RGD Reference Report - [Expressions of STAT3, VEGF and C-myc in seminoma and their significance] - Rat Genome Database

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[Expressions of STAT3, VEGF and C-myc in seminoma and their significance]

Authors: Li, W  Li, JJ  Li, GL 
Citation: Li W, etal., Zhonghua Nan Ke Xue. 2009 Jan;15(1):26-30.
RGD ID: 2315467
Pubmed: PMID:19288744   (View Abstract at PubMed)

OBJECTIVE: To understand the role of the JAK/STAT3 signal transduction pathway in the pathogenesis of seminoma by studying the expressions of signal transducers and activators of transcription-3 (STAT3), vascular endothelial growth factor (VEGF) and C-myc in seminoma. METHODS: We examined 38 paraffin specimens of seminoma and 10 samples of normal human testes by immunohistochemical staining using the antibodies of STAT3, VEGF and C-myc, and observed the staining intensity under the light microscope. RESULTS: The positive expression rates of STAT3, VEGF and C-myc were 76.3%, 71.1% and 84.2%, respectively, with statistically significant differences from the corresponding protein expressions in the normal testis tissues (P < 0.01), which gradually increased with the clinical stages of tumor, nodes and metastasis (TNM) classification. Different correlations were observed among the STAT3, VEGF and C-myc proteins in seminoma: STAT3 positively correlated with VEGF (r = 0.640, P < 0.01) and C-myc (r = 0.408, P < 0.05); C-myc positively correlated with VEGF (r = 0.459, P < 0.01). CONCLUSION: The JAK/STAT3 signal transduction pathway can facilitate the development and metastasis of seminoma by activating the expression of VEGF and meanwhile induce the malignant proliferation of primary reproductive cells and promote the pathogenesis and progression of seminoma by activating the expression of C-myc.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
seminoma disease_progressionIEP 2315467protein:increased expression:testisRGD 
seminoma disease_progressionISOVEGFA (Homo sapiens)2315467; 2315467protein:increased expression:testisRGD 

Objects Annotated

Genes (Rattus norvegicus)
Vegfa  (vascular endothelial growth factor A)

Genes (Mus musculus)
Vegfa  (vascular endothelial growth factor A)

Genes (Homo sapiens)
VEGFA  (vascular endothelial growth factor A)


Additional Information