F7 (coagulation factor VII (serum prothrombin conversion accelerator))

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Keyword

Gene: F7 (coagulation factor VII (serum prothrombin conversion accelerator)) Homo sapiens

Symbol:

Name:

coagulation factor VII (serum prothrombin conversion accelerator)

Description:

This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

coagulation factor VII; eptacog alfa; FVII coagulation protein; OTTHUMP00000018733; OTTHUMP00000018734; proconvertin; serum prothrombin conversion accelerator; SPCA; SPCA

Orthologs:

Mus musculus : F7 (coagulation factor VII) MGI
Rattus norvegicus : F7 (coagulation factor VII (serum prothrombin conversion accelerator))

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	13	94,698,084 - 94,712,988	+	NCBI
Human Genome Assembly HuRef	13	94,198,534 - 94,213,700	+	NCBI
Human Genome Assembly GRCh37	13	113,760,102 - 113,774,995	+	NCBI
Human Genome Assembly Build 36	13	112,808,106 - 112,822,996	+	NCBI
Human Cytogenetic Map	13	q34		NCBI
Human Genome Assembly	13	112,808,105 - 112,822,346		NCBI