RGD Reference Report - De novo synthesis of pyrimidine nucleotides; emerging interfaces with signal transduction pathways. - Rat Genome Database

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De novo synthesis of pyrimidine nucleotides; emerging interfaces with signal transduction pathways.

Authors: Huang, M  Graves, LM 
Citation: Huang M and Graves LM, Cell Mol Life Sci. 2003 Feb;60(2):321-36.
RGD ID: 5133414
Pubmed: PMID:12678497   (View Abstract at PubMed)

The de novo biosynthesis of pyrimidine nucleotides provides essential precursors for multiple growth-related events in higher eukaryotes. Assembled from ATP, bicarbonate and glutamine, the uracil and cytosine nucleotides are fuel for the synthesis of RNA, DNA, phospholipids, UDP sugars and glycogen. Over the past 2 decades considerable progress has been made in elucidating the mechanisms by which cellular pyrimidines are modulated to meet the needs of the cell. Recent studies demonstrate that CAD, a rate-limiting enzyme in the de novo synthesis of pyrimidines, is regulated through reversible phosphorylation, Myc-dependent transcriptional changes and caspase-mediated degradation. These studies point to increasing evidence for cooperation between key cell signaling pathways and basic elements of cellular metabolism, and suggest that these events have the potential to determine distinct cellular fates, including growth, differentiation and death. This review highlights some of the recent advances in the regulation of pyrimidine synthesis by growth-factor-stimulated signaling pathways.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

Objects Annotated

Genes (Rattus norvegicus)
Cmpk1  (cytidine/uridine monophosphate kinase 1)
Ctps1  (CTP synthase 1)

Genes (Mus musculus)
Cmpk1  (cytidine/uridine monophosphate kinase 1)
Ctps1  (cytidine 5'-triphosphate synthase 1)

Genes (Homo sapiens)
CMPK1  (cytidine/uridine monophosphate kinase 1)
CTPS1  (CTP synthase 1)

Objects referenced in this article
Gene NME1 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens
Gene NME2 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens
Gene Nme1 NME/NM23 nucleoside diphosphate kinase 1 Mus musculus
Gene Nme2 NME/NM23 nucleoside diphosphate kinase 2 Mus musculus
Gene Nme1 NME/NM23 nucleoside diphosphate kinase 1 Rattus norvegicus
Gene Nme2 NME/NM23 nucleoside diphosphate kinase 2 Rattus norvegicus

Additional Information