RGD Reference Report - Vascular endothelial growth factor exression in uterine cervical cancer: correlation with clinicopathologic characteristics and survival. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Vascular endothelial growth factor exression in uterine cervical cancer: correlation with clinicopathologic characteristics and survival.

Authors: Goncharuk, IV  Vorobjova, LI  Lukyanova, NY  Chekhun, VF 
Citation: Goncharuk IV, etal., Exp Oncol. 2009 Sep;31(3):179-81.
RGD ID: 2315454
Pubmed: PMID:19783962   (View Abstract at PubMed)

AIM: This retrospective study was performed to determine the vascular endothelial growth factor (VEGF) expression in cervical cancer cells, and to examine its correlation with clinicopathologic characteristics and survival of patients. METHODS: Seventy-five paraffinembedded primary tumors were stained immunohistochemically for VEGF expression, which was analysed semiquantitatively. RESULTS: The significant correlation between VEGF expression and stages of disease, as well as pelvic lymph node metastasis was observed. There were determined a negative correlations between VEGF expression in tumor cells and both overall and disease-free survival. CONCLUSION: VEGF expression in human cervical cancer may be used as a diagnostic parameter in the clinic. Our results are in accordance with literature data showing association of VEGF overexpression in tumor with a poorer patient survival.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Lymphatic Metastasis  IEP 2315454associated with Cervix NeoplasmsRGD 
Lymphatic Metastasis  ISOVEGFA (Homo sapiens)2315454; 2315454associated with Cervix NeoplasmsRGD 
Uterine Cervical Neoplasms disease_progressionIEP 2315454 RGD 
Uterine Cervical Neoplasms disease_progressionISOVEGFA (Homo sapiens)2315454; 2315454 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Vegfa  (vascular endothelial growth factor A)

Genes (Mus musculus)
Vegfa  (vascular endothelial growth factor A)

Genes (Homo sapiens)
VEGFA  (vascular endothelial growth factor A)


Additional Information