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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:619877 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of NME2 protein | CTD | PMID:16548065 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1552274 | 6480464 | Tetrachlorodibenzodioxin affects the expression of NME2 mRNA | CTD | PMID:21570461 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | RGD:1552274 | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of NME2 mRNA | CTD | PMID:18648102 | 4-hydroxynon-2-enal | decreases expression | EXP | | 6480464 | 4-hydroxy-2-nonenal results in decreased expression of NME2 mRNA | CTD | PMID:12419474 | 5-aza-2'-deoxycytidine | affects methylation | EXP | | 6480464 | decitabine affects the methylation of NME2 gene | CTD | PMID:17630775 | 5-azacytidine | increases expression | ISO | RGD:619877 | 6480464 | Azacitidine results in increased expression of NME2 protein | CTD | PMID:17105402 | 6-propyl-2-thiouracil | affects expression | ISO | RGD:619877 | 6480464 | Propylthiouracil affects the expression of NME2 mRNA | CTD | PMID:19483382 | amiodarone | affects expression | ISO | RGD:619877 | 6480464 | Amiodarone affects the expression of NME2 mRNA | CTD | PMID:19483382 | ammonium chloride | affects expression | ISO | RGD:619877 | 6480464 | Ammonium Chloride affects the expression of NME2 mRNA | CTD | PMID:16483693 | astaxanthin | multiple interactions | ISO | RGD:1552274 | 6480464 | astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NME2 mRNA] | CTD | PMID:16964424 | benzbromarone | affects expression | ISO | RGD:619877 | 6480464 | Benzbromarone affects the expression of NME2 mRNA | CTD | PMID:19483382 | calcitriol | decreases expression | EXP | | 6480464 | Calcitriol results in decreased expression of NME2 mRNA | CTD | PMID:16847355 PMID:15951637 | calcitriol | decreases expression | EXP | | 6480464 | Calcitriol results in decreased expression of NME2 mRNA | CTD | PMID:15951637 PMID:16847355 | capsaicin | increases expression | EXP | | 6480464 | Capsaicin results in increased expression of NME2 mRNA | CTD | PMID:21310942 | choline | multiple interactions | ISO | RGD:1552274 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NME2 gene | CTD | PMID:20938992 | clofibrate | affects expression | ISO | RGD:619877 | 6480464 | Clofibrate affects the expression of NME2 mRNA | CTD | PMID:19483382 | clofibric acid | multiple interactions | ISO | RGD:619877 | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of NME2 mRNA | CTD | PMID:17602206 | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of NME2 protein | CTD | PMID:19393250 | dibutyl phthalate | decreases expression | ISO | RGD:619877 | 6480464 | Dibutyl Phthalate results in decreased expression of NME2 mRNA | CTD | PMID:21266533 | dichlorine | multiple interactions | ISO | RGD:619877 | 6480464 | [Ozone co-treated with Chlorine] results in decreased expression of NME2 mRNA | CTD | PMID:18636392 | diethylstilbestrol | increases expression | EXP | | 6480464 | Diethylstilbestrol results in increased expression of NME2 mRNA | CTD | PMID:15766595 | disodium selenite | decreases expression | EXP | | 6480464 | Sodium Selenite results in decreased expression of NME2 mRNA | CTD | PMID:16705456 | doxorubicin | decreases expression | ISO | RGD:1552274 | 6480464 | Doxorubicin results in decreased expression of NME2 protein | CTD | PMID:16144979 | folic acid | multiple interactions | ISO | RGD:1552274 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NME2 gene | CTD | PMID:20938992 | hyaluronic acid | multiple interactions | ISO | RGD:619877 | 6480464 | Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of NME2 protein] | CTD | PMID:23178681 | hyaluronic acid | decreases expression | ISO | RGD:619877 | 6480464 | Hyaluronic Acid analog results in decreased expression of NME2 protein | CTD | PMID:23178681 | hydrogen peroxide | multiple interactions | ISO | RGD:619877 | 6480464 | Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of NME2 protein] | CTD | PMID:23178681 | hydrogen peroxide | decreases expression | ISO | RGD:619877 | 6480464 | Hydrogen Peroxide results in decreased expression of NME2 protein | CTD | PMID:23178681 | L-ethionine | affects expression | ISO | RGD:619877 | 6480464 | Ethionine affects the expression of NME2 mRNA | CTD | PMID:19483382 | L-methionine | multiple interactions | ISO | RGD:1552274 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NME2 gene | CTD | PMID:20938992 | lithium atom | increases expression | ISO | RGD:619877 | 6480464 | Lithium results in increased expression of NME2 protein | CTD | PMID:18296634 | mifepristone | multiple interactions | EXP | | 6480464 | Mifepristone inhibits the reaction [Progesterone results in increased expression of NME2 mRNA] | CTD | PMID:15674352 | N-nitrosodiethylamine | increases expression | ISO | RGD:1552274 | 6480464 | Diethylnitrosamine results in increased expression of NME2 protein | CTD | PMID:15928304 | N-nitrosodiethylamine | multiple interactions | ISO | RGD:619877 | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of NME2 mRNA | CTD | PMID:17602206 | omeprazole | affects expression | ISO | RGD:619877 | 6480464 | Omeprazole affects the expression of NME2 mRNA | CTD | PMID:19483382 | ozone | multiple interactions | ISO | RGD:619877 | 6480464 | [Ozone co-treated with Chlorine] results in decreased expression of NME2 mRNA | CTD | PMID:18636392 | paracetamol | affects expression | ISO | RGD:1552274 | 6480464 | Acetaminophen affects the expression of NME2 mRNA | CTD | PMID:17562736 | pirinixic acid | affects expression | ISO | RGD:619877 | 6480464 | pirinixic acid affects the expression of NME2 mRNA | CTD | PMID:19483382 | progesterone | increases expression | EXP | | 6480464 | Progesterone results in increased expression of NME2 mRNA | CTD | PMID:15674352 | progesterone | multiple interactions | EXP | | 6480464 | Mifepristone inhibits the reaction [Progesterone results in increased expression of NME2 mRNA] | CTD | PMID:15674352 | quinoline | increases expression | EXP | | 6480464 | quinoline analog results in increased expression of NME2 protein | CTD | PMID:18645022 | tert-butyl hydroperoxide | decreases expression | EXP | | 6480464 | tert-Butylhydroperoxide results in decreased expression of NME2 mRNA | CTD | PMID:12419474 | thioacetamide | affects expression | ISO | RGD:619877 | 6480464 | Thioacetamide affects the expression of NME2 mRNA | CTD | PMID:19483382 | zinc atom | increases expression | ISO | RGD:619877 | 6480464 | Zinc deficiency results in increased expression of NME2 mRNA | CTD | PMID:11717422 | zinc(0) | increases expression | ISO | RGD:619877 | 6480464 | Zinc deficiency results in increased expression of NME2 mRNA | CTD | PMID:11717422 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Metabolic pathways |
| Purine metabolism | |
| Pyrimidine metabolism | |
| Pathway Interaction Database | Validated targets of C-MYC transcriptional activation (PID:200056) |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Metabolic pathways |
| Purine metabolism | |
| Pyrimidine metabolism | |
| Pathway Interaction Database | Validated targets of C-MYC transcriptional activation (PID:200056) |
References - curated| 1. |
Fukuda M, etal., Int J Cancer. 1996 Feb 8;65(4):531-7. |
| 2. |
GOA_HUMAN data from the GO Consortium |
| 3. |
Huang M and Graves LM, Cell Mol Life Sci. 2003 Feb;60(2):321-36. |
| 4. |
Kanayama H, etal., Int J Urol. 1994 Dec;1(4):324-31. |
| 5. |
Konishi N, etal., Jpn J Cancer Res. 1993 Oct;84(10):1050-4. |
| 6. |
Lacombe ML, etal., J Bioenerg Biomembr. 2000 Jun;32(3):247-58. |
| 7. |
Lutz S, etal., Cardiovasc Res. 2001 Jan;49(1):48-55. |
| 8. |
Mandai M, etal., Cancer Res. 1994 Apr 1;54(7):1825-30. |
| 9. |
Marone M, etal., Br J Cancer. 1996 Oct;74(7):1063-8. |
| 10. |
Murty VV, etal., Oncogene. 1994 Aug;9(8):2245-51. |
| 11. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 12. |
Rayner K, etal., Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R743-50. Epub 2006 Aug 3. |
| 13. |
RGD automated import pipeline for gene-chemical interactions |
| 14. |
Schmidt B, etal., J Urol. 1997 Nov;158(5):2000-5. |
| 15. |
Watanabe J, etal., Br J Cancer. 1995 Dec;72(6):1469-73. |
| 16. |
Wei SJ, etal., J Biol Chem. 2004 Feb 13;279(7):5993-6004. Epub 2003 Nov 17. |
References - uncurated| PubMed | 11042679 |
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RGD Disease Portals| NME2 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| NME2 (Homo sapiens) |
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| Nme2 (Mus musculus) |
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| Nme2 (Rattus norvegicus) |
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Position Markers| RH80623 |
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| G43341 |
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| RH70845 |
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QTLs in Region (Human Genome Assembly GRCh37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001018137 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_001018138 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_001018139 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_001198682 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_002512 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | ABBA01041259 | (Get FASTA) | Search GEO for Microarray Profiles |
| AC005839 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AMYH01008482 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC002476 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC095458 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BE501156 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BF034471 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BF058708 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BM556410 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BT007045 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CA307456 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CB242387 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH471109 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CK023920 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CN267160 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CR541718 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D28391 | (Get FASTA) | Search GEO for Microarray Profiles | |
| DB454073 | (Get FASTA) | Search GEO for Microarray Profiles | |
| L16785 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M36981 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U29200 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X58965 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001018137 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_001018147 | |||||||||||||||||||||||||
| Peptide Label: | isoform a | |||||||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_002512 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_002503 | |||||||||||||||||||||||||
| Peptide Label: | isoform a | |||||||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001198682 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001185611 | ||||||||||||||||||||
| Peptide Label: | isoform b | ||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001018139 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_001018149 | |||||||||||||||||||||||||
| Peptide Label: | isoform a | |||||||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001018138 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_001018148 | |||||||||||||||||||||||||
| Peptide Label: | isoform a | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001018147 | (Get FASTA) |
| NP_001018148 | (Get FASTA) | |
| NP_001018149 | (Get FASTA) | |
| NP_001185611 | (Get FASTA) | |
| NP_002503 | (Get FASTA) | |
| GenBank Protein | AAA36369 | (Get FASTA) |
| AAA60228 | (Get FASTA) | |
| AAA86745 | (Get FASTA) | |
| AAH02476 | (Get FASTA) | |
| AAH95458 | (Get FASTA) | |
| AAP35694 | (Get FASTA) | |
| BAA05757 | (Get FASTA) | |
| CAB37870 | (Get FASTA) | |
| CAG46519 | (Get FASTA) | |
| EAW94564 | (Get FASTA) | |
| EAW94567 | (Get FASTA) | |
| P22392 | (Get FASTA) |
Promoters| RGD ID: | 6794000 | ||||||||||
| Promoter ID: | HG_KWN:26612 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | CD4+TCell, CD4+TCell_12Hour, HeLa_S3, Jurkat, K562, Lymphoblastoid, NB4 | ||||||||||
| Transcripts: | ENST00000393190, ENST00000393191, ENST00000393193, ENST00000393194, OTTHUMT00000268666, OTTHUMT00000268765 | ||||||||||
| Position: |
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| RGD ID: | 6851782 | ||||||||||
| Promoter ID: | EP73695 | ||||||||||
| Type: | initiation region | ||||||||||
| Name: | HS_NME2 | ||||||||||
| Description: | Non-metastatic cells 2, protein (NM23B) expressed in , nucleargene encoding mitochondrial protein. | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Experiment Methods: | NEDO full length human cDNA sequencing project.; Oligo-capping | ||||||||||
| Position: |
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External Database Links| Database | Acc Id | Source(s) |
| COSMIC | NME2 | COSMIC |
| Ensembl Genes | ENSG00000011052 | ENTREZGENE |
| ENSG00000243678 | ENTREZGENE | |
| Ensembl Protein | ENSP00000376886 | ENTREZGENE |
| ENSP00000376894 | ENTREZGENE | |
| ENSP00000426901 | ENTREZGENE | |
| ENSP00000426976 | ENTREZGENE | |
| Ensembl Transcript | ENST00000393190 | ENTREZGENE |
| ENST00000393198 | ENTREZGENE | |
| ENST00000503064 | ENTREZGENE | |
| ENST00000514264 | ENTREZGENE | |
| Entrez Gene | 4831 | ENTREZGENE |
| Gene3D-CATH | NDK | UniProtKB/Swiss-Prot |
| Germonline | ENSG00000011052 | |
| HGNC ID | 7850 | ENTREZGENE |
| HomoloGene Group ID | 39553 | ENTREZGENE |
| HPRD ID | 01132 | ENTREZGENE |
| InterPro | Nucleoside_diP_kinase | UniProtKB/Swiss-Prot |
| Nucleoside_diP_kinase_AS | UniProtKB/Swiss-Prot | |
| IPI | IPI00026260 | UniProtKB/Swiss-Prot |
| IPI00604590 | UniProtKB/TrEMBL | |
| IPI00790856 | UniProtKB/TrEMBL | |
| IPI00795292 | UniProtKB/Swiss-Prot | |
| KEGG Report | hsa:4831 | ENTREZGENE, UniProtKB/Swiss-Prot |
| hsa:654364 | UniProtKB/Swiss-Prot | |
| OMIM | 156491 | OMIM |
| PANTHER | Nuc_diP_kinase_core | UniProtKB/Swiss-Prot |
| Pfam | NDK | UniProtKB/Swiss-Prot |
| PharmGKB | PA250 | PharmGKB |
| PRINTS | NUCDPKINASE | UniProtKB/Swiss-Prot |
| PROSITE | NDP_KINASES | UniProtKB/Swiss-Prot |
| SMART | NDK | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | NDK | UniProtKB/Swiss-Prot |
| UniGene | Hs.463456 | ENTREZGENE |
| UniProt | F6XY72_HUMAN | UniProtKB/TrEMBL |
| J3KPD9_HUMAN | UniProtKB/TrEMBL | |
| NDKB_HUMAN | UniProtKB/Swiss-Prot | |
| Q32Q12_HUMAN | UniProtKB/TrEMBL | |
| Q6FHN3_HUMAN | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2012-05-29 | NME2 | NME/NM23 nucleoside diphosphate kinase 2 | NME2 | non-metastatic cells 2, protein (NM23B) expressed in | Symbol and/or name change | 39860 | APPROVED |
| 2011-08-16 | NME2 | non-metastatic cells 2, protein (NM23B) expressed in | NME2 | non-metastatic cells 2, protein (NM23B) expressed in | Symbol and/or name change | 39860 | APPROVED |
| 2011-07-27 | NME2 | non-metastatic cells 2, protein (NM23B) expressed in | NME2 | non-metastatic cells 2, protein (NM23B) expressed in | Symbol and/or name change | 39860 | APPROVED |
| More on NME2 | |||
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Entrez Gene | ||
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Ensembl Gene | ||
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HGNC Report | ||
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NCBI Map Viewer | ||
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Vista | ||
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Vista + UCSC | ||
| RGD Object Information | |
| RGD ID: | 1346564 |
| Created: | 2005-03-08 |
| Species: | Homo sapiens |
| Last Modified: | 2013-03-05 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




