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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-pilocarpine | multiple interactions | ISO | RGD:2846 | 6480464 | [cyanopindolol results in decreased activity of HTR1B protein] which results in decreased susceptibility to Pilocarpine | CTD | PMID:2533336 | (S)-nicotine | multiple interactions | ISO | RGD:2846 | 6480464 | Nicotine results in increased activity of [HTR1B protein binds to HTR2A protein] | CTD | PMID:21316381 | 17beta-estradiol | affects expression | ISO | RGD:2846 | 6480464 | Estradiol affects the expression of HTR1B mRNA | CTD | PMID:12008023 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:10746 | 6480464 | Tetrachlorodibenzodioxin affects the expression of HTR1B mRNA | CTD | PMID:21570461 | 3',5'-cyclic AMP | multiple interactions | EXP | | 6480464 | HTR1B affects the reaction [almotriptan inhibits the reaction [Forskolin results in increased abundance of Cyclic AMP]] | CTD | PMID:11134654 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | RGD:10746 | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of HTR1B mRNA | CTD | PMID:18648102 | 4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline dimaleate | affects binding | ISO | RGD:2846 | 6480464 | CGS 12066B binds to HTR1B protein | CTD | PMID:11888550 | 5-carboxamidotryptamine | affects binding | ISO | RGD:2846 | 6480464 | 5-carboxamidotryptamine binds to HTR1B protein | CTD | PMID:11888550 | almotriptan | multiple interactions | EXP | | 6480464 | HTR1B affects the reaction [almotriptan inhibits the reaction [Forskolin results in increased abundance of Cyclic AMP]] | CTD | PMID:11134654 | ammonium chloride | affects expression | ISO | RGD:2846 | 6480464 | Ammonium Chloride affects the expression of HTR1B mRNA | CTD | PMID:16483693 | amphetamine | increases response to substance | ISO | RGD:2846 | 6480464 | HTR1B protein results in increased susceptibility to Amphetamine | CTD | PMID:19817843 | capsaicin | multiple interactions | ISO | RGD:10746 | 6480464 | HTR1B protein inhibits the reaction [Capsaicin results in increased expression of FOS protein] | CTD | PMID:12110114 | chlorpyrifos | affects expression | ISO | RGD:2846 | 6480464 | Chlorpyrifos affects the expression of HTR1B mRNA | CTD | PMID:18835401 | choline | multiple interactions | ISO | RGD:10746 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HTR1B gene | CTD | PMID:20938992 | citalopram | decreases expression | ISO | RGD:2846 | 6480464 | Citalopram results in decreased expression of HTR1B protein | CTD | PMID:18157704 | cocaine | increases response to substance | ISO | RGD:10746 | 6480464 | HTR1B mutant form results in increased susceptibility to Cocaine | CTD | PMID:9603521 | cocaine | affects activity | ISO | RGD:2846 | 6480464 | Cocaine affects the activity of HTR1B protein | CTD | PMID:17074068 | cocaine | multiple interactions | ISO | RGD:2846 | 6480464 | [3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo(3,2-b)pyrid-5-one binds to and results in increased activity of HTR1B protein] which affects the susceptibility to Cocaine; more ... | CTD | PMID:9822762 | diazinon | increases expression | ISO | RGD:2846 | 6480464 | Diazinon results in increased expression of HTR1B mRNA | CTD | PMID:17452286 | fluoxetine | decreases expression | ISO | RGD:2846 | 6480464 | Fluoxetine results in decreased expression of HTR1B mRNA | CTD | PMID:10861803 | fluoxetine | increases expression | ISO | RGD:2846 | 6480464 | Fluoxetine results in increased expression of HTR1B mRNA | CTD | PMID:10665824 | fluoxetine | decreases expression | ISO | RGD:2846 | 6480464 | Fluoxetine results in decreased expression of HTR1B mRNA | CTD | PMID:10861803 PMID:8914125 | folic acid | multiple interactions | ISO | RGD:10746 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HTR1B gene | CTD | PMID:20938992 | GR 127935 | affects binding | ISO | RGD:2846 | 6480464 | GR 127935 binds to HTR1B protein | CTD | PMID:11888550 | L-methionine | multiple interactions | ISO | RGD:10746 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HTR1B gene | CTD | PMID:20938992 | lead diacetate | decreases expression | ISO | RGD:2846 | 6480464 | lead acetate results in decreased expression of HTR1B mRNA | CTD | PMID:11578147 | metergoline | affects binding | ISO | RGD:2846 | 6480464 | Metergoline binds to HTR1B protein | CTD | PMID:11888550 | methiothepin | affects binding | ISO | RGD:2846 | 6480464 | Methiothepin binds to HTR1B protein | CTD | PMID:11888550 | methysergide | affects binding | ISO | RGD:2846 | 6480464 | Methysergide binds to HTR1B protein | CTD | PMID:11888550 | naratriptan | affects binding | EXP | | 6480464 | naratriptan binds to HTR1B protein | CTD | PMID:9170336 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of HTR1B mRNA | CTD | PMID:22230336 | paraquat | decreases expression | ISO | RGD:2846 | 6480464 | Paraquat results in decreased expression of HTR1B mRNA | CTD | PMID:18198484 | paroxetine | decreases expression | ISO | RGD:2846 | 6480464 | Paroxetine results in decreased expression of HTR1B mRNA | CTD | PMID:10861803 | pindolol | affects binding | ISO | RGD:2846 | 6480464 | Pindolol binds to HTR1B protein | CTD | PMID:11888550 | propranolol | affects binding | ISO | RGD:2846 | 6480464 | Propranolol binds to HTR1B protein | CTD | PMID:11888550 | serotonin | affects binding | ISO | RGD:2846 | 6480464 | Serotonin binds to HTR1B protein | CTD | PMID:11888550 | sumatriptan | multiple interactions | ISO | RGD:2846 | 6480464 | Sumatriptan binds to and results in increased activity of HTR1B protein | CTD | PMID:11301495 | sumatriptan | affects binding | ISO | RGD:2846 | 6480464 | Sumatriptan binds to HTR1B protein | CTD | PMID:11888550 | valproic acid | affects expression | ISO | RGD:10746 | 6480464 | Valproic Acid affects the expression of HTR1B mRNA | CTD | PMID:17292431 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Neuroactive ligand-receptor interaction |
| Serotonergic synapse | |
Phenotype Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Neuroactive ligand-receptor interaction |
| Serotonergic synapse | |
Phenotype Annotations
References - curated| 1. |
Ansar S, etal., J Neurosurg. 2007 May;106(5):881-6. |
| 2. |
Banes AK and Watts SW, Hypertension. 2002 Feb;39(2 Pt 2):394-8. |
| 3. |
Carta M, etal., Brain. 2007 Jul;130(Pt 7):1819-33. Epub 2007 Apr 23. |
| 4. |
GOA_HUMAN data from the GO Consortium |
| 5. |
Holden JE, etal., Neuroscience. 2005;135(4):1255-68. Epub 2005 Sep 13. |
| 6. |
Janiak P, etal., Cardiovasc Res. 2002 Nov;56(2):293-302. |
| 7. |
Keegan A, etal., Circ Res. 2001 Dec 7;89(12):1231-9. |
| 8. |
Makarenko IG, etal., Neurosci Lett. 2005 Mar 11;376(2):71-5. Epub 2004 Dec 8. |
| 9. |
Park S, etal., Brain Res. 1999 Nov 13;847(1):90-7. |
| 10. |
Quist JF, etal., Mol Psychiatry 2003 Jan;8(1):98-102. |
| 11. |
RGD automated import pipeline for gene-chemical interactions |
| 12. |
Soyka M, etal., J Neural Transm 2004 Jan;111(1):101-9. Epub 2003 Dec 3. |
References - uncurated| PubMed | 11104852 |
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RGD Disease Portals| HTR1B has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| HTR1B (Homo sapiens) |
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| Htr1b (Mus musculus) |
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| Htr1b (Rattus norvegicus) |
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Position Markers| GDB:580593 |
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| GDB:580596 |
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| GDB:580599 |
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| GDB:580603 |
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| GDB:603594 |
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| PMC311033P3 |
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| HTR1B_992 |
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| RH47746 |
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| UniSTS:481202 |
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QTLs in Region (Human Genome Assembly GRCh37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_000863 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AB041370 | (Get FASTA) | Search GEO for Microarray Profiles |
| ABBA01040387 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK290080 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK315325 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AL049595 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AMYH01016445 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY225227 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC069065 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC096206 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC096207 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC096208 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH471051 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D10995 | (Get FASTA) | Search GEO for Microarray Profiles | |
| L09732 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M75128 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M81590 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M83180 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_000863 | |||||||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_000854 | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_000854 | (Get FASTA) |
| GenBank Protein | AAA36029 | (Get FASTA) |
| AAA36030 | (Get FASTA) | |
| AAA58675 | (Get FASTA) | |
| AAA60316 | (Get FASTA) | |
| AAH69065 | (Get FASTA) | |
| AAH96206 | (Get FASTA) | |
| AAH96207 | (Get FASTA) | |
| AAH96208 | (Get FASTA) | |
| AAO67712 | (Get FASTA) | |
| BAA01763 | (Get FASTA) | |
| BAA94455 | (Get FASTA) | |
| BAF82769 | (Get FASTA) | |
| BAG37726 | (Get FASTA) | |
| EAW48722 | (Get FASTA) | |
| P28222 | (Get FASTA) |
External Database Links| Database | Acc Id | Source(s) |
| COSMIC | HTR1B | COSMIC |
| Entrez Gene | 3351 | ENTREZGENE |
| Germonline | ENSG00000135312 | |
| HGNC ID | 5287 | ENTREZGENE |
| HomoloGene Group ID | 669 | ENTREZGENE |
| HPRD ID | 01634 | ENTREZGENE |
| InterPro | 5HT1B_rcpt | UniProtKB/Swiss-Prot |
| 5HT_rcpt | UniProtKB/Swiss-Prot | |
| 7TM_GPCR_Rhodpsn | UniProtKB/Swiss-Prot | |
| GPCR_Rhodpsn_supfam | UniProtKB/Swiss-Prot | |
| IPI | IPI00002184 | UniProtKB/Swiss-Prot |
| KEGG Report | hsa:3351 | ENTREZGENE, UniProtKB/Swiss-Prot |
| OMIM | 182131 | OMIM |
| Pfam | 7tm_1 | UniProtKB/Swiss-Prot |
| PharmGKB | HTR1B | RGD, PharmGKB |
| PRINTS | 5HT1BRECEPTR | UniProtKB/Swiss-Prot |
| 5HTRECEPTOR | UniProtKB/Swiss-Prot | |
| GPCRRHODOPSN | UniProtKB/Swiss-Prot | |
| PROSITE | G_PROTEIN_RECEP_F1_1 | UniProtKB/Swiss-Prot |
| G_PROTEIN_RECEP_F1_2 | UniProtKB/Swiss-Prot | |
| UniGene | Hs.123016 | ENTREZGENE |
| UniProt | 5HT1B_HUMAN | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2012-02-14 | HTR1B | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | HTR1B | 5-hydroxytryptamine (serotonin) receptor 1B | Symbol and/or name change | 39860 | APPROVED |
| 2011-08-16 | HTR1B | 5-hydroxytryptamine (serotonin) receptor 1B | HTR1B | 5-hydroxytryptamine (serotonin) receptor 1B | Symbol and/or name change | 39860 | APPROVED |
| 2011-07-27 | HTR1B | 5-hydroxytryptamine (serotonin) receptor 1B | HTR1B | 5-hydroxytryptamine (serotonin) receptor 1B | Symbol and/or name change | 39860 | APPROVED |
| More on HTR1B | |||
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Entrez Gene | ||
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Ensembl Gene | ||
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HGNC Report | ||
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NCBI Map Viewer | ||
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Vista | ||
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Vista + UCSC | ||
| RGD Object Information | |
| RGD ID: | 731005 |
| Created: | 2003-12-10 |
| Species: | Homo sapiens |
| Last Modified: | 2013-03-05 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




