RGD Reference Report - Hyperlipidemia, hypercoagulability, and accelerated thrombosis: studies in congenitally hyperlipidemic rats and in rats and monkeys with induced hyperlipidemia.

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Hyperlipidemia, hypercoagulability, and accelerated thrombosis: studies in congenitally hyperlipidemic rats and in rats and monkeys with induced hyperlipidemia.
Authors:	Kim, WM Merskey, C Deming, QB Adel, HN Wolinsky, H Clarkson, TB Lofland, HB
Citation:	Kim WM, etal., Blood. 1976 Feb;47(2):275-86.
RGD ID:	2312323
Pubmed:	PMID:812575 (View Abstract at PubMed)
Inbred Carworth Farms Nelson (CFN) congenitally hyperlipidemic rats had significantly shorter coagulation and prothrombin times and higher levels of coagulation factors, II, V, VII, VIII, and X than did controls. Conversely, congenitally hypolipidemic rats of the same strain had significantly longer coagulation and prothrombin times and lower levels of factors II, V, VII, X and XII and of blood platelets than did controls. A loop-shaped polyethylene cannula was inserted into the aorta to assess the potential for thrombosis. The hyperlipidemic group obstructed this significantly faster and the hypolipidemic group slower than did the controls. Normal CFN rats made hypertensive by unilateral renal artery clip developed hypertension together with significantly elevated serum cholesterol and factor VII and X levels. Rhesus monkeys with diet-induced hyperlipidemia showed shorter prothrombin times and higher factor X levels than did controls on normal diet. By selective breeding, two groups of squirrel monkeys were obtained. Both groups had similar serum cholesterol levels on a normal diet but one group (hyperresponders) showed higher serum cholesterol levels on a cholesterol-containing diet than did the other (hyporesponder) group. Both groups showed significantly elevated levels of factors II, V, VII, IX and X on a cholesterol-containing diet. There was good correlation between the levels of many coagulation factors and serum cholesterol in both rats and monkeys. If thrombosis is important in the genesis of atherosclerosis, these findings could indicate that elevation of plasma lipids may play a role, via the coagulation pathway, in the production of human vascular disease.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
hypertension		IEP		2312323	protein:increased activity:plasma (rat)	RGD
hypertension		ISO	F7 (Rattus norvegicus)	2312323; 2312323	protein:increased activity:plasma (rat)	RGD

Objects Annotated

Genes (Rattus norvegicus)

F7 (coagulation factor VII)

Genes (Mus musculus)

F7 (coagulation factor VII)

Genes (Homo sapiens)

F7 (coagulation factor VII)

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Hyperlipidemia, hypercoagulability, and accelerated thrombosis: studies in congenitally hyperlipidemic rats and in rats and monkeys with induced hyperlipidemia.