a time-dependent and reversible manner resulting in decrease of receptor expression in striatum 625756
gene_expression expressed in the midbrain raphe nuclei and dorsal raphe nucleus (DRN) and serotonergic neurons of brain 625756
gene_mutations_overexpression receptor overexpression in dorsal raphe nucleus mediates pathological response to behavioural disorders such as anxiety and stress 625756
gene_mutations_overexpression overexpression in dorsal raphe nucleus causes an increase in anxiety behavior 625756
gene_process involved in the negative feedback system regulating extracellular serotonin [ 5-HT ] neurotransmission 625756
gene_regulation upregulated in animals during behavior related learning periods and downregulated by antidepressants 625756
gene_regulation activated by subarachnoid hemorrhage 737621